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2022
Ibrahium, A. M., Y. H. Ahmed, and N. A. Shaker, "Anatomical, Histological and Radiological Studies of Parotid Salivary Glands of the Red Fox (Vulpes vulpes) with Comparison to Baladi Dog", International Journal of Veterinary Science, vol. 11, issue 4, pp. 414-419., 2022. 6-lbhth_lsds.pdf
Abdelzaher, H. A., M. K. Sidky, A. Awadein, and M. Hosny, "Aniseikonia and visual functions with optical correction and after refractive surgery in axial anisometropia.", International ophthalmology, vol. 42, issue 6, pp. 1669-1677, 2022. Abstract

PURPOSE: To evaluate differences in the subjective aniseikonia and stereoacuity in patients with axial anisometropia after full correction of the refractive error with spectacles, contact lenses, and refractive surgery.

METHODS: A prospective study was performed in Cairo University Hospitals on 20 patients with axial anisometropia caused by unilateral myopia > 5 D with > 4 D inter-ocular difference in spherical equivalent who were suitable candidates for excimer laser ablation (LASIK) or implantable collamer lens implantation (ICL). All patients had measurement of best-corrected visual acuity (BCVA), fusion, stereoacuity, and magnitude of aniseikonia with spectacles, contact lenses, and after surgery.

RESULTS: The mean age at time of surgery was 25.7 ± 3.1 years. There were no statistically significant differences in the BCVA or stereoacuity with spectacles, contact lenses, or after refractive surgery. Microkonia < 5%) was perceived with spectacles in 8 patients (40%) and remained unchanged in 7 of these 8 patients with contact lenses. Following LASIK (n = 11), there was an induced macrokonia < 2% in 4 patients (36%), persistent microkonia of 3% in 1 patient (9%), and no change in image size in 6 (55%) patients. Following ICL implantation (n = 9), there was a perceived macrokonia of 2% in 4 patients (44%), disappearance of microkonia in 1 patient (11%) and no change in 4 patients (44%).

CONCLUSIONS: Differences in BCVA, stereoacuity, and aniseikonia after correction of anisometropia by glasses, contact lens and surgery are both clinically and statistically insignificant. Retinal or neural adaptation might have a role in correction for differences in image size.

FAROUK, M., S. Kaddah, and M. Kotb, "Anorectal Malformation: An Atypical Association of Pierre Robin Sequence", Pediatric Sciences Journal, vol. 2, issue 1, pp. 104-107, 2022. Anorectal Malformation: An Atypical Association of Pierre Robin Sequence
Farouk, M., S. N. Kaddah, and M. A. Kotb, "Anorectal Malformation: An Atypical Association of Pierre Robin Sequence", Pediatric Sciences Journal, vol. 2, issue 1: Cairo University, Faculty of Medicine, Department of Pediatrics, pp. 104-107, 2022. Abstract
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Gaber, G. A., S. A. Abolkassem, O. Elkadi, M. Tash, and L. Z. Mohamed, "ANOVA and DOE of comparative studies of Cu/Mn efect on corrosion features of CoCrFeNi high entropy alloy immersed in diferent acidic media", Chemical Papers, vol. 76, issue 2, pp. 1675-1690, 2022. gaber2022_article_anovaanddoeofcomparativestudie.pdf
Gaber, G. A., S. A. Abolkassem, O. A. El Kady, M. Tash, and L. Z. Mohamed, "ANOVA and DOE of comparative studies of Cu/Mn effect on corrosion features of CoCrFeNi high entropy alloy immersed in different acidic media", Chemical Papers, vol. 76, pp. 1675–1690, 2022.
Elmaidomy, A. H., U. R. Abdelmohsen, F. Alsenani, H. F. Aly, S. G. E. Shams, E. A. Younis, K. A. Ahmed, A. M. Sayed, A. I. Owis, N. Afifia, et al., "The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches", RSC Advances, vol. 12, pp. 11769–11785, 2022.
Shahhat, D. A., M. M. ElMallah, M. A. Shalaby, and H. G. Elmasry, "Anti-oxidant and Anti-inflammatory Effects of Intermittent Fasting against Acetic Acid-Induced Ulcerative Colitis in Rats", NeuroQantology, vol. 20, issue 15, pp. 3741-3746., 2022.
Essa, E. E., D. Hamza, M. M. H. Khalil, H. Zaher, D. Salah, A. M. Alnemari, M. H. Rady, and S. A. A. Mo Men, "The Antibacterial Activity of Egyptian Wasp Chitosan-Based Nanoparticles against Important Antibiotic-Resistant Pathogens.", Molecules (Basel, Switzerland), vol. 27, issue 21, 2022. Abstract

