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Youssif, K. A., A. M. Elshamy, M. A. Rabeh, N. Gabr, W. M. Afifi, M. A. Salem, A. Albohy, U. R. Abdelmohsen, and E. G. Haggag, "Cytotoxic Potential of Green Synthesized Silver Nanoparticles of Lampranthus coccineus Extracts, Metabolic Profiling and Molecular Docking Study", ChemistrySelect, vol. 5, pp. 12278– 12286, 2020. anicancer_paper_khayrya-_2020.pdf
Melk, M. M., S. S. E. ‑deen El‑Hawary, F. R. Melek, D. O. Saleh, and N. M. Selim, "Cytotoxic Plumbagin‑5‑O‑α‑l‑Rhamnopyranoside from Plumbago indica", Revista Brasileira de Farmacognosia, vol. 31, pp. 838–841, 2021.
Sabry, O. M. M., D. E. Goeger, F. A. Valeriote, and W. H. Gerwick, "Cytotoxic halogenated monoterpenes from Plocamium cartilagineum", Natural product research, vol. 31, issue 3 , pp. 261-267, 2016. cytotoxic_halogenated_monoterpenes_from_plocamium_cartilagineum.pdf
Sabry, O. M. M., D. E. Goeger, F. A. Valeriote, and W. H. Gerwick, "Cytotoxic halogenated monoterpenes from Plocamium cartilagineum", Natural product research., vol. 31, issue (3), pp. 261-267, 2017. cytotoxic_halogenated_monoterpenes_from_plocamium_cartilagineum.pdf
Farag, M. A., M. I. Fekry, M. A. Al-Hammady, M. N. Khalil, H. R. El-Seedi, A. Meyer, A. Porzel, H. Westphal, and L. A. Wessjohann, "Cytotoxic Effects of Sarcophyton sp. Soft Corals—Is There a Correlation to Their NMR Fingerprints?", Marine drugs, vol. 15, issue 7: Multidisciplinary Digital Publishing Institute, pp. 211, 2017. Abstract
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Farag, M. A., M. I. Fekry, M. A. Al-Hammady, M. N. Khalil, H. R. El-Seedi, A. Meyer, A. Porzel, H. Westphal, and L. A. Wessjohann, "Cytotoxic Effects of Sarcophyton sp. Soft Corals-Is There a Correlation to Their NMR Fingerprints?", Marine drugs, vol. 15, issue 7, 2017 Jul 04. Abstract

sp. soft corals are rich in cembranoid diterpenes, which represent the main chemical defense of corals against their natural predators in addition to their myriad biological effects in humans. Quantitative NMR (qNMR) was applied for assessing the diterpene variation in 16 soft coral specimens in the context of their genotype, origin, and growing habitat. qNMR revealed high diterpene levels insp. compared toand, with (ent)sarcophines as major components (17-100 µg/mg) of the coral tissues. Multivariate data analysis was employed to classify samples based on the quantified level of diterpenes, and compared to the untargeted NMR approach. Results revealed that qNMR provided a stronger classification model ofsp. than untargeted NMR fingerprinting. Additionally, cytotoxicity of soft coral crude extracts was assessed against androgen-dependent prostate cancer cell lines (PC3) and androgen-independent colon cancer cell lines (HT-29), with ICvalues ranging from 10-60 µg/mL. No obvious correlation between the extracts' ICvalues and their diterpene levels was found using either Spearman or Pearson correlations. This suggests that this type of bioactivity may not be easily predicted by NMR metabolomics in soft corals, or is not strongly correlated to measured diterpene levels.

