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2022
El-Sherpieny, E. - S. A., H. Z. Muhammed, and E. M. Almetwally, "Bivariate Chen Distribution Based on Copula Function: Properties and Application of Diabetic Nephropathy", Journal of Statistical Theory and Practice, vol. 16, issue 3, pp. 1-33, 2022. bivariate_chen_distribution.pdf
eLsherpieny, E. A., E. M. Almetwally, and H. Z. Muhammed, "Bivariate Weibull-G Family Based on Copula Function: Properties, Bayesian and non-Bayesian Estimation and Applications", STATISTICS, OPTIMIZATION AND INFORMATION COMPUTING, vol. 10, issue June, pp. 678 - 709, 2022.
El-Sherpieny, E. - S. A., H. Z. Muhammed, and E. M. Almetwally, "Bivariate Weibull-G Family Based on Copula Function: Properties, Bayesian and non-Bayesian Estimation and Applications", Statistics, Optimization and Information Computing,, vol. 10, issue 3, pp. 678–709, 2022. bivariate_weibull-g_family.pdf
El-Sherpieny, E. - S. A., H. Z. Muhammed, and E. M. Almetwally, "Bivariate Weibull-G Family Based on Copula Function: Properties, Bayesian and non-Bayesian Estimation and Applications", Statistics, Optimization and Information Computing,, vol. 10, issue 3, pp. 678–709, 2022. bivariate_weibull-g_family.pdf
Helmy, M. A., L. M. Milad, A. Hasanin, E. A. Elsayed, O. Y. Kamel, M. Mostafa, S. Fathy, and M. Elsayad, "Bleeding and thrombotic complications in patients with severe COVID-19: A prospective observational study.", Health science reports, vol. 5, issue 4, pp. e736, 2022.
AbdElHaleem, S. H., A. G. Radwan, and S. K. Abd-El-Hafiz, "Blind Watermarking Using DCT and Fractional-Order Lorenz System", 2022 International Conference on Microelectronics (ICM): IEEE, pp. 94-97, 2022. Abstract
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Taha, M. H. N., M. H. N. Taha, and N. E. M. Khalifa, "Blockchain Technology and Machine Learning for Fake News Detection", Implementing and Leveraging Blockchain Programming, Singapore, Springer, 2022.
Hassanein, A. A., N. El-Tazi, and N. N. Mohy, "Blockchain, Smart Contracts, and Decentralized Applications: An Introduction", Implementing and Leveraging Blockchain Programming: Springer Singapore, 2022. Abstract

Blockchain, a most common synonym for distributed ledger (Tschorsch and Scheuermann in IEEE Commun Surv Tutor 18:2084–2123, 2016), is an emerging platform. Blockchain is used to support transactional services within a multi-party business network. The aim is to enable a significant reduction in cost and risk for all involved parties through the creation of novel and enhanced business models. Data maintained within the distributed ledger can only be accessed through the execution of a smart contract (Seijas, Scripting smart contracts for distributed ledger technology, International Association for Cryptologic Research, 1156, 2016) that governs a transaction with rules. The core driving idea for designing the architecture of a blockchain platform is to guarantee that no single business party can append, modify or delete any record residing within the ledger without going through the necessary consensus from other business parties within the network. This empowers the system and ensures the data is immutable. Examples of such data include but are not limited to legal and financial trails. Given the aforementioned important features, blockchain technology is a revolutionary trending technology with the ability to offer tremendous disrupting changes to different industries. Gartner’s 2016 research report (Gartner, Gartner’s 2016 hype cycle for emerging technologies special report, 2016) identified blockchain as one of the key platform-enabling technologies to track. While there is currently a lack of widely identified and accepted standards for blockchain technology, there is a rising agreement that blockchain is currently entering its height of extravagant expectations. The report anticipated that it would take 5 to 10 years for blockchain technology to be easily and widely adopted. Nowadays, almost five years later most blockchain efforts, especially the ones applied to business environments, are still in the early stages not reaching the widely adoption stage also not realizing a widely accepted standard so far. In this book chapter, an attempt will be made to cover the main concepts of blockchain, its underlying technologies, Smart Contracts, and Decentralized Applications (DApps).

