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Wolpert, B. J. a, S. a Amr, D. A. b Saleh, S. c Ezzat, I. d Gouda, I. d Loay, T. e Hifnawy, M. f Abdel-Hamid, N. N. g Mikhail, M. a Zhan, et al., "Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt", Urologic Oncology: Seminars and Original Investigations, vol. 30, no. 6, pp. 841-847, 2012. AbstractWebsite

Objectives:To examine associations between urinary bladder cancer risk and polymorphisms of the gene encoding the catechol estrogen-metabolizing enzyme, catechol-O-methyltransferase (COMT), among Egyptian women and men. Materials and methods:We used questionnaire and genotype data from a case-control study in Egypt. This analysis focused on South Egypt cases with confirmed urothelial (UC) or squamous cell (SCC) carcinoma of the bladder, and controls frequency-matched on sex, 5-year age-group, and residence governorate. Real-time PCR on blood specimen DNA was used to determine COMT genotypes encoding for Val/Val, Val/Met, and Met/Met, the enzyme forms associated with high, intermediate, or low activity, respectively. ResultsThe study sample, which included 255 women and 666 men, consisted of 394 cases with histologically confirmed UC (225) or SCC (n = 169), and 527 controls. The odds of having either type of bladder cancer were lower among men with genotypes encoding Val/Met or Met/Met than among those with the genotype encoding Val/Val, even after adjustment for other factors, such as smoking and schistosomiasis history [adjusted odds ratio (AOR): 0.64; 95% confidence interval (CI): 0.43, 0.96]; however, the association was statistically significant for SCC (AOR 0.57; 95% CI: 0.34, 0.96) but marginal for UC (AOR: 0.64; 95% CI: 0.39, 1.02). No significant associations were detected between bladder cancer risk and COMT genotypes among postmenopausal women.: Conclusions:These findings suggest that even after controlling for established risk factors, the involvement of COMT genotypes in bladder cancer risk differs among men compared with women in South Egypt. © 2012.

Wong, Y. Y., H. Rawindran, J. W. Lim, Z. W. Tiong, C. S. Liew, M. K. Lam, W. Kiatkittipong, E. M. A. N. A. L. A. A. E. L. D. I. N. ABDELFATTAH, W. - D. Oh, and Y. C. Ho, "Attached microalgae converting spent coffee ground into lipid for biodiesel production and sequestering atmospheric CO2 simultaneously", Algal Research, vol. 66: Elsevier, pp. 102780, 2022. Abstract
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Wong, Y. Y., H. Rawindran, J. W. Lim, Z. W. Tiong, C. S. Liew, M. K. Lam, W. Kiatkittipong, E. M. A. N. A. L. A. A. E. L. D. I. N. ABDELFATTAH, W. - D. Oh, and Y. C. Ho, "Attached microalgae converting spent coffee ground into lipid for biodiesel production and sequestering atmospheric CO2 simultaneously", Algal Research, vol. 66: Elsevier, pp. 102780, 2022. Abstract
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Wong, R., I. Yavaşoğlu, M. A. D. Yassin, P. Tarkun, S. Yoon, M. A. Samra, P. Angchaisuksiri, V. Pilipovic, and J. H. Jang, "Assessment of Eltrombopag in Patients with Chronic Immune Thrombocytopenia under Routine Clinical Practice in the Middle East, Turkey, Asia, And Australia.", 24th Congress of the European Hematology Association, June 2019, Abst. PF701 (Poster Presentation). , Amsterdam, The Netherlands, HemaSphere 2019, 3 (S1), pp. 305, 2019. assessment_of_eltrombopag_in_patients_with_chronic.pdf
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X. Huang, Q. Zhang, S. Chen, Y. Dong, M. Xiao, and HAMED L. M. M., "Aggregate Stability and Erodibility of Purple Soil on Sloping Farmland as affected by different Soil Thickness", 19th EGU General Assembly, EGU2017, proceedings from the conference held 23-28 April, 2017 in Vienna, Austria., p.3824, Vienna, Austria, 23-28 April, 2017. egu2017-3824-3.pdf
Xiao, K., S. H. Ho, and others, "Automatic unsupervised segmentation methods for mri based on modified fuzzy c-means", Fundamenta Informaticae, vol. 87, no. 3-4: IOS Press, pp. 465–481, 2008. Abstract
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Xiao, K., S. H. Ho, and A. E. Hassanien, "Aboul Ella Hassanien: Automatic Unsupervised Segmentation Methods for MRI Based on Modified Fuzzy C-Means", Fundamenta Informaticae, vol. 87, issue 3-4, pp. 465-481, 2008. Website
Xiao, K., S. H. Ho, and others, "Automatic unsupervised segmentation methods for mri based on modified fuzzy c-means", Fundamenta Informaticae, vol. 87, no. 3-4: IOS Press, pp. 465–481, 2008. Abstract
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Xu, D., and D. C. Neckers, "Aggregation of rose bengal molecules in solution", Journal of Photochemistry and Photobiology A: Chemistry, vol. 40, issue 2-3: Elsevier, pp. 361-370, 1987. Abstract
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Xuan, W., L. Huang, Y. Wang, X. Hu, G. Szewczyk, Y. Y. Huang, A. El-Hussein, J. C. Bommer, M. L. Nelson, T. Sarna, et al., "Amphiphilic tetracationic porphyrins are exceptionally active antimicrobial photosensitizers: in vitro and in vivo studies with the free-base and Pd-chelate.", Journal of Biophotonics, 2019.
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Y, S., A. A, S. DA, and D. W, "Adipokines and insulin resistance, predictors of response to therapy in Egyptian patients with chronic hepatitis C virus genotype 4", European Journal of Gastroenterology and Hepatology, vol. 25, issue 8, pp. 920-5, 2013. Abstractadipokines_and_insulin_resistance_final.pdf

