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2023
Yan, J., P. Wang, L. Wang, Q. Jin, A. S. Ali, Y. He, Y. Wang, Y. Sun, A. Li, W. Adwy, et al., Bio-decolorization of synthetic dyes by a novel endophytic fungus Penicillium janthinellum LM5 from blueberry pulp, , vol. 195, pp. 108909, 2023. AbstractWebsite

Synthetic dyes from textile, paper, leather, and plastic processing, etc. are the majority of the colored effluents and have a harmful impact on human health and environment. Dye biosorption through endophytic fungi will be a challenge. A new fungus isolated from blueberry pulp was identified morphologically and genetically as Penicillium janthinellum LM5. It was utilized for the biosorption of synthetic dyes by forming mycelium particles with efficient decolorization properties in the dye solution. The results of decolorization experiments exhibited that dye type, pH, temperature and time were the important factors and the best decolorization condition on Congo red was pH 6.0, 30 ℃ and 48 h. Moreover, LM5 can achieve 90% decolorization rate even under the high salt concentrations of 200 mg/mL. Based on spectral analysis, the decolorization of Congo red was mainly attributed to the biosorption of mycelium and its pellet structure. Additionally, the fungus adsorbed Congo red can be as an excellent electrode material with a long-cycle performance and stable capacitance property, being a good way for recycling. In summary, this research employed a novel dye treatment method with simultaneous culture and decolorization through an endophytic fungus LM5, being a promising biomaterial in the application of dye wastewater treatment.

Menjivar, N. G., A. Gad, R. E. Thompson, M. A. Meyers, F. K. Hollinshead, and D. Tesfaye, "Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress", BMC Genomics, vol. 24, issue 1, pp. 646, 2023. AbstractWebsite

The mammalian oviduct is a complex, fibromuscular organ known for its role in orchestrating a series of timely and dynamic changes to suitably support early embryogenesis. Climate change-induced heat stress (HS) is one of the largest single stressors compromising reproductive function in humans and farm animals via systemic changes in the redox status of the maternal environment, adversely affecting fertilization and early embryonic development. Oviductal organoids represent a unique 3-dimensional, biomimetic model to study the physiology of the oviduct and its subsequent impact on embryo development under various environmental conditions.

Abd El-Ghany, M. N., S. A. Hamdi, S. M. Korany, R. M. Elbaz, and M. G. farahat, "Biosynthesis of Novel Tellurium Nanorods by Gayadomonas sp. TNPM15 Isolated from Mangrove Sediments and Assessment of Their Impact on Spore Germination and Ultrastructure of Phytopathogenic Fungi", Microorganisms, vol. 11, issue 3, pp. 558, 2, 2023. AbstractPDFWebsite

The biosynthesis of nanoparticles using green technology is emerging as a cost-efficient, eco-friendly and risk-free strategy in nanotechnology. Recently, tellurium nanoparticles (TeNPs) have attracted growing attention due to their unique properties in biomedicine, electronics, and other industrial applications. The current investigation addresses the green synthesis of TeNPs using a newly isolated mangrove-associated bacterium, Gayadomonas sp. TNPM15, and their impact on the phytopathogenic fungi Fusarium oxysporum and Alternaria alternata. The biogenic TeNPs were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Raman spectroscopy and Fourier transform infrared (FTIR). The results of TEM revealed the intracellular biosynthesis of rod-shaped nanostructures with a diameter range from 15 to 23 nm and different lengths reaching up to 243 nm. Furthermore, the successful formation of tellurium nanorods was verified by SEM-EDX, and the XRD pattern revealed their crystallinity. In addition, the FTIR spectrum provided evidence for the presence of proteinaceous capping agents. The bioinspired TeNPs exhibited obvious inhibitory effect on the spores of both investigated phytopathogens accomplished with prominent ultrastructure alternations, as evidenced by TEM observations. The biogenic TeNPs impeded spore germination of F. oxysporum and A. alternata completely at 48.1 and 27.6 µg/mL, respectively. Furthermore, an increase in DNA and protein leakage was observed upon exposure of fungal spores to the biogenic TeNPs, indicating the disruption of membrane permeability and integrity. Besides their potent influence on fungal spores, the biogenic TeNPs demonstrated remarkable inhibitory effects on the production of various plant cell wall-degrading enzymes. Moreover, the cytotoxicity investigations revealed the biocompatibility of the as-prepared biogenic TeNPs and their low toxicity against the human skin fibroblast (HSF) cell line. The biogenic TeNPs showed no significant cytotoxic effect towards HSF cells at concentrations up to 80 μg/mL, with a half-maximal inhibitory concentration (IC50) value of 125 μg/mL. The present work spotlights the antifungal potential of the biogenic TeNPs produced by marine bacterium against phytopathogenic fungi as a promising candidate to combat fungal infections.

