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2023
Abdelhamid, I. A., M. R. Shaaban, and A. H. M. Elwahy, "Bis-aldehydes: Versatile precursors for bis-heterocycles", Advances in Heterocyclic Chemistry, vol. 139: Elsevier, pp. 135, 2023. Abstract
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Mekawy Ouda, A. M., "Block of ’the Royal Scribe’ Siesi at the Egyptian Museum Cairo (TR. 19.5.25.3)", Chronique d’Egypte , vol. XCVIII, 2023.
Gouda, M. B. Y., N. M. Hassan, and E. I. Kandil, "Bone marrow overexpression of SNAI1 is an early indicator of intrinsic drug resistance in patients with de novo acute myeloid leukemia.", The journal of gene medicine, vol. 25, issue 5, pp. e3443, 2023. Abstract

BACKGROUND: The lack of effectiveness of acute myeloid leukemia (AML) treatment remains a major challenge and resembles a principal cause of AML-related mortality owing to chemotherapy resistance. SNAI1 has been proved to be a leading factor in drug resistance in many cancer types. However, its relation to chemoresistance in AML is not well understood.

METHODS: In addition to standard lab work, the expression level of SNAI1 was determined in bone marrow samples of 109 adult and pediatric patients with de novo acute myeloid leukemia using RT-qPCR. The relation between SNAI1 and AML drug resistance and immunomodulatory genes was investigated using the STRING tool.

RESULTS: The SNAI1 expression level was upregulated in AML patients in particular samples with promyelocytic leukemia subtype against control cases. In the treatment response, SNAI1 was significantly higher in resistant patients in comparison with the complete remission group. SNAI1 overexpression was associated with high initial blasts and total leukocyte counts, but with HLA class II histocompatibility antigen DR downregulation. STRING analysis showed that multiple drug resistance and immunomodulatory genes of AML induce SNAI upregulation and activation. Kaplan-Meier analysis indicated that there was no relation between SNAI1 expression level and patient survival status.

CONCLUSION: We conclude that the SNAI1 expression level may be a predictor of intrinsic drug resistance incidence in AML patients.

Gaber, A., A. M. Elbakry, R. M. Aljarari, F. A. Jaber, Y. A. Khadrawy, D. Sabry, R. E. Abo-ELeneen, and O. M. Ahmed, "Bone Marrow-Derived Mesenchymal Stem Cells and -Secretase Inhibitor Treatments Suppress Amyloid-25-35-Induced Cognitive Impairment in Rat Dams and Cortical Degeneration in Offspring.", Stem cells international, vol. 2023, pp. 2690949, 2023. Abstract

Alzheimer's disease (AD) is the most frequent cause of age-related neurodegeneration and ensuing cognitive impairment. Progressive deposition of extracellular amyloid beta (A) aggregates (plaques) and intracellular hyperphosphorylated Tau protein (p-Tau) are the core pathological markers of AD but may precede clinical symptoms by many years, presenting a therapeutic window of opportunity. Females are more frequently afflicted by AD than males, necessitating evaluation of novel treatments for the female population. The current study examined the protective efficacies of intravenous bone marrow-derived mesenchymal stem cells (BM-MSCs) and oral gamma-secretase inhibitor-953 (GSI-953) during pregnancy on cognitive impairment in rat dams and neurodegeneration in offspring induced by intracerebroventricular injection of A25-35 prior to pregnancy. The A25-35 (AD) group exhibited significant ( < 0.001) impairments in the Y-maze and novel object recognition test performance prior to conception. Histological analysis of the offspring cortex revealed substantial dendritic shrinkage and activation of microglial cells, while neurochemical analysis demonstrated significant increases in the proinflammatory cytokine interleukin-1 (IL-1) and tumor necrosis factor- (TNF-). In contrast, BM-MSC or GSI-953 treatment of dams following A25-35 injection significantly ( < 0.001) reduced the number and size of activated microglial cells, markedly increased dendrite length, and reversed proinflammatory cytokine elevations in offspring. Moreover, BM-MSC or GSI-953 treatment reversed the A25-35-induced amyloid precursor protein and p-Tau elevations in the offspring brain; these changes were accompanied by upregulation of the brain-derived neurotrophic factor and downregulation of glycogen synthase kinase-3 in the serum and brain. Treatment with BM-MSCs or GSI-953 also reversed A25-35-induced elevations in different gene expressions in the neonatal cortex. Finally, treatment of dams with BM-MSCs or GSI-953 prevented the A25-35-induced disruption of newborn brain development. Thus, BM-MSC and GSI-953 treatments have broad-spectrum effects against A25-35-induced brain pathology, including the suppression of neural inflammation, restoration of developmental plasticity, and promotion of neurotrophic signaling.

