Macky, T. A.,
"Bimatoprost versus travoprost in an Egyptian population: a hospital-based prospective, randomized study.",
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, vol. 26, issue 6, pp. 605-10, 2010 Dec.
AbstractPURPOSE: To compare the efficacy of bimatoprost and travoprost on intraocular pressure (IOP) reduction in an Egyptian population.
METHODS: Patients with primary open-angle glaucoma or ocular hypertension were randomized to receive either bimatoprost 0.03% or travoprost 0.004% once daily. IOPs were measured at baseline; 2 weeks; and 1, 2, 4, and 6 months using Goldman applanation tonometery.
RESULTS: Seventy-two patients were included: 34 and 38 (P = 0.142) with a baseline mean IOP = 26.52 ± 5.185 and 26.36 ± 1.605 mm Hg (P = 0.629) for bimatoprost and travoprost, respectively. Both drops provided statistically significant IOP reductions from baseline at all visits (P < 0.001). Bimatoprost provided greater (nonsignificant) mean IOP reductions from baseline than travoprost at each visit. Mean IOP reductions was 8.77 mm Hg (33.39%) and 8.42 mm Hg (31.54%) at 2 weeks (P = 0.703), and 8.47 mm Hg (31.61%) and 7.84 mm Hg (29.50%) at 6 months (P = 0.536) for bimatoprost and travoprost, respectively. IOPs at 2 weeks were ≤18 mm Hg in 20 (58.8%) versus 19 (50%) eyes (P = 0.603), and ≤16 mm Hg in 12 (35%) versus 12 (32%) eyes (P = 0.456); and at 6 months ≤18 mm Hg in 22 (65%) versus 14 (37%) eyes (P = 0.045), and ≤16 mm Hg in 12 (35%) versus 7 (18%) eyes (P = 0.037) for bimatoprost and travoprost, respectively. Ocular adverse and clinical success occurred equally with both drops.
CONCLUSION: Both drops lowered IOP effectively but bimatoprost showed a greater non-significant reductions in mean IOP from baseline.
Ahmed, M. A., N. Okasha, S. F. Mansour, and S. I. El-dek,
"Bi-modal improvement of the physico-chemical characteristics of PEG and MFe2O4 subnanoferrite",
Journal of Alloys and Compounds, vol. 496, issue 1-2, pp. 345 - 350, 2010.
AbstractMFe2O4 (M = Mn2+, Ni2+, Co2+ and Cu2+) ferrite powders were prepared by flash auto-combustion reaction. The structural identification of the samples was carried out using X-ray diffraction (XRD), transmission electron microscope (TEM), selected area electron diffraction (SAED) and IR spectra. The study established the formation of sub-nanosized particles especially for MFe2O4 (M = Ni, Co and Cu) ferrites. MFe2O4/PEG (polyethylene glycol) composites were prepared by cold uniaxial pressing. The magnetic properties were studied by carrying out the hysteresis of MFe2O4 and PEG/MFe2O4 composite at room temperature. The data showed that MnFe2O4 has the highest saturation magnetization while CoFe2O4 has the largest coercive field due to the high anisotropy of Co2+ ions. The ac electrical conductivity as well as the dielectric constant ε′ and loss tangent tan δ were measured at different frequencies at room temperature. The highest conductivity is achieved for PEG/Ni Fe2O4 and the lowest value of tan δ is obtained for PEG/MnFe2O4 amongst all PEG/MFe2O4 nanocomposites. © 2010 Elsevier B.V. All rights reserved.
Hussein, M. M., S. M. Metwalli, A. - N. A. Mohamed, and A. A. Shabana,
"BELT DRIVE MECHANICS WITH ABSOLUTE NODAL COORDINATE FINITE ELEMENT VERIFICATION",
ASME 2010 International Mechanical Engineering Congress & Exposition, Vancouver, British Colombia, Canada, 12-18 November, 2010.
Ismail, I. H., C. Andrin, D. McDonald, and M. J. Hendzel,
"BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair.",
J Cell Biol, vol. 191, no. 1, United States, pp. 45-60, 10, 2010.
AbstractPolycomb group (PcG) proteins are major determinants of cell identity, stem cell pluripotency, and epigenetic gene silencing during development. The polycomb repressive complex 1, which contains BMI1, RING1, and RING2, functions as an E3-ubuiquitin ligase. We found that BMI1 and RING2 are recruited to sites of DNA double-strand breaks (DSBs) where they contribute to the ubiquitylation of $\gamma$-H2AX. In the absence of BMI1, several proteins dependent on ubiquitin signaling, including 53BP1, BRCA1, and RAP80, are impaired in recruitment to DSBs. Loss of BMI1 sensitizes cells to ionizing radiation to the same extent as loss of RNF8. The simultaneous depletion of both proteins revealed an additive increase in radiation sensitivity. These data uncover an unexpected link between the polycomb and the DNA damage response pathways, and suggest a novel function for BMI1 in maintaining genomic stability
M. Moustafa, Laila. A. Mohamed, M. A. Mahmoud, and E. -gendyM. Y. W.S. Soliman,
"Bacterial Infections Affecting Marine Fishes in Egypt",
Journal of American Science , vol. 6, no.11, pp. 603-612, 2010.