Qi, B., M. Marie, A. S. AbdelWahed, I. N. Khatatbeh, M. Omran, and A. A. Fayad, "Bank Risk Literature (1978–2022): A Bibliometric Analysis and Research Front Mapping", Sustainability, vol. 15, issue 5, pp. 4508, 2023.
Hassan, A. S., E. A. eLsherpieny, and A. M. Felife, "Bayesian and non-Bayesian analysis for the lifetime performance index based on generalized order statistics from Pareto distribution", Journal of Autonomous Intelligence, vol. 7, issue 2, 2023. life_time_performance_index.pdf
Elgarhy, M., A. Almutairi, A. S. Hassan, C. Chesneau, and A. H. Abdel-Hamid, "Bayesian and non-Bayesian estimations of truncated inverse power Lindley distribution under progressively type-II censored data with applications", AIP Advances , 2023.
Hassan, A. S., S. A. Atia, and H. Z. Muhammed, "Bayesian and Non-Bayesian Inference of Exponentiated Moment Exponential Distribution with Progressive Censored Samples", RT&A, vol. 18, issue 1, pp. 264-281, 2023. rta_1_2023-22-1.pdf
Fayomi, A., A. S. Hassan, H. M. Baaqeel, and E. M. Almetwally, "Bayesian Inference and Data Analysis of the Unit–Power Burr X Distribution", axioms, 2023. unit-power_burr_x.pdf
Elgarhy, M., N. Alsadat, A. S. Hassan, and C. Chesneau, "Bayesian inference using MCMC algorithm of sine truncated Lomax distribution with application", AIP Advances , vol. 13, 2023.
Amer, O., D. Aita, D. V. Bompa, E. k. Mohamed, A. Torky, Y. M. Hussein, and A. H. Ali, "Behavior of unreinforced multi-leaf stone masonry walls under axial compression: Experimental and numerical investigation", Engineering Structures, vol. 293, pp. 116621, 2023.
Khaled, A. M., A. O. Dabbous, A. F. A. Hady, D. M. A. Sabour, and R. A. Koura, "Behavioral Temporal Auditory Processing Tests in Adult Stutterers", EJENTAS, vol. 24, issue 4, pp. 1-10, 2023.
Hosny, S. A., A. M Abdelmenem, T. A. H. A. AZOUZ, S. S. Kamar, A. M. Shams Eldeen, and A. A El-Shafei, "Beneficial Effect of Erythropoietin on Ameliorating Propionic Acid-Induced Autistic-Like Features in Young Rats.", Acta histochemica et cytochemica, vol. 56, issue 5, pp. 77-86, 2023. Abstract

Autism is a neurodevelopmental disorder that impairs communication and social interaction. This study investigated the possible beneficial effects of erythropoietin (EPO) on experimental autistic-like behaviors induced by propionic acid (PPA). Twenty-four rats were distributed into three groups: (i) control; (ii) PPA_Gp: daily injected subcutaneously with PPA for five consecutive days; PPA+EPO-Gp: injected with PPA, then received intraperitoneal injection of EPO once daily for two weeks. Behavioral changes in the rats were assessed. Specimens from the cerebellar hemispheres were subjected to histological and ultrastructure examination, immunohistochemistry for glial fibrillary acidic protein (GFAP) and calbindin-D28K, and biochemical analysis for glutathione peroxidase (GSH-Px), malondialdehyde (MDA), gamma amino-butyric acid (GABA), and serotonin. PPA-Gp showed significant behavioral impairment, with a significant depletion in GSH-px, GABA, and serotonin and a significant increase in MDA. Histological examination revealed reduced Purkinje cell count with ultrastructural degeneration, irregularly arranged nerve fibers in the molecular layer, astrogliosis, and significantly decreased calbindin-immunostaining compared to the control. EPO protected cerebellar structure, increased Purkinje cell count, improved neuronal morphology, reduced PPA-induced autistic-like features, alleviated neuronal oxidative stress, increased intercellular antioxidant levels, and suppressed inflammation. EPO provided significant protection against PPA-induced autistic features in rats, with structural preservation of Purkinje cells.

