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2022
Adly, W. M. R. M., Y. S. A. Mazrou, M. E. EL-Denary, M. A. Mohamed, E. - S. T. Abd El-Salam, and A. S. Fouad, "Boosting Polyamines to Enhance Shoot Regeneration in Potato (Solanum tuberosum L.) Using AgNO3", Horticulturae, vol. 8, no. 2, 2022. AbstractWebsite

Advancements in shoot regeneration systems support biotechnology-based tools used in the genetic improvement of plant crops. This study aims to enhance shoot regeneration in potatoes by boosting polyamine content by adding AgNO3 to the shoot regeneration medium (MS medium supplemented with 30 g L−1 sucrose, 100 mg L−1 myoinositol, and 2.25 BA mg L−1). Five concentrations of AgNO3 (2, 4, 6, 8, and 10 mg L−1) were used in addition to a control. The effect of AgNO3 on regeneration assumed a more or less concentration-dependent bell-shaped curve peaking at 4 mg L−1. Enhancements in shoot regeneration were attributed to the known role of AgNO3 as an ethylene action blocker in addition to improvements in polyamine accumulation without an increase in H2O2 content, lipid peroxidation, or DNA damage. The uncoupling of shoot regeneration and polyamine content recorded at high AgNO3 concentrations can be attributed to the consumption of polyamines to counteract the synchronized oxidative stress manifested by increases in H2O2 content, lipid peroxidation, and DNA damage.

Rehab R. Kassem, MD, F. R. C. S.(G.), F. I. C. O. Ranya A. A. Badr, MRCSed, M. D.; Bandar K. A. Al Zarea, J. S. Almasaud, B. O. Fahad M. Alshomer, M. D. Mohammad A. El-Sada, and M. D. Rasha H. Zedan, "Botulinum Toxin Injection in Horizontal Rectus Muscles Without Electromyography Using an Open Sky Versus a Closed Sky Technique", J Pediatr Ophthalmol Strabismus, vol. 59, issue 6, pp. 388-395, 2022.
Du, X., S. A. Sherein, P. Liu, M. A. Haque, and A. Khan, "Bovine Mastitis: Behavioral Changes, Treatment and Control", Continental Veterinary Journal, vol. 1, issue 2, pp. 15-23, 2022. mastitis-cvj.pdf
Gadallah, N. S., H. Ghahari, and S. R. Shaw, Braconidae of the Middle East (Hymenoptera) Taxonomy, Distribution, Biology, and Biocontrol Benefits of Parasitoid Wasps, , United States of America, Academic Press (Elsevier), 2022.
, "Brain-Derived neurotrophic factor (BDNF) plasma level increases in patients with resistant schizophrenia treated with electroconvulsive therapy (ECT)", International Journal of Psychiatry in Clinical Practice, vol. 26, no. 4: Taylor & Francis, pp. 370–375, 2022. AbstractWebsite
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Shahin, O., S. M. Gohar, W. Ibrahim, S. M. El-Makawi, W. Fakher, D. B. Taher, M. A. Samie, M. A. Khalil, and A. A. Saleh, "Brain-Derived neurotrophic factor (BDNF) plasma level increases in patients with resistant schizophrenia treated with electroconvulsive therapy (ECT).", International journal of psychiatry in clinical practice, pp. 1-6, 2022. Abstract

OBJECTIVES: The study aimed to assess the effect of Electroconvulsive Therapy (ECT) on plasma BDNF levels in patients with resistant schizophrenia.

METHODS: It was a cohort study that included 60 patients with resistant schizophrenia fulfilling the DSM-5 criteria of schizophrenia and APA criteria of resistant schizophrenia. They were divided into two groups, followed over 4 weeks, and compared to their baseline assessment. Group (A) included 45 patients who received 4-10 sessions of ECT while Group (B) included 15 patients who received the usual treatment with antipsychotics without ECT. The assessment included the severity of psychotic symptoms assessed by the Positive and Negative Symptom Scale (PANSS) in addition to plasma BDNF level.

