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AHMAD H. ASHRY, M. S., M. D. WAEL M. AL-MAHDY, M. D. AHMAD S. HASSAN, M. D. OMAR M. AL-FALAKY, and M. D. MOHAMMED A. THABET, "Anterior Cervical Discectomy with Fusion Versus Posterior Cervical Foraminotomy in Single Unilateral Cervical Disc Prolapse", kasralainy journal of medicine , vol. 1, issue 6, 2016. Abstract

Objective: The aim of this work is to evaluate the role of posterior cervical foraminotomy for the treatment of cervical radiculopathy caused by single level cervical disc lesion as compared to anterior cervical discectomy and fusion by cage. Methods: Prospective randomised comparative study of a clinical series of 30 patients with unilateral cervical radiculopathy treated by either anterior cervical discectomy or fusion by cage (15 patients) or posterior cervical foraminotomy (15 patients) in Cairo University Hospitals. Results: Average age of presentation was 39 years. Males were more affected then females. Right sided radiculopathy was more commonthan left side. The most common operated level was C5-6. Excellent and good outcomes were obtained in 80% of the patients in ACDF group and 60% in posterior foraminotomy group. Conclusion: ACDF is superior to posterior cervical foraminotomy in treatment of single unilateral posterolateral cervical disc disease regarding operative time ,post operative hospital stay, complications, improvement of symptoms and short term follow up.

Fadda, S. H., I. H. Bassyouni, A. Hamdy, N. A. Foad, and I. E. Wali, "Anti-C1q in chronic hepatitis C virus genotype IV infection: association with autoimmune rheumatologic manifestations.", Immunol Invest. , vol. 44, issue 1, pp. 45-55, 2015.
Bassiouny, M., A. Mohsen, S. Khalaf, T. Dresing, K. Tarakji, M. Kanj, P. Tchou, B. Lindsay, O. Wazni, and W. Saliba, "Anti-coagulation cessation post atrial fibrillation ablation: impact of implantable loop recorder on decision-making", EUROPEAN HEART JOURNAL, vol. 35: OXFORD UNIV PRESS GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND, pp. 591–591, 2014. Abstract
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El-Rashidy, A., G. Waly, A. Gad, J. A. Roether, J. Hum, Y. Yang, R. Detsch, A. Hashem, I. Sami, W. G. H. H. Goldmann, et al., "Antibacterial activity and biocompatibility of zein scaffolds containing silver-doped bioactive glass", Biomedical Materials, 2018. AbstractWebsite

Abstract Composite 3D scaffolds combining natural polymers and bioceramics are promising candidates for bone tissue engineering (BTE). Zein, as a natural plant protein, offers several advantages, including biocompatibility, adequate strength properties, and low/no immunogenicity; however, it lacks bioactivity. Thus, composite zein:bioactive glass (BG) scaffolds are proposed as promising candidate for BTE applications, with silver-doping of bioactive glass providing an antibacterial effect against possible post-implantation infection. Therefore, the aim of this study was to investigate the in vitro antibacterial properties, biocompatibility, bioactivity and compressive strength of zein scaffolds containing silver-doped bioactive glass. BG nanoparticles, undoped and Ag-doped, were fabricated using the sol-gel method. 3D composite zein:BG scaffolds, containing 20 wt.% BG, were prepared and their antibacterial activity against E. coli and S. aureus was assessed using the disk diffusion assay. Human osteoblast-like MG-63 cells were used to evaluate the in vitro biocompatibility of the prepared scaffold groups. In addition, the compressive strength of the scaffolds was determined using uniaxial compression strength testing and the scaffold interconnected porosity was measured using helium pycnometer. Disc diffusion assay showed that only zein scaffolds containing Ag-doped sol-gel BG are antibacterially positive against E. coli and S. aureus. Pure zein scaffolds and zein scaffolds containing sol-gel-derived BG showed no negative influence on the growth of MG-63 cells, as evident by the cells’ ability to survive, proliferate, and function on these scaffolds. Moreover, incorporating sol-gel-derived BG into zein scaffolds at zein:BG of 80:20 ratio showed bioactive properties with adequate porosity without affecting the scaffolds’ compressive strengths, which was similar to that of trabecular bone, suggesting that the new composites have potential for BTE applications in non-loaded bearing areas.