Elsisi, H. F. E. M., Y. M. Aneis, G. E. E. Refaye, and H. O. Ghareeb, "Blood oxygenation response to aerobic exercise combined with breathing exercises in pregnant women: a randomized controlled trial", Bulletin of Faculty of Physical Therapy, Cairo University, vol. 27, issue 16, pp. 1-9, 2022.
Goubran, H., G. Ragab, J. Seghatchian, and T. Burnouf, "Blood transfusion in autoimmune rheumatic diseases", Transfusion and Apheresis Science, vol. 61, issue 6: Pergamon, pp. 103596, 2022. Abstract
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Fitieh, A., A. J. Locke, F. Mashayekhi, F. Khaliqdina, A. K. Sharma, and I. H. Ismail, "BMI-1 regulates DNA end resection and homologous recombination repair.", Cell reports, vol. 38, issue 12, pp. 110536, 2022. Abstract

BMI-1 is an essential regulator of transcriptional silencing during development. Recently, the role of BMI-1 in the DNA damage response has gained much attention, but the exact mechanism of how BMI-1 participates in the process is unclear. Here, we establish a role for BMI-1 in the repair of DNA double-strand breaks by homologous recombination (HR), where it promotes DNA end resection. Mechanistically, BMI-1 mediates DNA end resection by facilitating the recruitment of CtIP, thus allowing RPA and RAD51 accumulation at DNA damage sites. Interestingly, treatment with transcription inhibitors rescues the DNA end resection defects of BMI-1-depleted cells, suggesting BMI-1-dependent transcriptional silencing mediates DNA end resection. Moreover, we find that H2A ubiquitylation at K119 (H2AK119ub) promotes end resection. Taken together, our results identify BMI-1-mediated transcriptional silencing and promotion of H2AK119ub deposition as essential regulators of DNA end resection and thus the progression of HR.

Ismael, H. F., A. N. Akkilic, M. A. S. Murad, H. Bulut, W. Mahmoud, and M. S. Osman, "Boiti–Leon–Manna–Pempinelli equation including time-dependent coefficient (vcBLMPE): a variety of nonautonomous geometrical structures of wave solutions", Nonlinear Dynamics, vol. 110, pp. 3699–3712, 2022.
Kotb, M. A., L. A. Fawaz, R. A. Zeitoun, Y. M. Shaalan, N. Aly, H. Abd El Kader, G. Eltagy, H. Esmat, A. F. Hamza, and H. Abd El Baky, "Bone demineralization in a cohort of Egyptian pediatric liver transplant recipients: Single center pilot study.", Medicine, vol. 101, issue 45, pp. e31156, 2022. Abstract

Liver transplantation (LT) is the definitive treatment of end-stage liver disease. The long-term survival following LT spurred more interest in improving the quality of life of patients. This was a cohort study that included 23 pediatric liver transplant recipients who underwent LT due to hereditary or metabolic liver diseases. Bone health assessment was performed at their last follow up clinically (anthropometric measures), biochemically and radiologically (Dual Energy X-ray Absorptiometry [DEXA] scans). Poor bone health was defined as z-score <-1. Mean age at LT was 5.77 years (standard deviation [SD] 3.64) and 43% were males. Biliary atresia was the most common cause of end stage liver disease (35%). Mean age at follow up was 14 years (SD 5.48) and mean follow up was 8 years (SD 4.12 years). Eleven patients (48%) had poor bone health (osteopenia 22% and osteoporosis 26%). On univariate analysis, being on steroids at last follow up (odds ratio [OR] 13.2, 95% confidence interval [CI] 1.23-140.67, P = .03), weight at last follow up (OR 0.45, 95% CI 0.20-0.99, P = .04), platelets at last follow up (OR 0.98, 95% CI 0.96-s0.99, P = .02), hemoglobin at last follow up (OR 0.33, 95% CI 0.12-0.89, P = .03) were significantly associated with poor bone health. None of the variables were significant on multivariate analysis. At most recent follow up, 48% of patients demonstrated poor bone health by DEXA scans. More studies are required to evaluate predictors of poor bone health after LT in children.