Duan, C., M. Zhao, R. El-Bashar, S. S. A. Obayya, M. Hameed, and J. Dai, "Bottom interface passivation with benzylamine thiocyanate for improving the performance of inverted perovskite solar cells‏ ", Solid-State Electronics, vol. Volume 210, pp. 108799, 2023.
Abdelbari, M. A., A. A. El-Gazar, A. A. Abdelbary, A. H. Elshafeey, and S. Mosallam, "Brij® integrated bilosomes for improving the transdermal delivery of niflumic acid for effective treatment of osteoarthritis: In vitro characterization, ex vivo permeability assessment, and in vivo study", International Journal of Pharmaceutics, vol. 640, 2023. AbstractWebsite

Bilosomes are innovative vesicular carriers containing bile salt with a non-ionic surfactant. Being highly flexible, bilosomes can squeeze themselves through the skin carrying the drug to the action site and improving its skin penetration. The objective of this research was to encapsulate niflumic acid (NA), a non-steroidal anti-inflammatory drug into Brij® integrated bilosomes (BIBs) for effective treatment of osteoarthritis through transdermal delivery. BIBs were formulated using 100 mg of Span 20 with different amounts of sodium cholate (NaC), sodium taurocholate (NaTC), or sodium glycocholate (NaGC) as bile salt, with the addition of 5 mg of Brij-93 or Brij-35. BIBs were prepared utilizing ethanol injection method with the application of (31 × 22) complete factorial design using Design-Expert® software. The optimal BIBs formulation determined was (B5) which contains 5 mg of NaTC used as bile salt and 5 mg of Brij-93. B5 exhibited entrapment efficiency% = 95.21 ± 0.00%, particle size = 373.05 ± 0.07 nm, polydispersity index = 0.27 ± 0.01, and zeta potential = –32.00 ± 0.00 mV. It also had a high elasticity with a spherical shape. B5 gel displayed a sustained release profile with a significantly 2.3 folds’ higher drug permeation percent across rat skin than that permeated from NA gel. Moreover, in vivo anti-osteoarthritic and histopathological studies assured the efficacy and safety of B5 gel and its superiority over NA gel. Generally, the outcomes confirmed the great efficacy of NA loaded BIBs for the topical treatment of osteoarthritis. © 2023 Elsevier B.V.

2022
Shokry, A., R. El-Shiekh, G. Kamel, A. Bakr, and A. Ramadan, Bioactive Phenolics Fraction of Hedera helix L. (Common Ivy Leaf) Standardized Extract ameliorates LPS-induced Acute Lung Injury in The Mouse Model Through The Inhibition of Proinflammatory Cytokines and Oxidative Stress, , pp. e09477, 2022/05/01. Abstract

