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Zekri, A. R., A. A. Bahnassi, B. Bove, Y. Huang, I. H. Russo, A. Rogatko, S. Shaarawy, O. A. Shawki, M. R. Hamza, S. Omer, et al., "Allelic instability as a predictor of survival in Egyptian breast cancer patients.", International journal of oncology, vol. 15, no. 4, pp. 757-767, 1999. AbstractWebsite

This work was designed with the purpose of determining whether the presence of allelic imbalances (AI) such as microsatellite instability (MSI) and loss of heterozygosity (LOH) in chromosomes 2, 11, 13, and 17 in primary breast cancer could be used as prognostic indicators of patient survival. The DNA from breast cancers removed from 29 patients who were followed-up for up to five years was analyzed for MSI and LOH using a panel of 24 markers located at chromosome 2 (TPO, D2S131, D2S144, D2S171, D2S177, D2S119, D2S123, D2S147 and D2S136), chromosome 11 (C-RAS, Int-2, D11S940, D11S912), chromosome 13 (D13S289, D13S260, D13S267, D13S218, D13S263, D13S155, and D13S162), and chromosome 17 (D17S513, TP53, D17S855, and D17S785). The frequency of AI in the markers studied ranged from 30-55%, being highest for D11S912, D2S171, TP53 and D17S855. Univariate analysis showed association between overall survival rate and AI in 9 out of the 24 markers tested. Five of them were located at the area of the mismatch repair gene (MMR)-2 gene, two at 11p, one at 13q and one at 17p. Using multivariate analysis, it was observed that only pathological and clinical stage (defined as stage II or not) and AI at D2S171, D11S912, or D17STP53 generated significant predictive models for survival.

Zekri, W., M. Hammad, Y. ElBoraie, H. Taha, A. Refaat, A. S. AlFaar, and A. Younis, "Adrenocortical Carcinoma In The Pediatric Age Group; Experience At Children Cancer Hospital Of Egypt (CCHE)", American Society of Pediatric Hematology/Oncology, Chicago, 2014. Abstract
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Zekri, A. - R. N., A. A. Bahnassy, M. Hafez, A. M. El-Shehaby, G. M. Sherif, H. M. Khaled, and N. Zakhary, "Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma.", Journal of gastroenterology and hepatology, vol. 20, issue 1, pp. 87-94, 2005 Jan. Abstract

BACKGROUND AND AIM: The present study was conducted to address whether homozygous deletion (HZD) or transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of hepatitis C virus-associated hepatocellular carcinoma (HCC).

METHODS: Homozygous deletion of the FHIT gene at exons 3-9 was assessed as well as mRNA FHIT expression using reverse transcription polymerase chain reaction. The study included 23 samples of HCC, 11 on top of cirrhosis and 12 non-cirrhotic, in addition to five cases with chronic active hepatitis (CAH), as well as seven morphologically normal tissues distant to the tumor (NDT) and 10 normal liver samples from liver transplantation donors.

RESULTS: Homozygous deletion was found in 18 of 23 HCC cases. The highest incidence of deletion was detected in exon 9 (52.0%) and the lowest in exon 7 (4.3%). Ten of the 18 cases (55.5%) showed deletion in more than one exon, eight in two exons, one in three exons and one in five exons. There was a significant association between HZD of exons 5 and 9 and HCC arising on top of cirrhosis (P = 0.041 and 0.006, respectively) as well as between exons 8 and 9 and the presence of CAH (P = 0.029 and 0.034, respectively). Aberrant FHIT transcripts were detected in 15 HCC cases (65.2%), 13 of them showed complete reduction of the mRNA transcripts and two showed abnormal bands. Sequence analysis of abnormal-sized transcripts revealed that they were generated by the fusion of exons 5 and 7 as well as exons 7 and 9. In contrast, six of the seven NDT samples tested (85.6%) showed HZD in one or more exons. None of the normal liver samples from liver transplantation donors showed any changes. The highest incidence of HZD was detected in exon 9 (five of six cases representing 83.3%) and the lowest was in exon 4 (one of six cases representing 16.7%). Four cases showed the same aberrant FHIT HZD in both NDT and matched HCC.

