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Toulany, M., M. Iida, S. Keinath, F. F. Iyi, K. Mueck, B. Fehrenbacher, W. Y. Mansour, M. Schaller, D. L. Wheeler, and P. H. Rodemann, "Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.", Oncotarget, vol. 7, issue 28, pp. 43746-43761, 2016 Jul 12. Abstract

Despite the significant contribution of radiotherapy to non-small lung cancer (NSCLC), radioresistance still occurs. One of the major radioresistance mechanisms is the hyperactivation of the PI3K/Akt pathway in which Akt facilitates the repair of DNA double-strand breaks (DSBs) through the stimulation of DNA-PKcs. We investigated if targeting PI3K would be a potential approach for enhancing the radiosensitivity of K-RAS mutated (K-RASmut) NSCLC cell lines A549 and H460. Short-term (1-2 h) pre-treatment of cells with the PI3K inhibitor PI-103 (1 μM) inhibited Akt/DNA-PKcs activity, blocked DSBs repair and induced radiosensitivity, while long-term (24 h) pre-treatment did not. Lack of an effect after 24 h of PI-103 pre-treatment was due to reactivation of K-Ras/MEK/ERK-dependent Akt. However, long-term treatment with the combination of PI-103 and MEK inhibitor PD98059 completely blocked reactivation of Akt and impaired DSBs repair through non-homologous end joining (NHEJ) leading to radiosensitization. The effect of PI3K inhibition on Akt signaling was also tested in A549 mouse xenografts. P-Akt and P-DNA-PKcs were inhibited 30 min post-irradiation in xenografts, which were pretreated by PI-103 30 min before irradiation. However, Akt was reactivated 30 min post-irradiation in tumors, which were pre-treated for 3 h with PI-103 before irradiation. After a 24 h pretreatment with PI-103, a significant reactivation of Akt was achieved 24 h after irradiation. Thus, due to MEK/ERK-dependent reactivation of Akt, targeting PI3K alone is not a suitable approach for radiosensitizing K-RASmut NSCLC cells, indicating that dual targeting of PI3K and MEK is an efficient approach to improve radiotherapy outcome.

Toulany, M., M. Iida, S. Keinath, F. F. Iyi, K. Mueck, B. Fehrenbacher, W. Y. Mansour, M. Schaller, D. L. Wheeler, and P. H. Rodemann, "Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.", Oncotarget, vol. 7, issue 28, pp. 43746-43761, 2016 Jul 12. Abstract

Despite the significant contribution of radiotherapy to non-small lung cancer (NSCLC), radioresistance still occurs. One of the major radioresistance mechanisms is the hyperactivation of the PI3K/Akt pathway in which Akt facilitates the repair of DNA double-strand breaks (DSBs) through the stimulation of DNA-PKcs. We investigated if targeting PI3K would be a potential approach for enhancing the radiosensitivity of K-RAS mutated (K-RASmut) NSCLC cell lines A549 and H460. Short-term (1-2 h) pre-treatment of cells with the PI3K inhibitor PI-103 (1 μM) inhibited Akt/DNA-PKcs activity, blocked DSBs repair and induced radiosensitivity, while long-term (24 h) pre-treatment did not. Lack of an effect after 24 h of PI-103 pre-treatment was due to reactivation of K-Ras/MEK/ERK-dependent Akt. However, long-term treatment with the combination of PI-103 and MEK inhibitor PD98059 completely blocked reactivation of Akt and impaired DSBs repair through non-homologous end joining (NHEJ) leading to radiosensitization. The effect of PI3K inhibition on Akt signaling was also tested in A549 mouse xenografts. P-Akt and P-DNA-PKcs were inhibited 30 min post-irradiation in xenografts, which were pretreated by PI-103 30 min before irradiation. However, Akt was reactivated 30 min post-irradiation in tumors, which were pre-treated for 3 h with PI-103 before irradiation. After a 24 h pretreatment with PI-103, a significant reactivation of Akt was achieved 24 h after irradiation. Thus, due to MEK/ERK-dependent reactivation of Akt, targeting PI3K alone is not a suitable approach for radiosensitizing K-RASmut NSCLC cells, indicating that dual targeting of PI3K and MEK is an efficient approach to improve radiotherapy outcome.

