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2024
Mohamed, S. A., N. R. Kamel, A. E. Fouda, R. E. El Hawary, and M. A. Abdelmegeid, "Association of low vitamin D level and full-term early-onset neonatal sepsis; a case-control study.", Italian journal of pediatrics, vol. 50, issue 1, pp. 101, 2024. Abstract

BACKGROUND: Sepsis is one of the main causes of death in newborns worldwide. Vitamin D levels during fetal and neonatal periods have a significant role in the development of the immunological system. The study aims to evaluate the association between vitamin D levels and the risk of early-onset neonatal sepsis in full-term neonates in a developing country.

METHODS: This case-control study was conducted at the Neonatal Intensive Care Units (NICUs) of Kasr Alainy Hospital, Cairo, Egypt. The study was composed of two groups; the sepsis group involved full-term neonates appropriate for gestational age with sepsis-related clinical signs. The control group included newborns with no signs of clinical/laboratory infection within 72 h of life. Blood samples were collected on admission during the first three days of life in both groups for the measurement of 25-hydroxyvitamin D levels, Complete Blood Count (CBC), C reactive protein (CRP), and blood culture.

RESULTS: Forty-five newborns with clinical and laboratory findings of early-onset neonatal sepsis within 72 h of life were enrolled, and the control group included forty-five newborns with no evidence of sepsis. Vitamin D levels in the sepsis group were significantly lower than in the control group. Apgar score at the first minute was significantly lower in the sepsis group. 57.8% of neonates with sepsis had positive blood cultures. There was a statistical difference between deficient, insufficient, and sufficient vitamin D levels regarding the duration of the NICU stay, which was longer in neonates with deficient vitamin D levels. CRP was significantly higher in neonates with deficient vitamin D levels. The area under the receiver operating characteristic curve for serum vitamin D in the prediction of neonatal sepsis was 0.76 at a cutoff < 19.7(ng/ml).

CONCLUSION: In the current study, full-term newborns with EOS had considerably lower vitamin D levels than healthy controls. Through appropriate vitamin supplementation of the mothers during pregnancy, it could be possible to ensure adequate vitamin D levels for newborns. This may contribute to the reduction of the risk of EOS, together with the other well-known preventive measures (i.e. breastfeeding and intrapartum antibiotic prophylaxis).

Elgendy, H. A., A. M. A. Makky, Y. E. Elakkad, H. H. Awad, M. E. A. Hassab, and N. F. Younes, "Atorvastatin loaded lecithin‑coated zein nanoparticles based thermogel for the intra‑articular management of osteoarthritis: in‑silico, in‑vitro, and in‑vivo studies", Journal of Pharmaceutical Investigation, 2024.
Poznyak, A. S., H. Alazki, and H. M. Soliman, "Attractive ellipsoidal design for robust stabilization of time-delay stochastic power systems under a series of lightning surges", Computers and Electrical Engineering, vol. 116, pp. art. no. 109228, 2024.
Al-Khayri, J. M., and E. H. Khedr, "Augmenting apricot fruit quality and prolonging storage life via modulating ethylene metabolism and antioxidants with 1-(3-phenyl-propyl) cyclopropene and psyllium treatments", The Journal of Horticultural Science and Biotechnology: Taylor & Francis, pp. 1–17, 2024. Abstract
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Ghanem, D. M., N. M. Ammar, R. Kamel, R. A. Hussien, D. A. Mohamed, A. E. - Halawany, and S. S. El-Hawary, "Augmenting the cytotoxic effect of the aerial parts of Carissa macrocarpa (Eckl.) A. DC. cultivated in Egypt by using surfactant-free nanoemulsion.", Egyptian Journal of Chemistry, vol. 67, issue 1: National Information and Documentation Centre (NIDOC), Academy of Scientific …, pp. 193-204, 2024. Abstract
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Abdel-Hamid, N. R., E. A. Mohammed, E. A. Toraih, M. M. Kamel, A. S. Abdelhafiz, and F. M. Badr, "Author Correction: Circulating ESR1, long non-coding RNA HOTAIR and microRNA-130a gene expression as biomarkers for breast cancer stage and metastasis", Scientific Reports, vol. 14: Nature Publishing Group, 2024. Abstract
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El-Ghany, W. A. A., "Avian macrorhabdosis (Macrorhabdus ornithogaster) causing proventriculitis: Epidemiology, diagnosis, and control.", Veterinary Integrative Sciences, vol. 22, issue 3, pp. 921-931, 2024. vet_integ_sci.pdf
Taha, N. M., M. A. Sabry, M. M. El-Bahy, and R. M. Ramadan, "Awareness of parasitic zoonotic diseases among pet owners in Cairo, Egypt", Veterinary Parasitology: Regional Studies and Reports, , vol. 51, pp. 101025, 2024.
Taha, N. M., M. A. Sabry, M. M. El-Bahy, and R. M. Ramadan, "Awareness of parasitic zoonotic diseases among pet owners in Cairo, Egypt", Veterinary Parasitology: Regional Studies and Reports , vol. 51, pp. 101025, 2024.
Taha, N. M., M. A. Sabry, M. M. El-Bahy, and R. M. Ramadan, "Awareness of parasitic zoonotic diseases among pet owners in Cairo, Egypt.", Veterinary parasitology, regional studies and reports, vol. 51, pp. 101025, 2024. Abstract

