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Soliman, H. A.K., Goda S. K., E. M. H., and Alatar, A. A., "Cytotoxicity and mutagenic effects of soil radionuclides on some black sand.", Journal of Mediterranean Ecology, vol. 11, pp. 5-20, 2011.
man, M. S. A., A. K. Hegazy, S. K. Goda, M. H. Emam, and A. A. Al-Atar, "Cytotoxicity and mutagenic effects of soil radionuclides on some black sand plant species. ", Journal of Mediterranean Ecology, vol. 11, pp. 5-20, 2011. cytologyprotein_paper.pdf
Soliman, M. S. A., A. K. Hegazy, S. K. Goda, M. H. Emam, and A. A. Al-Atar, "Cytotoxicity and Mutagenic Effects of Soil Radionuclides on Some Black Sand Plant Species", Journal of Mediterranean Ecology, vol. 11, pp. 5-20, 2011. AbstractCU-PDF.pdf

Three plant species (CakilemaritimaScop., Senecioglaucus L. and RumexpictusForssk) were selected from three blacksand habitats along the Mediterranean coast in Egypt for cytogenetic studies and to recognizes the mechanism by whichplants withstand high concentration of the absorbed radionuclides through determination of the electrophoratic bandingpattern of protein and amino acid profiles. The study showed that exposure of the study plant species to soil radionuclidescauses decrease in the percentage of prophase and prophase to metaphase ratio, while the percentage of anaphase and telophaseincreases with soil radioactivity. The results revealed chromosomal aberrations, e.g., C-metaphase, star metaphase,chromosome stickiness at metaphase stage, C-anaphase and chromosomal breaks at the different mitotic stages with fluctuationin the index of mitotic phases. High radionuclide content of plants causes alterations in the bands relative mobility andintensities, expression of new proteins and suppression of some proteins.

Mohamed, R. R., M. A. H. Elella, and M. W. Sabaa, "Cytotoxicity and metal ions removal using antibacterial biodegradablehydrogels based on N-quaternized chitosan/poly(acrylic acid)", International Journal of Biological Macromolecules, vol. 98, pp. 302 - 313, 2017. _9__international_journal_of_biological_macromolecules.pdf
Mohamed, R. R., M. A. H. Elella, and M. W. Sabaa, "Cytotoxicity and metal ions removal using antibacterial biodegradablehydrogels based on N-quaternized chitosan/poly(acrylic acid)", International Journal of Biological Macromolecules, vol. 98, pp. 302-313, 2017. paper__2.pdf
Mohamed, R. R., M. A. H. Elella, and M. W. Sabaa, "Cytotoxicity and metal ions removal using antibacterial biodegradable hydrogels based on N-quaternized chitosan / poly(acrylic acid)", International Journal of Biological Macromolecules,, vol. 98, pp. 302–313, 2017. pagination_biomac_7014.pdf
Monem, A. S., F. A. -zahraa Sayed, M. M. Rageh, and N. Mohamed, "Cytotoxicity and genotoxicity of gold nanorods assisted photothermal therapy against Ehrlich carcinoma in-vivo", Life Sciences, vol. 257, pp. 118108, 2020.
Monem, A. S., F. A. -zahraa Sayed, M. M. Rageh, and N. Mohamed, "Cytotoxicity and genotoxicity of gold nanorods assisted photothermal therapy against Ehrlich carcinoma in-vivo", Life Sciences, vol. 257, issue 118108, 2020.
Morsy, E. A., A. M. Hussien, M. A. Ibrahim, K. Y. Farroh, and E. I. Hassanen, "Cytotoxicity and Genotoxicity of Copper oxide Nanoparticles in chickens", biological trace element research, 2021.
Elmegeed, G. A., W. K. B. Khalil, R. M. Mohareb, H. H. Ahmed, M. M. Abd-Elhalim, and G. H. Elsayed, "Cytotoxicity and Gene Expression Profiles of Novel Synthesized Steroid Derivatives as Chemotherapeutic Anti-Breast Cancer Agents", Bioorganic and Medicinal Chemistry, vol. 19, issue 22, pp. 6860–6872, 2011. CU-PDF.pdf
Elmegeed, G. A., W. K. B. Khalil, R. M. Mohareb, H. H. Ahmed, M. M. Abd-Elhalim, and G. H. Elsayed, "Cytotoxicity and Gene Expression Profiles of Novel Synthesized Steroid Derivatives as Chemotherapeutic Anti-Breast Cancer Agents", Bioorg, & Medicinal Chem., vol. 15, pp. 6860-6872, 2011.
El Sawi, N. M., N. S. Geweely, S. Qusti, M. Mohamed, and A. Kamel, "Cytotoxicity and antimicrobial activity of Nerium oleander extracts", Journal of Applied Animal Research, vol. 37, no. 1: Taylor & Francis, pp. 25–31, 2010. Abstract
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Ali, E. A. M., T. M. A. Abdel-Rahman, and H. A. Ebrahim, "Cytotoxicity and antimicrobial activity of alkaloids extracted from Catharanthus roseus associated endophytic fungi", Malaysian Journal of Microbiology, vol. 15, issue 1, pp. 16-23, 2019.
Mohareb, R. M., N. Y. M. Abdo, and A. A. Mohamed, "Cytotoxicity and Anti-proliferative Properties of Heterocyclic Compounds Derived from Progesterone", Anticancer Agent in Med Chemistry , vol. 16(8), pp. 1043 – 1054, 2016.
El-Hawary, S. S., O. M. Mousa, R. A. El-Fitiany, and R. E. A. Gedaily, "Cytotoxic, antimicrobial activities and phytochemical investigation of three peach cultivars and acerola leaves", Journal of Reports in Pharmaceutical Sciences, vol. 9, issue 2, pp. 221-236, 2020. cytotoxic_antimicrobial_activities_and_phytochemical_investigation_of.pdf
, "Cytotoxic Triterpenes from Diospyros kaki L. cv. Costata (Ebenaceae)", Journal of Pharmacognosy and Phytochemistry, vol. 3, issue 1, pp. 231-234, 2014.
Guindy, N. E. M., H. A. E. A. Ghaffar, R. E. M. Refai, and R. E. E. Hawary, "Cytotoxic T lymphocyte antigen-4 gene polymorphism in systemic lupus erythematosus Egyptian patients", Comparative Clinical Pathology, vol. 24, issue 1, pp. 41-45, 2015.
Guindy, N. E. M., H. A. E. A. Ghaffar, R. E. M. Refai, and R. E. E. Hawary, "Cytotoxic T lymphocyte antigen-4 gene polymorphism in systemic lupus erythematosus Egyptian patients", Comparative Clinical Pathology, vol. 24, issue 1, pp. 41-45, 2015. Abstract