Soliman, A. S. A., M. W. Abukhatwah, N. M. Kamal, E. M. M. Sweed, A. M. Alelyani, S. D. Althobaiti, M. A. Alzaedi, A. M. El-Rebigi, N. T. Besher, O. M. W. Abukhatwah, et al., "Bone densitometry in children with idiopathic nephrotic syndrome on prolonged steroid therapy: A tertiary multicenter study.", Medicine, vol. 101, issue 33, pp. e29860, 2022. Abstractbone_densitometry_in_children_with_idiopathic.22.pdf

Long-term glucocorticoids administration inhibits bone mineralization and has a negative impact on basic cellular mechanisms that are critical in the development and maintenance of bone strength. Steroids can cause osteoporosis in children and have a negative impact on bone mineral content (BMC) and bone mineral density (BMD). We aim to determine the BMD of children with idiopathic nephrotic syndrome (INS) who are on corticosteroids therapy. This cross-sectional study included 90 patients on corticosteroids therapy and 50 apparently healthy age and sex-matched children served as a control group. Renal functions, bone biochemistry, and parathyroid hormone (PTH) were measured in patients and controls. BMD was measured at the lumbar spinal region (L2-L4) using Dual-energy X-ray absorptiometry (DEXA) scan in both patients and controls groups. Serum PTH, phosphorous, and alkaline phosphatase levels were significantly higher in patients than in controls. There was a statistically significant reduction in blood calcium levels in patients compared to controls. Osteopenia was diagnosed by DEXA scan in 24 patients (26.7%) and osteoporosis in 12 patients (13.3 %). There was a statistically significant decline in BMD-z score, BMD, and BMC in patients compared to the healthy group. Patients with INS on corticosteroids treatment have a lower BMD than their peers. Pediatric INS patients had a high prevalence of osteopenia and osteoporosis as measured by DEXA. Steroid therapy has a deleterious impact on bone mineralization in children with INS.

Senosi, M. R., H. M. Fathi, N. A. M. Baki, O. Zaki, A. M. Magdy, and T. A. Gheita, "Bone mineral density, vitamin D receptor (VDR) gene polymorphisms, fracture risk assessment (FRAX), and trabecular bone score (TBS) in rheumatoid arthritis patients: connecting pieces of the puzzle.", Clinical rheumatology, 2022. Abstract

PURPOSE: To assess vitamin D receptor (VDR) gene polymorphisms and bone mineral density and to investigate the possible risk factors of osteoporosis and fracture in rheumatoid arthritis (RA).

METHODS: A total of 97 RA patients and 45 matched controls were enrolled. Serum vitamin D level, VDR genotyping, dual-energy X-ray absorptiometry (DEXA) scan, trabecular bone score (TBS), and fracture risk assessment (FRAX) in 10 years were assessed. Disease activity score (DAS28) and modified health assessment questionnaire (MHAQ) were measured.

RESULTS: The mean age of the patients was 47.9 ± 8.9 years; 85 females, 12 males (F:M 7.1:1) and mean disease duration 9.4 ± 6.2 years. DAS28 was 4.52 ± 1.04 and MHAQ 0.6 ± 0.4. There was a significant difference between cases and controls as regards DEXA and FRAX (p < 0.0001) but the TBS and VDR genotyping were comparable (p = 0.29 and p = 0.12, respectively). The vitamin D level was comparable with the control (9.3 ± 6.5 vs 10.4 ± 7.5 ng/mL, p = 0.4). None of the patients was receiving anti-osteoporotic therapy or biologic therapy. There was a significant association between the presence of osteoporosis and age, disease duration, menopause, and rheumatoid factor (RF) positivity. The TBS was significantly lower and FRAX higher in patients with positive RF and anti-CCP. FRAX was significantly related and the TBS inversely with the age, disease duration, serum uric acid, alkaline phosphatase, and MHAQ.