The current work discusses the production and characterization of new biodegradable nanoparticles for biomedical applications based on insect chitosan. Chitosan has numerous features due to the presence of primary amine groups in repeating units, such as antibacterial and anticancer activities. When polyanion tripolyphosphate is added to chitosan, it creates nanoparticles with higher antibacterial activity than the original chitosan. In this study, the ionic gelation technique was used to make wasp chitosan nanoparticles (WCSNPs) in which TEM and FTIR were used to investigate the physicochemical properties of the nanoparticles. In addition, the antibacterial activities of chitosan nanoparticles against extended-spectrum beta-lactamase (ESBL)- and carbapenemase-producing , , and were evaluated. The extracted wasp chitosan exhibited high solubility in acetic acid and met all standard criteria of all characterization testes for nanoparticles; the zeta potential indicated stable WCSNPs capable of binding to cellular membrane and increasing the cellular uptake. The produced WCSNPs showed growth inhibition activity against all tested strains, and the bacterial count was lower than the initial count. The inhibition percent of WCSNPs showed that the lowest concentration of WCSNPs was found to be effective against tested strains. WCSNPs' antibacterial activity implies that they could be used as novel, highly effective antibacterial agents in a variety of biological applications requiring antibacterial characteristics.

Deghadi, R. G., A. E. Elsharkawy, A. M. Ashmawy, and G. G. Mohamed, "Antibacterial and anticorrosion behavior of bioactive complexes of selected transition metal ions with new 2-acetylpyridine Schiff base", Applied Organometallic Chemistry, vol. 36, issue 4, pp. e6579, 2022.
Helmy, M. T., F. M. Sroor, K. F. Mahrous, K. Mahmoud, H. M. Hassaneen, F. M. Saleh, I. A. Abdelhamid, and M. A. Mohamed Teleb, "Anticancer activity of novel 3‐(furan‐2‐yl) pyrazolyl and 3‐(thiophen‐2‐yl) pyrazolyl hybrid chalcones: synthesis and in vitro studies", Archiv der Pharmazie, vol. 355, issue 3, pp. 2100381, 2022. Abstract
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Helmy, M. T., F. M. Sroor, K. F. Mahrous, K. Mahmoud, H. M. Hassaneen, F. M. Saleh, I. A. Abdelhamid, and M. A. Mohamed Teleb, "Anticancer activity of novel 3‐(furan‐2‐yl) pyrazolyl and 3‐(thiophen‐2‐yl) pyrazolyl hybrid chalcones: synthesis and in vitro studies", Archiv der Pharmazie, vol. 355, issue 3, pp. 2100381, 2022. Abstract
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Helmy, M. T., F. M. Sroor, K. F. Mahrous, K. Mahmoud, H. M. Hassaneen, F. M. Saleh, I. A. Abdelhamid, and M. A. Mohamed Teleb, "Anticancer activity of novel 3‐(furan‐2‐yl) pyrazolyl and 3‐(thiophen‐2‐yl) pyrazolyl hybrid chalcones: Synthesis and in vitro studies", Archiv der Pharmazie, vol. 355, issue 3, pp. 2100381, 2022. Abstract
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Amer, M. N., N. A. Atwa, A. I. Eldiwany, E. W. Elgammal, I. E. Dawoud, and F. M. Rashad, "Anticancer and antioxidant activities of l- asparaginase produced by local Weissella paramesenteroides MN2C2 strain", Egyptian Journal of Chemistry, vol. 65, issue 7, pp. 409 - 419, 2022.
Hamdan, D. I., S. Salah, W. H. B. Hassan, M. Morsi, H. M. A. Khalil, O. A. - H. Ahmed-Farid, R. A. El-Shiekh, M. A. E. Nael, and A. M. Elissawy, "Anticancer and Neuroprotective Activities of Ethyl Acetate Fractions from Miq. Plant Organs with Ultraperformance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Profiling.", ACS omega, vol. 7, issue 18, pp. 16013-16027, 2022. Abstract

