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Xiao, K., Alei Liang, Haibing Guan, and A. E. Hassanien, " Extraction and application of deformation-based feature in medical images.", Neurocomputing :, vol. 120, pp. 177-184, 2013. Website
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Xiao, K., S. H. Ho, A. E. Hassanien, V. N. Du, and Q. Salih, " Fuzzy C-means clustering with adjustable feature weighting distribution for brain MRI ventricles segmentation. ", SIP 2007: 466-471, Honolulu, Hawaii, USA, August 20-22, 2007.
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Nguyen, L., S. Abdou, M. Afify, J. Makhoul, S. Matsoukas, R. Schwartz, B. Xiang, L. Lamel, J. - L. Gauvain, G. Adda, et al., "The 2004 BBN/LIMSI 10xRT English broadcast news transcription system", 2004 Rich Transcriptions Workshop, Pallisades, NY, 2004. Abstract
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Xiao, K., S. H. Ho, and A. E. Hassanien, "Aboul Ella Hassanien: Automatic Unsupervised Segmentation Methods for MRI Based on Modified Fuzzy C-Means", Fundamenta Informaticae, vol. 87, issue 3-4, pp. 465-481, 2008. Website
El-dahshan, E., A. Redi, A. E. Hassanien, and K. Xiao, "Accurate detection of prostate boundary in ultrasound images using biologically-inspired spiking neural network", Intelligent Signal Processing and Communication Systems, 2007. ISPACS 2007. International Symposium on: IEEE, pp. 308–311, 2007. Abstract
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El-dahshan, E., A. Redi, A. E. Hassanien, and K. Xiao, "Accurate detection of prostate boundary in ultrasound images using biologically-inspired spiking neural network", Intelligent Signal Processing and Communication Systems, 2007. ISPACS 2007. International Symposium on: IEEE, pp. 308–311, 2007. Abstract
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El-dahshan, E., A. Redi, A. E. Hassanien, and K. Xiao, "Accurate detection of prostate boundary in ultrasound images using biologically-inspired spiking neural network", Intelligent Signal Processing and Communication Systems, 2007. ISPACS 2007. International Symposium on: IEEE, pp. 308–311, 2007. Abstract
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Jan, M. U., A. Xin, M. A. Abdelbaky, H. U. Rehman, and S. Iqbal, "Adaptive and Fuzzy PI Controllers Design for Frequency Regulation of Isolated Microgrid Integrated with Electric Vehicles", IEEE Access, vol. 8, pp. 87621-87632, 2020.
Cheng, L., Y. Wang, C. Wang, A. W. Mohamed, and T. Xiao, "Adaptive Differential Evolution Based on Successful Experience Information", IEEE Access, vol. 8, pp. 164611 - 164636, 2020. Abstract
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Sonousi, A., J. C. K. Quirke, P. Waduge, T. Janusic, M. Gysin, K. Haldimann, S. Xu, S. N. Hobbie, S. - H. Sha, J. Schacht, et al., "An Advanced Apralog with Increased in vitro and in vivo Activity toward Gram-negative Pathogens and Reduced ex vivo Cochleotoxicity", ChemMedChem, vol. 16, issue 2: John Wiley & Sons, Ltd, pp. 335 - 339, 2021. AbstractWebsite

Abstract We describe the convergent synthesis of a 5-O-?-D-ribofuranosyl-based apramycin derivative (apralog) that displays significantly improved antibacterial activity over the parent apramycin against wild-type ESKAPE pathogens. In addition, the new apralog retains excellent antibacterial activity in the presence of the only aminoglycoside modifying enzyme (AAC(3)-IV) acting on the parent, without incurring susceptibility to the APH(3?) mechanism that disables other 5-O-?-D-ribofuranosyl 2-deoxystreptamine type aminoglycosides by phosphorylation at the ribose 5-position. Consistent with this antibacterial activity, the new apralog has excellent 30?nM activity (IC50) for the inhibition of protein synthesis by the bacterial ribosome in a cell-free translation assay, while retaining the excellent across-the-board selectivity of the parent for inhibition of bacterial over eukaryotic ribosomes. Overall, these characteristics translate into excellent in?vivo efficacy against E. coli in a mouse thigh infection model and reduced ototoxicity vis à vis the parent in mouse cochlear explants.

