Publications

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2022
Saleh, M., D. A. Elmanakhly, E. A. Rashed, and M. Abdel-Basset, "BinHOA: Efficient Binary Horse Herd Optimization Method for Feature Selection: Analysis and Validations", IEEE Access, vol. 10, issue 2169-3536, pp. 26795-26816, 2022. binhoa_efficient_binary_horse_herd_optimization.pdf
Bashal, A. H., S. M. Riyadh, W. Alharbi, K. H. Alharbi, T. A. Farghaly, and K. D. Khalil, "Bio-Based (Chitosan-ZnO) Nanocomposite: Synthesis, Characterization, and Its Use as Recyclable, Ecofriendly Biocatalyst for Synthesis of Thiazoles Tethered Azo Groups", Polymers, vol. 14, pp. 386, 2022.
Bashal, A. H., S. M. Riyadh, W. Alharbi, K. H. Alharbi, T. A. Farghaly, and K. D. Khalil, "Bio-Based (Chitosan-ZnO) Nanocomposite: Synthesis, Characterization, and Its Use as Recyclable, Ecofriendly Biocatalyst for Synthesis of Thiazoles Tethered Azo Groups", Polymers, vol. 14, pp. 386, 2022. 7.pdf
Abdel-Halim, K., E. - M. S., A. Wanas, and N. A. Mostafa, "Bioaccumulation profiles of heavy metals in fish collected from Rosetta branch of Nile River, Egypt: A case study for organ's responsibility. . ", The Egyptian Journal of Chemistry, vol. 65 , issue (13), pp. 501-518, 2022.
Elchaghaby, M. A., SF Abd El-Kader, and M. M. Aly, "Bioactive composition and antibacterial activity of three herbal extracts (lemongrass, sage, and guava leaf) against oral bacteria: An in vitro study ", Journal of Oral Biosciences , vol. 64, issue 1, pp. 114-119, 2022.
Shokry, A. A., R. A. El-Shiekh, G. Kamel, A. F. Bakr, and A. Ramadan, "Bioactive phenolics fraction of L. (Common Ivy Leaf) standardized extract ameliorates LPS-induced acute lung injury in the mouse model through the inhibition of proinflammatory cytokines and oxidative stress.", Heliyon, vol. 8, issue 5, pp. e09477, 2022. Abstract

L. (family Araliaceae) is classified as a conventional plant used as a medicinal product in the cure and prevention of upper respiratory tract inflammation and infection due to its secretolytic and broncholytic effects. Our research was conducted to authenticate the anti-inflammatory effect of ivy leaves extract in the prevention of acute lung injury (ALI) caused by intranasal administration of lipopolysaccharides (LPS). antimicrobial, anti-inflammatory, and anti-oxidant were evaluated, in addition to the acute lung inflammation model induced by LPS in mice. The animals were divided into seven groups randomly (each group containing 10 mice): control negative (saline only), control positive (LPS group), standard (Dexamethasone 2 mg/kg), ethanolic ivy leaves extract (EIE, 100 mg/kg), ethanolic ivy leaves extract (EIE, 200 mg/kg), saponin rich fraction (SRF, 100 mg/kg) and phenolic rich fraction (PRF, 100 mg/kg). Right lungs were homogenized to determine the levels of SOD, MDA, catalase, IL-10, TNF-α, NO, IL-1β, IL-6, PGE2, and MPO. Left lungs were excised for histopathology and histomorphometry. Immunohistochemistry of Cox-2 and TNF-α levels were measured. Additionally, Western blotting was used to determine the levels of phosphorylated MAPK. Also, the ethanolic extract was also standardized through HPLC analysis for its content of rutin.The data showed that the oral supplementation with EIE, 200 mg/kg significantly ( < 0.05) decreased the pro-inflammatory mediators, and oxidative stress biomarkers induced by LPS. Interestingly, the phenolics showed promising activity, therefore they are responsible for the action. In conclusion, the standardized ivy leaf extract could be advised for acute lung injury for its antimicrobial, anti-oxidant, and anti-inflammatory activities.