CONCLUSIONS: Reduced BMD and increased tendency to fractures are remarkable in RA patients. Vitamin D level was decreased in patients and control, and VDR gene polymorphisms were not linked to RA. TBS and FRAX are effective tools to assess osteoporotic fractures in RA. Key Points • Reduced bone mineral density (BMD) and increased tendency to fractures are remarkable in rheumatoid arthritis (RA) patients. • Vitamin D level was decreased in patients and control, and VDR gene polymorphisms were not linked to RA. • Trabecular bone score (TBS) and fracture risk assessment (FRAX) in 10 years are effective tools to assess osteoporotic fractures in RA.

Ibrahim, M. A., A. M. Khalifa, A. A. Mohamed, R. A. Galhom, H. E. Korayem, N. M. Abd El-Fadeal, A. A. - E. Tammam, M. M. Khalifa, O. S. Elserafy, and R. I. Abdel-Karim, "Bone-Marrow-Derived Mesenchymal Stem Cells, Their Conditioned Media, and Olive Leaf Extract Protect against Cisplatin-Induced Toxicity by Alleviating Oxidative Stress, Inflammation, and Apoptosis in Rats.", Toxics, vol. 10, issue 9, 2022. Abstract

BACKGROUND: Hepatic and renal damage is a cisplatin (Cis)-induced deleterious effect that is a major limiting factor in clinical chemotherapy.

OBJECTIVES: The current study was designed to investigate the influence of pretreatment with olive leaf extract (OLE), bone-marrow-derived mesenchymal stem cells (BM-MSC), and their conditioned media (CM-MSC) against genotoxicity, nephrotoxicity, hepatotoxicity, and immunotoxicity induced by cisplatin in rats.

METHODS: The rats were randomly divided into six groups (six rats each) as follows: Control; OLE group, treated with OLE; Cis group, treated with a single intraperitoneal dose of Cis (7 mg/kg bw); Cis + OLE group, treated with OLE and cisplatin; Cis + CM-MSC group, treated with BM-MSC conditioned media and Cis; and Cis + MSC group, treated with BM-MSC in addition to Cis.

RESULTS: Cis resulted in a significant deterioration in hepatic and renal functions and histological structures. Furthermore, it increased inflammatory markers (TNF-α, IL-6, and IL-1β) and malondialdehyde (MDA) levels and decreased glutathione (GSH) content, total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD) activity in hepatic and renal tissues. Furthermore, apoptosis was evident in rat tissues. A significant increase in serum 8-hydroxy-2-deoxyguanosine (8-OH-dG), nitric oxide (NO) and lactate dehydrogenase (LDH), and a decrease in lysozyme activity were detected in Cis-treated rats. OLE, CM-MSC, and BM-MSC have significantly ameliorated Cis-induced deterioration in hepatic and renal structure and function and improved oxidative stress and inflammatory markers, with preference to BM-MSC. Moreover, apoptosis was significantly inhibited, evident from the decreased expression of Bax and caspase-3 genes and upregulation of Bcl-2 proteins in protective groups as compared to Cis group.

CONCLUSIONS: These findings indicate that BM-MSC, CM-MSC, and OLE have beneficial effects in ameliorating cisplatin-induced oxidative stress, inflammation, and apoptosis in the hepatotoxicity, nephrotoxicity, immunotoxicity, and genotoxicity in a rat model.