X. Huang, Q. Zhang, S. Chen, Y. Dong, M. Xiao, and HAMED L. M. M., "Aggregate Stability and Erodibility of Purple Soil on Sloping Farmland as affected by different Soil Thickness", 19th EGU General Assembly, EGU2017, proceedings from the conference held 23-28 April, 2017 in Vienna, Austria., p.3824, Vienna, Austria, 23-28 April, 2017. egu2017-3824-3.pdf
Huang, X., Q. Zhang, S. Chen, Y. Dong, M. Xiao, and L. MAMDOH MOHAMED HAMED, "Aggregate Stability and Erodibility of Purple Soil on Sloping Farmland as affected by different Soil Thickness", EGU General Assembly Conference Abstracts, vol. 19, pp. 3824, 2017. Abstract
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Iqbal, S., A. Xin, M. U. Jan, M. A. Abdelbaky, H. U. Rehman, S. Salman, S. A. A. Rizvi, and M. Aurangzeb, "Aggregation of EVs for Primary Frequency Control of an Industrial Microgrid by Implementing Grid Regulation & Charger Controller", IEEE Access, vol. 8, pp. 141977-141989, 2020.
Xu, D., and D. C. Neckers, "Aggregation of rose bengal molecules in solution", Journal of Photochemistry and Photobiology A: Chemistry, vol. 40, issue 2-3: Elsevier, pp. 361-370, 1987. Abstract
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Xuan, W., L. Huang, Y. Wang, X. Hu, G. Szewczyk, Y. Y. Huang, A. El-Hussein, J. C. Bommer, M. L. Nelson, T. Sarna, et al., "Amphiphilic tetracationic porphyrins are exceptionally active antimicrobial photosensitizers: in vitro and in vivo studies with the free-base and Pd-chelate.", Journal of Biophotonics, 2019.
Chatrchyan, S., V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, et al., "Angular analysis and branching fraction measurement of the decay B0→K*0μ+μ-", Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics, vol. 727, no. 1-3, pp. 77-100, 2013. AbstractWebsite
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Chen, G., X. Geng, T. W. Mohamed, H. Xu, Y. Mi, J. Kim, and D. E. Kim, "Ar plasma waveguide produced by a low-intensity femtosecond laser", Optics Communications, vol. 285, no. 10-11, pp. 2627-2631, 2012. AbstractWebsite

Using the interaction of a low-intensity femtosecond laser pulse (30 fs, 6 × 10 15 Wcm - 2) with argon cluster jet produced from a slit nozzle, we experimentally probe the formation of a uniform plasma waveguide by the interferogram analysis. The results about evolution of plasma channel demonstrate that it is feasible to produce the plasma waveguide for an fs laser pulse of low-intensity. It takes tens of nanoseconds to form a plasma waveguide. The simulation by one-dimensional Gaussian plasma hydrodynamic expansion model indicates that the temperature of plasma channel is not high under this condition. Thus it takes tens of nanoseconds to form a plasma waveguide. © 2012 Elsevier B.V. All rights reserved.

Chen, G., X. Geng, T. W. Mohamed, H. Xu, Y. Mi, J. Kim, and D. E. Kim, "Ar plasma waveguide produced by a low-intensity femtosecond laser", Optics Communications, vol. 285, no. 10-11: North-Holland, pp. 2627–2631, 2012. Abstract
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Chen, G., X. Geng, T. W. Mohamed, H. Xu, Y. Mi, J. Kim, and D. E. Kim, "Ar plasma waveguide produced by a low-intensity femtosecond laser", Optics Communications, vol. 285, issue 10-11: North-Holland, pp. 2627-2631, 2012. Abstract
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Fouda, A. Y., Z. Xu, E. shosha, T. Lemtalsi, J. Chen, H. A. Toque, R. Tritz, X. Cui, B. K. Stansfield, Y. Huo, et al., "Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses.", Cell death & disease, vol. 9, issue 10, pp. 1001, 2018 Sep 25. Abstract

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 (A1), in retinal ischemia-reperfusion (IR) injury. A1 competes with nitric oxide synthase (NOS) for their common substrate L-arginine. A1-mediated L-arginine depletion reduces nitric oxide (NO) formation by NOS leading to vascular dysfunction when endothelial NOS is involved but prevents inflammatory injury when inducible NOS is involved. Studies were performed using wild-type (WT) mice, global A1 knockout (KO), endothelial-specific A1 KO, and myeloid-specific A1 KO mice subjected to retinal IR injury. Global as well as myeloid-specific A1 KO mice showed worsened IR-induced neuronal loss and retinal thinning. Deletion of A1 in endothelial cells had no effect, while treatment with PEGylated (PEG) A1 improved neuronal survival in WT mice. In addition, A1 KO mice showed worsened vascular injury manifested by increased acellular capillaries. Western blotting analysis of retinal tissue showed increased inflammatory and necroptotic markers with A1 deletion. In vitro experiments showed that macrophages lacking A1 exhibit increased inflammatory response upon LPS stimulation. PEG-A1 treatment dampened this inflammatory response and decreased the LPS-induced metabolic reprogramming. Moreover, intravitreal injection of A1 KO macrophages or systemic macrophage depletion with clodronate liposomes increased neuronal loss after IR injury. These results demonstrate that A1 reduces IR injury-induced retinal neurovascular degeneration via dampening macrophage inflammatory responses. Increasing A1 offers a novel strategy for limiting neurovascular injury and promoting macrophage-mediated repair.

