Harmonic distortion levels in current power systems have increased due to technical advancements in industrial and renewable energy applications. So far, passive power filters have been widely employed to minimize harmonics and lessen their adverse effects. In this regard, this paper presents a novel bi-level design of damped double-tuned passive filters operating in a non-sinusoidal power system with nonlinearities at both the source and the load. A modern metaheuristic optimization technique known as wild horse optimization is applied to acquire the parameters of the used filters. Several objective functions, such as voltage total harmonic distortion, current total demand distortion, active power losses, and resonance-based metric minimization, were researched to improve the analyzed system's overall power quality performance. The mathematical derivations of the filter design expressions are given in detail. In the literature, there are several schemes for damped double-tuned filters. This paper investigates and analyses four schemes of this filter. The results are compared to those obtained from other metaheuristic optimization algorithms to ensure that the proposed algorithm produces the most effective outcomes. Statistical analysis is performed using many criteria to ensure the superiority of the proposed algorithm. Furthermore, depending on several assessment criteria, the analytical hierarchy process is employed to find the most effective candidate scheme. One of the schemes tested (scheme B) outperformed the others.

L. (family Araliaceae) is classified as a conventional plant used as a medicinal product in the cure and prevention of upper respiratory tract inflammation and infection due to its secretolytic and broncholytic effects. Our research was conducted to authenticate the anti-inflammatory effect of ivy leaves extract in the prevention of acute lung injury (ALI) caused by intranasal administration of lipopolysaccharides (LPS). antimicrobial, anti-inflammatory, and anti-oxidant were evaluated, in addition to the acute lung inflammation model induced by LPS in mice. The animals were divided into seven groups randomly (each group containing 10 mice): control negative (saline only), control positive (LPS group), standard (Dexamethasone 2 mg/kg), ethanolic ivy leaves extract (EIE, 100 mg/kg), ethanolic ivy leaves extract (EIE, 200 mg/kg), saponin rich fraction (SRF, 100 mg/kg) and phenolic rich fraction (PRF, 100 mg/kg). Right lungs were homogenized to determine the levels of SOD, MDA, catalase, IL-10, TNF-α, NO, IL-1β, IL-6, PGE2, and MPO. Left lungs were excised for histopathology and histomorphometry. Immunohistochemistry of Cox-2 and TNF-α levels were measured. Additionally, Western blotting was used to determine the levels of phosphorylated MAPK. Also, the ethanolic extract was also standardized through HPLC analysis for its content of rutin.The data showed that the oral supplementation with EIE, 200 mg/kg significantly ( < 0.05) decreased the pro-inflammatory mediators, and oxidative stress biomarkers induced by LPS. Interestingly, the phenolics showed promising activity, therefore they are responsible for the action. In conclusion, the standardized ivy leaf extract could be advised for acute lung injury for its antimicrobial, anti-oxidant, and anti-inflammatory activities.