Column chromatography afforded the isolation of seven secondary metabolites (1-(2,4,6-trihydroxy phenyl)-ethanone-4--β-d-glucopyranoside, naringenin-7--β-d-glucopyranoside, kaempferol-3--α-l-rhamnoside, kaempferol-3--β-d-glucopyranoside, quercetin-3--β-d-glucopyranoside, quercetin-3--β-d-galactopyranoside, rutin) from the ethyl acetate (ET) fractions of Miq. stems (S), leaves (L), and fruits (F). Their identification based on ultraviolet (UV), electron ionization (EI), electrospray ionization-mass spectrometry (ESI-MS), and 1D and 2D NMR data. In addition, profiling of ET fractions using ultraperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) resulted in the identification of 82 compounds belonging to different classes, mainly polyphenolic constituents. Chemical profiling as well as molecular docking directed us to biological evaluation. Interestingly, the ET-L fraction exhibited a robust cytotoxic activity against HepG-2, MCF-7, and HELA cell lines. Also, it displayed a neuromodulatory activity against cisplatin neurotoxicity in rats by ameliorating the neurobehavioral dysfunction visualized in the open field and Y-maze test and modulating the neurochemical parameters such as brain amino acid levels (glutamate, aspartate, serine, and histidine), oxidative stress markers (GSH, MDA, and 8-hydroxy-2'-deoxyguanosine), and purinergic cell energy (adenosine triphosphate (ATP) and adenosine monophosphate (AMP)). In conclusion, the isolated compounds (kaempferol-3--β-glucoside and quercetin-3--β-glucoside) from the ET-L fraction could serve as potent anticancer agents due to their strong antioxidant, cytotoxicity, and neuroprotective activity.

Elgazar, A. F., M. A. Shalaby, and A. M. A. Mohamed, "Anticarcinogenic effect of opuntia ficus indica juice, doxorubicin and their combination against breast cancer in rats.", The Pharmaceutical Journal of Negative Result, vol. 13, issue 7, pp. 6413-6422, 2022.
Khalil, H. M. A., D. B. Mahmoud, R. A. El-Shiekh, A. F. Bakr, A. A. Boseila, S. Mehanna, R. A. Naggar, and H. A. Eliwa, "Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats.", AAPS PharmSciTech, vol. 23, issue 7, pp. 243, 2022. Abstract

Hypericum perforatum (HP) is characterized by potent medicinal activity. However, the poor water solubility of many HP constituents limits their therapeutic effectiveness. Self-nanoemulsifying self-nanosuspension loaded with HP (HP.SNESNS) was formulated to improve the bioefficacy of HP. It was prepared using 10% triacetin, 57% Tween 20, and 33% PEG 400 and then incorporated with HP extract (100 mg/mL). HP.SNESNS demonstrated a bimodal size distribution (258.65 ± 29.35 and 9.08 ± 0.01 nm) corresponding to nanosuspension and nanoemulsion, respectively, a zeta potential of -8.03 mV, and an enhanced dissolution profile. Compared to the unformulated HP (100 mg/kg), HP.SNESNS significantly improved cardiac functions by decreasing the serum myocardial enzymes, nitric oxide (NO), and tumor necrosis factor- α (TNF-α) as well as restoring the heart tissue's normal architecture. Furthermore, it ameliorates anxiety, depressive-like behavior, and cognitive dysfunction by decreasing brain TNF-α, elevating neurotransmitters (norepinephrine and serotonin), and brain-derived neurotrophic factor (BDNF). In addition, HP.SNESNS augmented the immunohistochemical expression of cortical and hippocampal glial fibrillary acidic protein (GFAP) levels while downregulating the cortical Bcl-2-associated X protein (Bax) expression levels. Surprisingly, these protective activities were comparable to the HP (300 mg/kg). In conclusion, HP.SNESNS (100 mg/kg) exerted antidepressant and cardioprotective activities in the post-MI depression rat model.