Thanaa M. Fahim, Marwa Abd EL-Hameed Mohamed, S. A. D. L. S. M. M., "Beneficial Effect of Rosuvastatin Therapy on Spleen Injury Induced by Gamma Irradiation in Rats: Targeting Nrf2/EPRE Pathway", . Dose-Response. Volume 21, Issue 2, , 2023.
NH Hamouda, W. D. Saleh, N. F. Nasr, and E. M. I. Sabry, "Benefits and risks of using bacterial- and plant-produced nano-silver for Japanese quail hatching-egg sanitation", Archives of Microbiology, vol. 205, pp. 228, 2023.
NH Hamouda, W. D. Saleh, N. F. Nasr, and M. I. El Sabry, "Benefits and risks of using bacterial-and plant-produced nano-silver for Japanese quail hatching-egg sanitation", Archives of Microbiology, vol. 205, issue 6, pp. 1-11, 2023.
Khawari, S., M. Kneizeh, M. E. Borady, L. Thorne, A. Toma, and L. Watkins, "The benefits of automated CSF drainage in normal pressure hydrocephalus.", Acta neurochirurgica, vol. 165, issue 6, pp. 1505-1509, 2023. Abstract

BACKGROUND: The commonly used cerebrospinal fluid (CSF) drainage system remains the manual drip-chamber drain. The LiquoGuard (Möller Medical GmbH, Germany) is an automated CSF management device with dual functionality, measuring intracranial pressure and automatic pressure- or volume-led CSF drainage. There is limited research for comparison of devices, particularly in the neurosurgical field, where it has potential to reshape care.

OBJECTIVE: This study aims to compare manual drip-chamber drain versus LiquoGuard system, by assessing accuracy of drainage, associated morbidity and impact on length of stay.

METHOD: Inclusion criteria consisted of suspected normal pressure hydrocephalus (NPH) patients undergoing extended lumbar drainage. Patients were divided into manual drain group versus automated group.

RESULTS: Data was analysed from 42 patients: 31 in the manual group versus 11 in the LiquoGuard group. Volumetric over-drainage was seen in 90.3% (n = 28) versus 0% (p < 0.05), and under-drainage in 38.7% (n = 12) versus 0% (p < 0.05), in the manual and automatic group, respectively. Symptoms of over-drainage were noted in 54.8% (n = 17) of the manual group, all of which had episodes of volumetric over-drainage, versus 18.2% (n = 2) in automated group, of which neither had actual over-drainage (p < 0.05). Higher over-drainage symptoms of manual drain is likely due to increased fluctuation of CSF drainage, instead of smooth CSF drainage seen with LiquoGuard system. An increased length of stay was seen in 38.7% (n = 12) versus 9% (n = 1) (p < 0.05) in the manual and LiquoGuard group, respectively.

CONCLUSION: The LiquoGuard device is a more superior way of CSF drainage in suspected NPH patients, with reduced morbidity and length of stay.

