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Zaghloul, M. S., and A. G. Mousa, "Trimodality treatment for bladder cancer: does modern radiotherapy improve the end results?", Expert review of anticancer therapy, vol. 10, issue 12, pp. 1933-44, 2010 Dec. Abstract

With the advancement in endoscopic surgery, radiation treatment planning and execution, as well as the use of new chemotherapeutic regimens, bladder conservation has evolved into a competing alternative to radical cystectomy. Trimodality treatment has the great advantage of preserving a normally functioning urinary bladder. Despite the absence of direct randomized trials comparing both modalities, trimodality treatment comprising maximal transuretheral resection of bladder tumors followed by different regimens of combined radiochemotherapy achieved comparable results to radical cystectomy in many trials. Those who did not achieve complete remission after induction radiochemotherapy were salvaged by radical cystectomy. Improving the radiotherapeutic window is a challenging issue. In radiotherapy for bladder cancer, uncertainties include set-up errors, patient movement, internal organ movement and volume changes due to bladder filling (both inter- and intrafraction). The advancement in treatment verification procedures in modern radiotherapy and the use of fiducial markers reduces set-up errors, while adaptive radiotherapy could decrease the unnecessary irradiation of normal tissues by tracking bladder volume changes. In addition, new radiotherapeutic techniques, such as intensity-modulated radiotherapy and volume-modulated radiotherapy, permit dose escalation to the target without increasing the dose to the surrounding normal tissues.

Zaghloul, M. S., "Bladder cancer and schistosomiasis.", Journal of the Egyptian National Cancer Institute, vol. 24, issue 4, pp. 151-9, 2012 Dec. Abstract

Schistosoma-associated bladder cancer was believed, for several decades, to be a completely unique entity of disease, different from urothelial cancer. This was probably due to its distinct clinicopathologic and demographic features that varied from those of urothelial entity. The carcinogenesis is an extremely complex process resulting from the accumulation of many genetic and epigenetic changes leading to alterations in the cell proliferation regulation process. In bladder cancer, many of these carcinogenic cascades were not fully documented or somewhat conflicting. Inspite of the efforts performed, much is still needed to explore the presence or absence of the carcinogenic difference with a different etiology. The control of schistosomiasis in certain countries and the subsequent decrease in the intensity of infestation showed changing of features approaching that of urothelial tumors. However the schistosoma-associated bladder cancer presented in more advanced stages than schistosoma-non associated urothelial cancer. More recently, data are gathered that, upon applying the same treatment protocol and management care, stage by stage comparison of the treatment end-results were found to be similar in bladder cancer patients with a different etiology. All treatment options; including radical cystectomy with or without adjuvant or neoadjuvant chemo- or radiotherapy or trimodality bladder preserving treatment seem to lead to similar end-results regardless of etiologic factor(s) implicated in bladder cancer development.

Zaghloul, K. H., W. A. Omar, A. A. Abdel-Khalek, and S. Abo Hegab, "Ecological monitoring of Mediterranean Solea aegyptiaca transplanted into Lake Qaroun, Egypt.", Australian Journal of Basic and Applied Sciences, vol. 5, issue 7, pp. 851-862., 2011.
Zaghloul, A. H., S. S. El-Ballal, A. M. Morgan, and B. E. EL- Bialy, "Embryo and Feto-Toxicity Investigation of Deltamethrin in Rats.", Special issue for the 7th scientific conference of Faculty of Veterinary Medicine, Minufiya University, Egypt, April 24 -27, 2012 (Special issue (2012):262- 289, 26 April, 2012.
saied zaghloul, H., "Does Aroclor 1254 Affect the Reproductive and Thyroid Function Male Albino Rats? ", the 5th Annual Scientific Conference of Forensic Medicine and Toxicology Department, Faculty of Medicine, Cairo University, November, 2001, November,2001.
Zaghloul, M. S., "Adjuvant radiation therapy for muscle-invasive bladder cancer.", La Tunisie medicale, vol. 83 Suppl 12, pp. 92-3, 2005 Dec. Abstract
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Zaghloul, M. A. S., J. H. Mason, M. Wang, M. Buric, Z. Peng, S. Lee, P. Ohodnicki, H. Abernathy, and K. P. Chen, "High spatial resolution temperature profile measurements of solid-oxide fuel cells", Applied Energy, vol. 288: Elsevier, pp. 116633, 2021. Abstract
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Zaghloul, H., D. W. Elkassas, and M. F. Haridy, "Effect of incorporation of silane in the bonding agent on the repair potential of machinable esthetic blocks", European Journal of Dentistry,, vol. 8, issue 1, pp. 44-52, 2014. page_proof.pdf
saied zaghloul, H., and hala el Gindy, "Could Cadmium exposure potentiate Diabetic Nephropathy? ", The Medical Journal of Cairo Univerisity, vol. 67, issue 4, pp. 969-976, 1999.
Zaghloul, A. S., A. E. R. M. ElNashar, sameh fayek gamalEl Din, S. Z. Said, H. M. Saad, H. R. Eldebs, and I. A. L. Osman, "Smoking status and the baseline international index of erectile function score can predict satisfactory response to platelet rich plasma in patients with erectile dysfunction: A prospective pilot study", Andrologia, vol. 53, pp. e14162., 2021.
Zaghloul, M. S., "Single pediatric neuro-oncology center may make difference in low/middle-income countries.", Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, vol. 32, issue 2, pp. 241-2, 2016 Feb. Abstract
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d Zaghloul, M. S. a, M. a El Naggar, A. b El Deeb, H. c Khaled, and N. b Mokhtar, "Prognostic implication of apoptosis and angiogenesis in cervical uteri cancer", International Journal of Radiation Oncology Biology Physics, vol. 48, no. 5, pp. 1409-1415, 2000. AbstractWebsite