Egyptians are becoming more interested in owning and raising pets; however, most of them lack essential awareness about the risk of zoonotic parasites that could be transmitted. The objective of the present investigation was to evaluate the degree of awareness Egyptian pet owners possess concerning zoonotic parasitic diseases, the risk of transmission, and preventative measures. A cross-sectional study was conducted using an e-survey. Among 246 pet owners, 64.2% (158) were females, and 67.9% (167) belonged to the 20-30 age group. The majority, 78.9% (194), were raising cats. Only 13.8% (34) visited the veterinarian regularly, with significantly higher results among dog owners (p < 0.05). Only 31.3% (77) participants were regularly deworming their pets, and 19.9% (49) were giving their pets prophylaxis against ectoparasites, with significantly higher results among those who visited the veterinarian regularly (p < 0.0001) and among dog owners (p < 0.05). Only 54.1% (133) had heard about the term "zoonoses" before, and about 8.9% (22) of participants showed a history of zoonotic parasitic diseases, with significantly higher results among those who allowed their animals to play with other animals of neighbors and friends (p < 0.05). The obtained results concluded that the surveyed group had a relatively good degree of knowledge regarding pets as a source of zoonotic illness; raising pet owners' awareness regarding the importance of routine medical examinations and minimizing the contact of pets with other stray animals is essential.

2023
Maghraby, G., M. Elmeniawy, H. Mostafa, O. Shaker, M. habib, and R. Elgohary, "AB0129 EXPLORING LONG NON-CODING RNA GAS5 IN SLE PATIENTS AND ITS RELATION TO INTERFERON SIGNATURE", Scientific Abstracts: BMJ Publishing Group Ltd and European League Against Rheumatism, pp. 1243.3-1244, 6, 2023. Abstract
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Bui, D. T., J. Favell, E. N. Kitova, Z. Li, K. A. McCord, E. N. Schmidt, F. Mozaneh, M. Elaish, A. El-Hawiet, and Y. St-Pierre, Absolute affinities from quantitative shotgun glycomics using concentration-independent (COIN) native mass spectrometry, , vol. 9, issue 7: American Chemical Society, pp. 1374 - 1387, 2023. Abstract
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Tantawy, M. A., A. M. Yehia, and H. T. Elbalkiny, All-solid-state chip utilizing molecular imprinted polymer for erythromycin detection in milk samples: Printed circuit board-based potentiometric system, , vol. 190, issue 10, pp. 408, 2023. AbstractWebsite

