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Ivanova, E. A., M. A. Elmonem, I. Bongaerts, T. Luyten, L. Missiaen, L. P. van den Heuvel, E. N. Levtchenko, and G. Bultynck, "Ca(2+) signalling in human proximal tubular epithelial cells deficient for cystinosin.", Cell calcium, vol. 60, issue 4, pp. 282-7, 2016 Oct. Abstract

Nephropathic cystinosis is an autosomal recessive lysosomal storage disorder caused by loss-of-function mutations in the CTNS gene coding for the lysosomal cystine transporter, cystinosin. Recent studies have demonstrated that, apart from cystine accumulation in the lysosomes, cystinosin-deficient cells, especially renal proximal tubular epithelial cells are characterized by abnormal vesicle trafficking and endocytosis, possible lysosomal dysfunction and perturbed intracellular signalling cascades. It is therefore possible that Ca(2+) signalling is disturbed in cystinosis, as it has been demonstrated for other disorders associated with lysosomal dysfunction, such as Gaucher, Niemann-Pick type C and Alzheimer's diseases. In this study we investigated ATP-induced, IP3-induced and lysosomal Ca(2+) release in human proximal tubular epithelial cells derived from control and cystinotic patients. No major dysregulation of intracellular Ca(2+) dynamics was found, although ATP-induced Ca(2+) release appeared slightly sensitized in cystinotic cells compared to control cells. Hence, these subtle changes in Ca(2+) signals elicited by agonists may contribute to the pathogenesis of the disease.

Elkordy, A. R., A. S. Motahari, M. Nafie, and D. Gündüz, "Cache-Aided Combination Networks With Interference", IEEE Transactions on Wireless Communications, vol. 19, no. 1, pp. 148-161, 2020. Abstract
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Hanna, O. A., M. Nafie, and A. El-Keyi, "Cache-Aware Source Coding", IEEE Communications Letters, vol. 22, no. 6, pp. 1144-1147, June, 2018. Abstract
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Metwalli, S. M., H. A. Hegazi, and U. M. Abdel-Aal, "CAD of Disc Brakes by Multi-Objective Optimization", Proceedings of the 1999 ASME Design Engineering Technical Conference, Las Vegas, Nevada, 1999. Abstract
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Hossamel-deen, Y. H., S. M. Metwalli, and H. S. Abdel-hamed, "A CAD PROGRAM FOR OPTIMUM NONLINEAR CHARACTERISTICS OF A VEHICLE SHOCK ABSORBER", Computers in engineering, vol. 1: American Society of Mechanical Engineers, pp. 287, 1989. Abstract
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Soliman, N. S., M. E. Fouda, L. A. Said, A. G. Alharbi, A. H. Madian, and A. G. Radwan, "CAD Tool for Two-Digit Ternary Functions Design", 2019 Novel Intelligent and Leading Emerging Sciences Conference (NILES), vol. 1: IEEE, pp. 1–4, 2019. Abstract
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Soliman, N. S., M. E. Fouda, L. A. Said, A. G. Alharbi, A. H. Madian, and A. G. Radwan, "CAD Tool for Two-Digit Ternary Functions Design", 2019 Novel Intelligent and Leading Emerging Sciences Conference (NILES), vol. 1: IEEE, pp. 1-4, 2019. Abstract
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Osman, H. M., and others, "CAD-Based dynamic layout planning of construction sites using genetic algorithms", Faculty of Engineering. Cairo, Cairo University, vol. 129, 2002. Abstract
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Akın, O., "CAD/GIS Integration", CAD and GIS Integration, vol. 51, 2010. Abstract
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:, M. S., D. M. ELAbd, F. E. Shanawani, M. F. Moghazy, E. A. Abdallah, H. Darwish, A. Metwaly, and A. A. A. Hadi, "Cadherin 5 and Annexin V as Circulating Endothelial Microparticles: Markers for Atherosclerotic Vascular Lesions in Patients with Chronic Renal Failure", Kidney, 2010. 10_cadherin_5_and_annexin_v_paper.pdf
ElGhamrawy, T. A., D. Helmy, and H. F. A. Elall, "Cadherin and vimentin immunoexpression in the testis of normal and induced infertility models of albino rats.", Folia morphologica, vol. 73, issue 3, pp. 339-46, 2014. Abstract

BACKGROUND: Sertoli cells are important in determining the fate of spermatogenic cells by providing nutrition and structural support via cell junctions. Adhesion between Sertoli and germ cells is important for spermatogenesis. Cadherin are transmembrane proteins that mediate cell-cell adhesion, while, vimentin, the cytoskeletal intermediate filament plays an important role in spermatogenesis. The aim of the present study was to investigate cadherin and vimentin immunoexpression in the normal testis and in two types of altered spermatogenic states: the cyclophosphamide (CP) treatment and the cryptorchidism (Cx) models.