Fouda, A. Y., Z. Xu, E. shosha, T. Lemtalsi, J. Chen, H. A. Toque, R. Tritz, X. Cui, B. K. Stansfield, Y. Huo, et al., "Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses.", Cell death & disease, vol. 9, issue 10, pp. 1001, 2018. Abstract

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 (A1), in retinal ischemia-reperfusion (IR) injury. A1 competes with nitric oxide synthase (NOS) for their common substrate L-arginine. A1-mediated L-arginine depletion reduces nitric oxide (NO) formation by NOS leading to vascular dysfunction when endothelial NOS is involved but prevents inflammatory injury when inducible NOS is involved. Studies were performed using wild-type (WT) mice, global A1 knockout (KO), endothelial-specific A1 KO, and myeloid-specific A1 KO mice subjected to retinal IR injury. Global as well as myeloid-specific A1 KO mice showed worsened IR-induced neuronal loss and retinal thinning. Deletion of A1 in endothelial cells had no effect, while treatment with PEGylated (PEG) A1 improved neuronal survival in WT mice. In addition, A1 KO mice showed worsened vascular injury manifested by increased acellular capillaries. Western blotting analysis of retinal tissue showed increased inflammatory and necroptotic markers with A1 deletion. In vitro experiments showed that macrophages lacking A1 exhibit increased inflammatory response upon LPS stimulation. PEG-A1 treatment dampened this inflammatory response and decreased the LPS-induced metabolic reprogramming. Moreover, intravitreal injection of A1 KO macrophages or systemic macrophage depletion with clodronate liposomes increased neuronal loss after IR injury. These results demonstrate that A1 reduces IR injury-induced retinal neurovascular degeneration via dampening macrophage inflammatory responses. Increasing A1 offers a novel strategy for limiting neurovascular injury and promoting macrophage-mediated repair.

shosha, E., Z. Xu, H. Yokota, A. Saul, M. Rojas, W. R. Caldwell, R. B. Caldwell, and P. S. Narayanan, "Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury.", Cell death & disease, vol. 7, issue 11, pp. e2483, 2016 11 24. Abstract

Retinal ischemia is a major cause of visual impairment and blindness and is involved in various disorders including diabetic retinopathy, glaucoma, optic neuropathies and retinopathy of prematurity. Neurovascular degeneration is a common feature of these pathologies. Our lab has previously reported that the ureahydrolase arginase 2 (A2) is involved in ischemic retinopathies. Here, we are introducing A2 as a therapeutic target to prevent neurovascular injury after retinal ischemia/reperfusion (I/R) insult. Studies were performed with mice lacking both copies of A2 (A2) and wild-type (WT) controls (C57BL6J). I/R insult was conducted on the right eye and the left eye was used as control. Retinas were collected for analysis at different times (3 h-4 week after injury). Neuronal and microvascular degeneration were evaluated using NeuN staining and vascular digests, respectively. Glial activation was evaluated by glial fibrillary acidic protein expression. Necrotic cell death was studied by propidium iodide labeling and western blot for RIP-3. Arginase expression was determined by western blot and quantitative RT-PCR. Retinal function was determined by electroretinography (ERG). A2 mRNA and protein levels were increased in WT I/R. A2 deletion significantly reduced ganglion cell loss and microvascular degeneration and preserved retinal morphology after I/R. Glial activation, reactive oxygen species formation and cell death by necroptosis were significantly reduced by A2 deletion. ERG showed improved positive scotopic threshold response with A2 deletion. This study shows for the first time that neurovascular injury after retinal I/R is mediated through increased expression of A2. Deletion of A2 was found to be beneficial in reducing neurovascular degeneration after I/R.

Badawy, T., M. A. Attar, H. Xu, and A. Ghafourian, "Assessment of gasoline direct injector fouling effects on fuel injection, engine performance and emissions", Applied Energy, vol. 220, pp. 351-374, 2018.
Gao, W., A. O. Elnabawy, Z. D. Hood, Y. Shi, X. Wang, L. T. Roling, X. Pan, M. Mavrikakis, Y. Xia, and M. Chi, "Atomistic insights into the nucleation and growth of platinum on palladium nanocrystals", Nature communications, vol. 12, issue 1: Nature Publishing Group, pp. 1-10, 2021. Abstract
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Xiao, K., S. H. Ho, and others, "Automatic unsupervised segmentation methods for mri based on modified fuzzy c-means", Fundamenta Informaticae, vol. 87, no. 3-4: IOS Press, pp. 465–481, 2008. Abstract
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