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WZ Mikhail, MO Abd El-Samee, M. A. S. A. R. A. - A., "Use of Distillers Dried Grains with Solubles (DDGS) Supplemented with Enzymes in Quail Diets.", Egypt. Poult. Sci., vol. 33, pp. 805-823, 2013. Abstract
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Wurster, S., F. Hennes, A. C. Parplys, J. I. Seelbach, W. Y. Mansour, A. Zielinski, C. Petersen, T. S. Clauditz, A. Münscher, A. A. Friedl, et al., "PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.", Oncotarget, vol. 7, issue 9, pp. 9732-41, 2016 Mar 01. Abstract

There is a need to develop new, more efficient therapies for head and neck cancer (HNSCC) patients. It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' resistance to therapy. PARP1 inhibitors (PARPi) were found to be "synthetic lethal" in cancers deficient in BRCA1/2 with impaired homologous recombination. Since tumors rarely have these particular mutations, there is considerable interest in finding alternative determinants of PARPi sensitivity. Effectiveness of combined irradiation and PARPi olaparib was evaluated in ten HNSCC cell lines, subdivided into HR-proficient and HR-deficient cell lines using a GFP-based reporter assay. Both groups were equally sensitive to PARPi alone. Combined treatment revealed stronger synergistic interactions in the HR-deficient group. Because HR is mainly active in S-Phase, replication processes were analyzed. A stronger impact of treatment on replication processes (p = 0.04) and an increased number of radial chromosomes (p = 0.003) were observed in the HR-deficient group. We could show that radiosensitization by inhibition of PARP1 strongly correlates with HR competence in a replication-dependent manner. Our observations indicate that PARP1 inhibitors are promising candidates for enhancing the therapeutic ratio achieved by radiotherapy via disabling DNA replication processes in HR-deficient HNSCCs.

Wurster, S., F. Hennes, A. C. Parplys, J. I. Seelbach, W. Y. Mansour, A. Zielinski, C. Petersen, T. S. Clauditz, A. Münscher, A. A. Friedl, et al., "PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.", Oncotarget, vol. 7, issue 9, pp. 9732-41, 2016 Mar 01. Abstract

There is a need to develop new, more efficient therapies for head and neck cancer (HNSCC) patients. It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' resistance to therapy. PARP1 inhibitors (PARPi) were found to be "synthetic lethal" in cancers deficient in BRCA1/2 with impaired homologous recombination. Since tumors rarely have these particular mutations, there is considerable interest in finding alternative determinants of PARPi sensitivity. Effectiveness of combined irradiation and PARPi olaparib was evaluated in ten HNSCC cell lines, subdivided into HR-proficient and HR-deficient cell lines using a GFP-based reporter assay. Both groups were equally sensitive to PARPi alone. Combined treatment revealed stronger synergistic interactions in the HR-deficient group. Because HR is mainly active in S-Phase, replication processes were analyzed. A stronger impact of treatment on replication processes (p = 0.04) and an increased number of radial chromosomes (p = 0.003) were observed in the HR-deficient group. We could show that radiosensitization by inhibition of PARP1 strongly correlates with HR competence in a replication-dependent manner. Our observations indicate that PARP1 inhibitors are promising candidates for enhancing the therapeutic ratio achieved by radiotherapy via disabling DNA replication processes in HR-deficient HNSCCs.

