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Wolpert, B. J. a, S. a Amr, D. A. b Saleh, S. c Ezzat, I. d Gouda, I. d Loay, T. e Hifnawy, M. f Abdel-Hamid, N. N. g Mikhail, M. a Zhan, et al., "Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt", Urologic Oncology: Seminars and Original Investigations, vol. 30, no. 6, pp. 841-847, 2012. AbstractWebsite

Objectives:To examine associations between urinary bladder cancer risk and polymorphisms of the gene encoding the catechol estrogen-metabolizing enzyme, catechol-O-methyltransferase (COMT), among Egyptian women and men. Materials and methods:We used questionnaire and genotype data from a case-control study in Egypt. This analysis focused on South Egypt cases with confirmed urothelial (UC) or squamous cell (SCC) carcinoma of the bladder, and controls frequency-matched on sex, 5-year age-group, and residence governorate. Real-time PCR on blood specimen DNA was used to determine COMT genotypes encoding for Val/Val, Val/Met, and Met/Met, the enzyme forms associated with high, intermediate, or low activity, respectively. ResultsThe study sample, which included 255 women and 666 men, consisted of 394 cases with histologically confirmed UC (225) or SCC (n = 169), and 527 controls. The odds of having either type of bladder cancer were lower among men with genotypes encoding Val/Met or Met/Met than among those with the genotype encoding Val/Val, even after adjustment for other factors, such as smoking and schistosomiasis history [adjusted odds ratio (AOR): 0.64; 95% confidence interval (CI): 0.43, 0.96]; however, the association was statistically significant for SCC (AOR 0.57; 95% CI: 0.34, 0.96) but marginal for UC (AOR: 0.64; 95% CI: 0.39, 1.02). No significant associations were detected between bladder cancer risk and COMT genotypes among postmenopausal women.: Conclusions:These findings suggest that even after controlling for established risk factors, the involvement of COMT genotypes in bladder cancer risk differs among men compared with women in South Egypt. © 2012.

Wolff, D., F. Stieler, Y. Abo-Madyan, M. Polednik, V. Steil, S. Mai, F. Wenz, and F. Lohr, "Volumetric intensity modulated arc therapy (VMAT) vs. serial tomotherapy and segmental (step and shoot) IMRT for treatment of prostate cancer", International Journal of Radiation Oncology* Biology* Physics, vol. 72, no. 1: Elsevier, pp. S562, 2008. Abstract
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Wolff, D., F. Stieler, G. Welzel, F. Lorenz, Y. Abo-Madyan, S. Mai, C. Herskind, M. Polednik, V. Steil, F. Wenz, et al., "Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer", Radiotherapy and Oncology, vol. 93, no. 2: Elsevier, pp. 226–233, 2009. AbstractWebsite

Introduction

Volumetric modulated arc therapy (VMAT), a complex treatment strategy for intensity-modulated radiation therapy, may increase treatment efficiency and has recently been established clinically. This analysis compares VMAT against established IMRT and 3D-conformal radiation therapy (3D-CRT) delivery techniques.
Methods

Based on CT datasets of 9 patients treated for prostate cancer step-and-shoot IMRT, serial tomotherapy (MIMiC), 3D-CRT and VMAT were compared with regard to plan quality and treatment efficiency. Two VMAT approaches (one rotation (VMAT1x) and one rotation plus a second 200° rotation (VMAT2x)) were calculated for the plan comparison. Plan quality was assessed by calculating homogeneity and conformity index (HI and CI), dose to normal tissue (non-target) and D95% (dose encompassing 95% of the target volume). For plan efficiency evaluation, treatment time and number of monitor units (MU) were considered.
Results

For MIMiC/IMRTMLC/VMAT2x/VMAT1x/3D-CRT, mean CI was 1.5/1.23/1.45/1.51/1.46 and HI was 1.19/1.1/1.09/1.11/1.04. For a prescribed dose of 76 Gy, mean doses to organs-at-risk (OAR) were 50.69 Gy/53.99 Gy/60.29 Gy/61.59 Gy/66.33 Gy for the anterior half of the rectum and 31.85 Gy/34.89 Gy/38.75 Gy/38.57 Gy/55.43 Gy for the posterior rectum. Volumes of non-target normal tissue receiving ⩾70% of prescribed dose (53 Gy) were 337 ml/284 ml/482 ml/505 ml/414 ml, for ⩾ 50% (38 Gy) 869 ml/933 ml/1155 ml/1231 ml/1993 ml and for ⩾ 30% (23 Gy) 2819 ml/3414 ml/3340 ml/3438 ml /3061 ml. D95% was 69.79 Gy/70.51 Gy/71,7 Gy/71.59 Gy/73.42 Gy. Mean treatment time was 12 min/6 min/3.7 min/1.8 min/2.5 min.
Conclusion