Purpose: A retrospective study was performed to investigate the relationship between spontaneous apoptosis and angiogenesis uterine cervix squamous cell carcinoma patients. The prognostic value of each (and both) of these biologic parameters was also tested.Methods and Materials: The pathologic materials of 40 cervical uteri squamous cell carcinoma patients were examined and immunohistochemically stained to determine the tumor angiogenesis (tumor microvascular score), using factor VIII-related antigen, and their tumor apoptotic index (AI), using the TdT-mediated dUTP nick end-labeling (TUNEL) method. Three patients were Stage I, 18 were Stage II, 15 were Stage III, and 4 were Stage IV (FIGO classification). All patients were treated with radical radiotherapy and all had follow-up for more than 2 years.Results: The mean AI was 15.1 ± 12.8, with a median of 8.3. The mean tumor microvascular score was 3 9.7 ± 14.4, with a median of 3 8. The patients' age and tumor grade did not seem to significantly affect the prognosis. On the other hand, AI and angiogenesis (tumor microvascular score) were of high prognostic significance. The 3-year disease-free survival (DFS) rate for the patients having AI above the median was 78% (confidence interval [CI] 69-87%), compared to 32% (CI 22-42%) for those having AI below the median. The DFS was 18% (CI 9-27%) for patients having an angiogenesis score above the median, while it was 86% (CI 78-94%) for those patients having a score below the median.Conclusion: Determination of both tumor microvascular score and AI can identify patients with the best prognosis of 100% DFS (with low angiogenesis score and high AI). Women with a high score and low AI had the worst prognosis (DFS = 3%, CI 1-5%). Moreover, high AI can compensate partially for the aggressive behavior of tumors showing a high rate of angiogenesis. Copyright (C) 2000 Elsevier Science Inc.

Zaghloul, M. S., A. Nouh, M. Moneer, M. El-Baradie, M. Nazmy, and A. Younis, "Time-trend in epidemiological and pathological features of schistosoma-associated bladder cancer.", Journal of the Egyptian National Cancer Institute, vol. 20, issue 2, pp. 168-74, 2008 Jun. Abstract

OBJECTIVE: To investigate the different emerging trends in the features of bladder cancer along 17 years.

PATIENTS AND METHODS: During a 17-year period (1988- 2004), 5071 epithelial bladder cancer patients underwent radical cystectomy at the National Cancer Institute (NCI), Cairo University, Egypt. The time was divided into 3 time periods to detect changes of the clinicopathologic features of patients in these periods.

RESULTS: There was a significant progressive increase in the patients' age with time and decrease in squamous/transitional ratio, with transient increase in male predominance during the 2nd time period. Moreover, there was a decrease in the well differentiated (grade 1) tumor (p<0.001) and an increase in the frequency of pelvic nodal involvement (p<0.001). Transitional cell carcinoma (TCC) patients were significantly older than those with squamous cell carcinoma (SCC) (p<0.001). Progressive increase of age with time was evident in TCC, SCC and adenocarcinoma patients. Male to female ratio changed significantly in TCC and SCC.