Abstract Some fish species are suffering from continuous depletion due to devastating environmental changes at their native aquatic environment. Qarun Lake and Suez Gulf are among the most vulnerable areas. Thus, representative fish samples from those areas were inspected for the presence of any fish pathogenic bacteria. The inspected samples included six different species; Epinephelus tuvina, Siganus rivulatus, and Dedlechilus labiosus native to Suez Gulf at Suez governorate; Tilapia zilli, Mugil capito and Solea vulgaris native to Qarun Lake at El- Fayoum governorate. A total of 600 samples were examined throughout the different year seasons. Gram positive and negative fish pathogenic bacteria were isolated from a total of 245 fish sample. Among those samples, the following bacteria were retrieved in the following percentages respectively, 17.55% (V. anguillarum), 16.73% (V. alginolyticus), 15.51% (P. piscicida), 15.91% (Ps. fluorescens), 13.46% (S. fecalis), 11.02% (A. hydrophila), 6.12% (A. sobria) and 3.67% were infected with Staph. aureus. The Siganus rivulatus was the highest infected fish species with a prevalence of 8.33%, while Mugil capito was the lowest infected species (5.67 %). The highest total prevalence of bacterial infection was recorded in summer season (40.81%) while the lowest was recorded in winter (15.91%). The aforementioned bacterial isolates were successfully re-isolated from experimentally infected fish. The retrieved isolates were matched against standard isolates as well as confirmed to be positive using semi- automated (API 20 E) and conventional biochemical tests.
Moustafa, M., M. A. Laila, M. A. Mahmoud, and -gendyM. E. Y. W. S. Soliman,
"Bacterial Infections Affecting Marine Fishes in Egypt",
Journal of American Science , , , vol. vol. 6, no.11, pp. 603-612, 2010.
AbstractSome fish species are suffering from continuous depletion due to devastating environmental changes at their native aquatic environment. Qarun Lake and Suez Gulf are among the most vulnerable areas. Thus, representative fish samples from those areas were inspected for the presence of any fish pathogenic bacteria. The inspected samples included six different species; Epinephelus tuvina, Siganus rivulatus, and Dedlechilus labiosus native to Suez Gulf at Suez governorate; Tilapia zilli, Mugil capito and Solea vulgaris native to Qarun Lake at El- Fayoum governorate. A total of 600 samples were examined throughout the different year seasons. Gram positive and negative fish pathogenic bacteria were isolated from a total of 245 fish sample. Among those samples, the following bacteria were retrieved in the following percentages respectively, 17.55% (V. anguillarum), 16.73% (V. alginolyticus), 15.51% (P. piscicida), 15.91% (Ps. fluorescens), 13.46% (S. fecalis), 11.02% (A. hydrophila), 6.12% (A. sobria) and 3.67% were infected with Staph. aureus. The Siganus rivulatus was the highest infected fish species with a prevalence of 8.33%, while Mugil capito was the lowest infected species (5.67 %). The highest total prevalence of bacterial infection was recorded in summer season (40.81%) while the lowest was recorded in winter (15.91%). The aforementioned bacterial isolates were successfully re-isolated from experimentally infected fish. The retrieved isolates were matched against standard isolates as well as confirmed to be positive using semi- automated (API 20 E) and conventional biochemical tests.
Moustafa, M., AM Laila, A. M. Mahmoud, WS Soliman, and M. Y. El-Gendy,
"Bacterial Infections Affecting Marine Fishes in Egypt",
Journal of American Science, vol. 6, issue 11, pp. 603-612, 2010.
D, M., E. - E. N, E. - T. AM, and B. DA,
"Bcl-2 expression in mycosis fungoides before and after PUVA therapy",
Photodermatol Photoimmunol Photomed, vol. 26, issue 2, pp. 107-9, 2010.
AbstractPUVA is the first therapeutic choice in early stages of mycosis fungoides (MF). In this study the effect of PUVA on bcl-2 expression in MF was assessed in 15 patients (three stage Ia and 12 stage Ib) and 10 controls. Two biopsies were taken from each patient before and after 24 sessions of PUVA therapy. Histopathological assessment and immunohistochemical staining for bcl-2 was performed and showed positive bcl-2 staining of lymphocytes in 53% of MF cases (8/15) before PUVA, with no statistically significant difference in the bcl-2 level before and after PUVA therapy (P value 0.3). A statistically significant difference was found in the bcl-2 level between control samples and MF patients’ biopsies before (P value 0.02) and after PUVA therapy (P value 0.011). In conclusion, a lack of decline in the bcl-2 level and the absence of clinical or histopathological correlation with the bcl-2 level before and after PUVA therapy in MF patients suggest that PUVA-induced apoptosis in MF cases may occur through
pathways other than bcl-2 inhibition.