RESULTS: Patients in Group (A) had an increased level of BDNF after treatment with a statistically significant difference in comparison to their baseline BDNF level ( = 0.027). Meanwhile, patients in group (B) showed a non-significant increase in BDNF. Patients in both groups improved significantly in all PANSS subscales after treatment.

CONCLUSIONS: It was concluded that plasma BDNF levels in patients with resistant schizophrenia increase after electroconvulsive therapy in association with clinical improvement.Key pointsBDNF increases after ECT treatment of resistant schizophrenia.BDNF is not correlated with the severity of psychotic symptomsPatients treated with ECT showed a better response.

Al-Nassir, N. S. M., and S. S. Sakr, "Breastfeeding Situation in Saudi Arabia and Recent Approaches in The Development of Follow-on Formula for Facing Breastfeeding Difficulties", Journal of Food and Dairy Sciences, vol. 13, issue 4, pp. 71-76, 2022.
El-Broullesy, S. M., R. El-Bashar, M. R. I. Ramadan, S. Aboul-Enein, A. Ibrahim, D. H. Wood, M. F. O. Hameed, and S. S. A. Obayya, "Broadband absorption of modified conical nanowires for photovoltaic applications", Optik, 2022, vol. 271, pp. 170245., 2022.
Khairat, R., H. El-Karaksy, H. T. EL-Bassyouni, A. K. Saad, E. Rabie, K. Hamed, and N. A. Yassin, "Broadening the clinical spectrum of ALGS: an Egyptian cohort with five novel mutations in JAG1 gene", Egyptian Journal of Medical Human Genetics, vol. 23, no. 1: SpringerOpen, pp. 1–9, 2022. Abstract
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Atta, M. E. E. - D., D. K. Ibrahim, and M. I. gilany, "Broken Bar Fault Detection and Diagnosis Techniques for Induction Motors and Drives: State of the Art", IEEE Access, vol. 10, pp. 88504 - 88526, 2022. AbstractWebsite

Motors are the higher energy-conversion devices that consume around 40% of the global electrical generated energy. Induction motors are the most popular motor type due to their reliability, robustness, and low cost. Therefore, both condition monitoring and fault diagnosis of induction motor faults have motivated considerable research efforts. In this paper, a comprehensive review of the recent techniques proposed in the literature for broken bar faults detection and diagnosis is presented. This paper mainly investigates the fault detection methods in line-fed and inverter-fed motors proposed after 2015 and published in most relevant journals and conferences. The introduced review has deeply discussed the main features of the reported methods and compared them in many different aspects. Finally, the study has highlighted the main issues and the gaps that require more attention from researchers in this field.

Didamoony, M. A., A. M. Atwa, E. A. A. El-Haleim, and L. A. Ahmed, "Bromelain ameliorates D-galactosamine-induced acute liver injury: role of SIRT1/LKB1/AMPK, GSK3β/Nrf2 and NF-κB p65/TNF-α/caspase-8, -9 signalling pathways", Journal of Pharmacy and Pharmacology, vol. 74, pp. 1765-1775, 2022.
Didamoony, M. A., A. M. Atwa, E. A. Abd El-Haleim, and L. A. Ahmed, "Bromelain ameliorates D-galactosamine-induced acute liver injury: role of SIRT1/LKB1/AMPK, GSK3β/Nrf2 and NF-κB p65/TNF-α/caspase-8, -9 signalling pathways.", The Journal of pharmacy and pharmacology, vol. 74, issue 12, pp. 1765-1775, 2022. Abstract

OBJECTIVES: The present research focused on estimating, for the first time, the potential protective effects of bromelain against D-galactosamine-induced acute liver injury in rats as well as identifying the possible underlying mechanisms.

METHODS: Silymarin (100 mg/kg/day, p.o.) as a reference drug or bromelain (20 and 40 mg/kg/day, p.o.) were administered for 10 days, and on the 8th day of the experiment, a single dose of galactosamine (400 mg/kg/i.p.) induced acute liver injury.

