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2023
Ezzat, S. M., R. Merghany, N. E. M. Mahdy, and M. A. Salem, "Brain Function, Stroke, and Medicinal Herbs", Phytochemical Drug Discovery for Central Nervous System Disorders Biochemistry and Therapeutic Effects: Wiley, 2023.
Abdelbari, M. A., A. A. El-Gazar, A. A. Abdelbary, A. H. Elshafeey, and S. Mosallam, "Brij® integrated bilosomes for improving the transdermal delivery of niflumic acid for effective treatment of osteoarthritis: In vitro characterization, ex vivo permeability assessment, and in vivo study", International Journal of Pharmaceutics, vol. 640, 2023. AbstractWebsite

Bilosomes are innovative vesicular carriers containing bile salt with a non-ionic surfactant. Being highly flexible, bilosomes can squeeze themselves through the skin carrying the drug to the action site and improving its skin penetration. The objective of this research was to encapsulate niflumic acid (NA), a non-steroidal anti-inflammatory drug into Brij® integrated bilosomes (BIBs) for effective treatment of osteoarthritis through transdermal delivery. BIBs were formulated using 100 mg of Span 20 with different amounts of sodium cholate (NaC), sodium taurocholate (NaTC), or sodium glycocholate (NaGC) as bile salt, with the addition of 5 mg of Brij-93 or Brij-35. BIBs were prepared utilizing ethanol injection method with the application of (31 × 22) complete factorial design using Design-Expert® software. The optimal BIBs formulation determined was (B5) which contains 5 mg of NaTC used as bile salt and 5 mg of Brij-93. B5 exhibited entrapment efficiency% = 95.21 ± 0.00%, particle size = 373.05 ± 0.07 nm, polydispersity index = 0.27 ± 0.01, and zeta potential = –32.00 ± 0.00 mV. It also had a high elasticity with a spherical shape. B5 gel displayed a sustained release profile with a significantly 2.3 folds’ higher drug permeation percent across rat skin than that permeated from NA gel. Moreover, in vivo anti-osteoarthritic and histopathological studies assured the efficacy and safety of B5 gel and its superiority over NA gel. Generally, the outcomes confirmed the great efficacy of NA loaded BIBs for the topical treatment of osteoarthritis. © 2023 Elsevier B.V.

Sayed, A. A., A. M. Soliman, M. Marzouk, F. F. Mohammed, and S. Desouky, "Bromelain mitigates liver fibrosis via targeting hepatic stellate cells in vitro and in vivo", Tissue and Cell, vol. 82, issue 102118, 2023.
Muhammed, E., A. E. -Shazly, and S. Morsy, "Building rooftop extraction using machine learning algorithms for solar photovoltaic potential estimation", Sustainability, vol. 15, no. 14: MDPI, pp. 11004, 2023. Abstract
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Mario, E., D. Hamza, and K. Abdel-Moein, "The Burden of Escherichia coli Pathotypes among Diarrheic Farm Animals: A Possible Zoonotic Relevance", Journal of Advanced Veterinary Research , vol. 13, issue 7, pp. 1376-1380, 2023.
Abd El-Ghany, M. N., S. A. Hamdi, S. M. Korany, R. M. Elbaz, and M. G. farahat, "Biosynthesis of Novel Tellurium Nanorods by Gayadomonas sp. TNPM15 Isolated from Mangrove Sediments and Assessment of Their Impact on Spore Germination and Ultrastructure of Phytopathogenic Fungi", Microorganisms, vol. 11, issue 3, pp. 558, 2, 2023. AbstractPDFWebsite

The biosynthesis of nanoparticles using green technology is emerging as a cost-efficient, eco-friendly and risk-free strategy in nanotechnology. Recently, tellurium nanoparticles (TeNPs) have attracted growing attention due to their unique properties in biomedicine, electronics, and other industrial applications. The current investigation addresses the green synthesis of TeNPs using a newly isolated mangrove-associated bacterium, Gayadomonas sp. TNPM15, and their impact on the phytopathogenic fungi Fusarium oxysporum and Alternaria alternata. The biogenic TeNPs were characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), Raman spectroscopy and Fourier transform infrared (FTIR). The results of TEM revealed the intracellular biosynthesis of rod-shaped nanostructures with a diameter range from 15 to 23 nm and different lengths reaching up to 243 nm. Furthermore, the successful formation of tellurium nanorods was verified by SEM-EDX, and the XRD pattern revealed their crystallinity. In addition, the FTIR spectrum provided evidence for the presence of proteinaceous capping agents. The bioinspired TeNPs exhibited obvious inhibitory effect on the spores of both investigated phytopathogens accomplished with prominent ultrastructure alternations, as evidenced by TEM observations. The biogenic TeNPs impeded spore germination of F. oxysporum and A. alternata completely at 48.1 and 27.6 µg/mL, respectively. Furthermore, an increase in DNA and protein leakage was observed upon exposure of fungal spores to the biogenic TeNPs, indicating the disruption of membrane permeability and integrity. Besides their potent influence on fungal spores, the biogenic TeNPs demonstrated remarkable inhibitory effects on the production of various plant cell wall-degrading enzymes. Moreover, the cytotoxicity investigations revealed the biocompatibility of the as-prepared biogenic TeNPs and their low toxicity against the human skin fibroblast (HSF) cell line. The biogenic TeNPs showed no significant cytotoxic effect towards HSF cells at concentrations up to 80 μg/mL, with a half-maximal inhibitory concentration (IC50) value of 125 μg/mL. The present work spotlights the antifungal potential of the biogenic TeNPs produced by marine bacterium against phytopathogenic fungi as a promising candidate to combat fungal infections.