Helal, D. S., H. El-khawas, and T. A. R. E. K. R. ELSAYED, "Bioactive secondary metabolites extracted from the plant growth promoting bacteria Paraburkholderia tropica", Egyptian Journal of Chemistry, vol. 65, issue 6, pp. 611-620, 2022.
Goyal, A., Aditya Sharma Aditya, H. R. H. Mohamed., and et al, "Bioactive-Based Cosmeceuticals: An Update on Emerging Trends", Molecules , vol. 27, issue 3, pp. 828, 2022.
Geweely, N. S., H. A. M. Afifi, S. A. AbdelRahim, G. M. I. Kamh, M. M. Soliman, M. Abdelsattar, A. Ali, H. M., and M. Z. M. Salem, "Bioactivities of six plant essential oils against some isolated microbes from an archaeological limestone statue at the Saqqara excavation", BioResources, vol. 17, issue (1), pp. 543-573, 2022.
Mohammed, D. M., N. Elsayed, D. A. H. Baker, K. A. Ahmed, and undefined, "Bioactivity and antidiabetic properties of Malva parviflora L. leaves extract and its nano-formulation in streptozotocin-induced diabetic rats", Heliyon, vol. 8, pp. e12027, 2022. 8.pdf
Rudrapal, M., A. P. Kothawade, S. M. Ezzat, and C. Egbuna, "Bioanalysis: methods, techniques, and applications", Analytical Techniques in Biosciences: Elsevier, 2022.
Abdelhafiz, A. S., M. Ahram, M. E. Ibrahim, A. Elgamri, E. Gamel, R. Labib, and H. Silverman, "Biobanks in the low-and middle-income countries of the Arab Middle East region: challenges, ethical issues, and governance arrangements—a qualitative study involving biobank managers", BMC Medical Ethics, vol. 23, issue 1: BioMed Central London, pp. 83, 2022. Abstract
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M. M. Rahman, Md. R. Islam, S. Uddin, M. M. Rahman, A. Gaber, Y. S. Althobaiti, A. A. Abdelhadi, and M. M. R. Jahangir, "Biochar and Compost-Based Integrated Nutrient Management: Potential for Carbon and Microbial Enrichment in Degraded Acidic and Charland Soils", Frontiers in Environmental Science, vol. 9, issue 798729, pp. 1-16, 2022.
Soliman, M. H., H. A. S. Alhaithloul, H. E. A. Awad, M. J. Shahid, S. Ali, and A. E. A. Kelish, "Biochar {Magic} against {Abiotic} {Stresses}", Climate {Change} and {Ecosystems}: CRC Press, 2022. Abstract

Biochar Magic against Abiotic Stresses - 1

Khalil, N. M., H. M. Ali, and A. E. Ibrahim, "Biochemical Activity of Propolis Alcoholic Extracts against Fusarium oxysporum hm89", Egyptian Journal of Botany, vol. 62, issue 1, pp. 197-212 , 2022.
Senousy, H. H., M. M. El-Sheekh, A. A. Saber, H. M. Khairy, H. A. Said, W. A. Alhoqail, and A. M. Abu-Elsaoud, "Biochemical Analyses of Ten Cyanobacterial and Microalgal Strains Isolated from Egyptian Habitats, and Screening for Their Potential against Some Selected Phytopathogenic Fungal Strains", agronomy, vol. 12, pp. 1340, 2022.
Abd-Allah, E. R., A. - E. El-Ghareeb, O. S. Hafez, and H. A. A. El-Rahman, "Biochemical and histopathological evaluations of thiamethoxam on the male reproductive system", Egyptian Journal of Chemistry, vol. 65, issue 11, pp. 677 - 689, 2022. 5-_olfat_paper.pdf
Hoter, A., and H. Y. Naim, "Biochemical Characterization of SARS-CoV-2 Spike RBD Mutations and Their Impact on ACE2 Receptor Binding.", Frontiers in molecular biosciences, vol. 9, pp. 893843, 2022. Abstract

Infection of mammalian cells by SARS-CoV-2 coronavirus requires primary interaction between the receptor binding domain (RBD) of the viral spike protein and the host cell surface receptor angiotensin-converting enzyme 2 (ACE2) glycoprotein. Several mutations in the RBD of SARS-CoV-2 spike protein have been reported for several variants and resulted in wide spread of the COVID pandemic. For instance, the double mutations L452R and E484Q present in the Indian B.1.617 variant have been suggested to cause evasion of the host immune response. The common RBD mutations N501Y and E484K were found to enhance the interaction with the ACE2 receptor. In the current study, we analyzed the biosynthesis and secretion of the RBD double mutants L452R and E484Q in comparison to the wild-type RBD and the individual mutations N501 and E484K in mammalian cells. Moreover, we evaluated the interaction of these variants with ACE2 by means of expression of the S protein and co-immunoprecipitation with ACE2. Our results revealed that the double RBD mutations L452R and E484Q resulted in a higher expression level and secretion of spike S1 protein than other mutations. In addition, an increased interaction of these mutant forms with ACE2 in Calu3 cells was observed. Altogether, our findings highlight the impact of continuous S1 mutations on the pathogenicity of SARS-CoV-2 and provide further biochemical evidence for the dominance and high transmissibility of the double Indian mutations.

Reyad, N. E. - H. A., T. A. R. E. K. R. ELSAYED, D. M. Naguib, and S. N. Azoz, "Biocontrol of root rot in Geranium with antimycotic rhizobateria", Rhizosphere, vol. 24, pp. 100607, 2022.
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