Ibrahim, M. A., A. M. Khalifa, A. A. Mohamed, R. A. Galhom, H. E. Korayem, N. M. Abd El-Fadeal, A. A. - E. Tammam, M. M. Khalifa, O. S. Elserafy, and R. I. Abdel-Karim, "Bone-Marrow-Derived Mesenchymal Stem Cells, Their Conditioned Media, and Olive Leaf Extract Protect against Cisplatin-Induced Toxicity by Alleviating Oxidative Stress, Inflammation, and Apoptosis in Rats.", Toxics, vol. 10, issue 9, 2022. Abstract

BACKGROUND: Hepatic and renal damage is a cisplatin (Cis)-induced deleterious effect that is a major limiting factor in clinical chemotherapy.

OBJECTIVES: The current study was designed to investigate the influence of pretreatment with olive leaf extract (OLE), bone-marrow-derived mesenchymal stem cells (BM-MSC), and their conditioned media (CM-MSC) against genotoxicity, nephrotoxicity, hepatotoxicity, and immunotoxicity induced by cisplatin in rats.

METHODS: The rats were randomly divided into six groups (six rats each) as follows: Control; OLE group, treated with OLE; Cis group, treated with a single intraperitoneal dose of Cis (7 mg/kg bw); Cis + OLE group, treated with OLE and cisplatin; Cis + CM-MSC group, treated with BM-MSC conditioned media and Cis; and Cis + MSC group, treated with BM-MSC in addition to Cis.

RESULTS: Cis resulted in a significant deterioration in hepatic and renal functions and histological structures. Furthermore, it increased inflammatory markers (TNF-α, IL-6, and IL-1β) and malondialdehyde (MDA) levels and decreased glutathione (GSH) content, total antioxidant capacity (TAC), catalase (CAT), and superoxide dismutase (SOD) activity in hepatic and renal tissues. Furthermore, apoptosis was evident in rat tissues. A significant increase in serum 8-hydroxy-2-deoxyguanosine (8-OH-dG), nitric oxide (NO) and lactate dehydrogenase (LDH), and a decrease in lysozyme activity were detected in Cis-treated rats. OLE, CM-MSC, and BM-MSC have significantly ameliorated Cis-induced deterioration in hepatic and renal structure and function and improved oxidative stress and inflammatory markers, with preference to BM-MSC. Moreover, apoptosis was significantly inhibited, evident from the decreased expression of Bax and caspase-3 genes and upregulation of Bcl-2 proteins in protective groups as compared to Cis group.

CONCLUSIONS: These findings indicate that BM-MSC, CM-MSC, and OLE have beneficial effects in ameliorating cisplatin-induced oxidative stress, inflammation, and apoptosis in the hepatotoxicity, nephrotoxicity, immunotoxicity, and genotoxicity in a rat model.

Baibars, I.O., M. G. Abd El-Moghny, and M. S. El-Deab, "Boosted electrolytic hydrogen production at tailor-tuned nano-dendritic Ni-doped Co foam-like catalyst", Electrochimica Acta, , vol. 410, pp. 139992, 2022.
Kamel, A. S., A. Wahid, N. F. Abdelkader, and W. W. Ibrahim, "Boosting amygdaloid GABAergic and neurotrophic machinery via dapagliflozin-enhanced LKB1/AMPK signaling in anxious demented rats", Life Sciences , vol. 310, pp. 121002, 2022. paper-1_1.pdf
Kamel, A. S., A. Wahid, N. F. Abdelkader, and W. W. Ibrahim, "Boosting amygdaloid GABAergic and neurotrophic machinery via dapagliflozin-enhanced LKB1/AMPK signaling in anxious demented rats.", Life sciences, vol. 310, pp. 121002, 2022. Abstract

