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2021
Abd‐Elmoniem, K. Z., I. A. Yassine, N. S. Metwalli, A. Hamimi, R. Ouwerkerk, J. R. Matta, M. Wessel, M. A. Solomon, J. M. Elinoff, A. M. Ghanem, et al., "Direct pixel to pixel principal strain mapping from tagging MRI using end to end deep convolutional neural network (DeepStrain)", Scientific Reports, vol. 11, pp. 20321, 2021.
Ahmed, L. A., and K. F. Al-Massri, "Directions for Enhancement of the Therapeutic Efficacy of Mesenchymal Stem Cells in Different Neurodegenerative and Cardiovascular Diseases: Current Status and Future Perspectives.", Current stem cell research & therapy, vol. 16, issue 7, pp. 858-876, 2021. Abstract

Mesenchymal stem cells (MSCs) have shown promising therapeutic effects in a wide variety of medical conditions, including neurodegenerative disorders and cardiovascular diseases. Although preliminary research has emphasized the ability of MSCs to engraft at sites of injury, several studies have revealed that MSCs mediate their effects through the release of various paracrine factors and through their antioxidant, anti-inflammatory, immunomodulatory, and anti-apoptotic effects. The clinical implications of MSCs application are limited due to their low survival rate in conditions of inflammation, oxidative stress, and nutrient restriction in damaged areas. Furthermore, the function of isolated MSCs is usually affected by the patient's health. Therefore, it is necessary to develop new methods to enhance the therapeutic efficacy of MSCs under pathophysiological conditions. This review provides an overview of the general properties of MSCs, their therapeutic potential in neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease, as well as cardiovascular diseases such as myocardial infarction, diabetic cardiomyopathy, and dilated cardiomyopathy, and their related mechanisms. In addition, this review also discusses potential problems and side effects, as well as current and future directions for improvement of MSCs therapy and their implications and applications.

Metwally, S., "Disability-Free Life Expectancy at Old Ages in Egypt", Journal of Biosocial Science , vol. 53, issue 2, pp. 290-304, 2021.
Hanafi, M., X. Chen, and N. Neamati, "Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91", Journal of Medicinal Chemistry, vol. 64, issue 3, pp. 1626–1648, 2021.
Mustafa, M., G. E. - D. A. Abuo-Rahma, A. A. Abd El-Hafeez, E. R. Ahmed, D. A. ElHamid, P. Ghosh, and A. M. Hayallah, "Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton.", Bioorganic & medicinal chemistry letters, vol. 40, pp. 127965, 2021. Abstractdiscovery_of_antiproliferative_and_anti-fak_inhibitory_activity_of_124-triazole_derivatives_containing_acetamido_carboxylic_acid_skeleton.pdf

Small molecule inhibitors of the focal adhesion kinase are regarded as promising tools in our armamentarium for treating cancer. Here, we identified four 1,2,4-triazole derivatives that inhibit FAK kinase significantly and evaluated their therapeutic potential. Most tested compounds revealed potent antiproliferative activity in HepG2 and Hep3B liver cancer cells, in which 3c and 3d were the most potent (IC range; 2.88 ~ 4.83 µM). Compound 3d possessed significant FAK inhibitory activity with IC value of 18.10 nM better than the reference GSK-2256098 (IC = 22.14 nM). The preliminary mechanism investigation by Western blot analysis showed that both 3c and 3d repressed FAK phosphorylation comparable to GSK-2256098 in HepG2 cells. As a result of FAK inhibition, 3c and 3d inhibited the pro-survival pathways by decreasing the phosphorylation levels of PI3K, Akt, JNK, and STAT3 proteins. This effect led to apoptosis induction and cell cycle arrest. Taken together, these results indicate that 3d could serve as a potent preclinical candidate for the treatment of cancers.