CONCLUSION: Time trend was confirmed with relative decrease in frequency of SCC and increase of TCC with changes in their pathological details. The differences between their characteristics and that of the Western countries are decreasing.

Zaghloul, M. S., R. Boutrus, H. El-Hossieny, Y. AbdelKader, I. El-Attar, and M. Nazmy, "A prospective, randomized, placebo-controlled trial of zoledronic acid in bony metastatic bladder cancer.", International journal of clinical oncology, vol. 15, issue 4, pp. 382-9, 2010. Abstract

BACKGROUND: Zoledronic acid treatment reduces the incidence of skeletal-related events (SREs) in patients with bone metastases from breast, lung, and urologic cancers including prostate and renal cancer. The aim of this study was to evaluate the effect of zoledronic acid on SREs in patients with bone metastases from bladder cancer.

PATIENTS AND METHODS: Patients with bone metastases from bladder cancer who were receiving palliative radiotherapy were randomized to placebo or zoledronic acid (4 mg intravenous monthly) for 6 months.

RESULTS: The patients (n = 40) were evenly distributed between the two treatment groups, and the baseline demographics of the two groups were similar. The follow-up varied from 8 to 65 weeks (median 24 weeks). Compared with patients receiving placebo, those receiving zoledronic acid had a lower mean incidence of SREs (2.05 +/- 1.0 vs. 0.95 +/- 0.9, respectively), and a larger proportion did not experience an on-study SRE (2 vs. 8 patients, respectively). Zoledronic acid also prolonged the median time to first SRE compared with the placebo (16 vs. 8 weeks, respectively). Multiple event analysis of SREs revealed that zoledronic acid decreased the risk of SRE development by 59% (hazard ratio 0.413). Zoledronic acid also increased the 1-year survival rate compared with placebo (36.3 +/- 11.2 vs. 0%, respectively). Zoledronic acid was generally well tolerated in our patient population.

CONCLUSIONS: Zoledronic acid therapy decreased the incidence of SREs and improved the 1-year survival rate of patients with bone metastases from bladder cancer, potentially through its anticancer activity.

saied zaghloul, H., "Effect of Curcumin on Doxorubicin-Induced Chromosomal Damage in Albino Rats Bone Marrow Cells", The Egyptian Journal of Forensic Sciences and Applied Toxicology, vol. 4, issue 1, pp. 19-30, 2004.
Zaghloul, M. S., "In Regard to Reddy et al.", International journal of radiation oncology, biology, physics, vol. 95, issue 2, pp. 854, 2016 06 01. Abstract
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Zaghloul, M. S., "The First Children's Cancer Hospital, Egypt International Scientific Conference.", Expert review of anticancer therapy, vol. 9, issue 10, pp. 1435-7, 2009 Oct. Abstract

A wide gathering of scientists, clinicians, pharmacists and nurses specialized in pediatric oncology practice met to celebrate the second anniversary of Children's Cancer Hospital, Egypt (CCHE). The celebration was in the form of high-brow teaching lectures and reports presented by international experts in the fields of pediatric CNS tumors, solid tumors (neuroblastoma, nephroblastoma, soft tissue and bone tumors, lymphoma, leukemia and pediatric oncology nursing. The conference extends its activities to hospital management, clinical pharmacy and telemedicine. Furthermore, CCHE experts presented the efforts performed to establish a state-of-the-art pediatric oncology hospital equipped with all needed facilities to raise the standard of care to the highest levels.

Zaghloul, K. F., A. A. Wahdan, and R. R. Shahin, "Soil volume changes as affected by clay mineralogy of some soils of Egypt.", Annals of Agricultural Science, Moshtohor, 1983. Abstract
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Zaghloul, M. S., E. Eldebawy, S. Ahmed, A. G. Mousa, A. Amin, A. Refaat, I. Zaky, N. El Khateeb, and M. Sabry, "Hypofractionated conformal radiotherapy for pediatric diffuse intrinsic pontine glioma (DIPG): a randomized controlled trial.", Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, vol. 111, issue 1, pp. 35-40, 2014 Apr. Abstract

BACKGROUND: The pediatric diffuse intrinsic pontine glioma (DIPG) outcome remains dismal despite multiple therapeutic attempts.

