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Journal Article
Feigin, V. L., G. A. Mensah, B. Norrving, C. J. L. Murray, and G. A. Roth, "Atlas of the Global Burden of Stroke (1990-2013): The GBD 2013 Study.", Neuroepidemiology, vol. 45, issue 3, pp. 230-6, 2015. Abstract

BACKGROUND: World mapping is an important tool to visualize stroke burden and its trends in various regions and countries.

OBJECTIVES: To show geographic patterns of incidence, prevalence, mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs) and their trends for ischemic stroke and hemorrhagic stroke in the world for 1990-2013.

METHODOLOGY: Stroke incidence, prevalence, mortality, DALYs and YLDs were estimated following the general approach of the Global Burden of Disease (GBD) 2010 with several important improvements in methods. Data were updated for mortality (through April 2014) and stroke incidence, prevalence, case fatality and severity through 2013. Death was estimated using an ensemble modeling approach. A new software package, DisMod-MR 2.0, was used as part of a custom modeling process to estimate YLDs. All rates were age-standardized to new GBD estimates of global population. All estimates have been computed with 95% uncertainty intervals.

RESULTS: Age-standardized incidence, mortality, prevalence and DALYs/YLDs declined over the period from 1990 to 2013. However, the absolute number of people affected by stroke has substantially increased across all countries in the world over the same time period, suggesting that the global stroke burden continues to increase. There were significant geographical (country and regional) differences in stroke burden in the world, with the majority of the burden borne by low- and middle-income countries.

CONCLUSIONS: Global burden of stroke has continued to increase in spite of dramatic declines in age-standardized incidence, prevalence, mortality rates and disability. Population growth and aging have played an important role in the observed increase in stroke burden.

Kang, M., H. Abdelmageed, S. Lee, A. Reichert, K. S. Mysore, and R. D. Allen, "AtMBP-1, an alternative translation product of LOS2, affects abscisic acid responses and is modulated by the E3 ubiquitin ligase AtSAP5", The Plant Journal, vol. 76, no. 3: Wiley Online Library, pp. 481–493, 2013. Abstract

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Haggag, M., and undefined, "Atmosphere, Land Surface, Hydrology, Ocean Wave, and Ocean Current Model (ALHOM) in Asia Environmental Simulator", Journal of International Development and Cooperation, vol. 13, issue 1, pp. 119-130, 2007.
Mohamed, A. - A. H., S. M. Al Shariff, S. A. Ouf, and M. Benghanem, "Atmospheric pressure plasma jet for bacterial decontamination and property improvement of fruit and vegetable processing wastewater", Journal of Physics D: Applied Physics, vol. 49, no. 19: IOP Publishing, pp. 195401, 2016. Abstract
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Ahmed, T. S., "Atom canonicity and first order definability in algebras of relation", Studia Scientiarum Mathematicarum Hungarica, vol. 67, issue 3, pp. 1-51, 2020. 4220.pdf
Rateb, N. M., and H. F. Zohdi, "An atom efficient, solvent-free, green synthesis of chalcones under grinding", Synth. Commun. , vol. 39, pp. 2789–2794, 2009. syn_comm_39_2789_09.pdf
Marzouk, R., F. Alrowais, F. N. Al-Wesabi, and A. M. Hilal, "Atom Search Optimization with Deep Learning Enabled Arabic Sign Language Recognition for Speaking and Hearing Disability Persons", Healthcare, vol. 10, issue 9, pp. 1-15, 2022.
Refaie, A. I., "Atomic Data for S XIV for 6≤ n ≤10", I.RE.PHY, vol. 7, issue 6, pp. 407-417, 2013. Abstract

Energy levels, wavelengths, log gf and transition rates for E1 have been calculated for S XIV. Configuration interaction and relativistic effects have been included in the calculations. 69 fine structure energy levels and 545 transition rates have been listed for 6≤n≤10. The calculations are in a good agreement with the other literatures.