BACKGROUND:
Hepatitis C virus (HCV) infection has major health impact worldwide and is a significant cause of chronic liver disease. In Egypt, HCV is highly endemic (up to 15% of the population); 91% of the patients are infected with genotype 4. Searching for new predictors of response to therapy is mandatory to decrease the cost and the adverse effects of current therapy.
AIM:
The aim of this study was to clarify the usefulness of serum leptin, adiponectin, and insulin resistance (IR) as predictors of response to treatment in hepatitis C virus genotype 4 (HCVG4).
METHODS:
One hundred patients with chronic HCVG4 who were candidates for treatment with pegylated interferon α and ribavirin were included in the study. Age, sex, and BMI were determined, and quantitative HCV PCR, assessment of serum leptin, adiponectin, IR, and pretreatment liver profile, and liver biopsy were performed.
RESULTS:
The male to female ratio was 68/32; the mean age of the patients was 40.9 ± 7.8 years and BMI was 28.3 ± 10 kg/m. Sustained virological response (SVR) was achieved by 56% of the patients. On performing logistic regression, BMI [odds ratio (OR) 6.5; P=0.004], serum leptin (OR 27.8; P ≤ 0.001), aspartate aminotransferase (OR 1.06; P ≤ 0.001), IR (OR 1.15; P ≤ 0.001), histological activity index (OR 1.77; P=0.006), and fibrosis (OR 2.93; P=0.001) were found to be independent negative predictors of SVR, whereas serum adiponectin (OR 0.74; P ≤ 0.001) was found to be an independent positive predictor of SVR. Pretreatment adiponectin (cutoff 13.75; sensitivity 92.86%; specificity 86.86%) shows area under the curve of 0.879 (95% confidence interval 0.802-0.956; P<0.001) and insignificant area under the curve for leptin or IR.
CONCLUSION:
BMI, pretreatment high leptin levels, and IR are negative predictors for SVR and pretreatment low adiponectin levels are an independent positive predictor for SVR in HCVG4.

Y, K., A. - W. M. M., and A. A., "Analysis and forecasting of dust storms, ", The International Journal of Meteorology , 2008.
Y, K., A. - W. M. M, and A. A., "Analysis and forecasting of dust storms,", The International Journal of Meteorology , 2008.
Y., Z., A. E. Safty, E. E, and S. M. Han., "Alteration in the Balance between Type 1 and Type 2 Immune Responses among Lead Exposed Population.", Current Journal of Applied Science and Technology, vol. 7, issue 3, pp. 289-294., 2015.
Y.H, E., A. A. Khalil, and M. M. Abdel-Wahab, "Assessment of Agricultural Drought under Climate Change.", Research Journal of Fisheries and Hydrobiology, vol. 11, issue 6, pp. 1-11, 2016.
YA, K., H. EN, M. M, and M. HS, "Antidepressant effects of curcumin-coated iron oxide nanoparticles in a rat model of depression", Eur J Pharmacol., vol. 908, pp. 174384, 2021.
Yacoub, K. A. H., The Achaemenid Empire Kings’ Religious Tolerance, , Cairo, Cairo Univercity, 2014. abstract.docx
Yacoub, A. S., H. O. Ammar, M. Ibrahim, S. M. Mansour, and N. M. El Hoffy, "Artificial intelligence-assisted development of forming nanoparticles for arthritis therapy via intra-articular delivery.", Drug delivery, vol. 29, issue 1, pp. 1423-1436, 2022. Abstract