Yan, J., P. Wang, L. Wang, Q. Jin, A. S. Ali, Y. He, Y. Wang, Y. Sun, Ali, W. Adwy, et al., "Bio-decolorization of synthetic dyes by a novel endophytic fungus Penicillium janthinellum LM5 from blueberry pulp", Biochemical Engineering Journal, vol. 195, 2023. AbstractWebsite
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Yan, J., P. Wang, L. Wang, Q. Jin, A. S. Ali, Y. He, Y. Wang, Y. Sun, A. Li, W. Adwy, et al., Bio-decolorization of synthetic dyes by a novel endophytic fungus Penicillium janthinellum LM5 from blueberry pulp, , vol. 195, pp. 108909, 2023. AbstractWebsite

Synthetic dyes from textile, paper, leather, and plastic processing, etc. are the majority of the colored effluents and have a harmful impact on human health and environment. Dye biosorption through endophytic fungi will be a challenge. A new fungus isolated from blueberry pulp was identified morphologically and genetically as Penicillium janthinellum LM5. It was utilized for the biosorption of synthetic dyes by forming mycelium particles with efficient decolorization properties in the dye solution. The results of decolorization experiments exhibited that dye type, pH, temperature and time were the important factors and the best decolorization condition on Congo red was pH 6.0, 30 ℃ and 48 h. Moreover, LM5 can achieve 90% decolorization rate even under the high salt concentrations of 200 mg/mL. Based on spectral analysis, the decolorization of Congo red was mainly attributed to the biosorption of mycelium and its pellet structure. Additionally, the fungus adsorbed Congo red can be as an excellent electrode material with a long-cycle performance and stable capacitance property, being a good way for recycling. In summary, this research employed a novel dye treatment method with simultaneous culture and decolorization through an endophytic fungus LM5, being a promising biomaterial in the application of dye wastewater treatment.

Elarabi, N. I., AA Abdelhadi, A. A. Nassrallah, M. S. M. Mohamed, and H. A. R. Abdelhaleem, "Biodegradation of isoproturon by Escherichia coli expressing a Pseudomonas putida catechol 1,2-dioxygenase gene", AMB Express, vol. 13, issue 1, 2023. Abstract

The phenylurea herbicides are persistent in soil and water, necessitating the creation of methods for removing them from the environment. This study aimed to examine the soil microbial diversity, searching for local bacterial isolates able to efficiently degrade the phenylurea herbicide isoproturon, 3-(4-isopropylphenyl)-1, 1-dimethylurea (IPU). The best isolates able to effectively degrade IPU were selected, characterized, and identified as Pseudomonas putida and Acinetobacter johnsonii. The catechol 1, 2-dioxygenase enzyme's catA gene was amplified, cloned, and expressed in E. coli M15. The Expressed E. coli showed high degradation efficiency (44.80%) as analyzed by HPLC after 15 days of inoculation in comparison to P. putida (21.60%). The expression of the catA gene in P. putida and expressed E. coli was measured using quantitative polymerase chain reaction (qPCR). The results displayed a significant increase in the mRNA levels of the catA gene by increasing the incubation time with IPU. Hydrophilic interaction chromatography (HILIC) mass spectrometry analysis revealed that three intermediate metabolites, 1-(4-isopropylphenyl)-3-methylurea (MDIPU), 4-Isopropylaniline (4-IA) and 1-(4-isopropylphenyl) urea (DDIPU) were generated by both P. putida and expressed E. coli. In addition, IPU-induced catA activity was detected in both P. putida and expressed E. coli. The supernatant of both P. putida and expressed E. coli had a significant influence on weed growth. The study clearly exhibited that P. putida and expressed E. coli were capable of metabolizing IPU influentially and thus could be utilized for bioremediation and biodegradation technology development. © 2023, Springer-Verlag GmbH Germany, part of Springer Nature.