Towaij, S. J., M. A. K. Hamid, and A. Mohsen, "Diffraction by an infinite corner reflector transversely loaded by concentric dielectric slabs†", International Journal of Electronics, vol. 33, no. 3: Taylor & Francis, pp. 241–253, 1972. Abstract
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Towaij, S. J., M. A. K. Hamid, and A. Mohsen, "Diffraction by an infinite corner reflector transversely loaded by concentric dielectric slabs†", International Journal of Electronics, vol. 33, no. 3: Taylor & Francis, pp. 241–253, 1972. Abstract
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Towaij, S. J., M. A. K. Hamid, and A. Mohsen, "Diffraction by an infinite corner reflector transversely loaded by concentric dielectric slabs†", International Journal of Electronics, vol. 33, no. 3: Taylor & Francis, pp. 241–253, 1972. Abstract
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Treutter, D., D. Wang, M. A. Farag, G. D. Baires, and M. Neumüller., "Diversity of Phenolic Profiles in the Fruit Skin of Prunus domestica Plums and related species", J Agric Food Chem, vol. 60, issue 48, pp. 12011-12019. , 2012. farag_et_al._2012_journal_of_agric_food_chem.pdf
Tu, R., I. Kamel, A. Wang, B. Abdulhai, and M. Hatzopoulou, "Developing Policy-Sensitive Transportation GHG Emission Inventories: which model resolution and input detail is appropriate?", Proceedings of the 97th Annual Meeting of the Transportation Research Board, Washington D.C., United States, 2018.
Tu, R., I. Kamel, A. Wang, B. Abdulhai, and M. Hatzopoulou, "Development of a hybrid modelling approach for the generation of an urban on-road transportation emission inventory", Transportation Research Part D: Transport and Environment, vol. 62, pp. 604-618, 2018.
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UM, F., S. MM, S. E. NM, E. KA, T. HA, and S. SM, "Diclofenac plus lidocaine gel for pain relief during intrauterine device insertion. A randomized, double-blinded, placebo-controlled study.", Contraception., vol. 93, issue 6, pp. 513-8. , 2016.
undefined, L. HM, M. A, K. AM, and F. N, "Damage index in childhood-onset systemic lupus erythematosus in Egypt.Pediatr Rheumatol ", Pediatr Rheumatology., vol. 9, issue 1, 2011. damage_index_jsle.pdf
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V, N., K. CY, I. SA,, Jouini R, and et al, "Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression", Carcinogenesis, vol. 30(3):397-407, 2009.
Valdebran, M., A. Elbendary, Z. Kolansky, R. Sainai, and E. Blochin, "Desmoplastic trichilemmoma of the scalp", Dermatology online journal, vol. 7, issue 2, pp. 238-239, 2016.
Vartoukian, S. R., W. M. Tilakaratne, N. Seoudi, M. Bombardieri, L. Bergmeier, A. R. Tappuni, and F. Fortune, "Dysregulation of the suppressor of cytokine signalling 3-signal transducer and activator of transcription-3 pathway in the aetiopathogenesis of Sjögren's syndrome.", Clinical and experimental immunology, vol. 177, issue 3, pp. 618-29, 2014 Sep. Abstract