Intra-articular (IA) injection is grasping much interest due to the poor drug bioavailability at the targeted site of action which minimizes the effect of the orally administered moiety. Based on the integral role of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of Rheumatoid Arthritis (RA), much effort is exerted to develop novel localized drug delivery systems to increase their bioavailability and minimize their side effects. Artificial intelligence (AI) is acquiring an increasing role in the design of experiments being an effective tool for saving both time and resources. Hence, the aim of this work was to develop, characterize and optimize targeted forming nano particles (ISNs) for IA delivery of piroxicam using Design Expert as an AI-based application where a 3 full factorial experimental design was adopted. Morphological investigation, injectability, rheological studies, Fourier Transform Infrared Radiation (FTIR) as well as biological, histopathological, and biochemical examinations were performed to evaluate the optimized-ISNs. The optimized formulation, exhibiting a nano-sized particle size with a dense core, showed significant improvement in the histopathological findings compared to both the oral solution and the placebo. Additionally, the once-a-week IA administration of the optimized-ISNs proved a significant reduction in the protein expression of both STAT-3 and RANKL and the levels of anti-CCP and MCP-1 by almost 54 and 73%, respectively, coupled with a marked decline in the content of IL-17, MMP-3, NF-κB and TNF-α as compared to the positive control. In conclusion, the use of ISNs for intra-articular injection has demonstrated their effectiveness in piroxicam delivery for RA treatment.

Yacoub, A. S., H. O. Ammar, M. Ibrahim, S. M. Mansour, and undefined, "Artificial intelligence-assisted development of insitu forming nanoparticles for arthritis therapy via intra-articular delivery", Drug Delivery , vol. 29, issue 1, pp. 1423–1436, 2022.
Yahia, Z., U. Rashad, and R. Mohammed, "Assessment of malalignment of trunk and pelvis in stroke patients", Egypt J Neurol Psychiat Neurosurg., vol. 47, issue 4, 2010. Abstract

Background: The appearance of scoliosis is one of the largest problems among stroke patients. Trunk and
pelvis abnormalities begin as a result of unequal weight distribution and muscle tightness. Presence of scoliosis
usually affect the position of scapula and pelvis which in turn causes impairments of motor, sensory and perceptual
functions of the upper and lower extremities. Objective: To assess trunk and pelvis malalignment in stroke patients in
relation to the duration of illness and degrees of spasticity. Methods: This study included sixty stroke patients, their
age ranged from 45 to 65 years. They were divided into equal groups according to the duration of illness. Each group
was subdivided into two subgroups according to the degree of spasticity. Clinical and neurological examination, brain
CT and MR imaging, assessment of muscle tone, trunk control and trunk range of motion were performed to each
patient. Results: There was no statistically significant difference concerning trunk flexion and extension among
patients in all groups. There was a statistical significant difference for trunk side bending among all patients. There
was a significant correlation between the degree of spasticity and both lateral trunk deviation and lateral pelvis tilting
as well as between duration of illness and abnormal trunk movements in all groups. Conclusion: Stroke patients
suffer usually from back and pelvis malalignment which are more manifested in long-standing patients with high
degrees of spasticity.

Yahia, N., "Applications to Biomedical Data by Using Volume Biased Rayleigh Model", Journal of Computational and Theoretical Nanoscience, vol. 18, issue 6, pp. 1724-1729, 2021. 0008_18ctn06-9724.pdf
Yamada, Y., A. S. Wifi, and T. Hirakawa, "Analysis of large deformation and stress in metal forming processes by the finite element method", Metal Forming Plasticity$\backslash$ Proc. Conf.$\backslash$, Tutzing, Germany, Aug.-Sept. 1978,, pp. 158–176, 1979. Abstract
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Yamada, Y., T. Hirakawa, and A. S. Wifi, "Analysis of large deformation and bifurcation in plasticity problems by the finite element method", Finite elements in non-linear mechanics, pp. 393–412, 1977. Abstract
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Yamani, H. M., A. M. Attiya, and A. K. Abdelmageed, "Approximate analytical technique to design reflectarray antenna", Advanced electromagnetics, vol. 5, no. 1, pp. 41–45, 2016. Abstract
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