CONCLUSIONS: The results of the present study indicate that the FHIT gene is a frequent target in hepatitis C virus-associated HCC and that alterations affecting this gene could be an early event in this type of neoplasm as they were detected in cirrhotic and CAH patients. However, this should be confirmed by a larger, extended study including more cases of cirrhotic and CAH patients as well as matched tumor and normal samples.

Zekri, W., M. Hammad, Y. Elborai, H. Taha, A. Refaat, A. S. Alfaar, B. Abdalla, and A. Younis, "Adrenocortical Carcinoma in the Pediatric Age Group; Experience at Children Cancer Hospital of Egypt (CCHE)", Pediatric Blood & Cancer, vol. 61, issue S1, pp. S35, 2014. pediatric_blood_and_cancer_aspho_abstract_2014.pdf
Zekri, W., M. Hammad, Y. Elborai, H. Taha, A. Refaat, A. Alfaar, B. Abdalla, and A. Younis, "Adrenocortical Carcinoma in the Pediatric Age Group; Experience at Children Cancer Hospital of Egypt (CCHE)", Pediatric Blood & Cancer. DOI: 10.1002/pbc.25032. https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.25032, vol. 61, issue S1, no. S1: WILEY-BLACKWELL, pp. S35–S36, 2014. Abstractadrenocortical_carcinoma_in_the_pediatric_age_group_experience_at_children_cancer_hospital_of_egypt_cche.pdf

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Zekri, A. R., A. A. Bahnassi, B. Bove, Y. Huang, I. H. Russo, A. Rogatko, S. Shaarawy, O. A. Shawki, M. R. Hamza, S. Omer, et al., "Allelic instability as a predictor of survival in Egyptian breast cancer patients.", International journal of oncology, vol. 15, issue 4, pp. 757-67, 1999 Oct. Abstract

This work was designed with the purpose of determining whether the presence of allelic imbalances (AI) such as microsatellite instability (MSI) and loss of heterozygosity (LOH) in chromosomes 2, 11, 13, and 17 in primary breast cancer could be used as prognostic indicators of patient survival. The DNA from breast cancers removed from 29 patients who were followed-up for up to five years was analyzed for MSI and LOH using a panel of 24 markers located at chromosome 2 (TPO, D2S131, D2S144, D2S171, D2S177, D2S119, D2S123, D2S147 and D2S136), chromosome 11 (C-RAS, Int-2, D11S940, D11S912), chromosome 13 (D13S289, D13S260, D13S267, D13S218, D13S263, D13S155, and D13S162), and chromosome 17 (D17S513, TP53, D17S855, and D17S785). The frequency of AI in the markers studied ranged from 30-55%, being highest for D11S912, D2S171, TP53 and D17S855. Univariate analysis showed association between overall survival rate and AI in 9 out of the 24 markers tested. Five of them were located at the area of the mismatch repair gene (MMR)-2 gene, two at 11p, one at 13q and one at 17p. Using multivariate analysis, it was observed that only pathological and clinical stage (defined as stage II or not) and AI at D2S171, D11S912, or D17STP53 generated significant predictive models for survival.

g Zekri, A. - R. N. a, A. A. c Bahnassy, M. A. Hafez, A. M. R. f El-Shehaby, G. M. d Sherif, H. M. e Khaled, and N. b Zakhary, "Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma", Journal of Gastroenterology and Hepatology (Australia), vol. 20, no. 1, pp. 87-94, 2005. AbstractWebsite