Hedera helix L. (family Araliaceae) is classified as a conventional plant used as a medicinal product in the cure and prevention of upper respiratory tract inflammation and infection due to its secretolytic and broncholytic effects. Our research was conducted to authenticate the anti-inflammatory effect of ivy leaves extract in the prevention of acute lung injury (ALI) caused by intranasal administration of lipopolysaccharides (LPS). In-vitro antimicrobial, anti-inflammatory, and anti-oxidant were evaluated, in addition to the in-vivo acute lung inflammation model induced by LPS in mice. The animals were divided into seven groups randomly (each group containing 10 mice): control negative (saline only), control positive (LPS group), standard (Dexamethasone 2 mg/kg), ethanolic ivy leaves extract (EIE, 100 mg/kg), ethanolic ivy leaves extract (EIE, 200 mg/kg), saponin rich fraction (SRF, 100 mg/kg) and phenolic rich fraction (PRF,100 mg/kg). Right lungs were homogenized to determine the levels of SOD, MDA, catalase, IL-10, TNF-α, NO, IL-1β, IL-6, PGE2, and MPO. Left lungs were excised for histopathology and histomorphometry. Immunohistochemistry of Cox-2 and TNF-α levels were measured. Additionally, Western blotting was used to determine the levels of phosphorylated MAPK. The data showed that the oral supplementation with EIE, 200 mg/kg significantly (P<0.05) decreased the pro-inflammatory mediators, and oxidative stress biomarkers induced by LPS. Interestingly, the phenolics showed promising activity, therefore they are responsible for the action. The ethanolic extract was also standardized through HPLC analysis for its content of rutin. In conclusion, the standardized ivy leaf extract could be advised for acute lung injury for its antimicrobial, anti-oxidant, and anti-inflammatory activities.

Alfaar, A., "Building registries is hard, how can we make it even harder?", Kongress der Deutschen Ophthalmologischen Gesellschaft [The Congress of the German Ophthalmological Society], Berlin, Springer, pp. S215 - S215, 2022///. Abstract

Registries resemble a systematic way of collecting data for a specific theme or a population. As well-built registries represent a wealth of information for scientists, huge investments are paid to ensure their quality. The quality of the data gathered depends on a rigorous process of data validation and updating and, the comprehensiveness of the sources providing the data. Therefore, the data release may take years after the data collection. The advancement in information and computer technologies has helped in the progress of building better disease registries. In the process of learning from experiences in building registries, we aim in this presentation at discussing the lessons learned from building cancer (and other diseases) registries in different setups to facilitate building better ophthalmological registries. Moreover, to discuss the most common mistakes that lead to delayed collection and publishing of the data.

Soliman, M. H., G. S. H. Alnusairi, A. A. Khan, T. S. Alnusaire, M. A. Fakhr, A. M. Abdulmajeed, H. S. Aldesuquy, M. Yahya, and U. Najeeb, "Biochar and Selenium Nanoparticles Induce Water Transporter Genes for Sustaining Carbon Assimilation and Grain Production in Salt-Stressed Wheat", Journal of Plant Growth Regulation, 2022. AbstractWebsite

Abstract
In a controlled environment experiment, we studied how physiological changes in leaves during the vegetative phase regulate final grain yield of wheat crops in salt-affected soils. We also hypothesized that amendments such as biochar (SB) and selenium-chitosan nanoparticles (Se-NPs) can protect wheat plants from salt injury. 20-day-old wheat plants were submitted to 4-week salt stress (3000 ppm NaCl). Soybean straw biochar was mixed with soil media at planting and Se-NPs (30 ppm) was sprayed 5 days after the first salt stress treatment. At the end of 4-week Se-NPs treatment, one set of plants was harvested for studying leaf level physiological changes. The salt-stressed plants accumulated significantly high leaf Na
+
(~ 13-fold increase), which trigged oxidative and osmotic damage. This salt-induced cellular injury was evident from significantly high levels of lipid membrane peroxidation and inhibited photosynthesis. Our study suggested that leaf physiological impairment in wheat plants was translated into poor biomass production and grain yield loss at crop maturity. Compared with control, salt-stressed plants produced 43% lesser biomass during vegetative phase, and 62% lesser grain yield at maturity. Amendments such as SB and Se-NPs protected the plants from salt-induced cellular injury by restricting Na
+
transport toward leaf tissues. Plants treated with NaCl + SB + Se-NPs accumulated 50% less Na
+
concentrations in leaves compared with NaCl-treated plants. Our study also suggested that SB and Se-NPs can restore ionic homeostasis and carbon assimilation in salt-stressed wheat by upregulating key transporter genes in leaves.

