An important element in the integration of the fourth industrial revolution is the development of efficient algorithms to deal with dynamic scheduling problems. In dynamic scheduling, jobs can be admitted during the execution of a given schedule, which necessitates appropriately planned rescheduling decisions for maintaining a high level of performance. In this paper, a dynamic case of the multiprocessor open shop scheduling problem is addressed. This problem appears in different contexts, particularly those involving diagnostic operations in maintenance and health care industries. Two objectives are considered simultaneously—the minimization of the makespan and the minimization of the mean weighted flow time. The former objective aims to sustain efficient utilization of the available resources, while the latter objective helps in maintaining a high customer satisfaction level. An exact algorithm is presented for generating optimal Pareto front solutions. Despite the fact that the studied problem is NP-hard for both objectives, the presented algorithm can be used to solve small instances. This is demonstrated through computational experiments on a testbed of 30 randomly generated instances. The presented algorithm can also be used to generate approximate Pareto front solutions in case computational time needed to find proven optimal solutions for generated sub-problems is found to be excessive. Furthermore, computational results are used to investigate the characteristics of the optimal Pareto front of the studied problem. Accordingly, some insights for future metaheuristic developments are drawn.

. We report a case of a 1-year-old girl who was referred to us with a cerebellar anomaly and delayed growth and development for bilateral ptosis and poor fixation. Based on our ophthalmologic examination, we concluded that she has bilateral persistent fetal vasculature (PFV) with morning glory syndrome (MGS). A closer look into her neurologic condition revealed that she has Joubert's syndrome. . External examination revealed bilateral symmetrical ptosis with syndromic facies and her fundus examination revealed a large dysplastic optic disc with anomalous radiating vessels and a fibrous tissue tuft originating from the disc. The left eye showed similar findings in addition to a central excavation and a fibrovascular stalk extending from the optic disc. These findings were consistent with bilateral MGS and bilateral PFV. The brain imaging included a computed tomography scan and magnetic resonance imaging, both of which revealed a "molar tooth appearance" of the midbrain and an anomalous cerebellum suggestive of Joubert's syndrome. . This is the first case report of a case of bilateral MGS and bilateral PFV associated with Joubert's syndrome. This case report documents the associated optic nerve disease in these patients, not previously described, which are additive causes of visual compromise in addition to the brain insult.

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Siraitia grosvenorii fruit (SGF) has been used as a natural sweetener and traditional medicine in China for more than two centuries. This study evaluated the effect of SGF extract supplementation (0.5%, 1%, and 2%) on the chemical, microbial and sensory properties of probiotic yogurt. The antioxidant, angiotensin-converting-enzyme inhibitory (ACE-I) and antibacterial bioactivities were determined. SGF extract supplementation improved some of the chemical and physicochemical characteristics. Probiotic yogurt with the fruit extract had significantly more Lactobacillus casei and Lactobacillus bulgaricus, whereas there was no significant effect on the number of Streptococcus thermophiles. The bioactivities were significantly increased by SGF extract supplementation. Probiotic yogurt with 2% SGF extract showed the highest antioxidant, ACE-I, and antibacterial activities, whereas the one with 1% SGF extract conferred the highest sensory attributes score. Overall, SGF extract offers a promising option as a dietary supplement to produce novel dairy products that have high nutritional and bioactivity values.