Detection of erythromycin (ERY) residues in commercial milk samples is crucial for the safety assessment. Herein, a printed circuit board was patterned as a feasible miniaturized potentiometric sensor for ERY determination in dairy samples. The proposed chip design fits to a 3.5-mm female audio plug to facilitate the potential measurements of working electrode versus reference one in this all-solid-state system. The sensor utilizes molecular imprinted polymer (MIP) for the selective recognition of the studied drug in such challenging matrix. The electrode stability is achieved through the addition of poly (3,4-ethylenedioxythiophene) nano-dispersion on its surface. The proposed device detects down to 6.6 × 10−8 M ERY with a slope of 51 mV/decade in the 1 × 10−7–1 × 10−3 M range. The results display high accuracy (99.9% ± 2.6) with satisfactory relative standard deviation for repeatability (1.6%) and reproducibility (5.0%). The effect of common antibiotic classes, namely, amphenicols, beta-lactams, fluoroquinolones, sulfonamides, and tetracyclines, can be neglected as evidenced by their calculated binding capacities towards the proposed MIP. The calculated selectivity coefficients also show a good electrode performance in the presence of naturally present inorganic ions allowing its application to different milk samples.

Farrag, H. H., I. M. Al-Akraa, N. K. Allam, and A. M. Mohammad, "Amendment of palladium nanocubes with iron oxide nanowires for boosted formic acid electro−oxidation", Arabian Journal of Chemistry, vol. 16, issue 3: Elsevier B.V., 2023. AbstractWebsite

To quickly move the formic acid (FA) fuel cells closer to a real commercialization, an inexpensive, efficient, and durable electrocatalyst for the direct FA electro-oxidation (FAEO) was developed. This involved a sequential modification of a glassy carbon (GC) substrate with palladium nanocubes (ca. 70 nm, nano-Pd) and iron oxide nanowires (nano-FeOx, ca. 40 nm and 150 nm in average diameter and length, respectively). The deposition sequence and loading level of nano-FeOx in the catalyst were optimized to minimize the catalyst's poisoning with CO that might probably release from a parallel dehydration of FA or from CO2 reduction. Surprisingly, the FeOx/Pd/GC catalyst exhibited a high (21.6 mA cm−2) specific activity for FAEO, which denoted ca. 7 times that of the “pristine” Pd/GC catalyst. This was synchronized with a better (up to fivefold increase in turnover frequency) “long-termed” stability that extended for 90 min of continuous electrolysis at room temperature. A successful effort was dedicated to improving more the catalyst's stability by activating the catalyst electrochemically at –0.5 V vs Ag/AgCl/KCl (sat.) in 0.2 mol L−1 NaOH. The CO stripping agreed perfectly with the impedance analysis in appending the observed enhancement in the catalytic efficiency of FAEO to a favorable electronic modulation at the Pd surface that boosted the oxidative desorption of poisoning CO species at a lower potential. © 2022 The Authors

Abu-Mahfouz, A., M. Ali, and A. ELFIKY, "Anti-breast cancer drugs targeting cell-surface glucose-regulated protein 78: a drug repositioning in silico study", Journal of Biomolecular Structure and Dynamics, vol. 41, issue 16, pp. 7794 - 7808, 2023. AbstractWebsite