The suppressor of cytokine signalling 3 (SOCS3) negatively regulates the Janus kinase (JAK)/signal transducer and activator of transcription-3 (STAT-3)/interleukin (IL)-17 pathway. The proinflammatory cytokine IL-17 is over-expressed in Sjögren's syndrome (SS) and is a key factor in its pathogenesis. We hypothesized that IL-17 over-expression in SS results from ineffective regulation by SOCS3. The expression of SOCS3 was analysed in peripheral blood mononuclear cells (PBMC) from SS cases, sicca controls (SC) and healthy controls (HC) and tissue samples from SS, SC and healthy salivary glands (HSG). PBMC and salivary gland tissue from SS and controls were dual-immunostained for SOCS3 and IL-17. IL-6-stimulated PBMC from SS and controls were evaluated for time-dependent STAT-3 activation and SOCS3 induction, and for IL-17 expression. Immunoblotting revealed greater levels of SOCS3 in PBMC from SS than SC (P = 0·017) or HC (P < 0·001). Similarly, the proportion of salivary-gland tissue cells staining for SOCS3 was significantly higher in SS than SC (P = 0·029) or HSG (P = 0·021). The cells in PBMC/salivary gland samples from controls predominantly expressed either SOCS3 or IL-17. However, there was a high frequency of SOCS3/IL-17 co-expression within cells of SS samples. IL-6-stimulation of PBMC from SS cases revealed prolonged activation of STAT-3 with reduced negative regulation by SOCS3, and enhanced expression of IL-17. This study showed that SOCS3 expression is up-regulated in SS. However, the absence in SS of the normal inverse relationship between SOCS3 and pSTAT-3/IL-17 indicates a functional disturbance in this signalling cascade. Consequently, a reduction in function, rather than a reduction in expression of SOCS3 accounts for the unregulated expression of IL-17 in SS, and may play a crucial role in aetiopathogenesis.

Vater, J., A. S. Bhagwat, M. A. A. M. SHALLAN, A. Blokesch, and J. Salnikow, "DETECTION OF NEAREST-NEIGHBOR RELATIONSHIPS AMONG THE PROTEIN-COMPONENTS OF THE CYTOCHROME B6/F-COMPLEX FROM SPINACH THYLAKOIDS BY CHEMICAL CROSS-LINKING", PHOTOSYNTHESIS RESEARCH, vol. 34, no. 1: KLUWER ACADEMIC PUBL SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS, pp. 153–153, 1992. Abstract
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van der Velde, R., Z. Su, L. Dente, W. Jun, Y. Ma, K. Yang, and O. A. A. Mohamed, "Dragon soil moisture research on the Tib0etan Plateau : powerpoint.. 1s-24s", Abstract from ESA - MOST Dragon 2 symposium, Prague, Czech Republic, 20-24 June, 2011.
Vilay, M. A., M. Grio, D. D. DePestel, K. M. Sowinski, L. Gao, M. Heung, N. N. Salama, and B. A. Mueller, "Daptomycin Pharmacokinetics in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis", Critical Care Medicine, vol. 39, issue 1, 2011. Abstract

Objective: To investigate daptomycin pharmacokinetics in critically ill patients receiving continuous venovenous hemodialysis to develop dosing recommendations.

Vitale, A., F. Della Casa, G. Ragab, I. A. Almaghlouth, G. Lopalco, R. M. Pereira, S. Guerriero, M. Govoni, P. P. Sfikakis, R. Giacomelli, et al., "Development and implementation of the AIDA International Registry for patients with Behçet’s disease", Internal and Emergency Medicine: Springer Science and Business Media Deutschland GmbH, 2022. AbstractWebsite
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Vitale, A., F. Della Casa, G. Lopalco, R. M. Pereira, P. Ruscitti, R. Giacomelli, G. Ragab, F. La Torre, E. Bartoloni, E. Del Giudice, et al., "Development and Implementation of the AIDA International Registry for Patients With Still's Disease", Frontiers in Medicine, vol. 9: Frontiers Media S.A., 2022. AbstractWebsite
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Vivante, A., O. S. Chacham, S. Shril, R. Schreiber, S. M. Mane, B. Pode-Shakked, N. A. Soliman, I. Koneth, M. Schiffer, Y. Anikster, et al., "Dominant PAX2 mutations may cause steroid-resistant nephrotic syndrome and FSGS in children.", Pediatric nephrology (Berlin, Germany), vol. 34, issue 9, pp. 1607-1613, 2019. Abstract

BACKGROUND: Heterozygous PAX2 mutations cause renal coloboma syndrome (RCS) [OMIM no. 120330]. RCS is a renal syndromic disease encompassing retinal coloboma and sensorineural hearing loss. Recently, a causative role for PAX2 was reported in adult-onset nephrotic syndrome secondary to focal segmental glomerulosclerosis (FSGS). However, the prevalence of PAX2 mutations among large cohort of children with steroid-resistant nephrotic syndrome (SRNS) and FSGS has not been systematically studied.

