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Wolpert, B. J., S. Amr, D. 'aA. Saleh, S. Ezzat, I. Gouda, I. Loay, T. Hifnawy, M. Abdel-Hamid, N. N. Mikhail, M. Zhan, et al., "Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt.", Urologic oncology, vol. 30, issue 6, pp. 841-7, 2012 Nov-Dec. Abstract

OBJECTIVES: To examine associations between urinary bladder cancer risk and polymorphisms of the gene encoding the catechol estrogen-metabolizing enzyme, catechol-O-methyltransferase (COMT), among Egyptian women and men.

MATERIALS AND METHODS: We used questionnaire and genotype data from a case-control study in Egypt. This analysis focused on South Egypt cases with confirmed urothelial (UC) or squamous cell (SCC) carcinoma of the bladder, and controls frequency-matched on sex, 5-year age-group, and residence governorate. Real-time PCR on blood specimen DNA was used to determine COMT genotypes encoding for Val/Val, Val/Met, and Met/Met, the enzyme forms associated with high, intermediate, or low activity, respectively.

RESULTS: The study sample, which included 255 women and 666 men, consisted of 394 cases with histologically confirmed UC (225) or SCC (n = 169), and 527 controls. The odds of having either type of bladder cancer were lower among men with genotypes encoding Val/Met or Met/Met than among those with the genotype encoding Val/Val, even after adjustment for other factors, such as smoking and schistosomiasis history [adjusted odds ratio (AOR): 0.64; 95% confidence interval (CI): 0.43, 0.96]; however, the association was statistically significant for SCC (AOR 0.57; 95% CI: 0.34, 0.96) but marginal for UC (AOR: 0.64; 95% CI: 0.39, 1.02). No significant associations were detected between bladder cancer risk and COMT genotypes among postmenopausal women.

CONCLUSIONS: These findings suggest that even after controlling for established risk factors, the involvement of COMT genotypes in bladder cancer risk differs among men compared with women in South Egypt.

Wolpert, B. J., S. Amr, S. Ezzat, D. 'a Saleh, I. Gouda, I. Loay, T. Hifnawy, N. N. Mikhail, M. Abdel-Hamid, M. Zhan, et al., "Estrogen exposure and bladder cancer risk in Egyptian women.", Maturitas, vol. 67, issue 4, pp. 353-7, 2010 Dec. Abstract

OBJECTIVE: To examine associations between reproductive history and urinary bladder cancer in Egyptian women.

METHODS: We used questionnaire data from an ongoing, multicenter case-control study in Egypt. Controls were matched on age and residence area. This analysis focused on female cases with confirmed urothelial (UC) and squamous cell (SCC) carcinoma of the bladder.

RESULTS: We recruited 779 women (540 controls, 239 cases; >98.0% nonsmokers). Younger age at menopause (<45 y) and older age at first pregnancy (>18 y) were factors significantly associated with increased risk of bladder cancer, even after adjusting for schistosomiasis history and other covariates in the multivariable logistic model; adjusted odds ratio and 95% confidence intervals were 1.98 (1.41, 2.77) and 6.26 (3.46, 11.34), respectively. On the other hand, multiple pregnancies or use of oral contraceptives were associated with decreased odds of having bladder cancer. Similar associations were observed with UC and SCC when analyzed separately; however, the magnitude of association with SCC was lower than with UC.

CONCLUSION: Our data suggest that early estrogen exposure, or the relative lack of it, plays a role in urinary bladder carcinoma development among Egyptian women.

Wolpert, B. J. a, S. a Amr, D. A. b Saleh, S. c Ezzat, I. d Gouda, I. d Loay, T. e Hifnawy, M. f Abdel-Hamid, N. N. g Mikhail, M. a Zhan, et al., "Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt", Urologic Oncology: Seminars and Original Investigations, vol. 30, no. 6, pp. 841-847, 2012. AbstractWebsite

