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El Kassas, M., M. Alboraie, D. Omran, M. Salaheldin, M. N. Wifi, M. Elbadry, adel el tahan, S. Ezzat, E. Moaz, A. M. Farid, et al., "An account of the real-life hepatitis C management in a single specialized viral hepatitis treatment centre in Egypt: results of treating 7042 patients with 7 different direct acting antiviral regimens.", Expert review of gastroenterology & hepatology, pp. 1-8, 2018 May 24. Abstract

BACKGROUND: A large Egyptian treatment program for HCV was launched in2014 after the introduction of direct-acting antiviral agents (DAAs). This program depended mainly on establishing specialized independent centres for HCV treatment. These centres represent the major strengths in the Egyptian model of care, as they provide integrated care for HCV patients and have enabled Egypt to treat more than one million patients in 3 years. The New Cairo Viral Hepatitis Treatment Center (NCVHTC) is an example of these specialized centres.

METHODS: The Egyptian experience in the management of HCV was evaluated by analysing the data of real-life HCV management in the NCVHTC from 2014 to 2017. Results of different treatment regimens in addition to their strengths, limitations and areas for improvement are discussed in this report.

RESULTS: A total of 7042 HCV patients have been evaluated for treatment in the NCVHTC. Among them, 5517 patients received treatment by seven different DAA regimens with excellent results.

CONCLUSIONS: All regimens were highly effective at treating HCV in a real-life setting, apart from SOF/RBV, which was the least effective. A nationwide screening program and enhancing the follow-up of treated patients are the main missing pillars in the Egyptian model.

El Kassas, M., M. Alboraie, D. Omran, M. Salaheldin, M. N. Wifi, M. Elbadry, adel el tahan, S. Ezzat, E. Moaz, A. M. Farid, et al., "An account of the real-life hepatitis C management in a single specialized viral hepatitis treatment centre in Egypt: results of treating 7042 patients with 7 different direct acting antiviral regimens.", Expert review of gastroenterology & hepatology, pp. 1-8, 2018 May 24. Abstract

BACKGROUND: A large Egyptian treatment program for HCV was launched in2014 after the introduction of direct-acting antiviral agents (DAAs). This program depended mainly on establishing specialized independent centres for HCV treatment. These centres represent the major strengths in the Egyptian model of care, as they provide integrated care for HCV patients and have enabled Egypt to treat more than one million patients in 3 years. The New Cairo Viral Hepatitis Treatment Center (NCVHTC) is an example of these specialized centres.

METHODS: The Egyptian experience in the management of HCV was evaluated by analysing the data of real-life HCV management in the NCVHTC from 2014 to 2017. Results of different treatment regimens in addition to their strengths, limitations and areas for improvement are discussed in this report.

RESULTS: A total of 7042 HCV patients have been evaluated for treatment in the NCVHTC. Among them, 5517 patients received treatment by seven different DAA regimens with excellent results.

CONCLUSIONS: All regimens were highly effective at treating HCV in a real-life setting, apart from SOF/RBV, which was the least effective. A nationwide screening program and enhancing the follow-up of treated patients are the main missing pillars in the Egyptian model.

El Kassas, M., M. Alboraie, D. Omran, M. Salaheldin, M. N. Wifi, M. Elbadry, adel el tahan, S. Ezzat, E. Moaz, A. M. Farid, et al., "An account of the real-life hepatitis C management in a single specialized viral hepatitis treatment centre in Egypt: results of treating 7042 patients with 7 different direct acting antiviral regimens.", Expert review of gastroenterology & hepatology, vol. 12, issue 12, pp. 1265-1272, 2018. Abstract

BACKGROUND: A large Egyptian treatment program for HCV was launched in2014 after the introduction of direct-acting antiviral agents (DAAs). This program depended mainly on establishing specialized independent centres for HCV treatment. These centres represent the major strengths in the Egyptian model of care, as they provide integrated care for HCV patients and have enabled Egypt to treat more than one million patients in 3 years. The New Cairo Viral Hepatitis Treatment Center (NCVHTC) is an example of these specialized centres.

