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Eissa, I. H., H. Mohammad, O. A. Qassem, W. Younis, T. M. Abdelghany, A. Elshafeey, M. A. R. M. Moustafa, M. N. Seleem, and A. S. Mayhoub, "{Diphenylurea derivatives for combating methicillin-and vancomycinresistant Staphylococcus aureus}", {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, vol. {130}, {23 RUE LINOIS, 75724 PARIS, FRANCE}, {ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER}, pp. {73-85}, {APR 21}, Submitted. Abstract

{A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin-and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound 3 that carries an aminoguanidine functionality from one side and a n-butyl moiety on the other ring, several analogues were prepared. Considering the pharmacokinetic parameters as a key factor in structural optimization, the structureactivity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analogue 21n as a potential drug-candidate. This compound has several notable advantages over vancomycin and linezolid including rapid killing kinetics against MRSA and the ability to target and reduce the burden of MRSA harboring inside immune cells (macrophages). Furthermore, the potent anti-MRSA activity of 21n was confirmed in vivo using a Caenorhabditis elegans animal model. The present study provides a foundation for further development of diphenylurea compounds as potential therapeutic agents to address the burgeoning challenge of bacterial resistance to antibiotics. (C) 2017 Elsevier Masson SAS. All rights reserved.}

Akah, M. M., L. Daifala, and M. M. Yousry, "Bonding of Bulk Fill versus Contemporary Resin Composites: A Systematic Review and Meta-analysis", Indian journal of Science and Technology, Submitted. mai_paper_dr.mai_.docx
N.A., A., B. I.H., E. Y., A. E. - W. G.A, M. M. A. Hamdy G.c, and M. M.A., "CD4+CD25+ regulatory Tcells (TREG) in Systemic Lupus Erythematosus (SLE) patients: The possible influence of treatment with corticosteroids", Clinical immunology, vol. 127, issue 2, pp. 151-157, Submitted.
Franco, M., R. Rocha, M. Costa, and M. Yehia, "Characteristics of NH3/H2/air flames in a combustor fired by a swirl and bluff-body stabilized burner", Proceedings of Combustion Institute, Submitted.
Husseiny, N. E. M., A. E. Sobky, A. M. Khalaf, M. Fateen, D. E. M. Demerdash, H. Youssef, M. Salah, S. E. S. A. E. Ghany, S. E. Husseiny, and M. Gamil, "Chronic immune thrombocytopenia. Egyptian experience", Comp Clin Pathol , issue 1618-5641, Submitted.
Husseiny, N. E. M., A. E. Sobky, A. M. Khalaf, M. Fateen, D. E. M. Demerdash, H. Youssef, M. Salah, S. E. S. A. E. Ghany, S. E. Husseiny, and M. Gamil, "Chronic immune thrombocytopenia. Egyptian experience", Comp Clin Pathol , issue 1618-5641, Submitted.
Tamymy, M. E. M., Y. A. Bassiouny, H. E. ashmawy, M. A. Hamza, and A. Yehia, "Comparison between laparoscopic tubal disconnection and hysteroscopic tubal occlusion for the management of hydrosalpinx prior to ICSI ", Reproductive Health & Population Science , vol. 42, pp. 95-111, Submitted.
Yousif, A., T. Dicknson, A. S. Z. Moustafa, M. Said, and O. Young, Counseling on marijuana use during pregnancy: sending a more effective message to our patients., , Submitted.
K.Ramadan, N., A. O.Mohamed, S. E.Shawky, and M. Y.Salem, "Different stability–indicating techniques for the determination of triclabendazole", Analytical Chemistry An Indian Journal, vol. 12, issue 11, pp. 428-438, Submitted. paper_final_sara_analytical_chemistry_an_indian_journal.pdf
Akah, M. M., E. H. Mobarak, and M. M. Yousry, "Effect of Temperature of Single-step Self-etch Adhesives on Bonding to Tooth Substrates ", Cairo Dental Journal, Submitted.
y, S., A. M, A. M, and G. S, "Patterns of violent deaths associated with positive ethanol finding in eastern province, saudi arabia", Egyptian journal of forensic sciences, vol. 6, pp. 388-395, Submitted.
Youssef, S. S., A. S. Nasr, T. E. Zanaty, R. S. E. Rawi, and M. M. Mattar, "Prevalence of occult hepatitis C virus in egyption patients with chronic lymphoproliferative disorders", Hepatitis research and treatment, vol. 2012 (2012) , issue Epub 2012 Dec 12, pp. 429784-429789, Submitted.
Farouk, K., Maged Abo El Magd, T. Fahmy, T. E. Gohary, and M. Yehia, "Propofol versus Midazolam for sedation in mechanically ventilated ICU patients.", Egyptian Heart Journal, Vol. vol. 60, No. 3, Sep. 2008 , Submitted.
Loffredo-Verde E, Abdel-Aziz I, Albrecht J, El-Guindy N, Yacob M, Protzer U, Busch DH, Layland LE, and P. da Costa, "Schistosome infection aggravates HCV related liver disease and induces changes in theregulatory T-cell phenotype. ", Parasite Immunol., vol. Feb;37, issue (2), pp. 97-104, Submitted.
Loffredo-Verde E, Abdel-Aziz I, Albrecht J, El-Guindy N, Yacob M, Protzer U, Busch DH, Layland LE, and P. da Costa, "Schistosome infection aggravates HCV related liver disease and induces changes in theregulatory T-cell phenotype. ", Parasite Immunol., vol. Feb;37, issue (2), pp. 97-104, Submitted.
Mohamed, H. M. H., Y. Chung, and A. E. Yousef, Sensitization of Bacillus cereus spores to high pressure processing by gamma irradiation , , Submitted.
Mohamed, H. M. H., M. Yamaguchi, and A. E. Yousef, Ultrastructural changes of beef muscle after high pressure processing and gamma irradiation , , Submitted.
Chigai, T., Y. Kimura, T. Yamamoto, Z. Awad, and O. Shalabiea, ????????????: CO ???????????????????????????, , Submitted. Abstract
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Ohmura, S., K. Nagaya, F. Shimojo, and M. Yao, "Ab Initio MOLECULAR-DYNAMICS STUDY OF NONEQUILIBRIUM PHENOMENA IN DISORDERED MATERIALS", MODELS IN BIOSCIENCE AND MATERIALS RESEARCH, pp. 1, Submitted. Abstract
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Ohmura, S., K. Nagaya, F. Shimojo, and M. Yao, "Ab Initio MOLECULAR-DYNAMICS STUDY OF NONEQUILIBRIUM PHENOMENA IN DISORDERED MATERIALS", MODELS IN BIOSCIENCE AND MATERIALS RESEARCH, pp. 1, Submitted. Abstract
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