El-Awady, R. A., E. M. Saleh, R. Hamoudi, and W. S. Ramadan, "Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents", Bioorganic& Medicinal Chemistry, vol. 42, issue 0968-0896, pp. 116251, 2021.
El-Awady, R. A., E. M. Saleh, R. Hamoudi, and W. S. Ramadan, "Discovery of novel class of histone deacetylase inhibitors as potential anticancer agents", Bioorganic& Medicinal Chemistry, vol. 42, issue 0968-0896, pp. 116251, 2021. hdacis.pdf
Robertson, A. W., J. Sandoval, O. G. Mohamed, Y. Zhuang, E. E. Gallagher, J. Schmidt, L. Caratelli, A. Menon, P. J. Schultz, and R. M. Torrez, "Discovery of surfactins as inhibitors of microRNA processing using cat-ELCCA", ACS Medicinal Chemistry Letters, vol. 12, issue 6: American Chemical Society, pp. 878-886, 2021. Abstract
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El-Moeid, A. A., A. H. El-Deeb, A. H. El-Deeb, R. A. Soliman, M. M. EL-Safty, and H. A. Hussein, "Discrepancies in the efficacy of H5 inactivated avian influenza vaccines in specific-pathogen-free chickens against challenge with the Egyptian H5N8 clade 2.3.4.4 Group B virus isolated in 2018", Veterinary World, vol. 14, issue 8, pp. 2131-2141, 2021. amena_article.pdf
Abdel-Gawad, H. I., and A. H. Abdel-gawad, "Discrete and continuum models of COVID-19 virus, formal solutions, stability and comparison with real data", Mathematics and Computers in Simulation, vol. 190, pp. 222-230, 2021.
Yahia, N., H. fawzy, and H. baaqeel, "Discrete Type II Topp Leone Inverted Weibull Distribution: Properties and Estimation", Journal of Computational and Theoretical Nanoscience, vol. 18, issue 6, pp. 1744-1753, 2021. 0011_18ctn06-9733.pdf
Yahia, N., H. fawzy, and H. baaqeel, "Discrete Type II Topp Leone Inverted Weibull Distribution: Properties and Estimation", Journal of Computational and Theoretical Nanoscience, vol. 18, issue 6, pp. 1744-1753, 2021. 0011_18ctn06-9733.pdf
Wahdan, H. G., H. E. Abdelslam, T. H. M. Abou-El-Enien, and S. S. Kassem, "Discretization of Emperor Penguins Colony Algorithms with Application to Modular Product Design", Journal Européen des Systèmes Automatisés , vol. 54, issue 1, pp. 35-44, 2021.
Wahdan, H. G., H. E. Abdelslam, T. H. M. Abou-El-Enien, and S. S. Kassem, "Discretization of Emperor Penguins Colony algorithms with application to modular product design", Journal Européen des Systèmes Automatisés, vol. 54 , issue 1, pp. 35-44, 2021.
OKBA, M. O. N. A. M., P. M. AbdelBaki, A. E. Khaleel, M. M. El-Sherei, and M. A. Salem, "Discrimination of common Iris species from Egypt based on their genetic and metabolic profiling", Phytochemical Analysis, vol. 32, issue 2, pp. 172-182, 2021.
Youssef, F. S., R. M. Labib, A. A. Sleem, and K. M. Meselhy, "Discrimination of Vitis vinifera varieties using DNA fingerprinting and NMR coupled with chemometrics and their impact on the efficacy of fluoxetine and indomethacin in vivo", Journal of Food Processing and Preservation,, vol. 45, issue 6, pp. 1-10(e15500), 2021.
Elhalwagy, M., "Disinfection With Peracetic Acid: Understanding The Impact Of Solids Accumulation And Sunlight Irradiation", 5th International Conference on Ecotechnologies for Wastewater Treatment , Milan, Italy, 2021.
Elhalwagy, M., P. Chowdhury, S. Sarathy, B. Wisdom, and et al, "Disinfection With Peracetic Acid: Understanding The Impact Of Solids Accumulation And Sunlight Irradiation", 5th International Conference on Ecotechnologies for Wastewater Treatment , Milan, Italy, 2021.
Elhalwagy, M., "Disinfection With Peracetic Acid: Understanding The Impact Of Solids Accumulation And Sunlight Irradiation", 5th International Conference on Ecotechnologies for Wastewater Treatment , Milan, Italy, 2021.
Elhalwagy, M., P. Chowdhury, S. Sarathy, B. Wisdom, J. Goldman-Torres, J. McQuarrie, I. Mello, R. Biabani, G. Bertanza, J. Walton, et al., "Disinfection With Peracetic Acid: Understanding The Impact Of Solids Accumulation And Sunlight Irradiation", 5th International Conference on Ecotechnologies for Wastewater Treatment , Milan, Italy, 2021.
Elbadawy, M., A. Soliman, A. Abugomaa, A. Alkhedaide, M. O. H. A. M. E. D. M. O. H. A. M. E. D. SOLIMAN, and M. Aboubakr, "Disposition of Cefquinome in Turkeys (Meleagris gallopavo) Following Intravenous and Intramuscular Administration", pharmaceutics, vol. 13, pp. 1804, 2021. pharmaceutics-13-01804.pdf
El-Mofty, S. E., P.Patra, A. A. El-Midany, and P.Somasundaran, "Dissolved Ca2+ ions adsorption and speciation at calcite-water interfaces: Dissolution and zeta potential studies", Separation and purification technology, vol. 257, 2021.
El-Mofty, S. E., P.Patra, A. A. El-Midany, and P.Somasundaran, "Dissolved Ca2+ ions adsorption and speciation at calcite-water interfaces: Thermodynamics and spectroscopic studies", Separation and purification technology, vol. 257, pp. 117834, 2021.
Ezzat, A. A. M., M. A. R. Soliman, M. Baraka, M. E. Shimy, A. Ezz, and E. E. L. Refaee, "Distant large acute epidural hematoma after closed cerebrospinal fluid tapping through the anterior fontanelle: A case report and its pathogenesis.", Surgical neurology international, vol. 12, pp. 59, 2021. Abstract