METHODS: The Egyptian experience in the management of HCV was evaluated by analysing the data of real-life HCV management in the NCVHTC from 2014 to 2017. Results of different treatment regimens in addition to their strengths, limitations and areas for improvement are discussed in this report.

RESULTS: A total of 7042 HCV patients have been evaluated for treatment in the NCVHTC. Among them, 5517 patients received treatment by seven different DAA regimens with excellent results.

CONCLUSIONS: All regimens were highly effective at treating HCV in a real-life setting, apart from SOF/RBV, which was the least effective. A nationwide screening program and enhancing the follow-up of treated patients are the main missing pillars in the Egyptian model.

Hanafy, M. S., S. M. Rahman, M. M. Khalafalla, H. A. EL-SHEMY, Y. Nakamoto, M. Ishimoto, and K. Wakasa, "Accumulation of free tryptophan in azuki bean (Vigna angularis) induced by expression of a gene (OASA1D) for a modified α-subunit of rice anthranilate synthase", Plant Science, vol. 171, issue 6: Elsevier, pp. 670-676, 2006. Abstract
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Ismail, M., M. M. Botros, and A. A. Wheida, "Accuracy of the multipole expansion of density distribution in the presence of octupole deformation", International Journal of Modern Physics E, vol. 20, no. 12, pp. 2407-2415, 2011. AbstractWebsite

The accuracy of multipole expansion of density distribution for deformed nuclei is tested. The interaction potential for a deformed-spherical pair of nuclei was calculated using the folding model derived from zero-range nucleonnucleon (NN) interaction. We considered two spherical projectiles Ca 40 and Pb 208 scattered on U 238 deformed target nucleus. The error in the heavy ion (HI) potential resulting from using a truncated multipole density expansion is evaluated for each case in the presence of octupole deformation δ 3 besides quadrupole δ 2. We are interested in the value of error for R < R T (touching distance). We found that for values of |δ 3|≤0.1 the error at R = R T reaches reasonable values when six terms expansion is used. For |δ 3| = 0.2, we calculated the Coulomb barrier parameters using realistic NN force and found that the large error present in six terms for zero range force decreases strongly to less than 1% when the zero range is added to finite range forces and Coulomb interaction to form the Coulomb barrier. It is noted that the negative value of octupole deformation parameters δ 3 = -0.1 produce error at orientation angle θ equal in value to that produced at angle (180°-θ) for the positive values δ 3 = 0.1. We also found that the error decreases as the mass number of the projectile nucleus increases. © 2011 World Scientific Publishing Company.

M.Ismail, M. M. Botros, and A. A. Wheida, "Accuracy of the multipole expansion of density distribution in the presence of octupole deformation.", International Journal of Modern Physics E ,, vol. 20 (, pp. 2407–2415., 2011.
Wei, L., A. A. Hussein, Y. Ma, G. Azabdaftari, Y. Ahmed, L. P. Wong, Q. Hu, W. Luo, V. N. Cranwell, B. L. Bunch, et al., "Accurate Quantification of Residual Cancer Cells in Pelvic Washing Reveals Association with Cancer Recurrence Following Robot-Assisted Radical Cystectomy.", The Journal of urology, 2019 Feb 05. Abstract

BACKGROUND: Bladder cancer recurrence following cystectomy remains a significant cause of bladder cancer-specific mortality. Residual cancer cells (RCCs) contribute to cancer recurrence due either to tumor spillage or undetectable pre-existing micrometastatic tumor clones. We sought to detect and quantify RCCs in pelvic washing using ultra-deep targeted sequencing (UTS) and compare the levels of RCCs with clinical variables and cancer recurrence.

