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2022
Mahrous, A. A., O. Tarek, and W. Kortam, "Adding bricks to clicks: Which characteristic of a showroom affects consumers when they shop online?", EuroMed J. Management, vol. 4, issue 4, pp. 332-344, 2022. 2022_bricks_to_clicks.pdf
Mansour, R. M., N. S. El Sayed, M. A. E. Ahmed, and A. E. El-Sahar, "Addressing Peroxisome Proliferator-Activated Receptor-gamma in 3-Nitropropionic Acid-Induced Striatal Neurotoxicity in Rats.", Molecular neurobiology, vol. 59, issue 7, pp. 4368-4383, 2022. Abstract

Telmisartan (TEL) is an angiotensin II type 1 receptor blocker and a partial activator of peroxisome proliferator-activated receptor-gamma (PPARγ), which regulates inflammatory and apoptotic pathways. Increasing evidence has demonstrated the PPARγ agonistic property of TEL in several brain disorders. This study aims to explore the neuroprotective impact of TEL in 3-nitropropionic acid (3-NP)-induced neurotoxicity in rats. The PPARγ effect of TEL was affirmed by using the PPARγ agonist pioglitazone (PIO), and the antagonist GW9662. 3-NP led to a significant reduction in body weight alongside motor and cognitive functioning. The striata of the 3-NP-treated rats showed energy-deficit, microglia-mediated inflammatory reactions, apoptotic damage as well as histopathological lesions. PIO and TEL improved motor and cognitive perturbations induced by 3-NP, as confirmed by striatal histopathological examination, energy restoration, and neuronal preservation. Both drugs improved mitochondrial biogenesis evidenced by elevated mRNA expression of PPARγ, PGC-1α, and TFAM, alongside increased striatal ATP and SDH. The mitochondrial effect of TEL was beyond PPARγ activation. As well, their anti-inflammatory effect was attributed to suppression of microglial activation, and protein expression of pS536 p65 NF-κB with marked attenuation of striatal inflammatory mediator's release. Anti-inflammatory cytokine IL-10 expression was concurrently increased. TEL effectively participated in neuronal survival as it promoted phosphorylation of Akt/GSK-3β, further increased Bcl-2 expression, and inhibited cleavage of caspase-3. Interestingly, co-treatment with GW9662 partially revoked the beneficial effects of TEL. These findings recommend that TEL improves motor and cognitive performance, while reducing neuronal inflammation and apoptosis in 3-NP-induced neurotoxicity via a PPARγ-dependent mechanism.

Shalaby, H. N., H. F. Zaki, A. A. A. Ain‑Shoka, and R. A. Mohammed, "Adenosine A2A Receptor Blockade Ameliorates Mania Like Symptoms in Rats: Signaling to PKC‑α and Akt/GSK‑3β/β‑Catenin", Molecular Neurobiology, vol. 59, pp. 6397–6410, 2022. adenosine_final.pdf
Alasmari, W. A., S. Hosny, H. Fouad, K. Al Quthami, E. A. M. Althobiany, and E. M. Faruk, "Adipose-Derived Stem Cells and Extracellular Vesicles Reverse the Effect of Experimental Model of Cardio-renal Syndrome type III: Molecular and Cellular Mechanisms", Tissue and Cell: Churchill Livingstone, pp. 101842, 2022. Abstract
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Saad, A. S., M. E. Draz, I. A. Naguib, H. E. Zaazaa, A. S. Lashien, and F. F. Abdallah, "Adoption of Advanced Chemometric Methods for Determination of Pyridoxine HCl, Cyclizine HCl, and Meclizine HCl in the Presence of Related Impurities: A Comparative Study", Journal of AOAC International, vol. 105, issue 2, pp. 630-640, 2022.
Mostafa, N. G., A. F. Yunnus, and A. Elawwad, "Adsorption of Pb(II) from Water onto ZnO, TiO2, and Al2O3: Process Study, Adsorption Behaviour, and Thermodynamics", Adsorption Science & Technology, vol. 2022, issue 4, pp. 1-13, 2022.
Safwat, S. M., N. Y. Mohamed, M. N. A. Meshref, and A. Elawwad, "Adsorption of Phenol onto Aluminum Oxide Nanoparticles: Performance Evaluation, Mechanism Exploration, and Principal Component Analysis (PCA) of Thermodynamics", Adsorption Science & Technology, vol. 2022, pp. 1-14, 2022.
Adly, A., N. G. Mostafa, and A. Elawwad, "Adsorption of phosphorus onto nanoscale zero-valent iron/activated carbon: removal mechanisms, thermodynamics, and interferences", Journal of Water Reuse and Desalination, vol. 12, issue 1, pp. 111-130, 2022.
Ali, M. A., M. F. Mubarak, M. Keshawy, M. A. Zayed, and M. Ataalla, "Adsorption of Tartrazine anionic dye by Novel Fixed Bed Core-Shell- Polystyrene Divinyl benzene /Magnetite Nanocomposite, ", Alexandria Engineering Journal, vol. 61, issue 2, pp. 1335–1352, 2022. 2022_paper-1.pdf
Hassan, S. A., N. W. Nashat, M. R. Elghobashy, S. S. Abbas, and A. A. Moustafa, "Advanced chemometric methods as powerful tools for impurity profiling of drug substances and drug products: Application on bisoprolol and perindopril binary mixture", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 267: Elsevier, pp. 120576, 2022. Abstract
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Hassan, S. A., N. W. Nashat, M. R. Elghobashy, S. S. Abbas, and A. A. Moustafa, "Advanced chemometric methods as powerful tools for impurity profiling of drug substances and drug products: Application on bisoprolol and perindopril binary mixture", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, vol. 267: Elsevier, pp. 120576, 2022. Abstract
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Lazarus, J. V., H. E. Mark, Q. M. Anstee, J. P. Arab, R. L. Batterham, L. Castera, H. Cortez-Pinto, J. Crespo, K. Cusi, A. M. Dirac, et al., "Advancing the global public health agenda for NAFLD: a consensus statement.", Nature reviews. Gastroenterology & hepatology, vol. 19, issue 1, pp. 60-78, 2022. Abstract