Aziz, M. S. A., and H. E. Salama, "Biocompatible and antimicrobial carboxymethyl xanthan/zinc physical hydrogels", Polymer Bulletin, vol. 79, issue 5, pp. 3219 - 3231, 2022. AbstractWebsite
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Aziz, M. S. A., and H. E. Salama, "Biocompatible and antimicrobial carboxymethyl xanthan/zinc physical hydrogels", Polymer Bulletin, vol. 79, issue 5, pp. 3219 - 3231, 2022. AbstractWebsite
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Hassan, H. E., Y. M. Asal, A. M. Mohammad, and I. M. Al-Akraa, "BIODIESEL PRODUCTION FROM CASTOR OIL: MIXING OPTIMIZATION DURING TRANSESTERIFICATION", ARPN Journal of Engineering and Applied Sciences, vol. 17, issue 8, pp. 844 - 848, 2022. AbstractWebsite

With the growing warning for accrediting the traditional combustion of fossil fuels for energy production, not only for their limited supply but also for their environmental risks (air pollution, climate change, …. etc), it became necessary to realize alternative greener and abundant sources for energy. Instead, the interest to sustain biodiesel for the energy production has recently been renewed as a replacement for petroleum diesel in conventional diesel engines. This was due to its renewable nature, low toxicity, high degradability and unique physical properties (high flash points & lubrication). Castor oil, in particular, appeared promising for biodiesel production with extremely low cloud and pour points; making it suitable for tropical climates. Blending petroleum diesel with castor oil biodiesel has been proven efficient for enhancing both the environmental effect and the kinematic flow properties of the mineral fuel. Nonetheless, because of the current market price of conventional diesel, the blended product appeared cost-ineffective; steering research to tune the use of castor oil biodiesel alone. In this study, a simple method is recommended to produce biodiesel from castor oil by a transesterification process. The effect of mixing time of oil and alcohol is optimized with a thorough analysis to optimize the best condition for the biodiesel production © 2006-2022 Asian Research Publishing Network (ARPN). All rights reserved

Abdelsattar, A. S., A. Dawoud, S. Makky, R. Nofal, R. K. Aziz, and A. El-Shibiny, Bacteriophages: from isolation to application., , 2021, 2022. Abstract

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Shater, H., M. Fawzy, A. Farid, A. El-Amir, S. Fouad, and N. Madbouly, "B-cell activating factor and a proliferation-inducing ligand in relation to intima-media thickness as biomarkers of premature atherosclerosis in systemic lupus erythematosus patients", The American Journal of the Medical Sciences, 2022.
Shater, H., M. Fawzy, A. Farid, A. El-Amir, S. Fouad, and N. Madbouly, "B-cell activating factor and a proliferation-inducing ligand in relation to intima-media thickness as biomarkers of premature atherosclerosis in systemic lupus erythematosus …", The American Journal of the Medical Sciences, vol. 2022, 2022.
Fouad, A. S., A. B. Hamed, W. M. Amer, and R. M. Hafez, "Barcoding of some plant species using rbcl gene in the mediterranean Oolitic sand dunes west of alexandria, Egypt.", Egyptian J of Botany , vol. 62, issue 1, pp. 159-168, 2022. ejbo_volume_62_issue_1_pages_159-168_1.pdf
Fouad, A., A. Hamed, W. amer, and R. Hafez, "Barcoding of some plant species using rbcL gene ‎in the Mediterranean oolitic sand dunes west of Alexandria, Egypt ", https://scholar.google.com/citations?hl=en&user=dNXDRs4AAAAJ, 2022. 2022_barcoding_of_the_oolitic_species_ejb.pdf
Fouad, A. S., A. B. Hamed, W. M. Amer, and R. M. Hafez, "Barcoding of Some Plant Species Using the rbcL Gene in the Mediterranean Oolitic Sand Dunes West of Alexandria, Egypt", Egyptian Journal of Botany, vol. 62, issue 1: National Information and Documentation Center (NIDOC), Academy of Scientific Research and Technology (ASRT), pp. 159-168, 2022. AbstractWebsite