Wu, B., F. Tian, M. Zhang, S. Piao, H. Zeng, W. Zhu, J. Liu, A. Elnashar, and Y. Lu, "Quantifying global agricultural water appropriation with data derived from earth observations", Journal of Cleaner Production, vol. 358, pp. 131891, 2022. AbstractWebsite

Agricultural water appropriation has undergone rapid changes in recent decades, but estimates of global water appropriation have not been updated with the latest data and consistent methods. Documenting these changes is challenging given the heterogeneous water use landscape and the growing influence of human activities worldwide, and this complexity cannot be well addressed with the existing methodology, which is subject to large model uncertainties. Here, a spatial analysis and aggregated method was proposed to quantify and refine estimates of global agricultural water appropriation (GAWA) in terms of consumptive freshwater use, with data derived from Earth observations, independent of estimates from hydrological models. The results show the global water appropriation at the pixel scale, in agroecological zones and in the main water-consuming countries, including global maps of rainfed and irrigated cropland evapotranspiration (ET), net water consumption due to irrigation, natural ET and renewable freshwater resources (RFWR), and indicate that agriculture remains the largest user in terms of both water consumption and withdrawals worldwide, representing 87% of global water consumption, with approximately 60% of global freshwater withdrawals devoted to irrigation circa 2015. The percentage of withdrawals devoted to irrigation has decreased in recent decades when compared to the previous estimate of 70%. The results reveal the actual global crop consumptive use (8053.6 km3/yr) of blue and green water and the total human water consumption (8442 km3/yr), which represents the part of the water cycle affected by human intervention, mainly (95.4%) by agriculture. This study reveals that high-resolution irrigated croplands are essential for accurate estimations of water use appropriation and demonstrates that earth observation-derived data can provide a new understanding of global water use landscape. The study can support decision making in sustaining food and water security, and implementing water-adapted sustainable agricultural policies.

Wu, S., H. Hamza, and M. E. Fayad, "Implementing pattern languages using stability concepts", ChiliPLoP 03', Carefree, Arizona, USA, 2003. Abstract
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Wu, C., W. Darwish, S. Tang, and W. Li, "Precise Calibration and Error Modeling For Indoor 3D Modelling Sensors", The 9th International Symposium on Mobile Mapping Technology, MMT2015, pp. 1–5, 2015. Abstract
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Wu, G. Y., and M. H. Halim, "Schistosomiasis: progress and problems", World journal of gastroenterology, vol. 6, issue 1: Baishideng Publishing Group Inc, pp. 12, 2000. Abstract
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Wu, S., H. Hamza, and M. E. Fayad, "Implementing pattern languages using stability concepts", ChiliPLoP 03', Carefree, Arizona, USA, 2003. Abstract
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Wu, K., W. Shi, and W. Ahmed, "Grid-based approach for the segmentation of multiple rooms from unstructured indoor point clouds", Journal of Applied Remote Sening, vol. 15, issue 4, pp. 1-17, 2021.
Wu, S., H. Hamza, and M. E. Fayad, "Implementing pattern languages using stability concepts", ChiliPLoP 03', Carefree, Arizona, USA, 2003. Abstract
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Wu, Z. Q., J. Jiang, and Y. H. Peng, "Computational Intelligence on Medical Imaging with Artificial Neural Networks in", Computational intelligence in medical imaging techniques and applications, 2009. Abstract
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Wu, W., H. Ouyang, A. W. Mohamed, C. Zhang, and S. Li, Enhanced harmony search algorithm with circular region perturbation for global optimization problems, , vol. 50, issue 3, pp. 951 - 975, 2020. AbstractWebsite

To improve the searching effectiveness of the harmony search (HS) algorithm, an enhanced harmony search algorithm with circular region perturbation (EHS_CRP) is proposed in this paper. In the EHS_CRP algorithm, a global and local dimension selection strategy is designed to accelerate the search speed of the algorithm. A selection learning operator based on the global and local mean level is proposed to improve the balance between exploration and exploitation. Circular region perturbation is employed to avoid the algorithm stagnation and get a better exploration region. To assess performance, the proposed algorithm is compared with 10 state-of-the-art swarm intelligent approaches in a large set of global optimization problems. The simulation results confirm that EHS_CRP has a significant advantage in terms of accuracy, convergence speed, stability and robustness. Moreover, EHS_CRP performs better than other tested methods in engineering design optimization problems. Thus, the EHS_CRP algorithm is a viable and reliable alternative for some difficult and multidimensional real-world problems.