Breast cancer (BC) is prevalent worldwide and is a leading cause of death among women. However, cell-surface glucose-regulated protein 78 (cs-GRP78) is overexpressed in several types of cancer and during pathogen infections. This study examines two well-known BC drugs approved by the FDA as BC treatments to GRP78. The first type consists of inhibitors of cyclin-based kinases 4/6, including abemaciclib, palbociclib, ribociclib, and dinaciclib. In addition, tunicamycin, and doxorubicin, which are among the most effective anticancer drugs for early and late-stage BC, are tested against GRP78. As (−)-epiGallocatechin gallate inhibits GRP78, it is also being evaluated (used as positive control). Thus, using molecular dynamics simulation approaches, this study aims to examine the advantages of targeting GRP78, which represents a promising cancer therapy regime. In light of recent advances in computational drug response prediction models, this study aimed to examine the benefits of GRP78 targeting, which represents a promising cancer therapy regime, by utilizing combined molecular docking and molecular dynamics simulation approaches. The simulated protein (50 ns) was docked with the drugs, then a second round of dynamics simulation was performed for 100 ns. After that, the binding free energies were calculated from 30 to 100 ns for each complex during the simulation period. These findings demonstrate the efficacy of abemaciclib, ribociclib, and tunicamycin in binding to the nucleotide-binding domain of the GRP78, paving the way for elucidating the mode of interactions between these drugs and cancer (and other stressed) cells that overexpress GRP78. Communicated by Ramaswamy H. Sarma. © 2022 Informa UK Limited, trading as Taylor & Francis Group.

Kelani, K. M., M. A. Hegazy, A. M. Hassan, and M. A. Tantawy, Application of multivariate chemometrics tools for spectrophotometric determination of naphazoline HCl, pheniramine maleate and three official impurities in their eye drops, , vol. 13, issue 1, pp. 19678, 2023. AbstractWebsite

This work is concerned with exploiting the power of chemometrics in the assay and purity determination of naphazoline HCl (NZ) and pheniramine maleate (PN) in their combined eye drops. Partial least squares (PLS) and artificial neural network (ANN) were the chosen models for that purpose where three selected official impurities, namely; NZ impurity B and PN impurities A and B, were successfully determined. The quantitative determinations of studied components were assessed by percentage recoveries, standard errors of prediction as well as root mean square errors of prediction. The developed models were constructed in the ranges of 5.0–13.0 μg mL−1 for NZ, 10.0–60.0 μg mL−1 for PN, 1.0–5.0 μg mL−1 for NZ impurity B and 2.0–14.0 μg mL−1 for two PN impurities. The proposed models could determine NZ and PN with respective detection limits of 0.447 and 1.750 μg mL−1 for PLS, and 0.494 and 2.093 μg mL−1 for ANN. The two established models were compared favorably with official methods where no significant difference observed.

Helal, M., M. A. Ali, A. H. Nadrin, Y. I. Awad, N. K. Younis, B. M. Alasyed, M. Jamal, D. H. Eid, H. A. Soliman, S. A. Eissa, et al., "Association between IRS-1, PPAR-γ and LEP genes polymorphisms and growth traits in rabbits", Animal BiotechnologyAnimal Biotechnology, vol. 34, issue 7: Taylor & Francis, pp. 2391 - 2399, 2023. AbstractWebsite
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Ahmed, S. H., A. A. E. M. ElSayed, F. A. W. A. Maksoud, L. M. Fathi, and S. B. Soliman, "The Association Between Plasma C-Type Lectin Like Receptors 2 (CLEC-2) and STEMI and its Correlation With Clinicolaboratory Data", Egyptian Journal of Critical Care Medicine, vol. 10, issue 4, 2023. AbstractWebsite

Objectives:To assess the association between plasma C-type lectin-like receptor 2 (CLEC-2) and ST elevation myocardial infarction (STEMI) and its correlation with clinicolaboratory data.

Methods:

This case-control study included 88 individuals divided into two groups. Group I (the cases group): 50 patients diagnosed with STEMI. Group II (control group): 38 sex-matched and age-matched healthy individuals. All patients were subjected to the assessment of CLEC-2, using enzyme-linked immunosorbent assay (ELIZA) kit.