Anxiety is a neuropsychiatric disturbance that is commonly manifested in various dementia forms involving Alzheimer's disease (AD). The mechanisms underlying AD-associated anxiety haven't clearly recognized the role of energy metabolism in anxiety represented by the amygdala's autophagic sensors; liver kinase B1 (LKB1)/adenosine monophosphate kinase (AMPK). Dapagliflozin (DAPA), a SGLT2 inhibitor, acts as an autophagic activator through LKB1 activation in several diseases including AD. Herein, the propitious yet undetected anxiolytic potential of DAPA as an autophagic enhancer was investigated in AD animal model with emphasis on amygdala's GABAergic neurotransmission and brain-derived neurotrophic factor (BDNF). Alzheimer's disease was induced by ovariectomy (OVX) along with seventy-days-D-galactose (D-Gal) administration (150 mg/kg/day, i.p). On the 43rd day of D-Gal injection, OVX/D-Gal-subjected rats received DAPA (1 mg/kg/day, p.o) alone or with dorsomorphin the AMPK inhibitor (DORSO, 25 μg/rat, i.v.). In the amygdala, LKB1/AMPK were activated by DAPA inducing GABA receptor stimulation; an effect that was abrogated by DORSO. Dapagliflozin also replenished the amygdala GABA, NE, and 5-HT levels along with glutamate suppression. Moreover, DAPA triggered BDNF production with consequent activation of its receptor, TrkB through activating GABA-related downstream phospholipase C/diacylglycerol/protein kinase C (PLC/DAG/PKC) signaling. This may promote GABA expression, verifying the crosstalk between GABA and GABA. The DAPA's anxiolytic effect was visualized by improved behavioral traits in elevated plus maze together with amendment of amygdala' histopathological abnormalities. Thus, the present study highlighted DAPA's anxiolytic effect which was attributed to GABA activation and its function to induce BDNF/TrkB and GABA expression through PLC/DAG/PKC pathway in AMPK-dependent manner.

Kamel, A. S., A. Wahid, N. F. Abdelkader, and W. W. Ibrahim, "Boosting amygdaloid GABAergic and neurotrophic machinery via dapagliflozin-enhanced LKB1/AMPK signaling in anxious demented rats.", Life sciences, vol. 310, pp. 121002, 2022. Abstract

Anxiety is a neuropsychiatric disturbance that is commonly manifested in various dementia forms involving Alzheimer's disease (AD). The mechanisms underlying AD-associated anxiety haven't clearly recognized the role of energy metabolism in anxiety represented by the amygdala's autophagic sensors; liver kinase B1 (LKB1)/adenosine monophosphate kinase (AMPK). Dapagliflozin (DAPA), a SGLT2 inhibitor, acts as an autophagic activator through LKB1 activation in several diseases including AD. Herein, the propitious yet undetected anxiolytic potential of DAPA as an autophagic enhancer was investigated in AD animal model with emphasis on amygdala's GABAergic neurotransmission and brain-derived neurotrophic factor (BDNF). Alzheimer's disease was induced by ovariectomy (OVX) along with seventy-days-D-galactose (D-Gal) administration (150 mg/kg/day, i.p). On the 43rd day of D-Gal injection, OVX/D-Gal-subjected rats received DAPA (1 mg/kg/day, p.o) alone or with dorsomorphin the AMPK inhibitor (DORSO, 25 μg/rat, i.v.). In the amygdala, LKB1/AMPK were activated by DAPA inducing GABA receptor stimulation; an effect that was abrogated by DORSO. Dapagliflozin also replenished the amygdala GABA, NE, and 5-HT levels along with glutamate suppression. Moreover, DAPA triggered BDNF production with consequent activation of its receptor, TrkB through activating GABA-related downstream phospholipase C/diacylglycerol/protein kinase C (PLC/DAG/PKC) signaling. This may promote GABA expression, verifying the crosstalk between GABA and GABA. The DAPA's anxiolytic effect was visualized by improved behavioral traits in elevated plus maze together with amendment of amygdala' histopathological abnormalities. Thus, the present study highlighted DAPA's anxiolytic effect which was attributed to GABA activation and its function to induce BDNF/TrkB and GABA expression through PLC/DAG/PKC pathway in AMPK-dependent manner.

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