Wu, K., W. Shi, and W. Ahmed, "Structural Elements Detection and Reconstruction (SEDR): A Hybrid Approach for Modeling Complex Indoor Structures", ISPRS International Journal of Geo-Information, vol. 9, issue 12, 2020.
WS, E. S., M. MG, and E. - S. GH, "IMPACT OF DUST EXPOSURE AMONG STONE QUARRY WORKERS ON VENTILATORY FUNCTIONS AND SERUM LEVEL OF TUMOUR NECROSIS FACTOR- ALPHA (TNF-α)", Egyptian Journal of Occupational Medicine. , vol. 42, issue 3, pp. 443-452, 2018.
WS, E. S., M. MG, and E. - S. GH, "SERUM LEVEL OF INTERLEUKIN-1BETA (IL-1β) AND SPIROMETRIC PARAMETERS AMONG CEMENT PRODUCTION WORKERS", Egyptian Journal of Occupational Medicine. , vol. 42, issue 1, pp. 93-104, 2018.
WS, S., S. AA, E. - J. J, and T. LA, "Immunological Efficacy of Different Brucella S19 Proteins Extracts for Controlling of Brucellosis in Sheep.", World Applied Sciences Journal. , vol. 29(5):, pp. 623-629., 2014.
Writer, E. Y., and L. Y. Translator, A 1/4 Gram, , Cairo, Al Dar Al Masriah Al Lubnaniah, 2009.
Wrigley, S. N., K. Elbedweihy, D. Reinhard, A. Bernstein, and F. Ciravegna, {Results of the first evaluation of semantic search tools}, : SEALS Consortium, November, 2010. Abstract
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Wrigley, S. N., D. Reinhard, K. Elbedweihy, A. Bernstein, and F. Ciravegna, "{Methodology and campaign design for the evaluation of semantic search tools}", Proceedings of the 3rd International Semantic Search Workshop, pp. 10:1-10:10, 2010. Abstract
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Wrigley, S. N., K. Elbedweihy, D. Reinhard, A. Bernstein, and F. Ciravegna, "{Evaluating Semantic Search Tools using the SEALS platform}", Proceedings of the International Workshop on Evaluation of Semantic Technologies (IWEST 2010), ISWC 2010, 2010. Abstract
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Wrigley, S. N., K.Elbedweihy, A. L. Gentile, V. Lanfranchi, and A. - S. Dadzie, {Results of the second evaluation of semantic search tools}, , no. D13.6: SEALS Consortium, 2012. Abstract
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Wrigley, S. N., D. Reinhard, K. Elbedweihy, A. Bernstein, and F. Ciravegna, "{Campaign Design for the Evaluation of Semantic Search Tools}", Proceedings of Semantic Search 2010 Workshop at the 19th Int. World Wide Web Conference (WWW2010), 2010. Abstract
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Wrigley, S. N., D. Reinhard, K. Elbedweihy, A. Bernstein, and F. Ciravegna, {Services for the automatic evaluation of semantic search tools}, : SEALS Consortium, July, 2010. Abstract
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Wright, N. J., A. J. M. Leather, N. Ade-Ajayi, N. Sevdalis, J. Davies, D. Poenaru, E. Ameh, A. Ademuyiwa, K. Lakhoo, E. R. Smith, et al., "Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study", The Lancet, vol. 398, no. 10297, pp. 325-339, 2021. AbstractWebsite

{Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40]

Wright, N. J., A. J. M. Leather, N. Ade-Ajayi, N. Sevdalis, J. Davies, D. Poenaru, E. Ameh, A. Ademuyiwa, K. Lakhoo, E. R. Smith, et al., Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study, , vol. 398, issue 10297, pp. 325 - 339, 2021. AbstractWebsite

SummaryBackground
Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality.
Methods
We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis.
Findings
We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation
Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030.
Funding
Wellcome Trust.

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