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Wu, G. Y., and M. H. Halim, "Schistosomiasis: progress and problems", World journal of gastroenterology, vol. 6, issue 1: Baishideng Publishing Group Inc, pp. 12, 2000. Abstract
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Wu, K., W. Shi, and W. Ahmed, "Structural Elements Detection and Reconstruction (SEDR): A Hybrid Approach for Modeling Complex Indoor Structures", ISPRS International Journal of Geo-Information, vol. 9, issue 12, 2020.
Wu, K., W. Shi, and W. Ahmed, "Grid-based approach for the segmentation of multiple rooms from unstructured indoor point clouds", Journal of Applied Remote Sening, vol. 15, issue 4, pp. 1-17, 2021.
Wu, C., W. Darwish, S. Tang, and W. Li, "Precise Calibration and Error Modeling For Indoor 3D Modelling Sensors", The 9th International Symposium on Mobile Mapping Technology, MMT2015, pp. 1–5, 2015. Abstract
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Wurster, S., F. Hennes, A. C. Parplys, J. I. Seelbach, W. Y. Mansour, A. Zielinski, C. Petersen, T. S. Clauditz, A. Münscher, A. A. Friedl, et al., "PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.", Oncotarget, vol. 7, issue 9, pp. 9732-41, 2016 Mar 01. Abstract

There is a need to develop new, more efficient therapies for head and neck cancer (HNSCC) patients. It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' resistance to therapy. PARP1 inhibitors (PARPi) were found to be "synthetic lethal" in cancers deficient in BRCA1/2 with impaired homologous recombination. Since tumors rarely have these particular mutations, there is considerable interest in finding alternative determinants of PARPi sensitivity. Effectiveness of combined irradiation and PARPi olaparib was evaluated in ten HNSCC cell lines, subdivided into HR-proficient and HR-deficient cell lines using a GFP-based reporter assay. Both groups were equally sensitive to PARPi alone. Combined treatment revealed stronger synergistic interactions in the HR-deficient group. Because HR is mainly active in S-Phase, replication processes were analyzed. A stronger impact of treatment on replication processes (p = 0.04) and an increased number of radial chromosomes (p = 0.003) were observed in the HR-deficient group. We could show that radiosensitization by inhibition of PARP1 strongly correlates with HR competence in a replication-dependent manner. Our observations indicate that PARP1 inhibitors are promising candidates for enhancing the therapeutic ratio achieved by radiotherapy via disabling DNA replication processes in HR-deficient HNSCCs.

Wurster, S., F. Hennes, A. C. Parplys, J. I. Seelbach, W. Y. Mansour, A. Zielinski, C. Petersen, T. S. Clauditz, A. Münscher, A. A. Friedl, et al., "PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response.", Oncotarget, vol. 7, issue 9, pp. 9732-41, 2016 Mar 01. Abstract

There is a need to develop new, more efficient therapies for head and neck cancer (HNSCC) patients. It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' resistance to therapy. PARP1 inhibitors (PARPi) were found to be "synthetic lethal" in cancers deficient in BRCA1/2 with impaired homologous recombination. Since tumors rarely have these particular mutations, there is considerable interest in finding alternative determinants of PARPi sensitivity. Effectiveness of combined irradiation and PARPi olaparib was evaluated in ten HNSCC cell lines, subdivided into HR-proficient and HR-deficient cell lines using a GFP-based reporter assay. Both groups were equally sensitive to PARPi alone. Combined treatment revealed stronger synergistic interactions in the HR-deficient group. Because HR is mainly active in S-Phase, replication processes were analyzed. A stronger impact of treatment on replication processes (p = 0.04) and an increased number of radial chromosomes (p = 0.003) were observed in the HR-deficient group. We could show that radiosensitization by inhibition of PARP1 strongly correlates with HR competence in a replication-dependent manner. Our observations indicate that PARP1 inhibitors are promising candidates for enhancing the therapeutic ratio achieved by radiotherapy via disabling DNA replication processes in HR-deficient HNSCCs.

WZ Mikhail, MO Abd El-Samee, M. A. S. A. R. A. - A., "Use of Distillers Dried Grains with Solubles (DDGS) Supplemented with Enzymes in Quail Diets.", Egypt. Poult. Sci., vol. 33, pp. 805-823, 2013. Abstract
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