El-Rashidy, A. A., G. Waly, A. Gad, J. A. Roether, J. Hum, Y. Yang, R. Detsch, A. A. Hashem, I. Sami, W. H. Goldmann, et al., "Antibacterial activity and biocompatibility of zein scaffolds containing silver-doped bioactive glass.", Biomedical materials (Bristol, England), vol. 13, issue 6, pp. 065006, 2018 Aug 24. Abstract

Composite 3D scaffolds combining natural polymers and bioceramics are promising candidates for bone tissue engineering (BTE). Zein, as a natural plant protein, offers several advantages, including biocompatibility, adequate strength properties, and low/no immunogenicity; however, it lacks bioactivity. Thus, composite zein: bioactive glass (BG) scaffolds are proposed as promising candidate for BTE applications, with silver-doping of bioactive glass providing an antibacterial effect against possible post-implantation infection. Therefore, the aim of this study was to investigate the in vitro antibacterial properties, biocompatibility, bioactivity and compressive strength of zein scaffolds containing silver-doped bioactive glass. BG nanoparticles, undoped and Ag-doped, were fabricated using the sol-gel method. 3D composite zein:BG scaffolds, containing 20 wt% BG, were prepared and their antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was assessed using the disc diffusion assay. Human osteoblast-like MG-63 cells were used to evaluate the in vitro biocompatibility of the prepared scaffold groups. In addition, the compressive strength of the scaffolds was determined using uniaxial compression strength testing and the scaffold interconnected porosity was measured using helium pycnometer. Disc diffusion assay showed that only zein scaffolds containing Ag-doped sol-gel BG are antibacterially positive against E. coli and S. aureus. Pure zein scaffolds and zein scaffolds containing sol-gel-derived BG showed no negative influence on the growth of MG-63 cells, as evident by the cells' ability to survive, proliferate, and function on these scaffolds. Moreover, incorporating sol-gel-derived BG into zein scaffolds at zein:BG of 80:20 ratio showed bioactive properties with adequate porosity without affecting the scaffolds' compressive strengths, which was similar to that of trabecular bone, suggesting that the new composites have potential for BTE applications in non-loaded bearing areas.

Barsoum, R., H. Wanas, and T. Shehab, Anticoagulation in Patients with Renal Insufficiency, , pp. 203 - 238, 2020/01/01. Abstract

The retained metabolic products in kidney insufficiency are toxic to two main cells connected with blood coagulation, namely, the endothelial cells and the blood platelets. These interact with each other, with leukocytes and with a complex metabolic network involving inflammation, complement activation, coagulation, fibrinolysis, and others. Owing to the unstable nature of kidney insufficiency, the associated coagulation disorders vary from a procoagulant state where endothelial cell injury predominates, to a bleeding disorder where platelet dysfunction supervenes. Amid all that, patients with kidney insufficiency may need anticoagulation either for the commonly associated heart disease, venous thrombosis, antiphospholipid syndrome, etc., for the treatment of certain intrinsic renal disease, or for extracorporeal therapy. This requires a careful benefit/risk balance that can be quantitated by validated scores. As the decision to anticoagulate is made, several practical issues emerge, including the choice of pharmacokinetically compatible agents, their dose in relation to the degree of impairment of kidney function, and potential drug-drug interactions. The decision is confounded by the plethora of currently available anticoagulants, often with superior efficacy, less bleeding tendency, and limited need for monitoring and frequent dose tailoring compared to the traditional heparin and warfarin.