METHODS: 17 patients underwent robotic-assisted radical cystectomy (RARC) with primary tumor specimen available. All tumors had negative surgical margins. Pelvic washes and blood were collected intra-operatively: before RARC, after RARC, after pelvic lymph node dissection (PLND), and in the suction fluid collected during the procedure. A two-step sequencing, including whole-exome sequencing (WES) followed by UTS (>50,000X), was used to quantify RCCs in each sample. Eight patients were excluded due to sample quality issues. The final analysis cohort included nine patients. RCC level was quantified for each sample as the relative cancer cell fraction (RCCF), and compared between different time points. The peak RCCF (pRCCF) of each patient was correlated with clinical and pathological variables.

RESULTS: RCCs were detected in approximately half of the pelvic washing specimens during or after RARC, but not before it. Higher levels of RCCs were associated with aggressive variant histology and cancer recurrence. Verifying the feasibility of using RCCs as a novel biomarker for recurrence requires larger cohorts.

CONCLUSIONS: Detection of RCCs in intra-operative peritoneal washes of bladder cancer patients undergoing radical cystectomy may represent a robust biomarker of tumor aggressiveness and metastatic potential.

Gao, S., K. L. Chung, A. Cui, M. Ghannam, J. Luo, L. Wang, M. Ma, and Z. Liao, "Accurate strength prediction models of ordinary concrete using early-age complex permittivity", Materials and Structures/Materiaux et Constructions, vol. 54, no. 4, 2021. AbstractWebsite
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Ali, A., A. Hussein, A. El-Rouby, M. Mahmoud, and A. Wassal, "Accurate Timing Analysis of Combinational Logic Cells Engine Using Adaptive Technique Based on Current Source Model", in Proceedings of the 2013 Saudi International Electronics, Communications and Photonics Conference,, Riyadh, KSA, April 27-30, 2013.
Lin, S., G. Zhang, J. Sun, S. He, C. Chen, A. M. Morsy, and X. Wang, "Acoustic Performance Optimization of a Cementitious Composite with a Porous Medium", Journal of Building Engineering, vol. 44, 2021.
Slater, J. G., D. E. Protsenko, N. Carbone, J. P. Jones, and B. J. F. Wong, "Acoustic response of cartilage during laser-mediated stress relaxation", IEEE Journal of selected topics in quantum electronics, vol. 11, issue 4: IEEE, pp. 846-853, 2005. Abstract
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Altinok, A., M. El-Saban, A. J. Peck, L. Wilson, S. C. Feinstein, B. S. Manjunath, and K. Rose, "Activity analysis in microtubule videos by mixture of hidden Markov models", 2006 IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR'06), vol. 2: IEEE, pp. 1662–1669, 2006. Abstract
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Altinok, A., M. El-Saban, A. J. Peck, L. Wilson, S. C. Feinstein, B. S. Manjunath, and K. Rose, "Activity analysis in microtubule videos by mixture of hidden Markov models", 2006 IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR'06), vol. 2: IEEE, pp. 1662–1669, 2006. Abstract
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Altinok, A., M. El-Saban, A. J. Peck, L. Wilson, S. C. Feinstein, B. S. Manjunath, and K. Rose, "Activity analysis in microtubule videos by mixture of hidden Markov models", 2006 IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR'06), vol. 2: IEEE, pp. 1662–1669, 2006. Abstract
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Park, W. S., Y. K. Son, N. Kim, J. - H. Ko, S. H. Kang, M. Warda, Y. E. Earm, I. D. Jung, Y. - M. Park, and J. Han, "Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels.", Pflügers Archiv : European journal of physiology, vol. 454, issue 6, pp. 1023-30, 2007 Sep. Abstract