Objectives:To examine associations between urinary bladder cancer risk and polymorphisms of the gene encoding the catechol estrogen-metabolizing enzyme, catechol-O-methyltransferase (COMT), among Egyptian women and men. Materials and methods:We used questionnaire and genotype data from a case-control study in Egypt. This analysis focused on South Egypt cases with confirmed urothelial (UC) or squamous cell (SCC) carcinoma of the bladder, and controls frequency-matched on sex, 5-year age-group, and residence governorate. Real-time PCR on blood specimen DNA was used to determine COMT genotypes encoding for Val/Val, Val/Met, and Met/Met, the enzyme forms associated with high, intermediate, or low activity, respectively. ResultsThe study sample, which included 255 women and 666 men, consisted of 394 cases with histologically confirmed UC (225) or SCC (n = 169), and 527 controls. The odds of having either type of bladder cancer were lower among men with genotypes encoding Val/Met or Met/Met than among those with the genotype encoding Val/Val, even after adjustment for other factors, such as smoking and schistosomiasis history [adjusted odds ratio (AOR): 0.64; 95% confidence interval (CI): 0.43, 0.96]; however, the association was statistically significant for SCC (AOR 0.57; 95% CI: 0.34, 0.96) but marginal for UC (AOR: 0.64; 95% CI: 0.39, 1.02). No significant associations were detected between bladder cancer risk and COMT genotypes among postmenopausal women.: Conclusions:These findings suggest that even after controlling for established risk factors, the involvement of COMT genotypes in bladder cancer risk differs among men compared with women in South Egypt. © 2012.

Wong, D. C., R. Schlechter, A. Vannozzi, J. Höll, I. Hmmam, J. Bogs, G. B. Tornielli, S. D. Castellarin, and J. T. Matus, "A systems-oriented analysis of the grapevine R2R3-MYB transcription factor family uncovers new insights into t he regulation of stilbene accumulation.", DNA research, vol. 23, issue 5, pp. 451-466, 2016. Abstract

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Wong, D. C. J., R. Schlechter, A. Vannozzi, J. Holl, I. Hmmam, J. Bogs, G. B. Tornielli, S. D. Castellarin, and J. T. Matus, "A systems-oriented analysis of the grapevine R2R3-MYB transcription factor family uncovers new insights into the regulation of stilbene accumulation", DNA Research, vol. 23, issue 5, pp. 451-466, 2016.
Wong, V. S. H., and S. El-Massah, "Recent Evidence on the Oil Price Shocks on Gulf Corporation Council Stock Markets", International Journal of the Economics of Business, vol. 25, issue 2, pp. 297-312, 2018.
Wong, D. C. J., R. Schlechter, A. Vannozzi, J. Höll, I. Hmmam, J. Bogs, G. B. Tornielli, S. D. Castellarin, and J. T. Matus, "A systems-oriented analysis of the grapevine R2R3-MYB transcription factor family uncovers new insights into the regulation of stilbene accumulation", DNA research, vol. 23, issue 5: Oxford University Press, pp. 451-466, 2016. Abstract
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Wong, R., I. Yavaşoğlu, M. A. D. Yassin, P. Tarkun, S. Yoon, M. A. Samra, P. Angchaisuksiri, V. Pilipovic, and J. H. Jang, "Assessment of Eltrombopag in Patients with Chronic Immune Thrombocytopenia under Routine Clinical Practice in the Middle East, Turkey, Asia, And Australia.", 24th Congress of the European Hematology Association, June 2019, Abst. PF701 (Poster Presentation). , Amsterdam, The Netherlands, HemaSphere 2019, 3 (S1), pp. 305, 2019. assessment_of_eltrombopag_in_patients_with_chronic.pdf
Wong, B. J. F., T. E. Milner, B. Anvari, A. Sviridov, A. Omel'chenko, V. V. Bagratashvili, E. Sobol, and J. S. Nelson, "Measurement of radiometric surface temperature and integrated backscattered light intensity during feedback-controlled laser-assisted cartilage reshaping", Lasers in Medical Science, vol. 13, issue 1: Springer-Verlag, pp. 66-72, 1998. Abstract
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Wood, K. M., H. Salim, P. L. McEwen, I. B. Mandell, S. P. Miller, and K. C. Swanson, "The effect of corn or sorghum dried distillers grains plus solubles on growth performance and carcass characteristics of cross-bred beef steers", Animal feed science and technology, vol. 165, issue 1-2: Elsevier, pp. 23-30, 2011. Abstract
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Wood-Harper, T., "Research methods in information systems: using action research", Research {Methods} in {Information} {Systems}, {Proceedings} of the {IFIP} {Colloquim}, {Manchester} {Business} {School}, 1-3 {September} 1984, 1985. Abstract
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Wood-Harper, A. T., and G. Fitzgerald, "A {Taxonomy} of {Current} {Approaches} to {Systems} {Analysis}", The Computer Journal, vol. 25, pp. 12–16, 1982. Abstract

