Liver Cirrhosis is a serious and irreversible disease characterized by replacement of liver tissue by fibrotic scar tissue as well as regenerative nodules. Patients with chronic liver disease experience a variety of symptoms with profound negative impact on their self-care practices and healthy life. Working with patients with chronic liver disease requires not just dealing with the medical aspects of their disorder, but also working with the whole person-physically, emotionally and socially. The aim of this study was to assess self-care practices among liver cirrhotic patients. Descriptive correlational research design was utilized in the current study. The present study was applied on 100 adult male and female patients with confirmed diagnosis of liver cirrhosis in the hepatology units at Mansoura University hospital was involved in this study. Data related to this study were collected through designed Patient Interviews Questionnaires and Self Care Assessment Questionnaire by the researcher based on recent relevant literatures. The Study findings revealed that the majority of the study sample had the highest scores of self-care practices for physical practice, followed by spiritual practice. On the other hand, the lowest scores of self-care practices are for psychological aspect., There was inverse statistical significant relation between scores of physical, patient knowledge about liver cirrhosis and patients' age ,also there was positive statistical significant relation between scores of spiritual self-care practices, psychological self-care practices and patients' age., and there was a statistically significant relation between scores of physical self-care practices and patients' educational status., also there was a statistically significant relation between scores of social self-care practices and patients' marital status, and there was inverse statistical significance between total self-care practices and patient knowledge. Based on the findings of the study, the researcher recommended that patients should be provided simple, illustrated guide booklet, video tape, pamphlets about liver cirrhosis and its management ., cooperation of multi-disciplinary health team members to overcome their problems and needs which reflect on overall self-care practices of patients' with liver cirrhosis.

Suicidality is undoubtedly a pressing clinical issue. It represents a significant
public health problem worldwide. Suicide represents a complex and multi factorial
human behavior, mental illness, genetics, biological, psychosocial and cultural
factors that contribute to the etiology of suicidal behavior. Effective treatment of
suicidal behavior can potentially save an individual's life; therefore, this study was
conducted to assess the suicidality risk factors and its management. A descriptive
correlational design was utilized in this study. A sample is convenient; all patients
who were admitted to Poison Control Center, Cairo University over three months
were recruited. Socio-demographic/medical data sheet, Perceived Social Support
Scale, Beck Depressive Inventory Scale, Beck Suicidal Ideation Scale, Life
Stressors questionnaire and Management questionnaire were used to achieve the
purpose of this study. Results revealed that most of attempters were female
adolescents, showed a higher tendency to be single, unemployed, moderate
education , resided urban areas, using drug self poisoning ,showed none previous
attempts ,high suicidal ideation and moderate depression. The most prominent
problems were family problems. Attempters found low family support and high
friend support and without receiving any type of management except medical
management. To conclude suicide attempters need social and emotional support
from their significant others. Further studies about suicidal ideation assessment
among group at risk for early detection are recommended.

The aim of this study was of two folds 1) Assessment of quality of life among systemic lupus women patients and 2) Identification of associates of quality of life among systemic lupus women under the study. A convenient sample of 60 adult women were recruited for this study; 30 with a definite diagnosis of systemic lupus erythematosus and the other 30 were healthy secretary women working at Al-manial Cairo University Hospital. The study was conducted at Rheumatology and Rehabilitation Department and at three medical units (9,19.31). Data pertinent to the study were collected through semi-structured interview using the following tools; 1) Socio-demographic Data Sheets (SDS) which were developed by the investigator, 2) The Translated Modified Arabic Version of Quality of Life Index Scale Cancer version by (Ferrell, Grant & Schmidt, 1992) used for SLE women patients & 3) The Combined Translated Modified Arabic Version of Quality of Life Index Scales by (Ferrans 1984; Ferrell, Grant & Schmidt, 1992 ) used for healthy women. The study findings answered the two stated research questions by documenting that no one of SLE women had reported high Quality of life as they had reported moderate Quality of life scores (164-346) to low Quality of life scores (347-520). Systemic lupus women had reported low QOL in the following dimensions respectively; psychological (83.3%), social (43.3%) spiritual (36.6%) and physical (33.3%). Socio-demographic characteristics of systemic lupus women revealed no statistical significant relation with their total quality of life scores except for significant others as the married systemic lupus women who recognized their spouse as significant others had reported the best quality of life total index scores. It is worth noting that even though socio-demographic characteristics of systemic lupus women revealed no statistical significant relation with their quality of life total index scores, the findings of the mean QOL total index scores showed that being single or housewife, having secondary school education, residing in rural areas and having first degree relatives as main significant others were associates of best QOL total index scores among the studied SLE women subjects. The current study concluded to the evidence of altered QOL among SLE women. Replication of this study is highly warranted to achieve more generaliazble results.

Background: Vitiligo is the commonest hypopigmented skin disorder. Taurine upregulated gene1(TUG1), one of Long noncoding RNAs (LncRNA) that plays a role in melanogenesis. microRNA-377 (miRNA-377) is a conserved non-coding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. PPARγ activators stimulate melanogenesis. Interleukin-17(IL17) has been implicated in the pathogenesis of several immunological diseases.
Aim: This work aimed to detect the expression levels of TUG1, miRNA-377, PPARγ and IL-17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo.
Methods: This study was conducted on 30 healthy control and 30 vitiligo patients. TUG1 and miRNA-377 were detected in serum by real- time-PCR, Also PPARγ and IL-17 were assessed in tissue by Real-time PCR.
Results: TUG1and PPARγ level was significantly down regulated in vitiligo group compared to control group, on the other hand miRNA-377 and IL-17 was significantly up regulated in vitiligo group compared to control group.
Conclusion: This study demonstrated the dysregulated expressions of TUG1 and miR-377 in patients with vitiligo and suggested that both contributed to its pathogenesis and that might be through PPARγ and IL-17.
Key words: Vitiligo /TUG1/ miRNA377/ PPAR γ / IL17.