Abdel-Hafez, A. A., M. R. Meselhy, N. Nakamura, M. Hattori, H. WATANABE, Y. MURAKAMI, M. A. EL-GENDY, N. M. MAHFOUZ, and T. A. MOHAMED, "Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis", Biological and Pharmaceutical Bulletin, vol. 22, issue 5: The Pharmaceutical Society of Japan, pp. 491-497, 1999. Abstract
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Mabkhot, Y. N., F. Alatibi, N. N. E. El-Sayed, S.Al-Showiman, N. A. Kheder, A. Wadood, A. Rauf, S.Bawazeer, and B. T. Hadda, "Antimicrobial Activity of Some Novel Armed Thiophene Derivatives and Petra/Osiris/Molinspiration (POM) Analyses", Molecules, vol. 21, pp. 222, 2016. paper_4.pdf
Bakr, R. O., S. S. Zaghloul, R. A. Hassan, A. Sonousi, R. Wasfi, and M. A. A. Fayed, "Antimicrobial activity of Vitex agnus-castus Essential Oil and Molecular Docking Study of Its Major Constituents", Journal of Essential Oil Bearing Plants, vol. 23, issue 1: Taylor & Francis, pp. 184 - 193, 2020. AbstractWebsite

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Bakr, R. O., S. S. Zaghloul, R. A. Hassan, A. Sonousi, R. Wasfi, and M. A. A. Fayed, "Antimicrobial activity of Vitex agnus-castus Essential Oil and Molecular Docking Study of Its Major Constituents", Journal of Essential Oil Bearing Plants, vol. 23, issue 1, pp. 184-193, 2020.
Wang, Y., X. Wu, J. Chen, R. Amin, M. Lu, B. Bhayana, J. Zhao, C. K. Murray, M. R. Hamblin, D. C. Hooper, et al., "Antimicrobial blue light inactivation of gram-negative pathogens in biofilms: in vitro and in vivo studies.", The Journal of infectious diseases, 2016 Feb 17. Abstract

BACKGROUND:  Biofilms affect more than 80% bacterial infections in human and are usually difficult to eradicate due to their inherent drug resistance.

METHODS:  We investigated the effectiveness of antimicrobial blue light (aBL; 415 nm) inactivation of Acinetobacter baumannii or Pseudomonas aeruginosa biofilms in 96-well microplates and in infected mouse burns.

RESULTS:  In vitro in 96-well microplates, 24-h and 72-h old biofilms of A. baumannii exposed to 432 J/cm(2) aBL had 3.59- and 3.18-log10 inactivation, respectively. For P. aeruginosa biofilms, a similar 3.02- and 3.12-log10 inactivation was achieved. In mouse burns infected with 5×10(6) CFU of A. baumannii, approximately 360 and 540 J/cm(2) aBL was required to achieve 3-log10 inactivation of biofilms when aBL was delivered at 24 and 48 h post-inoculation, respectively. High-performance liquid chromatography (HPLC) analysis revealed the presence of endogenous porphyrins in both A. baumannii and P. aeruginosa cells. Using the TUNEL assay, no apoptotic cells were detected in aBL-irradiated mouse skin at up to 24 h after aBL exposure (540 J/cm(2)).

CONCLUSIONS:  aBL has antimicrobial activity in biofilms of A. baumannii and P. aeruginosa, and is a potential approach for biofilm-related infections.

Seoudi, N., N. Hojjat, C. Wilkinson, W. Turner, and J. Buchanan, "Antimicrobial prescribing patterns in secondary dental care ", Federation of Infection Societies, Glasgow, UK, 21 November 2015.
Pankhurst, C., R. Rautemaa-Richardson, N. Seoudi, A. Smith, and M. Wilson, "Antimicrobial resistance: Antibiotics and consultant oral microbiologist posts.", British dental journal, vol. 220, issue 1, pp. 2-3, 2016 Jan 15.
Desta, K. T., W. S. Lee, S. J. Lee, Y. - H. Kim, G. - S. Kim, S. J. Lee, S. T. Kim, A. A. M. El-Aty, M. Warda, H. - C. Shin, et al., "Antioxidant activities and liquid chromatography with electrospray ionization tandem mass spectrometry characterization and quantification of the polyphenolic contents of Rumex nervosus Vahl leaves and stems.", Journal of separation science, 2016 Feb 22. Abstract