Al-Qodami, B. A., S. Y. Sayed, H. H. Alalawy, I. M. Al-Akraa, N. K. Allam, and A. M. Mohammad, "Boosted formic acid electro-oxidation on platinum nanoparticles and “mixed-valence” iron and nickel oxides", RSC Advances, vol. 13, issue 30: Royal Society of Chemistry, pp. 20799 - 20809, 2023. AbstractWebsite

The modification of Pt nanoparticles (nano-Pt, assembled electrochemically onto a glassy carbon (GC) substrate) with hybrid multivalent nickel (nano-NiOx) and iron (nano-FeOx) oxide nanostructures was intended to steer the mechanism of the formic acid electro-oxidation (FAO) in the desirable dehydrogenation pathway. This binary modification with inexpensive oxides succeeded in mediating the reaction mechanism of FAO by boosting reaction kinetics “electron transfer” and amending the surface geometry of the catalyst against poisoning. The sequence of deposition was optimized where the a-FeOx/NiOx/Pt/GC catalyst (where “a” denotes a post-activation step for the catalyst at −0.5 V in 0.5 mol L−1 NaOH) reserved the best hierarchy. Morphologically, while nano-Pt appeared to be spherical (ca. 100 nm in average diameter), nano-NiOx appeared as flowered nanoaggregates (ca. 56 nm in average diameter) and nano-FeOx (after activation) retained a plate-like nanostructure (ca. 38 nm in average diameter and 167 nm in average length). This a-FeOx/NiOx/Pt/GC catalyst demonstrated a remarkable catalytic efficiency (125 mA mgPt−1) for FAO that was ca. 12.5 times that of the pristine Pt/GC catalyst with up to five times improvement in the catalytic tolerance against poisoning and up to −214 mV shift in the FAO's onset potential. Evidences for equipping the a-FeOx/NiOx/Pt/GC catalyst with the least charge transfer resistance and the highest stability among the whole investigated catalysts are provided and discussed. © 2023 The Royal Society of Chemistry.

Menjivar, N. G., A. Gad, R. E. Thompson, M. A. Meyers, F. K. Hollinshead, and D. Tesfaye, "Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress", BMC Genomics, vol. 24, issue 1, pp. 646, 2023. AbstractWebsite

The mammalian oviduct is a complex, fibromuscular organ known for its role in orchestrating a series of timely and dynamic changes to suitably support early embryogenesis. Climate change-induced heat stress (HS) is one of the largest single stressors compromising reproductive function in humans and farm animals via systemic changes in the redox status of the maternal environment, adversely affecting fertilization and early embryonic development. Oviductal organoids represent a unique 3-dimensional, biomimetic model to study the physiology of the oviduct and its subsequent impact on embryo development under various environmental conditions.

Madadi, M., M. Elsayed, G. Song, R. Kumar, M. Mahmoud-Aly, B. Basak, B. - H. Jeon, and F. Sun, "Biphasic lignocellulose fractionation for staged production of cellulose nanofibers and reactive lignin nanospheres: A comparative study on their microstructures and effects as chitosan film reinforcing", Chemical Engineering Journal, vol. 465, 2023///. AbstractWebsite
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2024
Abdel-Hamid, R. M., A. Bayoum, M. S. Abdellateif, H. A. Nooh, L. Refaat, E. Z. Kandeel, and S. S. Hassan, Bacterial Co-Infections in Cancer Patients with COVID-19: Predictors and Antimicrobial Resistance Trends, , 2024.
Abdel-Hamid, R. M., A. Bayoum, M. S. Abdellateif, H. A. Nooh, L. Refaat, E. Z. Kandeel, and S. S. Hassan, Bacterial Co-Infections in Cancer Patients with COVID-19: Predictors and Antimicrobial Resistance Trends, , 2024.
Hassan, A. S., M. Elgarhy, C. H. R. I. S. T. O. P. H. E. CHESNEAU, and H. F. Nagy, Bayesian analysis of multi-component stress-strength reliability using improved record values, , 2024.
Hassan, A. S., E. A. eLsherpieny, and A. M. Felife, "Bayesian and non-Bayesian analysis for the lifetime performance index based on generalized order statistics from Pareto distribution", Journal of Autonomous Intelligence, vol. 7, issue 2, 2024. life_time_performance_index.pdf
Hassan, A. S., E. A. Elsherpieny, and R. E. Mohamed, Bayesian Estimation of Stress Strength Modeling Using MCMC Method Based on Outliers, , 2024.
El-Ghannam, G., M. Moawad, M. T. Abo-Elfadl, and S. A. Elfeky, "Beetroot extract@chitosan nanocomposite as a promising approach towards cancer therapy", International Journal of Biological Macromolecules, 2024.
Bibi, S., T. Zhu, A. Rateb, B. R. Scanlon, M. A. Kamran, A. El Nashar, A. Bennour, and C. Li, "Benchmarking multimodel terrestrial water storage seasonal cycle against Gravity Recovery and Climate Experiment (GRACE) observations over major global river basins", Hydrology and Earth System Sciences, vol. 28, issue 7, pp. 1725-1750, 2024. AbstractWebsite