We examined the effects of acute hypoxia on vascular tone and coronary blood flow (CBF) in rabbit coronary arteries. In the pressurized arterial preparation of small arteries (<100 mum) and the Langendorff-perfused rabbit hearts, hypoxia induced coronary vasodilation and increased CBF in the presence of glibenclamide (K(ATP) channel blocker), Rp-8-Br-PET-cGMPs [cyclic guanosine monophosphate (cGMP)-dependent protein kinase inhibitor, Rp-cGMPs], and methionyl transfer RNA synthetase (MRS) 1334 (adenosine A(3) receptor inhibitor); these increases were inhibited by the inward rectifier K(+) (Kir) channel inhibitor, Ba(2+). These effects were blocked by the adenylyl cyclase inhibitor SQ 22536 and by the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) inhibitors Rp-8-CPT-cAMPs (Rp-cAMPs) and KT 5720. However, cGMP-dependent protein kinase was not involved in the hypoxia-induced increases of the vascular diameter and CBF. In summary, our results suggest that acute hypoxia can induce the opening of Kir channels in coronary artery that has small diameter (<100 mum) by activating the cAMP and PKA signalling pathway, which could contribute to vasodilation and, therefore, increased CBF.

Park, W. S., Y. K. Son, N. Kim, J. - H. Ko, S. H. Kang, M. Warda, Y. E. Earm, I. D. Jung, Y. - M. Park, and J. Han, "Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels.", Pflugers Archiv : European journal of physiology, vol. 454, issue 6, pp. 1023-30, 2007 Sep. Abstract

We examined the effects of acute hypoxia on vascular tone and coronary blood flow (CBF) in rabbit coronary arteries. In the pressurized arterial preparation of small arteries (<100 mum) and the Langendorff-perfused rabbit hearts, hypoxia induced coronary vasodilation and increased CBF in the presence of glibenclamide (K(ATP) channel blocker), Rp-8-Br-PET-cGMPs [cyclic guanosine monophosphate (cGMP)-dependent protein kinase inhibitor, Rp-cGMPs], and methionyl transfer RNA synthetase (MRS) 1334 (adenosine A(3) receptor inhibitor); these increases were inhibited by the inward rectifier K(+) (Kir) channel inhibitor, Ba(2+). These effects were blocked by the adenylyl cyclase inhibitor SQ 22536 and by the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) inhibitors Rp-8-CPT-cAMPs (Rp-cAMPs) and KT 5720. However, cGMP-dependent protein kinase was not involved in the hypoxia-induced increases of the vascular diameter and CBF. In summary, our results suggest that acute hypoxia can induce the opening of Kir channels in coronary artery that has small diameter (<100 mum) by activating the cAMP and PKA signalling pathway, which could contribute to vasodilation and, therefore, increased CBF.

AT, A., K. AH, W. K, and M. W, "Adaptive Control Hemodialysis System: Conceptualization and Research Design", 2nd International conference on Advanced Control Circuits & systems (ACCS'08), Cairo, 2008.
Cheng, L., Y. Wang, C. Wang, A. W. Mohamed, and T. Xiao, "Adaptive Differential Evolution Based on Successful Experience Information", IEEE Access, vol. 8, pp. 164611 - 164636, 2020. Abstract
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Abo-Madyan, Y., H. - J. Wertz, R. Bogulla, J. Boda-Heggemann, F. Lohr, and F. Wenz, "Adaptive radiotherapy of prostate cancer", STRAHLENTHERAPIE UND ONKOLOGIE, vol. 183: URBAN & VOGEL NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY, pp. 45–46, 2007. Abstract