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics - from epidemiology, awareness, care and treatment to public health policies and leadership - that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD.

El Sayed, M. M., G. E. Elrefaye, A. Rabiee, S. Abouzeid, and H. F. Elsisi, "Aerobic exercise with diet induces hormonal, metabolic, and psychological changes in postmenopausal obese women", Heliyon, vol. 8, issue 3, 2022.
El Sayed, M. M., G. E. Elrefaye, A. Rabiee, S. Abouzeid, and H. F. Elsisi, "Aerobic exercise with diet induces hormonal, metabolic, and psychological changes in postmenopausal obese women", Heliyon, vol. 8, issue 3, 2022.
Abdelfattah, E. A., African Journal of Biological Sciences, , 2022. Abstract
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Hedia, M., and A. El-Shalofy, "Ageing affects plasma steroid concentrations and testicular volume, echotexture and haemodynamics in rams", Andrologia, vol. 54, issue 1, pp. e14309, 2022.
Hassan, M. A., L. Al-Ghussain, A. D. Ahmad, A. M. Abubaker, and A. Khalil, "Aggregated independent forecasters of half-hourly global horizontal irradiance", Renewable Energy, vol. 181: Pergamon, pp. 365-383, 2022. Abstract
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Salman, A. A. A., M. A. Salman, M. Said, H. Elkassar, M. El Sherbiny, A. Youssef, M. Elbaz, A. M. Elmeligui, M. B. Hassan, M. G. Omar, et al., "Albuminuria as a predictor of mortality in type II diabetic patients after living-donor liver transplantation.", Annals of medicine, vol. 54, issue 1, pp. 2598-2605, 2022. Abstract

PURPOSE: Diabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection. Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality. This study evaluated albuminuria as a predictor of the outcome of living donor liver transplantation (LDLT) in patients with pre-existing DM.

METHODS: This retrospective study involved 103 type II diabetic patients with end-stage liver disease who received LDLT. Preoperative spot urine albumin: creatinine ratio was used to determine the degree of albuminuria. The primary outcome measure was the impact of urinary albumin excretion on the 3-year mortality rate after LDLT in this diabetic cohort.

RESULTS: Hepatitis C virus infection was the main cause of cirrhosis. Albuminuria was detected in 41 patients (39.8%); 15 had macroalbuminuria, while 26 had microalbuminuria. Patients with microalbuminuria were significantly older than those with macroalbuminuria and normal albumin in urine. After 3 years, twenty-four patients (23.3%) died within 3 years after LT. Myocardial infarction was the leading cause of death (25%). Albuminuria was an independent factor affecting 3-year mortality with an odds ratio of 5.17 (95% CI: 1.86-14.35).

CONCLUSION: Preoperative albuminuria is an independent factor affecting mortality within 3 years after LDLT in type II diabetic patients. Myocardial infarction was the leading cause of death in 25% of cases, followed by hepatocellular carcinoma recurrence, sepsis, and graft failure.KEY MESSAGESDiabetes mellitus (DM) increases the risk of morbidity and mortality after liver resection.Albuminuria is associated with a higher risk for all-cause and cardiovascular mortality.Preoperative albuminuria is a significant predictor of mortality within 3 years after LDLT in diabetic patients.

Fayek, M. A., A. A. Rashedy, and A. E. M. Ali, "Alleviating the adverse effects of deficit irrigation in Flame seedless grapevine via Paulsen interstock", Revista Brasileira de Fruticultura, vol. 44, issue 1, pp. 1-11, 2022.
Fayek, M. A., A. A. Rashedy, and A. E. M. Ali, "Alleviating the adverse effects of deficit irrigation in Flame seedless grapevine via Paulsen interstock", Rev. Bras. Frutic., vol. 44, issue 839, pp. 11, 2022.
Farid, A., H. Haridyy, S. Ashraf, S. Ahmed, and G. Safwat, "Aloe vera gel as a stimulant for mesenchymal stem cells differentiation and a natural therapy for radiation induced liver damage", Journal of Radiation Reserch and Aplied Sciences, vol. 15, issue 3, pp. 270-278, 2022.
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