Farag, M. A., M. I. Fekry, A. - H. L.A., M. N. A. Khalil, H. R. El-Sedi, A. Meyer, A. Prozel, H. Westphal, and L. Wessjohan, "Cytotoxic effects of Sarcophyton sp. Soft corals-Is there a correlation to their NMR fingerprints", Marine Drugs, vol. 51, pp. 211-224, 2017.
El-Halawany, A. M., S. M. Osman, and H. M. Abdallah, "Cytotoxic constituents from Vicia monantha subsp. monantha seeds", Natural product research: Taylor & Francis, pp. 1-4, 2018. Abstract
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El-Halawany, A. M., S. M. Osman, and H. M. Abdallah, "Cytotoxic constituents from Vicia monantha subsp. monantha seeds", Natural product research, vol. 33, issue 12: Taylor & Francis, pp. 1783-1786, 2019. Abstract
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Salama, M. M., Z. A. Kandil, and W. T. Islam, "Cytotoxic compounds from the leaves of Gaillardia aristata Pursh. growing in Egypt", Natural Product Research , vol. 26, issue 2, pp. 2057–2062 , 2012. final_published_article.pdf
Abdelhady, M. I. S., and A. A. Motaal, "A cytotoxic C-glycosylated derivative of apigenin from the leaves of Ocimum basilicum var. thyrsiflorum", Revista Brasileira de Farmacognosia, vol. 26 , pp. 763–766, 2016. 1-s2.0-s0102695x16301867-final_ocimum.pdf
Badr-Eldin, S. M., N. A. Alhakamy, U. A. Fahmy, O. A. A. Ahmed, H. Z. Asfour, A. A. Althagafi, H. M. Aldawsari, W. Y. Rizg, W. A. Mahdi, A. F. Alghaith, et al., "Cytotoxic and Pro-Apoptotic Effects of a Sub-Toxic Concentration of Fluvastatin on OVCAR3 Ovarian Cancer Cells After its Optimized Formulation to Melittin Nano-Conjugates.", Frontiers in pharmacology, vol. 11, pp. 642171, 2020. Abstract

Fluvastatin (FLV) is a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor often used to lower total and low-density lipoprotein (LDL) cholesterol and for the prevention of adverse cardiovascular events. This drug as well as melittin (MEL), the major component of honeybee venom (), has shown antineoplastic activity, then representing promising approaches for cancer therapy. However, adverse effects related to the use of FLV and MEL have been reported and very few studies have been carried out to obtain an optimized formulation allowing for combining the two drugs and then maximizing the anticancer activity, then minimizing the needed dosage. In the present study, an optimized formulation in terms of minimized particle size and maximized zeta potential was investigated for its cytotoxic potential in human OVCAR3 ovarian cancer cells. FLV-MEL nano-conjugates, containing a sub-toxic concentration of drug, demonstrated an improved cytotoxic potential (IC50 = 2.5 µM), about 18-fold lower, compared to the free drug (IC50 = 45.7 µM). Cell cycle analysis studies demonstrated the significant inhibition of the OVCAR3 cells proliferation exerted by FLV-MEL nano-conjugates compared to all the other treatments, with a higher percentage of cells accumulating on G2/M and pre-G1 phases, paralleled by lower percentage of cells in G0/G1 and S phases. The synergistic antineoplastic activity of FLV and MEL combined in the optimized formula was also showed by the marked pronecrotic and pro-apoptotic activities, the latter mediated by the modulation of BAX/BCL-2 ratio in favor of BAX. Our optimized FLV-MEL formulation might therefore represents a novel path for the development of specific and more effective antineoplastic drugs directed against ovarian cancer.