Interfractional prostate motion during radiotherapy can have deleterious clinical consequences. If the prostate or OAR are not in the correct position during treatment, the dose distribution
will be different from treatment planning. This can result in a loss of tumor control rate by several percent (despite generous margins) [1] but even more when margins are reduced. In patients with prostate cancer, De Crevoisier et al. reported a reduction in 5-year biochemical control rates of about 30% when the treatment planning CT was performed with a distended rectum [2], thus introducing a systematic error into the daily dose delivery. Daily image guided positioning based on soft tissue imaging with stereotactic ultrasound or cone beam CT (CBCT) is now a reality and is advantageous in mobile organs such as the prostate [3], especially when a 3D-conformal technique [4, 5] or an IMRTtechnique is used. For single treatment fractions, organ motion without correction may decrease the volume of the prostate encompassed by the 95%-isodose (V95%) by up to -24%-p (percentage
points) in our experience. The mean rectum dose increases by up to 41%-p. Linear translational correction increases V95% of the prostate by up to 17%-p while the mean rectum
dose can be reduced by up to -23%-p compared to the uncorrected setup.

This simulation shows that dosimetric deviations can be reduced due to an isocenter correction within certain limits. When the rectum distention causes a larger displacement of the prostate rotational offsets and the deformation of the organs become more relevant. The problems caused by the change in prostate shape can only be resolved by means of adaptive radiotherapy i.e. by reshaping the beams to the new shape of the target. The prerequisite for this approach is daily volume imaging providing a basis for on-line treatment planning.
Kilovoltage cone beam Computer Tomography (kV CBCT) images have been acquired in most body parts [6] for image guidance and verification, can be acquired at low doses (around
20mGy per volume acquisition [7] and may therefore be used as such a basis. Several problems have to be solved, however, among them missing tissue issues as well as artifacts and a problematic calculation of electron density distribution. Several approaches are currently evaluated to overcome these obstacles [8, 9] and our own preliminary data show excellent prospects, suggesting that dose calculation on a CBCT can be performed with an error of no more than 1–2% when compared with a regular CT.

The remaining link on the way to fully adaptive Radiotherapy are on-line treatment planning tools that provide the possibility to produce an adapted plan within a very short time after imaging [10]. Such a tool is now available with the ActiveRx™ module in Corvus 6.0 (Nomos Inc.), an interface that enables manual intuitive isodose shaping (re-draw, erase, push/pull the isodose lines in sagittal, coronal, and axial plane) on the basis of an existing plan. First model calculations on CT-datasets of patients with different rectal filling showed clearly that in selected patients this fully adaptive approach combining isocenter shift and reshaping of isodoses can reduce mean rectal dose by 5% while improving tumor dose by up to 30% over isocenter shifts alone (see Figure 1 as example).

In conclusion, the necessary tools for fully adaptive radiotherapy of prostate cancer are currently being developed and will be available in clinical practice in the near future. While numerically the therapeutic window can be further broadened based on this ultimate optimization of the dose distribution on a daily basis, the clinical impact remains to be evaluated.

Wessam, R., M. Gomaa, M. A. F. Hafez, S. Mokhtar, and Yasmin, "Added value of contrast-enhanced mammography in assessment of breast asymmetries", British Journal of radiology, vol. 92, issue 1098, pp. 1-7, 2019. lbhth_lthmn.pdf
Alharbi, N., D. Wismeijer, and R. B.Osman, "Additive manufacturing techniques in Prosthodontics, where do we currently stand? A Critical review", The International Journal of Prosthodontics, vol. 30, pp. 474-484, 2017.
Mylvaganam, S., E. J. Conroy, P. R. Williamson, N. L. P. Barnes, R. I. Cutress, M. D. Gardiner, A. Jain, J. M. Skillman, S. Thrush, L. J. Whisker, et al., "Adherence to best practice consensus guidelines for implant-based breast reconstruction: Results from the iBRA national practice questionnaire survey.", European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, vol. 44, issue 5, pp. 708-716, 2018 05. Abstract

INTRODUCTION: The 2008 National Mastectomy and Breast Reconstruction Audit demonstrated marked variation in the practice and outcomes of breast reconstruction in the UK. To standardise practice and improve outcomes for patients, the British professional associations developed best-practice guidelines with specific guidance for newer mesh-assisted implant-based techniques. We explored the degree of uptake of best-practice guidelines within units performing implant-based reconstruction (IBBR) as the first phase of the implant Breast Reconstruction Evaluation (iBRA) study.