KEY FINDINGS: Pretreatment with bromelain improved liver functions and histopathological alterations induced by galactosamine. Bromelain ameliorated oxidative stress by inducing SIRT1 protein expression and increasing LKB1 content. This resulted in phosphorylating the AMPK/GSK3β axis, which stimulated Nrf2 activation in hepatic cells and thus increased the activity of its downstream antioxidant enzymes [HO-1 and NQO1]. Besides, bromelain exerted significant anti-apoptotic and anti-inflammatory effects by suppressing hepatic contents of TNF-α, NF-κB p65, as well as caspase-8 and caspase-9. The protective effects of bromelain40 were proved to be better than silymarin and bromelain20 in most of the assessed parameters.

CONCLUSIONS: Our results highlight the significant hepatoprotective effects of bromelain against acute liver injury through modulation of SIRT1/LKB1/AMPK, GSK3β/Nrf2 signalling in addition to NF-κB p65/TNF-α/ caspase-8 and -9 pathway.

Hua, G., H. Abdel-Shafy, T. Deng, Y. Zhou, and W. Y. Low, Buffalo Genetics and Genomics, , Lausanne, Frontiers Media SA, 2022.
Hawash, M. B. F., M. A. El-Deeb, R. Gaber, and K. S. Morsy, "The buried gems of disease tolerance in animals: Evolutionary and interspecies comparative approaches: ", BioEssays : news and reviews in molecular, cellular and developmental biology, vol. 44, issue 10, pp. e2200080, 2022. Abstract

Host defense mechanisms are categorized into different strategies, namely, avoidance, resistance and tolerance. Resistance encompasses mechanisms that directly kill the pathogen while tolerance is mainly concerned with alleviating the harsh consequences of the infection regardless of the pathogen burden. Resistance is well-known strategy in immunology while tolerance is relatively new. Studies addressed tolerance mainly using mouse models revealing a wide range of interesting tolerance mechanisms. Herein, we aim to emphasize on the interspecies comparative approaches to explore potential new mechanisms of disease tolerance. We will discuss mechanisms of tolerance with focus on those that were revealed using comparative study designs of mammals followed by summarizing the reasons for adopting comparative approaches on disease tolerance studies. Disease tolerance is a relatively new concept in immunology, we believe combining comparative studies with model organism study designs will enhance our understanding to tolerance and unveil new mechanisms of tolerance.

Shah, H., and E. H. Taha, "Busemann functions in asymptotically harmonic Finsler manifolds", J. Math, Phys., Analy. Geom., 2022.
Abdelsattar, A. S., A. Dawoud, S. Makky, R. Nofal, R. K. Aziz, and A. El-Shibiny, Bacteriophages: from isolation to application., , 2021, 2022. Abstract

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Mabrouk, M., E. Ismail, H. Beherei, M. T. Abo-Elfadl, Z. A. Salem, D. B. Das, and N. AbuBakr, Biocompatibility of hydroxyethyl cellulose/glycine/RuO2 composite scaffolds for neural-like cells, , vol. 209, pp. 2097 - 2108, 2022. AbstractWebsite