MATERIALS AND METHODS: Twenty four male albino rats were divided into control group: 6 rats receiving saline orally and the other 6 were sham-operated. CP group (n = 6): given 6 mg/kg/day of CP orally for 4 weeks. Cx group (n = 6): the left testis was surgically freed from the scrotum and fixed in the abdomen. Animals were sacrificed and the left testis dissected and prepared to be stained with haematoxylin and eosin stain and immunohistochemical stain against cadherin and vimentin. Morphometric measurements and statistical analysis were done.

RESULTS: In CP-treated group there was degeneration of spermatocytes, vacuolations of Sertoli cells and absence of spermatozoa. These changes were more prominent in Cx group, in addition to interstitial hypercellularity. There was alsoa significant decrease in cadherin and vimentin immunostaining in CP-treated group that was more marked in the cryptorchidism group.

CONCLUSIONS: A downregulation of both cadherin and vimentin was associated with both models of impaired spermatogenesis. This impairment could be attributed to disruption of the junctions between Sertoli and germ cells.

Moussaa, T. A. A., M. M. S. Eldinc, and A. Alkaldia, "Cadmium (II) ions removal using dried banana bunch powder: experimental, kinetics, and equilibria", Desal. Water Treat., vol. 226: DESALINATION PUBL 36 WALCOTT VALLEY DRIVE,, HOPKINTON, MA 01748 USA, pp. 263 - 275, 2021. Abstract

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Refae, R. I., "Cadmium accumulation by microbial consortium known in Egypt as "Samakat El-Sheffa"", J. Agric. Sci. Mansoura Univ., vol. 25, issue 10, pp. 6439-6450, 2000.
Chaudri, A. M., C. M. G. Allain, S. H. Badawy, M. L. Adams, S. P. McGrath, and B. J. Chambers, "Cadmium content of wheat grain from a long-term field experiment with sewage sludge", Journal of environmental quality, vol. 30, issue 5: American Society of Agronomy, Crop Science Society of America, Soil Science Society, pp. 1575-1580, 2001. Abstract
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LM, S., A. ER, G. AF, S. HS, U. DM, A. MA, K. NM, S. MA, and G. W, Cadmium status among pediatric cancer patients in Egypt., , 2015. cad_1.pdf
El-Beltagi, H. S., A. A. Mohamed, and M. M. Rashed, "CADMIUM STRESS INDUCED CHANGE IN SOME HYDROLYTIC ENZYMES, FREE RADICAL FORMATION AND ULTRASTRUCTURAL DISORDERS IN RADISH PLANT", EJEAFChe., vol. 8, issue 10, pp. 969-983, 2009.
Amal, M. A., S. Hossam, and M. Mohamed, "Cadmium stress induced change in some hydrolytic enzymes, free radical formation and ultrastructural disorders in radish plant", Elec. J. Env. Agricult. Food Chem, vol. 8, pp. 969-983, 2009. Abstract
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Imam, R. A., A. G. Motawie, and A. W. A. Algaleel, "Cadmium-induced adrenal cortical autophagy in rats: possible modulation by sildenafil", Folia Morphologica, vol. Vol. 79, issue 4, pp. 709–719, 2020. final_camium_adrena_published_research.pdf
Salama, S. A., H. H. Arab, M. H. Hassan, M. M. Al Robaian, and I. A. Maghrabi, "Cadmium-induced hepatocellular injury: Modulatory effects of γ-glutamyl cysteine on the biomarkers of inflammation, DNA damage, and apoptotic cell death.", Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), vol. 52, pp. 74-82, 2019. Abstract

Cadmium is an extremely toxic pollutant that reaches human body through intake of the industrially polluted food and water as well as through cigarette smoking and exposure to polluted air. Cadmium accumulates in different body organs especially the liver. It induces tissue injury largely through inflammation and oxidative stress-based mechanisms. The aim of the current study was to investigate the ability of γ glutamyl cysteine (γGC) to protect against cadmium-induced hepatocellular injury employing Wistar rats as a mammalian model. The results of the current work indicated that γGC upregulated the level of the anti-inflammatory cytokine IL-10 and downregulated the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) in the cadmium-exposed rats. In addition, γGC reduced the liver tissues cadmium content in the cadmium-treated rats, suppressed the cadmium-induced hepatocellular apoptosis and oxidative modifications of cellular DNA, lipids, and proteins. Additionally, γGC enhanced the antioxidant potential of the liver tissues in the cadmium-treated rats as evidenced by a remarkable increase in the activity of the antioxidant enzymes superoxide dismutase and glutathione peroxidase and significant increase in the levels of the total antioxidant capacity and reduced glutathione as well as a significant reduction in oxidized to reduced glutathione (GSSG/GSH) ratio. Moreover, it effectively improved liver cell integrity in the cadmium-treated rats as demonstrated by a significant reduction in the serum activity of the liver enzymes (ALT and AST) and amelioration of the cadmium-evoked histopathological alterations. Together, these findings underscore, for the first time, the alleviating effects of γGC against cadmium-induced hepatocellular injury that is potentially mediated through reduction of liver tissue cadmium content along with modulation of both hepatocellular redox status and inflammatory cytokines.