METHODS: A questionnaire developed by the iBRA Steering Group was completed by trainee and consultant leads at breast and plastic surgical units across the UK. Simple summary statistics were calculated for each survey item to assess compliance with current best-practice guidelines.

RESULTS: 81 units from 79 NHS Trusts completed the questionnaire. Marked variation was observed in adherence to guidelines, especially those relating to clinical governance and infection prevention strategies. Less than half (n = 28, 47%) of units obtained local clinical governance board approval prior to offering new mesh-based techniques and prospective audit of the clinical, cosmetic and patient-reported outcomes of surgery was infrequent. Most units screened for methicillin-resistant staphylococcus aureus prior to surgery but fewer than 1 in 3 screened for methicillin-sensitive strains. Laminar-flow theatres (recommended for IBBR) were not widely-available with less than 1 in 5 units having regular access. Peri-operative antibiotics were widely-used, but the type and duration were highly-variable.

CONCLUSIONS: The iBRA national practice questionnaire has demonstrated variation in reported practice and adherence to IBBR guidelines. High-quality evidence is urgently required to inform best practice.

El-Malla, H., N. Y. Helm, U. Wilderäng, Y. E. S. Elborai, G. Steineck, and U. Kreicbergs, "Adherence to medication: A nation-wide study from the Children’s Cancer Hospital, Egypt", World Journal of Psychiatry, vol. 3, issue 2, pp. 25-33, 2013.
Y, S., A. A, S. DA, and D. W, "Adipokines and insulin resistance, predictors of response to therapy in Egyptian patients with chronic hepatitis C virus genotype 4", European Journal of Gastroenterology and Hepatology, vol. 25, issue 8, pp. 920-5, 2013. Abstractadipokines_and_insulin_resistance_final.pdf

BACKGROUND:
Hepatitis C virus (HCV) infection has major health impact worldwide and is a significant cause of chronic liver disease. In Egypt, HCV is highly endemic (up to 15% of the population); 91% of the patients are infected with genotype 4. Searching for new predictors of response to therapy is mandatory to decrease the cost and the adverse effects of current therapy.
AIM:
The aim of this study was to clarify the usefulness of serum leptin, adiponectin, and insulin resistance (IR) as predictors of response to treatment in hepatitis C virus genotype 4 (HCVG4).
METHODS:
One hundred patients with chronic HCVG4 who were candidates for treatment with pegylated interferon α and ribavirin were included in the study. Age, sex, and BMI were determined, and quantitative HCV PCR, assessment of serum leptin, adiponectin, IR, and pretreatment liver profile, and liver biopsy were performed.
RESULTS:
The male to female ratio was 68/32; the mean age of the patients was 40.9 ± 7.8 years and BMI was 28.3 ± 10 kg/m. Sustained virological response (SVR) was achieved by 56% of the patients. On performing logistic regression, BMI [odds ratio (OR) 6.5; P=0.004], serum leptin (OR 27.8; P ≤ 0.001), aspartate aminotransferase (OR 1.06; P ≤ 0.001), IR (OR 1.15; P ≤ 0.001), histological activity index (OR 1.77; P=0.006), and fibrosis (OR 2.93; P=0.001) were found to be independent negative predictors of SVR, whereas serum adiponectin (OR 0.74; P ≤ 0.001) was found to be an independent positive predictor of SVR. Pretreatment adiponectin (cutoff 13.75; sensitivity 92.86%; specificity 86.86%) shows area under the curve of 0.879 (95% confidence interval 0.802-0.956; P<0.001) and insignificant area under the curve for leptin or IR.
CONCLUSION:
BMI, pretreatment high leptin levels, and IR are negative predictors for SVR and pretreatment low adiponectin levels are an independent positive predictor for SVR in HCVG4.

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