Issa, Y. M., A. F. Shoukry, H. Ibrahim, and S. K. Mohamed, "Atomic Emission Spectrometric Determination of Antazoline, Hydralazine, Amiloride, Thiamine and Quinine Based on Formation of Ion Associates with Ammonium Reineckate", Analytical Letters, vol. 27, pp. 731–742, 1994. Abstract
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Hendrickson, W. A., and K. B. Ward, "Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin.", Biochemical and biophysical research communications, vol. 66, issue 4, pp. 1349-56, 1975 Oct 27. Abstract
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Abdelaziz, W. S., M. E. Ahmed, S. Sayed, and L. Gaabour, "Atomic structure data for neon like-VXIV ", Journal of Computational and Theoretical Nanoscience, vol. 14, 2017.
, "An atomic Theory with no prime models", Australasian Journal of Logic , vol. 5, issue 1, pp. 85-88, 2007.
Gao, W., A. O. Elnabawy, Z. D. Hood, Y. Shi, X. Wang, L. T. Roling, X. Pan, M. Mavrikakis, Y. Xia, and M. Chi, "Atomistic insights into the nucleation and growth of platinum on palladium nanocrystals", Nature communications, vol. 12, issue 1: Nature Publishing Group, pp. 1-10, 2021. Abstract
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El-Yamany, M. F., S. M. Farrag, M. A. Hamzawy, M. Asaad, and N. N. Nassar, "Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats", Life Sciences, vol. 203, pp. 129-140, 2018.
Farrag, S. M., M. A. Hamzawy, M. F. El-Yamany, M. Asaad, and N. N. Nassar, "Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats", Life Sciences, vol. 203, pp. 129-140, 2018. AbstractWebsite
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Farrag, S. M., M. A. Hamzawy, M. F. El-Yamany, M. Asaad, and N. N. Nassar, "Atorvastatin in nano-particulate formulation abates muscle and liver affliction when coalesced with coenzyme Q10 and/or vitamin E in hyperlipidemic rats.", Life sciences, vol. 203, pp. 129-140, 2018. Abstract

AIMS: Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 and nano vitamin E.

MATERIALS AND METHODS: Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10 mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH), triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and antioxidants "reduced glutathione (GSH) and superoxide dismutase (SOD)" were measured. Additionally quadriceps muscles and liver tissues were used for histopathological examination.

KEY FINDINGS: The antihyperlipidemic effect of statins was not altered when formulated as nanoparticles; albeit the former showed a prominent reduction in the liver and muscle enzymes and histopathological alterations together with a marked decline in the oxidative stress as compared to the free particulate form. These results were augmented when atorvastatin was combined with CoQ10 and/or Vit.E.

SIGNIFICANCE: Nanoparticulate formulation alleviated the statins induced liver and muscle damage especially when combined with CoQ10 and/or Vit.E.

Elgendy, H. A., A. M. A. Makky, Y. E. Elakkad, H. H. Awad, M. E. A. Hassab, and N. F. Younes, "Atorvastatin loaded lecithin‑coated zein nanoparticles based thermogel for the intra‑articular management of osteoarthritis: in‑silico, in‑vitro, and in‑vivo studies", Journal of Pharmaceutical Investigation, 2024.
Taha, N. M., H. - A. S. A. Yousof, S. H. El-Sayed, undefined, and M. S. I. Negm, "Atorvastatin repurposing for the treatment of cryptosporidiosis in experimentally immunosuppressed mice", Experimental Parasitology , vol. 181 , pp. 57-69, 2017.
Taha, N. M., H. E. B. A. T. - A. L. L. A. H. S. A. YOUSOF, S. H. El-Sayed, A. I. Younis, and M. S. I. Negm, "Atorvastatin repurposing for the treatment of cryptosporidiosis in experimentally immunosuppressed mice", Experimental parasitology , vol. 181, pp. 57-69 , 2017.
Taha, N. M., H. - A. S. A. Yousof, S. H. El-Sayed, A. I. Younis, and M. S. I. Negm, "Atorvastatin repurposing for the treatment of cryptosporidiosis in experimentally immunosuppressed mice", Experimental parasitology, vol. 181: Academic Press, pp. 57–69, 2017. Abstract
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