In the present study, four compounds, viz. chlorogenic acid, catechin, orientin, and apigenin-O-acetylglycoside among 18 polyphenol compounds (17 flavonoids and one hydroxycinnamic acid derivative) were characterized for the first time in Rumex nervosus leaves and stems by using liquid chromatography with electrospray ionization tandem mass spectrometry. Method validation in terms of determination coefficient, limits of detection, and quantification were ≥ 0.9979, 0.68-1.61, and 2.27-5.38 mg/L, respectively. Accuracy, expressed as percent recovery for two spiking levels (10 and 50 mg/L), were in the range 78.9-110.6% with the exception of caffeic acid. The relative standard deviations were 1-17%. The total polyphenol content was higher by approximately two times in the leaf (1073 mg/kg fresh sample) than in the stem (519.86 mg/kg fresh sample). The antioxidant effects increased in a dose-dependent manner, and the scavenging activities, investigated by measuring 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) scavenging activity, ferrous ions chelating activity, superoxide anion radical scavenging activity, and ferric reducing antioxidant power activity, were significant (P < 0.05) using low concentrations of the leaf extract. Overall, the present study suggests that different parts of R. nervosus have great potential for producing a range of extracts with potential applications in medicine. This article is protected by copyright. All rights reserved.

Gaballa, H. S., M. N. Wahba, and N. H. Magda, "Antioxidant and insecticidal effect of squirting cucumber, Ecballium elaterium extracts against Aphis craccivora and Phthorimaea operculella", Journal of Entomology and Zoology Studies, vol. 5, issue 5, pp. 1980-1985, 2017. 5-5-30_1.pdf
EA, A. G., A. W, A. AA, Y. ER, and H. JS, "Antioxidant profiles and markers of oxidative stress in preterm neonates.", Paediatr Int Child Health, vol. 36, issue 2, pp. 134-40, 2016. antioxidantprofilesnew.pdf
Attia, K. A., A. F. Abdelkhalik, M. H. Ammar, C. Wei, J. Yang, D. A. Lightfoot, W. M. El-Sayed, and H. A. EL-SHEMY, "Antisense phenotypes reveal a functional expression of OsARF1, an auxin response factor, in transgenic rice", Current issues in molecular biology, vol. 11, issue 1, pp. I29, 2009. Abstract
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soliman Nasr, A., S. Sharkawy, T. Abdelmoniem, H. Al-Inany, and O. Wahba, "Antral follicular count is a better indicator for the assessment of ovarian reserve", Evidence Based Women’s Health Journal, vol. 2, issue 4, pp. 126-132, 2012.
F.M.Gomaa, G.H.Ahmed, W.A.Attia, and L.A.Ibrahim, "aortopathy after surgical repair of Fallot tetralogy, does it correlate with the postoperative duration?", Journal of Arab Child, 2014.
Wanas, M. I., M. E. Kahil, and K. M. M., "An AP Structure with Finslerian Flavor: Path Equations", Gravitational and Cosmology, vol. 22, issue 4, pp. 345-354, 2016.
El-Hawary, S. S., W. E. Hammam, M. E. - M. El-Tantawi, N. A. Z. Yassin, F. A. R. I. D. N. KIROLLOS, M. F. Abdelhameed, M. A. O. Abdelfattah, M. Wink, and M. Sobeh, "Apple leaves and their major secondary metabolite phlorizin exhibit distinct neuroprotective activities: Evidence from in vivo and in silico studies", Arabian Journal of Chemistry , vol. 14, pp. 103188- 103197, 2021. apple_leaves_and_their_major_secondary_metabolite.pdf
W.Osman, K. M. El-Kourghly, W. El-Gammal, M. S. El-Tahawy, M. Abdelati, and A. Abdelsalam, "Application of a hybrid method for efficiency calibration of NaI detector", Applied Radiation and Isotopes, vol. 171, issue 109632, pp. 11-7, 2021. application_of_hybrid_method.pdf
Wadie, B. S., A. M. Badawi, M. B. A. Ghoneim, and M. A., "The application of artificial neural network (ANN) in the detection of BOO. A model based on objective parameters", 37th Annual Congress of the Egyptian Urological Association October 2-6, 2002. Luxor. Egypt. Egypt. J. Urol., vol. 9, no. 36: Egy. J. Urol., pp. 61, 2002. Abstract
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