Fabrication of scaffolds for nerve regeneration is one of the most challenging topics in regenerative medicine at the moment, which is also interlinked with the development of biocompatible substrates for cells growth. This work is targeted towards the development of green biomaterial composite scaffolds for nerve cell culture applications. Hybrid scaffolds of hydroxyethyl cellulose/glycine (HEC/Gly) composite doped with different concentrations of green ruthenium oxide (RuO2) were synthesized and characterized via a combination of different techniques. X-rays diffraction (XRD) and differential scanning calorimetry (DSC) analyses showed a crystalline nature for all the samples with noticeable decrease in the peak intensity of the fabricated scaffolds as compared to that for pure glycine. Fourier transform infrared spectroscopy (FTIR) tests revealed an increase in the vibrational bands of the synthesized RuO2 containing scaffolds which are related to the functional groups of the natural plant extract (Aspalathuslinearis) used for RuO2 nanoparticles (NPs) synthesis. Scanning electron microscopy (SEM) results revealed a 3D porous structure of the scaffolds with variant features attributed to the concentration of RuO2 NPs in the scaffold. The compressive test results recorded an enhancement in mechanical properties of the fabricated scaffolds (up to 8.55 MPa), proportionally correlated to increasing the RuO2 NPs concentration in HEC/Gly composite scaffold. Our biocompatibility tests revealed that the composite scaffolds doped with 1 and 2 ml of RuO2 demonstrated the highest proliferation percentages (152.2 and 135.6%) compared to control. Finally, the SEM analyses confirmed the impressive cells attachments and differentiation onto the scaffold surfaces as evidenced by the presence of many neuron-like cells with apparent cell bodies and possessing few short neurite-like processes. The presence of RuO2 and glycine was due to their extraordinary biocompatibility due to their cytoprotective and regenerative effects. Therefore, we conclude that these scaffolds are promising for accommodation and growth of neural-like cells.

Aziz, M. S. A., and H. E. Salama, "Biocompatible and antimicrobial carboxymethyl xanthan/zinc physical hydrogels", Polymer Bulletin, vol. 79, issue 5, pp. 3219 - 3231, 2022. AbstractWebsite
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Aziz, M. S. A., and H. E. Salama, "Biocompatible and antimicrobial carboxymethyl xanthan/zinc physical hydrogels", Polymer Bulletin, vol. 79, issue 5, pp. 3219 - 3231, 2022. AbstractWebsite
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Hassan, H. E., Y. M. Asal, A. M. Mohammad, and I. M. Al-Akraa, "BIODIESEL PRODUCTION FROM CASTOR OIL: MIXING OPTIMIZATION DURING TRANSESTERIFICATION", ARPN Journal of Engineering and Applied Sciences, vol. 17, issue 8, pp. 844 - 848, 2022. AbstractWebsite

With the growing warning for accrediting the traditional combustion of fossil fuels for energy production, not only for their limited supply but also for their environmental risks (air pollution, climate change, …. etc), it became necessary to realize alternative greener and abundant sources for energy. Instead, the interest to sustain biodiesel for the energy production has recently been renewed as a replacement for petroleum diesel in conventional diesel engines. This was due to its renewable nature, low toxicity, high degradability and unique physical properties (high flash points & lubrication). Castor oil, in particular, appeared promising for biodiesel production with extremely low cloud and pour points; making it suitable for tropical climates. Blending petroleum diesel with castor oil biodiesel has been proven efficient for enhancing both the environmental effect and the kinematic flow properties of the mineral fuel. Nonetheless, because of the current market price of conventional diesel, the blended product appeared cost-ineffective; steering research to tune the use of castor oil biodiesel alone. In this study, a simple method is recommended to produce biodiesel from castor oil by a transesterification process. The effect of mixing time of oil and alcohol is optimized with a thorough analysis to optimize the best condition for the biodiesel production © 2006-2022 Asian Research Publishing Network (ARPN). All rights reserved

Attia, Y. A., E. Abdelsalam, S. Saeed, M. S. M. Mohamed, and M. Samer, "Bioethanol Production from Potato Peels Using Saccharomyces cerevisiae Treated with ZnO and ZnO/g-C3N4 Nanomaterials", Egyptian Journal of Chemistry, vol. 65, issue 13, pp. 309 - 315, 2022. Abstract