PURPOSE: To compare the results of treatment of pediatric diffuse intrinsic pontine glioma (DIPG) using hypofractionated versus conventional radiotherapy.

PATIENTS AND METHODS: Seventy-one newly diagnosed DIPG children were randomized into hypofractionated (HF) (39Gy/13 fractions in 2.6weeks) and conventional (CF) arm (54Gy/30 fractions in 6weeks).

RESULTS: The median and one-year overall survival (OS) was 7.8months and 36.4±8.2% for the hypofractionated arm, and 9.5 and 26.2±7.4% for the conventional arm respectively. The 18-month OS difference was 2.2%. The OS hazard ratio (HR) was 1.14 (95% CI: 0.70-1.89) (p=0.59). The hypofractionated arm had a median and one-year progression-free survival (PFS) of 6.6months and 22.5±7.1%, compared to 7.3 and 17.9±7.1% for the conventional arm. The PFS HR was 1.10 (95% CI: 0.67-1.90) (p=0.71). The 18-month PFS difference was 1.1%. These differences exceed the non-inferiority margin. The immediate and delayed side effects were not different in the 2 arms.

CONCLUSIONS: Hypofractionated radiotherapy offers lesser burden on the patients, their families and the treating departments, with nearly comparable results to conventional fractionation, though not fulfilling the non-inferiority assumption.

saied zaghloul, H., "Quantitative Relationships of Postmortem Ethanol concentrations in Blood, Vitreous Humor, Urine and Liver of Adult Albino Rats.", The Egyptian Journal of Forensic Sciences and Applied Toxicology, vol. 3, issue 2, pp. 1-22, 2003.
Zaghloul, M. S., "The need to revisit adjuvant and neoadjuvant radiotherapy in bladder cancer.", Expert review of anticancer therapy, vol. 10, issue 10, pp. 1527-8, 2010 Oct. Abstract
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Zaghloul, M. S., A. G. Mousa, E. Eldebawy, E. Attalla, H. Shafik, and S. Ezzat, "Comparison of electronic portal imaging and cone beam computed tomography for position verification in children.", Clinical oncology (Royal College of Radiologists (Great Britain)), vol. 22, issue 10, pp. 850-61, 2010 Dec. Abstract

AIM: To compare the accuracy of radiotherapy set-up using an electronic portal imaging device (EPID) versus megavoltage cone beam computed tomography (MV-CBCT) in paediatric patients.

MATERIALS AND METHODS: In total, 204 pairs of EPID and MV-CBCT were carried out for 72 patients in the first 3 treatment days and weekly thereafter.

RESULTS: For the whole group, the mean systematic EPID set-up errors were 1.8 (±1.7), 1.6 (±1.3), 1.4 (±1.5) mm and 2.3 (±1.7), 1.6 (±1.3), 2.4 (±1.6) mm for MV-CBCT in the longitudinal, lateral and vertical directions, respectively, whereas the mean EPID random errors were 2.0 (±1.7), 1.4 (±1.5), 1.2 (±1.6) and 1.9 (±1.5), 1.5 (±1.3), 2.1 (±1.7) mm for MV-CBCT in the longitudinal, lateral and vertical directions, respectively. For systematic errors of head and neck patients, there was a statistically significant difference in the lateral and vertical directions (P=0.027, 0.003), whereas in the non-head and neck patients there was a statistically significant difference in the lateral direction only (P=0.031). In head and neck patients, the mean random errors were significantly different in the vertical and lateral directions, whereas in non-head and neck patients, they were significantly different in the vertical direction only. The larger values alternate between the two modalities. The systematic and random errors (detected by EPID and MV-CBCT) were significantly correlated in almost all direction in all tumour sites.

CONCLUSIONS: The comparison between set-up error in EPID and MV-CBCT was not in favour of any of the two modalities. However, the two modalities were strongly correlated but fairly agreed and the differences between the shifts reported were small and hardly influenced the recommended planning target volume margin.

Zaghloul AM, E. G. E. Mohamed, A. B. Frederic, and S. S. Mona, "Impact of social and personl factors on the prevalence of work related diseases", Egyptian J of Occupational Medicine, vol. 13, issue 2, pp. 127-146., 1989.
Zaghloul AM, E. G. E. Mohamed, A. B. Frederic, and S. S. Mona, "Role of the type of job on the prevalence of work related diseases", Egyptian J of Occupational Medicine, vol. 13, issue 2, pp. 147-158, 1989.
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