El-Kahawy, R. M., and M. S. Mabrouk, "Benthic foraminifera as bioindicators for the heavy metals in the severely polluted Hurghada Bay, Red Sea coast, Egypt", Environmental Science and Pollution Research , vol. 30, pp. 70437–70457, 2023. s11356-023-27242-4_1.pdf
El-Kahawy, R. M., and M. S. Mabrouk, "Benthic foraminifera as bioindicators for the heavy metals in the severely polluted Hurghada Bay, Red Sea coast, Egypt", Environmental Science and Pollution Research , vol. 30, pp. 70437–70457, 2023. s11356-023-27242-4_1.pdf
Moustafa, M., M. H. Mousa, M. S. Saad, T. Basha, and S. M. Elbasiouny, "Bifurcation analysis of motoneuronal excitability mechanisms under normal and ALS conditions.", Frontiers in cellular neuroscience, vol. 17, pp. 1093199, 2023. Abstract

INTRODUCTION: Bifurcation analysis allows the examination of steady-state, non-linear dynamics of neurons and their effects on cell firing, yet its usage in neuroscience is limited to single-compartment models of highly reduced states. This is primarily due to the difficulty in developing high-fidelity neuronal models with 3D anatomy and multiple ion channels in XPPAUT, the primary bifurcation analysis software in neuroscience.

METHODS: To facilitate bifurcation analysis of high-fidelity neuronal models under normal and disease conditions, we developed a multi-compartment model of a spinal motoneuron (MN) in XPPAUT and verified its firing accuracy against its original experimental data and against an anatomically detailed cell model that incorporates known MN non-linear firing mechanisms. We used the new model in XPPAUT to study the effects of somatic and dendritic ion channels on the MN bifurcation diagram under normal conditions and after amyotrophic lateral sclerosis (ALS) cellular changes.

RESULTS: Our results show that somatic small-conductance Ca-activated K (SK) channels and dendritic L-type Ca channels have the strongest effects on the bifurcation diagram of MNs under normal conditions. Specifically, somatic SK channels extend the limit cycles and generate a subcritical Hopf bifurcation node in the V-I bifurcation diagram of the MN to replace a supercritical node Hopf node, whereas L-type Ca channels shift the limit cycles to negative currents. In ALS, our results show that dendritic enlargement has opposing effects on MN excitability, has a greater overall impact than somatic enlargement, and dendritic overbranching offsets the dendritic enlargement hyperexcitability effects.

DISCUSSION: Together, the new multi-compartment model developed in XPPAUT facilitates studying neuronal excitability in health and disease using bifurcation analysis.

Moustafa, M., M. H. Mousa, M. S. Saad, T. Basha, and S. M. Elbasiouny, "Bifurcation analysis of motoneuronal excitability mechanisms under normal and ALS conditions.", Frontiers in cellular neuroscience, vol. 17, pp. 1093199, 2023. Abstract

INTRODUCTION: Bifurcation analysis allows the examination of steady-state, non-linear dynamics of neurons and their effects on cell firing, yet its usage in neuroscience is limited to single-compartment models of highly reduced states. This is primarily due to the difficulty in developing high-fidelity neuronal models with 3D anatomy and multiple ion channels in XPPAUT, the primary bifurcation analysis software in neuroscience.

METHODS: To facilitate bifurcation analysis of high-fidelity neuronal models under normal and disease conditions, we developed a multi-compartment model of a spinal motoneuron (MN) in XPPAUT and verified its firing accuracy against its original experimental data and against an anatomically detailed cell model that incorporates known MN non-linear firing mechanisms. We used the new model in XPPAUT to study the effects of somatic and dendritic ion channels on the MN bifurcation diagram under normal conditions and after amyotrophic lateral sclerosis (ALS) cellular changes.

RESULTS: Our results show that somatic small-conductance Ca-activated K (SK) channels and dendritic L-type Ca channels have the strongest effects on the bifurcation diagram of MNs under normal conditions. Specifically, somatic SK channels extend the limit cycles and generate a subcritical Hopf bifurcation node in the V-I bifurcation diagram of the MN to replace a supercritical node Hopf node, whereas L-type Ca channels shift the limit cycles to negative currents. In ALS, our results show that dendritic enlargement has opposing effects on MN excitability, has a greater overall impact than somatic enlargement, and dendritic overbranching offsets the dendritic enlargement hyperexcitability effects.

DISCUSSION: Together, the new multi-compartment model developed in XPPAUT facilitates studying neuronal excitability in health and disease using bifurcation analysis.