El-Khatib, A. A., A. K. Hegazy, and A. Abo-El-Kassem, "Cadmium-induced response of protein profile and antioxidant enzymes in aquatic macrophytes Myriophyllum spicatum and Ceratophyllum demersum.", Journal of Environmental Studies [JES], vol. 7, pp. 17-23, 2011.
Moghadam, H. S., M. Khademi, Z. Hu, R. J. Stern, J. F. Santos, and Y. Wu, "Cadomian (Ediacaran–Cambrian) arc magmatism in the ChahJam–Biarjmand metamorphic complex (Iran): Magmatism along the northern active margin of Gondwana", Gondwana Research, vol. 27, no. 1, pp. 439 - 452, 2015. AbstractWebsite

Abstract The ChahJam–Biarjmand complex (CJBC), flanked by the Alborz Mountains in the north and the Lut–Tabas block to the south, is part of Central Iranian block, where the oldest continental crust of Iran is found. This complex contains granitic to tonalitic orthogneissic rocks (old plutons) and associated metasediments, amphibolites and paragneisses. Metamorphosed granitic and granodioritic dikes intrude orthogneisses as well as metasediments and are abundant close to the plutons (orthogneissic rocks). Based on the results of bulk rock trace and rare earth elements, the orthogneissic rocks are inferred to have crystallized from subduction-related melts. Amphibolites also have subduction-related signatures and are inferred to have formed both as metamorphosed volcanoclastic sediments and as attenuated basic dikes. The presence of para-amphibolites associated with paragneisses and metasediments (mica schists) could represent a sedimentary basin filled with magmatic arc erosional products. U–Pb zircon dating of the ChahJam–Biarjmand rocks yielded 238U/206Pb crystallization ages of ca. 550 to 530 Ma (Ediacaran–early Cambrian). Sr–Nd isotope systematics on whole rocks (εNd(t) = − 2.2 to − 5.5) and zircon Hf isotope results indicate that \{CJBC\} Cadomian granitic rocks contain older, possible Mesoproterozoic, continental crust in their source. The ChahJam–Biarjmand granitic–tonalitic gneissic rocks are coeval with other similar-aged metagranites and gneisses within Iranian basement exposed in Central Iran, the Sanandaj–Sirjan Zone and the Alborz Mountains, as well as in the Tauride–Anatolide platform in western Anatolia and in \{NW\} Turkey. All these dispersed Cadomian basement rocks are interpreted to show fragments of Neoproterozoic–early Cambrian continental arcs bordering the northern active margin of Gondwana.

Moghadam, H. S., M. Khademi, Z. Hu, R. J. Stern, J. F. Santos, and Y. Wu, "Cadomian (Ediacaran–Cambrian) arc magmatism in the ChahJam–Biarjmand metamorphic complex (Iran): Magmatism along the northern active margin of Gondwana", Gondwana Research, vol. 27, no. 1, pp. 439 - 452, 2015. AbstractWebsite

Abstract The ChahJam–Biarjmand complex (CJBC), flanked by the Alborz Mountains in the north and the Lut–Tabas block to the south, is part of Central Iranian block, where the oldest continental crust of Iran is found. This complex contains granitic to tonalitic orthogneissic rocks (old plutons) and associated metasediments, amphibolites and paragneisses. Metamorphosed granitic and granodioritic dikes intrude orthogneisses as well as metasediments and are abundant close to the plutons (orthogneissic rocks). Based on the results of bulk rock trace and rare earth elements, the orthogneissic rocks are inferred to have crystallized from subduction-related melts. Amphibolites also have subduction-related signatures and are inferred to have formed both as metamorphosed volcanoclastic sediments and as attenuated basic dikes. The presence of para-amphibolites associated with paragneisses and metasediments (mica schists) could represent a sedimentary basin filled with magmatic arc erosional products. U–Pb zircon dating of the ChahJam–Biarjmand rocks yielded 238U/206Pb crystallization ages of ca. 550 to 530 Ma (Ediacaran–early Cambrian). Sr–Nd isotope systematics on whole rocks (εNd(t) = − 2.2 to − 5.5) and zircon Hf isotope results indicate that \{CJBC\} Cadomian granitic rocks contain older, possible Mesoproterozoic, continental crust in their source. The ChahJam–Biarjmand granitic–tonalitic gneissic rocks are coeval with other similar-aged metagranites and gneisses within Iranian basement exposed in Central Iran, the Sanandaj–Sirjan Zone and the Alborz Mountains, as well as in the Tauride–Anatolide platform in western Anatolia and in \{NW\} Turkey. All these dispersed Cadomian basement rocks are interpreted to show fragments of Neoproterozoic–early Cambrian continental arcs bordering the northern active margin of Gondwana.