The human cytotoxic T lymphocyte antigen-4 (CTLA-4) gene has been confirmed to be associated with several autoimmune diseases. In this study, we investigated the CTLA-4 gene polymorphism in systemic lupus erythematosus (SLE) Egyptian patients. A polymerase chain reaction was conducted to amplify CTLA-4 gene, followed by restriction fragment length polymorphism (RFLP) assay to detect candidate genetic polymorphism at positions -1722 T/C and -1661 A/G. Sixty SLE patients (55 females and 5 males) with mean age 28.5 ± 7 years and 40 healthy controls (31 females and 9 males) with mean age 27.8 ± 6.2 years were included in this study. The genotypic distribution at position -1661 of CTLA-4 gene was GG (11.7 %), AA (70 %), and AG (18.3 %) in SLE patients versus GG (20 %), AA (65 %), and AG (15 %) in the control (P value 0.508); regarding the position -1772 of CTLA-4 gene, the distribution was TT (83.3 %) and TC (16.7 %) in SLE patients versus TT (77.5 %) and TC (22.5 %) in the controls (P value 0.466). On studying the clinicopathological impact of the studied single nucleotide polymorphism (SNPs) with the disease severity, there is a statistical significance (P = 0.011) for the presence of AA genotype and severity of disease at -1661 genotype. AA genotype at -1661 was protective against discoid rash (P = 0.005), TC genotype at -1772 site is protective against serositis (P = 0.05), and serositis occurs more commonly with the AG genotype at -1661 site (P = 0.038). In our study, we concluded that the studied SNPs at positions -1772 and -1661 of CTLA-4 gene were not associated with SLE risk in Egyptian population.

Guindy, N. M.  E., H. A.  A. E. Ghaffar, R. M.  E. Refai, and R. E.  E. Hawary, "Cytotoxic T lymphocyte antigen-4 gene polymorphism in systemic lupus erythematosus Egyptian patients", comparative clinical pathology, vol. 22, issue 1618-5641, 2013.
Yousif, M. F., H. H. Eid, and S. M. Ezzat, "Cytotoxic Sterols and Triterpenes from Ficus binnendijkii (Miq.) Miq Cultivated in Egypt.", Egyptian Journal of Biomedical Sciences, vol. 29, no. March, pp. 241–248, 2009. Abstract

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Mahmoud, A. M., and H. A. El-Shemy, "Cytotoxic profiling of some compounds of nat-ural origin against HepG2 liver cancer cell line in-vitro", J Arid Land Stud, vol. 22, issue 1, pp. 191-4, 2012. Abstract
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Kandil, A. S., F. Abou-Elella, and H. A. El Shemy, "Cytotoxic profile activities of ethanolic and methanolic extracts of chicory plant (Cichorium intybus L.)", Journal of Radiation Research and Applied SciencesJournal of Radiation Research and Applied Sciences, vol. 12, issue 1: Taylor & Francis, pp. 106 - 111, 2019. AbstractWebsite

ABSTRACTThis study aims to highlight the antioxidant and cytotoxic effects of Cichorium intybus L.. The cytotoxic activity for cancer cell lines was evaluated by MTT assay. Total phenol and flavonoid content were examined using chemical analysis methodology. The highest content of phenols and flavonoids have occurred in the methanolic extract (1162.29 ± 103.4 µg.g?1 GAE D.W, 167.47 ± 5.83 µg QE.g?1 D.W), respectively, followed by ethanolic extract (153.83 ± 10.25 µg GAE.g`1 D.W, 36.56 ± 5.95 µgQE.g?1 D.W), respectively. The cytotoxic effect of methanolic extract on MCF-7 cell line was achieved at 500 µg.mL?1. The results showed that methanolic extract possessed potent cytotoxic activity while ethanol extract possessed antioxidant activity. In conclusion, natural plant extract might be prevent and working as a defense by enhancing the immune system against cancer.

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