Background and Aim: The present study was conducted to address whether homozygous deletion (HZD) or transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of hepatitis C virus-associated hepatocellular carcinoma (HCC). Methods: Homozygous deletion of the FHIT gene at exons 3-9 was assessed as well as mRNA FHIT expression using reverse transcription polymerase chain reaction. The study included 23 samples of HCC, 11 on top of cirrhosis and 12 non-cirrhotic, in addition to five cases with chronic active hepatitis (CAH), as well as seven morphologically normal tissues distant to the tumor (NDT) and 10 normal liver samples from liver transplantation donors. Results: Homozygous deletion was found in 18 of 23 HCC cases. The highest incidence of deletion was detected in exon 9 (52.0%) and the lowest in exon 7 (4.3%). Ten of the 18 cases (55.5%) showed deletion in more than one exon, eight in two exons, one in three exons and one in five exons. There was a significant association between HZD of exons 5 and 9 and HCC arising on top of cirrhosis (P = 0.041 and 0.006, respectively) as well as between exons 8 and 9 and the presence of CAH (P = 0.029 and 0.034, respectively). Aberrant FHIT transcripts were detected in 15 HCC cases (65.2%), 13 of them showed complete reduction of the mRNA transcripts and two showed abnormal bands. Sequence analysis of abnormal-sized transcripts revealed that they were generated by the fusion of exons 5 and 7 as well as exons 7 and 9. In contrast, six of the seven NDT samples tested (85.6%) showed HZD in one or more exons. None of the normal liver samples from liver transplantation donors showed any changes. The highest incidence of HZD was detected in exon 9 (five of six cases representing 83.3%) and the lowest was in exon 4 (one of six cases representing 16.7%). Four cases showed the same aberrant FHIT HZD in both NDT and matched HCC. Conclusions: The results of the present study indicate that the FHIT gene is a frequent target in hepatitis C virus-associated HCC and that alterations affecting this gene could be an early event in this type of neoplasm as they were detected in cirrhotic and CAH patients. However, this should be confirmed by a larger, extended study including more cases of cirrhotic and CAH patients as well as matched tumor and normal samples. © 2005 Blackwell Publishing Asia Pty Ltd.

Zekri, J., M. Mansour, and S. M. Karim, "The anti-tumour effects of zoledronic acid", Journal of bone oncology, vol. 3, issue 1, pp. 25-35, 2014. anti_tumour_of_zoledronic_acid.pdf
Zeitoun, R., and M. H. Abdelsattar, "Approach to interpret images produced by new generations of multidetector CT scanners in postoperative spine", british journnal of radiology, 2017.
Zeinab Sarhan, Mohsen Askar, F. Zyada, and D. Reyad, "Assessment of coping strategies in a sample of risky suicidal Egyptian psychiatric outpatients", egyptjpsychiatr, issue 34:, pp. 177–185, 2012. egyptjpsychiatr343177-690209_001130_1.pdf
Zeid, F. A., E. M. Harb, E. A. Omer, A. H. Hanafy Ahmed, and S. H. A. I. M. A. A. A. H. HANAFY, "Alleviating effect of sodium nitroprusside on growth, biochemical composition, essential oil in chervil plant subjected to salinity stress", BIOSCIENCE RESEARCH, vol. 15, issue 4, pp. 4433-4451, 2018.
Zehra, A, Gul, B., Ansari, R., Alatar, A. A., A. K. Hegazy, and M. A. Khan, "Action of plant growth regulators in alleviating salinity and temperature effects on the germination of hragmiteskarka.", Pakistan Journal of Botany, vol. 45, issue 6, pp. 1919-1924, 2013.
Zeeneldin, A. A., "Adherence of non-pharmaceutically sponsored oncology trial protocols to the International Conference on Harmonization (ICH) guidelines in an academic institution outside the ICH jurisdictions and the impact of IRB implementation on this adherence.", Journal of the Egyptian National Cancer Institute, vol. 25, issue 2, pp. 71-8, 2013 Jun. Abstract

PURPOSE: To assess adherence of non-pharmaceutically sponsored trials (non-PSTs) to ICH protocol structure guidelines and to estimate the effect of implementing Institutional Review Board's (IRB) review on this adherence.