Bioethanol is a promising biofuel produced from agricultural wastes. The problem is that the bioconversion of cellulose to bioethanol takes a long time for excellent results. Predominantly, efficient enzymes and active microorganisms (yeast) can enhance the enzymatic saccharification and fermentation bioprocesses, respectively. The addition of nutrients and electron acceptors in form of nanomaterials was found to modify the bioenvironment and to biostimulate the microorganisms to accomplish the target bioprocesses efficiently. The objective of this investigation was to increase bioethanol production from agricultural wastes using nanomaterials. In this study, the bioethanol production from potato peels (as an example of agricultural wastes) was increased using ZnO nanomaterials and ZnO/g-C3N4 nanomaterials with the concentration of 5, 10, 15, 50, 100, and 150 mg/L each as well as the control (without the addition of nanomaterials). It was hypothesized that yeast treatment with nanomaterials (nutrients) leads to biostimulate yeast cells and increases cell activity. Consequently, it is hypothesized that these procedures increase bioethanol production from potato peels over a shorter Hydraulic Retention Time (HRT), i.e., residence time. It was found that the biostimulation of the fungi (yeast) Saccharomyces cerevisiae using 150 mg/L of ZnO/g-C3N4 nanomaterials generated the highest bioethanol concentration of 33.2% compared to all other treatments. © 2022 National Information and Documentation Center (NIDOC)

Alfaar, A., "Building registries is hard, how can we make it even harder?", Kongress der Deutschen Ophthalmologischen Gesellschaft [The Congress of the German Ophthalmological Society], Berlin, Springer, pp. S215 - S215, 2022///. Abstract

Registries resemble a systematic way of collecting data for a specific theme or a population. As well-built registries represent a wealth of information for scientists, huge investments are paid to ensure their quality. The quality of the data gathered depends on a rigorous process of data validation and updating and, the comprehensiveness of the sources providing the data. Therefore, the data release may take years after the data collection. The advancement in information and computer technologies has helped in the progress of building better disease registries. In the process of learning from experiences in building registries, we aim in this presentation at discussing the lessons learned from building cancer (and other diseases) registries in different setups to facilitate building better ophthalmological registries. Moreover, to discuss the most common mistakes that lead to delayed collection and publishing of the data.

Shokry, A., R. El-Shiekh, G. Kamel, A. Bakr, and A. Ramadan, Bioactive Phenolics Fraction of Hedera helix L. (Common Ivy Leaf) Standardized Extract ameliorates LPS-induced Acute Lung Injury in The Mouse Model Through The Inhibition of Proinflammatory Cytokines and Oxidative Stress, , pp. e09477, 2022/05/01. Abstract

Hedera helix L. (family Araliaceae) is classified as a conventional plant used as a medicinal product in the cure and prevention of upper respiratory tract inflammation and infection due to its secretolytic and broncholytic effects. Our research was conducted to authenticate the anti-inflammatory effect of ivy leaves extract in the prevention of acute lung injury (ALI) caused by intranasal administration of lipopolysaccharides (LPS). In-vitro antimicrobial, anti-inflammatory, and anti-oxidant were evaluated, in addition to the in-vivo acute lung inflammation model induced by LPS in mice. The animals were divided into seven groups randomly (each group containing 10 mice): control negative (saline only), control positive (LPS group), standard (Dexamethasone 2 mg/kg), ethanolic ivy leaves extract (EIE, 100 mg/kg), ethanolic ivy leaves extract (EIE, 200 mg/kg), saponin rich fraction (SRF, 100 mg/kg) and phenolic rich fraction (PRF,100 mg/kg). Right lungs were homogenized to determine the levels of SOD, MDA, catalase, IL-10, TNF-α, NO, IL-1β, IL-6, PGE2, and MPO. Left lungs were excised for histopathology and histomorphometry. Immunohistochemistry of Cox-2 and TNF-α levels were measured. Additionally, Western blotting was used to determine the levels of phosphorylated MAPK. The data showed that the oral supplementation with EIE, 200 mg/kg significantly (P<0.05) decreased the pro-inflammatory mediators, and oxidative stress biomarkers induced by LPS. Interestingly, the phenolics showed promising activity, therefore they are responsible for the action. The ethanolic extract was also standardized through HPLC analysis for its content of rutin. In conclusion, the standardized ivy leaf extract could be advised for acute lung injury for its antimicrobial, anti-oxidant, and anti-inflammatory activities.