METHODS: We employed whole-exome sequencing (WES) to identify the percentage of SRNS cases explained by monogenic mutations in known genes of SRNS/FSGS. As PAX2 mutations are not an established cause of childhood FSGS, we evaluated a cohort of 215 unrelated families with SRNS, in whom no underlying genetic etiology had been previously established.

RESULTS: Using WES, we identified 3 novel causative heterozygous PAX2 mutations in 3 out of the 215 unrelated index cases studied (1.3%). All three cases were detected in individuals from families with more than one affected and compatible with an autosomal dominant mode of inheritance (3/57 familial cases studied (5.2%)). The clinical diagnosis in three out of four pediatric index patients was done during routine medical evaluation.

CONCLUSIONS: Our findings demonstrate high frequency of PAX2 mutations in familial form of SRNS (5.2%) and further expand the phenotypic spectrum of PAX2 heterozygous mutations to include autosomal dominant childhood-onset FSGS. These results highlight the importance of including PAX2 in the list of genes known to cause FSGS in children.

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W., A. N., A. N. S., A. M. M, E. - Z. B. A., and T. S. I., "Development and validation of spectrophotometric and high-performance thin-layer chromatographic methods for the determination of folic acid in the presence of its impurities (degradation products)", JPC - Journal of Planar Chromatography - Modern TLC, vol. 31, issue 5, 2018.
W.M.Mostafa, T.S.Sobh, and A.Badr, "A Design of an Immunity System for Detecting Network Anomaly", Al-Azhar Engineering Journal, 2007.
Wade, A. D., R. Beckett, G. Conlogue, G. Garvin, S. Saleem, G. Natale, D. Caramella, and A. Nelson, "Diagnosis by consensus: A case study in the importance of interdisciplinary interpretation of mummified remains.", International journal of paleopathology, vol. 24, issue March, pp. 144-153, 2018 Oct 30, 2019. Abstract

OBJECTIVE: The goal of this study is to demonstrate the need for interdisciplinary consensus and inclusion of mummy radiology specialists in analyses of mummified remains.

MATERIALS: This study uses paleoimaging data for an ancient Egyptian mummy at the Museum of Human Anatomy "Filippo Civinini".

METHODS: This study demonstrates the benefit of evaluation of mummified remains in a multi-disciplinary interpretive team.

RESULTS: The authors propose a diagnosis of DISH, additional signs of undifferentiated spondyloarthropathy, and lumbarisation of S1.

CONCLUSIONS: The process of diagnosis by consensus is essential to the analysis of mummified remains, which are complexly altered through natural and anthropogenic processes in the millennia subsequent to the individual's death.

SIGNIFICANCE: Mummy paleoimaging and paleopathology lacks a unifying set of standards. We present an example of the value to be found in the multi-disciplinary diagnosis by consensus approach.

LIMITATIONS: We discuss numerous challenges to accurate and meaningful interpretation that radiography of mummified remains pose.

SUGGESTIONS FOR FURTHER RESEARCH: While the authors do not seek to impose any single set of standards, we do recommend a larger discussion on the topic of (culture-specific) standardisation in mummy paleoimaging and paleopathology. We further recommend the development of an international, multi-disciplinary panel of paleoimaging interpreters.

Wade, A. D., R. Beckett, G. Conlogue, G. Garvin, S. Saleem, G. Natale, D. Caramella, and A. Nelson, "Diagnosis by consensus: Interpreting mummified pathological conditions", American Journal of Physical Anthropology, vol. 156, pp. 315-316, 2015.
Wael, M. K., and M. G. Husein, "Diagnosis of recurrent pyoderma in dogs by traditional and molecular based diagnostic assays and its therapeutic approach", Journal of American Science, vol. 7, no. 3, pp. 120–134, 2011. Abstract
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