The increasing reliance on global models for evaluating climate- and human-induced impacts on the hydrological cycle underscores the importance of assessing the models' reliability. Hydrological models provide valuable data on ungauged river basins or basins with limited gauge networks. The objective of this study was to evaluate the reliability of 13 global models using the Gravity Recovery and Climate Experiment (GRACE) satellite's total water storage (TWS) seasonal cycle for 29 river basins in different climate zones. Results show that the simulated seasonal total water storage change (TWSC) does not compare well with GRACE even in basins within the same climate zone. The models overestimated the seasonal peak in most boreal basins and underestimated it in tropical, arid, and temperate zones. In cold basins, the modeled phase of TWSC precedes that of GRACE by up to 2–3 months. However, it lagged behind that of GRACE by 1 month over temperate and arid to semi-arid basins. The phase agreement between GRACE and the models was good in the tropical zone. In some basins with major underlying aquifers, those models that incorporate groundwater simulations provide a better representation of the water storage dynamics. With the findings and analysis of our study, we concluded that R2 (Water Resource Reanalysis tier 2 forced with Multi-Source Weighted Ensemble Precipitation (MSWEP) dataset) models with optimized parameterizations have a better correlation with GRACE than the reverse scenario (R1 models are Water Resource Reanalysis tier 1 and tier 2 forced with the ERA-Interim (WFDEI) meteorological reanalysis dataset). This signifies an enhancement in the predictive capability of models regarding the variability of TWSC. The seasonal peak, amplitude, and phase difference analyses in this study provide new insights into the future improvement of large-scale hydrological models and TWS investigations.

Ali, H. A. E. ‑S., M. H. Alham, and D. K. Ibrahim, "Big data resolving using Apache Spark for load forecasting and demand response in smart grid: a case study of Low Carbon London Project", Journal of Big Data, vol. 11, issue 1, pp. Article no. 59, 2024. Abstract

Using recent information and communication technologies for monitoring and management initiates a revolution in the smart grid. These technologies generate massive data that can only be processed using big data tools. This paper emphasizes the role of big data in resolving load forecasting, renewable energy sources integration,
and demand response as significant aspects of smart grids. Meters data from the Low Carbon London Project is investigated as a case study. Because of the immense stream of meters’ readings and exogenous data added to load forecasting models, addressing the problem is in the context of big data. Descriptive analytics are developed using Spark SQL to get insights regarding household energy consumption. Spark MLlib is utilized for predictive analytics by building scalable machine learning models accommodating meters’ data streams. Multivariate polynomial regression and decision tree models are preferred here based on the big data point of view and the literature that ensures they are accurate and interpretable. The results confirmed the descriptive
analytics and data visualization capabilities to provide valuable insights, guide the feature selection process, and enhance load forecasting models’ accuracy. Accordingly, proper evaluation of demand response programs and integration of renewable energy resources is accomplished using achieved load forecasting results.

Zabady, M. K., A. M. Abu-Seida, F. A. Al-Hizab, M. M. Hasseeb, and A. Al-Saad, "BILATERAL GIANT SUBCUTANEOUS LIPOMAS IN ONE-HUMPED CAMEL (Camelus dromedarius)", Journal of Camel Practice and Research, vol. 31, issue 1, pp. 83-86, 2024. camels-_bilateral_giant_subcutaneous.pdf
Nabeel, M., A. M.Abu‑Seida, A. A. Elgendy, and H. M.Tawfk, "Biocompatibility of mineral trioxide aggregate and biodentine as root‑end flling materials: an in vivo study", Scientific Reports, vol. 14, pp. 3568 , 2024. biocompatability_of_mta_and_biodentine.pdf
Mourad, B. H., "BIOMONITORING IN OCCUPATIONAL MEDICINE (REVIEW ARTICLE)", Egyptian Journal of Occupational Medicine, vol. 48, issue 1, pp. 47-61, 2024.
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