Results:

CLEC-2 levels in group I were higher than group II (P value <0.001). CLEC-2 serum levels were not affected by the site of MI, site of occluded vessels, and systolic function. CLEC-2 serum levels were higher in patients with dilated left ventricle and those with diastolic dysfunction; however, these findings were not statistically significant. By using the ROC curve for determining the possibility of using CLEC-2 as a marker for STEMI it showed that the best cutoff value is >121, area under the curve 0.73, sensitivity 76%, specificity 63.2% (P < 0.001), 95 CI (0.63–0.84).

Conclusions:

CLEC-2 levels can be used as a diagnostic marker but not suitable to be a prognostic factor.

Alaasar, M., C. Anders, R. Pashameah, and A. F. Darweesh, "Azopyridine-based hydrogen-bonded liquid crystals with thioether tail", Liquid Crystals: Taylor & Francis, pp. 1 - 16, 2023. Abstract

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Gemaiey, G. E., "Al Shakhloba village: Site management plan for a sustainable development", Egyptian culture heritage now (ECHN), American research center in Cairo, 11-13 Nov. 2023.
Meshrif Alruily, Sameh Abd El-Ghany, A. M. M. M. E., and A. A. Abd El-Aziz, "A-Tuning Ensemble Machine Learning Technique for Cerebral Stroke Prediction", Applied Sciences, vol. 13, no. 8, pp. 5047–5066, 2023. Abstract
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, "Absent Azygos Vein in a neonate with oesophageal atresia and tracheoesophageal fistula", Journal of Pediatric Surgery Case Reports, vol. 90, pp. 102588, 2023. AbstractWebsite

Absent azygos vein is a rare anomaly of the venous system, which is commonly an incidental finding, with only few publications reporting it. Due to the scarcity of cases, it is rarely reported with oesophageal atresia ± tracheoesophageal fistula (OA ± TOF), which is usually accompanied with cardiac anomalies in up to 80% of the cases. This association has only been reported thrice in literature. We report a 6-day-old female who was referred to our centre after diagnosis of OA + TOF. The patient had no associated anomalies apart from small patent foramen ovale and small ventricular septal defect; however, there was no functional compromise. Upon thoracoscopic exploration, azygos vein could not be visualised. Thoracoscopic repair was performed, and the postoperative period was uneventful. On follow-up, the patient had no postoperative complications. Absent azygos vein is a rare anomaly with few cases reported throughout the literature. Azygos vein is considered an important landmark intraoperatively because it guides the surgeon to the TOF site. Moreover, it might be important in other patients with major cardiac anomalies with abnormal venous drainage who might need further surgical correction.

Obeida, A., B. Magdy, H. Taher, M. Qinawy, and M. Elbarbary, "Absent Azygos Vein in a neonate with oesophageal atresia and tracheoesophageal fistula", Journal of Pediatric Surgery Case Reports, vol. 90, pp. 102588, 2023. AbstractWebsite

Absent azygos vein is a rare anomaly of the venous system, which is commonly an incidental finding, with only few publications reporting it. Due to the scarcity of cases, it is rarely reported with oesophageal atresia ± tracheoesophageal fistula (OA ± TOF), which is usually accompanied with cardiac anomalies in up to 80% of the cases. This association has only been reported thrice in literature. We report a 6-day-old female who was referred to our centre after diagnosis of OA + TOF. The patient had no associated anomalies apart from small patent foramen ovale and small ventricular septal defect; however, there was no functional compromise. Upon thoracoscopic exploration, azygos vein could not be visualised. Thoracoscopic repair was performed, and the postoperative period was uneventful. On follow-up, the patient had no postoperative complications. Absent azygos vein is a rare anomaly with few cases reported throughout the literature. Azygos vein is considered an important landmark intraoperatively because it guides the surgeon to the TOF site. Moreover, it might be important in other patients with major cardiac anomalies with abnormal venous drainage who might need further surgical correction.

, "Accepting Living Kidney Donors with Preexisting Diabetes Mellitus A Perspective on the Recent OPTN Policy Change—July 2022", Clinical Journal of American Society of Nephrology , vol. 18, issue 1, pp. 127 - 129, 2023.