critique of GST

Woodall, W. H., and M. A. Mahmoud, "The Inertial Properties of Quality Control Charts", Technometrics, vol. 47, pp. 425-436, 2005.
Woodland, P. C., H. Chan, G. Evermann, M. Gales, D. Kim, X. Liu, D. Mrva, K. Sim, L. Wang, K. Yu, et al., "SuperEARS: Multi-site broadcast news system", Rich Transcription (RT-04F) Workshop, 2004. Abstract
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Woolgar, S., "Rethinking {Requirements} {Analysis}: {Some} implications of recent research into producer-consumer relationships in {IT} development", Requirements {Engineering} - {Social} and {Technical} {Issues}, London, Academic Press, pp. 201–216, 1994. Abstract
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Wordsworth, J. B., Software {Development} with {Z}, , Wokingham, England, Addison Wesley, 1992. Abstract
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work, my art work 2020, , cairo, opra house, pp. q, 2020. paint01.jpg
work, my art work 2020, , cairo, opra house, pp. q, 2020. paint01.jpg
Wright, N. J., A. J. M. Leather, N. Ade-Ajayi, N. Sevdalis, J. Davies, D. Poenaru, E. Ameh, A. Ademuyiwa, K. Lakhoo, E. R. Smith, et al., Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study, , vol. 398, issue 10297, pp. 325 - 339, 2021. AbstractWebsite

SummaryBackground
Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality.
Methods
We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis.
Findings
We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation
Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between low-income, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030.
Funding
Wellcome Trust.

Wright, T. M., S. Elmasry, P. K. Sculco, M. B. Cross, G. H. Westrich, C. W. Imhauser, and D. J. Mayman, "A NEW GEOMETRIC RATIO FOR LIGAMENT BALANCING IN ANTERIOR AND POSTERIOR REFERENCED TOTAL KNEE ARTHROPLASTY", Orthopaedic Proceedings, vol. 100, issue SUPP_12: The British Editorial Society of Bone & Joint Surgery, pp. 23-23, 2018. Abstract
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Wright, R., D. E. Protsenko, S. Diaz, K. Ho, and B. Wong, "Shape retention in porcine and rabbit nasal septal cartilage using saline bath immersion and Nd: YAG laser irradiation", Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery, vol. 37, issue 3: Wiley Subscription Services, Inc., A Wiley Company Hoboken, pp. 201-209, 2005. Abstract
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Wright, A., W. A. Bubb, C. L. Hawkins, and M. J. Davies, "Singlet Oxygen–mediated Protein Oxidation: Evidence for the Formation of Reactive Side Chain Peroxides on Tyrosine Residues¶", Photochemistry and photobiology, vol. 76, issue 1: Blackwell Publishing Ltd Oxford, UK, pp. 35-46, 2002. Abstract
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Wright, N. J., A. J. M. Leather, N. Ade-Ajayi, N. Sevdalis, J. Davies, D. Poenaru, E. Ameh, A. Ademuyiwa, K. Lakhoo, E. R. Smith, et al., "Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study", The Lancet, vol. 398, no. 10297, pp. 325-339, 2021. AbstractWebsite

{Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung's disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung's disease) from 264 hospitals (89 in high-income countries, 166 in middle-income countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in low-income countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40]

Wrigley, S. N., K. Elbedweihy, D. Reinhard, A. Bernstein, and F. Ciravegna, "{Evaluating Semantic Search Tools using the SEALS platform}", Proceedings of the International Workshop on Evaluation of Semantic Technologies (IWEST 2010), ISWC 2010, 2010. Abstract
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Tourism