Background: Cerebrospinal fluid (CSF) infection is one of the most common and serious complications of shunt placement. The CSF shunt infections are preferably treated with intravenous antibiotics, infected shunt removal, repeated tapping (infants) or placement of an external ventricular drainage (EVD) device, and placement of a new shunt once the CSF is sterile. The tapping through the anterior fontanelle is commonly used instead of the EVD in developing countries to manage CSF infection in open anterior fontanelle patients. To the best of our knowledge, this would be considered the first reported case of distant epidural hematoma after closed ventricular tapping.

Case Description: We report a case of 6-months child with Chiari malformation (Type II) presenting to us with a shunt infection with possible obstruction. CSF was aspirated for examination through a tap through the anterior fontanelle followed by the development of extradural hemorrhage far from the tapping site.

Conclusion: EDH after a transfontanellar ventricular tap can rapidly evolve and lead to patient death. This report raises the awareness of the neurosurgeons to this possible complication that can happen and leads to major complications. Monitoring the conscious level would be needed after ventricular tapping to detect this possible complication.

Ezzat, A. A. M., M. A. R. Soliman, M. Baraka, M. E. Shimy, A. Ezz, and E. E. L. Refaee, "Distant large acute epidural hematoma after closed cerebrospinal fluid tapping through the anterior fontanelle: A case report and its pathogenesis.", Surgical neurology international, vol. 12, pp. 59, 2021. Abstract

BACKGROUND: Cerebrospinal fluid (CSF) infection is one of the most common and serious complications of shunt placement. The CSF shunt infections are preferably treated with intravenous antibiotics, infected shunt removal, repeated tapping (infants) or placement of an external ventricular drainage (EVD) device, and placement of a new shunt once the CSF is sterile. The tapping through the anterior fontanelle is commonly used instead of the EVD in developing countries to manage CSF infection in open anterior fontanelle patients. To the best of our knowledge, this would be considered the first reported case of distant epidural hematoma after closed ventricular tapping.

CASE DESCRIPTION: We report a case of 6-months child with Chiari malformation (Type II) presenting to us with a shunt infection with possible obstruction. CSF was aspirated for examination through a tap through the anterior fontanelle followed by the development of extradural hemorrhage far from the tapping site.

CONCLUSION: EDH after a transfontanellar ventricular tap can rapidly evolve and lead to patient death. This report raises the awareness of the neurosurgeons to this possible complication that can happen and leads to major complications. Monitoring the conscious level would be needed after ventricular tapping to detect this possible complication.

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