El-Hawary, S., F. A. Ahmed, M. Sheashea, and M. I. Ezzat, "Antiinflammatory and antioxidant activity of Hypericum sinaicum Boiss. growing widely in Egypt", Natural Product Research, vol. 36, issue 11, pp. 2913-2916, 2022.
Sabra, S., S. Althobaiti, H. H. Kesba, N. Yousif, H. ELzilal, S. F. Mahmoud, F. Althobaiti, A. Gaber, and Samy Sayed, "Antimicrobial effects of three medicinal plant extracts cultivated at high altitude against various pathogenic bacteria and fungi", Fresenius Environmental Bulletin, vol. 31, issue 6, pp. 5766-5772., 2022. samy08_feb_3106_5766-5772.pdf
Abdelrahman, R. E., A. A. A. Khalaf, M. A. Elhady, Marwa A Ibrahim, E. I. Hassanen, and P. A. Noshy, "Antioxidant and antiapoptotic effects of quercetin against ochratoxin A-induced nephrotoxicity in broiler chickens.", Environmental toxicology and pharmacology, vol. 96, pp. 103982, 2022. Abstract

The mycotoxin ochratoxin A (OTA) is produced by the fungi Aspergillus and Penicillium. The flavonoid quercetin (QUE) is distinguished by its antioxidant, anti-inflammatory, and antiapoptotic properties. This study was designed to determine whether QUE can protect broiler chickens against OTA-induced nephrotoxicity. Forty broiler chicks were randomly divided into four equal groups: control, OTA, QUE, and OTA + QUE. For 6 weeks, OTA (0.5 mg/kg) and/or QUE (0.5 g/kg) were added to the diet of chickens. The results demonstrated that OTA exposure increased serum levels of creatinine, uric acid, and blood urea nitrogen. OTA exposure also increased renal malondialdehyde content but decreased renal antioxidants. OTA-exposed chickens exhibited multiple pathological kidney lesions. Moreover, OTA exposure induced apoptosis in renal tissue, which was manifested by the up-regulation of proapoptotic genes and down-regulation of antiapoptotic genes via the suppression of the PI3K/AKT pathway. In addition, coadministration of QUE and OTA mitigated most of these nephrotoxic effects.

Abdel-Naeem, H. H. S., H. A. Elshebrawy, K. Imre, A. Morar, V. Herman, R. Pascalău, and K. I. Sallam, "Antioxidant and Antibacterial Effect of Fruit Peel Powders in Chicken Patties", Foods, vol. 11, 301, 2022.
Talaat, N. B., and D. Todorova, "Antioxidant Machinery and Glyoxalase System Regulation Confers Salt Stress Tolerance to Wheat (Triticum aestivum L.) Plants Treated with Melatonin and Salicylic Acid", Journal of Soil Science and Plant Nutrition, vol. 22, pp. 3527–3540, 2022.
El-Beltagi, H. S., K. M. A. RAMADAN, A. T. Mansour, and S. Tarek A, "Antioxidant, Anti-Cancer Activity and Phytochemicals Profiling of Kigelia pinnata Fruits", Separation, vol. 9, pp. 379, 2022.
Hassan, M. S. A., E. M. Ahmed, A. A. El‐Malah, and A. S. M. A. A. E. KASSAB, "Anti‐inflammatory activity of pyridazinones: A review", Arch. Pharm., vol. 355, pp. e2200067, 2022.
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