METHODS: This is a retrospective exploratory study where 60 non-PST clinical trial protocols (CTPs) were reviewed and halved to IRB-reviewed CTPs (IRCTPs) and non-IRB-reviewed CTPs (non-IRCTPs). Adherence score (AS) was calculated as the number of fulfilled items or sub-items divided by their total number.

RESULTS: Three adherence patterns were encountered: (1) items consistently present in both groups e.g. general and background information, objectives, inclusion criteria and intervention details, (2) items consistently absent in both groups and included contact information of investigators and trial sites, product accountability, randomization codes' management, interim analyses and many other statistical aspects, and (3) items variably present in both groups where the effect of IRB was verifiable. Trial site details, potential benefits, discontinuation and exclusion criteria, and follow up for adverse events were more encountered in IRCTPs than non-IRCTPs. Withdrawal criteria and monitoring of treatment compliance showed a reverse pattern (p<0.05 for all). The total AS, administrative AS and ethics AS for IRCTPs was 43%, 22% and 70% compared to 38%, 16% and 33% for non-IRCTPs (p<0.003, <0.001, 0.004), respectively. The scientific AS was 54% for both groups (p=0.87).

CONCLUSIONS: IRB-implementation at NCI-Egypt improved ethical and administrative sections of academic protocols. However, this improvement is modest and needs further actions including adoption of protocol templates. Scientific sections were as good after IRB-implementation as they were before that.

Zedan, A. F., and S. Y. AlQaradawi, "Activity and Kinetic Study of CO Oxidation over Mesoporous CuO/TiO 2 Catalysts", 25th North American Catalysis Society Meeting: NAM, 2017. Abstract

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Zedan, A. F., and S. Y. AlQaradawi, "Activity and Kinetic Study of CO Oxidation over Mesoporous CuO/TiO 2 Catalysts", 25th North American Catalysis Society Meeting: NAM, 2017. Abstract
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Zedan, H. H., and F. M. Serry, "Antimicrobial effectiveness of some preservatives in certain eye and nasal drops. ", Egypt. J. Pharm. Sci. , vol. 23, pp. 66-76, 1982.
Zedan, S. Y., S. A. - R. Mohamed, and M. A. - E. Ibrahim, "Assessment of Mothers' Knowledge Regarding Care of Children Connected with Permanent Pacemaker ", Medical Journal of Cairo University, vol. 87, issue 3, pp. 1605-1613, 2019.
Zedan, I. A., K. M. Elsayed, and Eid Emary, "Abrupt Cut Detection in News Videos using Dominant Colors Representation", Proceedings of the 2nd International Conference on Advanced Intelligent Systems and Informatics (AISI 2016), Cairo, Egypt, 25 October, 2016.
Zedan, M. H., and H. A. Hassan, "An Aligned Assessment Item Authoring Environment based on Interoperability Standards,", International Journal of Modern Education and Computer Science (IJMECS), vol. 5, issue 12, 2013.
abdelghany zeada, "ada", the faculty of arts, 2014. myn_ydhb_nhyy_mjl_ladb_llqhr_-_copy_-_copy_-_copy.pdf
Zayed, A. A., and A. A. Ali, "Abusing Female children by circumcision is continued in Egypt.", Journal of Forensic and Legal Medicine, 2012.
Zayed, R. A., D. Omran, D. A. Mokhtar, Z. ZAKARIA, S. Ezzat, M. A. Soliman, L. Mobarak, H. El-Sweesy, and G. Emam, "Association of Toll-Like Receptor 3 and Toll-Like Receptor 9 Single Nucleotide Polymorphisms with Hepatitis C Virus Infection and Hepatic Fibrosis in Egyptian Patients.", Am J Trop Med Hyg., vol. 96, issue 3, pp. 720-726, 2017.
Zayed, N., A. B. Awad, W. El-Akel, W. Doss, T. Awad, A. Radwan, and M. Mabrouk, "The assessment of data mining for the prediction of therapeutic outcome in 3719 Egyptian patients with chronic hepatitis C", Clinics and research in hepatology and gastroenterology, vol. 37, no. 3: Elsevier, pp. 254–261, 2013. Abstract
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