Meselhy, K. M., "Cytotoxic and insect-repellent activities of surface flavonoids from Datura stramonium L. Grown in Egypt", Life Sci J, vol. 9, no. 4: Citeseer, pp. 3154–8, 2012. Abstract
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Yehia, S., I. M. Abdel-Salam, B. M. Elgamal, B. El-Agamy, G. M. Hamdy, and H. M. Aldesouki, "Cytotoxic and Apoptotic Effects of Luffa Cylindrica Leaves Extract against Acute Lymphoblastic Leukemic Stem Cells", Asian Pac J Cancer Prev, vol. 21, issue 12, pp. 3661–3668, 2020.
Aboul-Enein, A. M., S. M. M. Shanab, E. A. Shalaby, M. M. Zahran, D. A. Lightfoot, and H. A. Elshemy, "Cytotoxic and antioxidant properties of active principles isolated from water hyacinth against four cancer cell lines", BMC Complementary and Alternative Medicine , vol. 14, issue 1, pp. 397, 2014.
Aboul-Enein, A. M., S. M. M. Shanab, E. A. Shalaby, M. M. Zahran, D. A. Lightfoot, and H. A. EL-SHEMY, "Cytotoxic and antioxidant properties of active principals isolated from water hyacinth against four cancer cells lines", BMC Complementary and Alternative Medicine , vol. 14, pp. 397-408, 2014. Cytotoxic and antioxidant properties of active principals isolated from water hyacinth against four cancer cells lines.pdf
Aboul-Enein, A. M., S. M. M. Shanab, E. A. Shalaby, M. M. Zahran, D. A. Lightfoot, and H. A. EL-SHEMY, "Cytotoxic and antioxidant properties of active principals isolated from water hyacinth against four cancer cells lines", BMC complementary and alternative medicine, vol. 14, no. 1: BioMed Central Ltd, pp. 397, 2014. Abstract
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Aboul-Enein, A. M., S. M. M. Shanab, E. A. Shalaby, M. M. Zahran, D. A. Lightfoot, and H. A. EL-SHEMY, "Cytotoxic and antioxidant properties of active principals isolated from water hyacinth against four cancer cells lines", BMC complementary and alternative medicine, vol. 14, issue 1: BioMed Central, pp. 397, 2014. Abstract
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Shabana, M. M., F. I. Fathy, M. M. Salama, and M. M. Hashem, "Cytotoxic and Antioxidant Activities of the Volatile Constituents of Brassica tournefortii Gouan: Growing in Egypt", Cancer Science & Research, vol. 1(1): 4., pp. 1-4, 2013. volatile_constituents_brassica.pdf
Ghozlan, S. A. S., M. F. Mohamed, A. G. Ahmed, S. A. Shouman, Y. M. Attia, and I. A. Abdelhamid, "Cytotoxic and antimicrobial evaluations of novel apoptotic and anti-angiogenic spiro cyclic 2-oxindole derivatives of 2-amino-tetrahydroquinolin-5-one.", Archiv der Pharmazie, vol. 348, issue 2, pp. 113-24, 2015 Feb. Abstract

A novel series of cyclic 2-oxindole derivatives incorporating 2-amino-tetrahydroquinolin-5-one were prepared. The structures of the prepared compounds were elucidated using different spectral tools. The regio-orientation of the reaction products was elucidated through NOE difference experiments and through using substituents on the ortho position to affect further cyclization. Antitumor and antimicrobial evaluations were performed on the prepared compounds. Most of these compounds exhibited high to moderate antimicrobial activity. With respect to the antitumor activity, the compounds showed more potent cytotoxic effect only toward the human breast cancer cell line MCF-7. Also, we found that derivatives containing an ester group (8c, 11b, 14b, and 15b) are more active than those containing a cyanide group (8a, 11a, 14a, and 15a). Moreover, compounds 15b and 8b are the most active derivatives in this group. These two compounds showed apoptotic inhibition of the proliferation of human breast adenocarcinoma MCF-7 cells through DNA fragmentation, induction of the tumor suppressor protein p53, induction of caspase-9, and finally the inhibition of angiogenesis by decreasing vascular endothelial growth factor expression and secretion.

Ghozlan, S. A. S., M. F. Mohamed, A. G. Ahmed, S. A. Shouman, Y. M. Attia, and I. A. Abdelhamid, "Cytotoxic and Antimicrobial Evaluations of Novel Apoptotic and Anti-Angiogenic Spiro Cyclic 2-Oxindole Derivatives of 2-Amino-tetrahydroquinolin-5-one", Archiv der Pharmazie, vol. 348, no. 2, pp. 113–124, 2015. Abstract
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Ghozlan, S. A. S., M. F. Mohamed, A. G. Ahmed, S. A. Shouman, Y. M. Attia, and I. A. Abdelhamid, "Cytotoxic and antimicrobial evaluations of novel apoptotic and anti-angiogenic spiro cyclic 2-oxindole derivatives of 2-amino-tetrahydroquinolin-5-one", Archiv der Pharmazie, vol. 348, issue 2, pp. 113 - 124, 2015. AbstractWebsite
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Ghozlan, S. A. S., M. F. Mohamed, A. G. Ahmed, Y. M. Attia, S. A. Shouman, and I. A. Abdelhamid, "Cytotoxic and Antimicrobial Evaluations of a Novel Apoptotic and Anti-angiogenic Spiro Cyclic 2-Oxindole Derivatives of 2-amino-tetrahydroquinolin-5-one", Arch. Pharm. Chem. Life Sci., vol. 384, pp. 113-124, 2015.