IN the Mediterranean Basin, oolitic sand dunes extend along the northeastern coast of Africa between the Gulf of Gabes (Tunisia) and the Nile Delta (Egypt), attenuating coastal vulnerability to storms and saltwater intrusion and protecting inland infrastructure. Psammophytes are typical and distinctive plants for dune habitats; they are the primary drivers for dune growth and stabilization by trapping sand particles in their shoot and root systems. The Anthropocene fingerprint may create an environment favorable for nonpsammophyte invasion and subsequent alteration in sand dune habitat structure and functions. The authentication of sand dune-inhabiting species should be a priority for conservation or restoration measures concerning sand dune habitats. This study is the first rbcL-based DNA barcoding documentation of 20 plant species inhabiting the vulnerable Egyptian oolitic sand dune habitats in Burg El Arab area, west of Alexandria. Results highlighted the applicability of the rbcL locus sequence for species authentication and recognition of the examined plant taxa sharing the same habitat. The phylogenetic analysis of rbcL barcode polymorphism revealed current taxonomic relationships among the assigned species. Results added valuable information to the authentication of sand dune plants, providing the first rbcL barcodes for species growing in oolitic sand dune habitats in Egypt, six of which were submitted for the first time to GenBank.

Rider, L. G., C. G. Parks, J. Wilkerson, A. I. Schiffenbauer, R. K. Kwok, P. Noroozi Farhadi, S. Nazir, R. Ritter, E. Sirotich, K. Kennedy, et al., "Baseline Factors Associated with Self-reported Disease Flares Following COVID-19 Vaccination among Adults with Systemic Rheumatic Disease: Results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.", Rheumatology (Oxford, England), 2022. Abstract

OBJECTIVE: To examine the frequency of, and risk factors for, disease flare following COVID-19 vaccination in patients with systemic rheumatic disease (SRD).

METHODS: An international study was conducted from April 2 to August 16, 2021, using an online survey of 5619 adults with SRD for adverse events following COVID-19 vaccination, including flares of disease requiring a change in treatment. We examined risk factors identified a priori based on published associations with SRD activity and SARS-CoV-2 severity, including demographics, SRD type, comorbidities, vaccine type, cessation of immunosuppressive medications around vaccination, and history of reactions to non-COVID-19 vaccines, using multivariable logistic regression.

RESULTS: Flares requiring a change in treatment following COVID-19 vaccination were reported by 4.9% of patients. Compared with rheumatoid arthritis, certain SRD, including systemic lupus erythematosus (OR 1.51, 95%CI 1.03, 2.20), psoriatic arthritis (OR 1.95, 95%CI 1.20, 3.18), and polymyalgia rheumatica (OR 1.94, 95%CI 1.08, 2.48) were associated with higher odds of flare, while idiopathic inflammatory myopathies were associated with lower odds for flare (OR 0.54, 95%CI 0.31-0.96). The Oxford-AstraZeneca vaccine was associated with higher odds of flare relative to the Pfizer-BioNTech vaccine (OR 1.44, 95%CI 1.07, 1.95), as were a prior reaction to a non-COVID-19 vaccine (OR 2.50, 95%CI 1.76, 3.54) and female sex (OR 2.71, 95%CI 1.55, 4.72).

CONCLUSION: SRD flares requiring changes in treatment following COVID-19 vaccination were uncommon in this large international study. Several potential risk factors, as well as differences by disease type, warrant further examination in prospective cohorts.

Hassan, A. S., A. Fayomi, A. Algarni, and E. M. Almetwally, "Bayesian and Non-Bayesian Inference for Unit-Exponentiated Half-Logistic Distribution with Data Analysis", Applied Sciences, 2022. applsci-12-11253.pdf
Yousef, M. M., A. S. Hassan, A. H. Al-Nefaie, E. M. Almetwally, and H. M. Almongy, "Bayesian Estimation Using MCMC Method of System Reliability for Inverted Topp–Leone Distribution Based on Ranked Set Sampling", Mathematics, 2022. rss_itl_mathematics.pdf
AlSadaty, A., "Bazaar Abbas, Port Said, Egypt: A Nineteenth Century Market Building and Centre of Cultural Exchange.", Architecture and Urban Transformation of Historical Markets: Cases from the Middle East and North Africa: Routledge Series of Architecture and Urbanism in the Global South, Routledge., 2022.
H, O. S. K. | Ü. A. | E. M. | S. S. | J. R. | E. E. - H. | M. Y. M. R. A. S., "The beneficial effects of citrus peel waste and its extract on fish performance and health status: A review", Aquaculture research, 2022. 2022-citrus_peel.pdf