All approaches yield treatment plans of improved quality when compared to 3D-conformal treatments, with serial tomotherapy providing best OAR sparing and VMAT being the most efficient treatment option in our comparison. Plans which were calculated with 3D-CRT provided good target coverage but resulted in higher dose to the rectum.
Keywords

Volumetric modulated arc therapy (VMAT);
Intensity-modulated radiotherapy (IMRT);
Sequential tomotherapy;
Prostate cancern/a

Wolff, D., F. Stieler, F. Lohr, M. Polednik, V. Steil, Y. Abo-Madyan, and F. Wenz, "Comparison of intensity modulated Arc Therapy (IMAT) with the serial TomoTherapy and the Step-and-Shoot IMRT for the radiation therapy of the prostate carcinoma with regard to efficiency and plan-quality", STRAHLENTHERAPIE UND ONKOLOGIE, vol. 184: URBAN & VOGEL NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY, pp. 56–57, 2008. Abstract
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Wolff, D., Y. Abo-Madyan, B. Dobler, F. Lohr, S. Mai, M. Polednik, and F. Wenz, "Serielle Tomotherapie vs. MLC-IMRT (Multileaf Collimator Intensity Modulated Radiotherapy) für die simultane Boostbestrahlung mehrerer größerer Hirnfiliae", Zeitschrift für Medizinische Physik, vol. 19, no. 1: Elsevier, pp. 58–66, 2009. Abstract
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Wolff, D., Y. Abo-Madyan, B. Hermann, U. Kraus-Tiefenbacher, S. Mai, M. Polednik, A. Rahn, and F. Wenz, "Tomotherapy vs. MLC-IMRT for boost radiation in prostate cancer with consideration of the field access problem in a tomotherapeutic approach", STRAHLENTHERAPIE UND ONKOLOGIE, vol. 183: URBAN & VOGEL NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY, pp. 37–37, 2007. Abstract
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Wolabu1, T. W., H. Wang, D. Tadesse1, F. Zhang1, M. Behzadirad, V. E. Tvorogova, H. Abdelmageed, N. C. Ye Liu7, J. Chen, R. D. Allen, et al., "WOX9 functions antagonistic to STF and LAM1 to regulate leaf blade expansion in Medicago truncatula and Nicotiana sylvestris", New Phytologist, vol. 229, pp. 1582–1597, 2021.
Wohllebe, S., R. Richter, P. Richter, and D. - P. Häder, "Photodynamic control of human pathogenic parasites in aquatic ecosystems using chlorophyllin and pheophorbid as photodynamic substances", Parasitology research, vol. 104, issue 3: Springer-Verlag, pp. 593-600, 2009. Abstract
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Woerlee, P. H., T. M. El Sherbini, F. J. De Heer, and F. W. Saris, "Energy spectra of electrons produced in collisions of multiply charged neon ions with noble-gas atoms", Journal of Physics B: Atomic and Molecular Physics, vol. 12, issue 7: IOP Publishing, pp. L235, 1979. Abstract
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WMM, D., E. B. MMA, E. GEM, and E. SB, "Efficacy of rotary versus hand instrumentation techniques in reducing bacterial population of root canals", EDJ, vol. 53, pp. 2479-2486, 2007.
WK, A., I. AA, A. OW, H. M. Hussein, A. SM, and AlsubaieSF, "Effect of twelve-week concurrent aerobic and resisted exercise training in non-dialysis day on functional capacity and quality of life in chronic kidney disease patients", Eur Rev Med Pharmacol Sci, vol. 26, issue 17, pp. 6098-6106, 2022. abdelbasit_et_al_2022.pdf
Wissema, J. G., and T. T. A. P. H. by Ead, Towards Third Generation University, Managing the university in transition, , Alexandria, Egypt, Dar Alwafa for Printing and Publishing, 2019.
Wissam, F., P. Szabó, M. S. A. EL-Kader, and M. Gustafsson, "Molecular dynamics calculations of collision-induced absorption in a gas mixture of neon and krypton", Journal of Chemical physics, vol. 152, pp. 234302, 2020.
wissa, D., A. Ward, S. A. gad, S. Ibrahim, and S. Khairy, "High -k Green Polymer Nano composites Based on Polyvinyl Alcohol for Electrostatic Dissipation Applications", Egyptian Journal of Chemistry, 2022.
Wishahy, A. M. K., H. Seleim, M. Qinawy, W. Mohamed, O. Mansour, K. S. Abdullateef, R. Elkadi, H. Raslan, A. Arafa, and T. Yassin, "Short-term Effects of Mitomycin C Infiltration for Caustic Oesophageal Strictures in Children", Journal of Pediatric Gastroenterology and Nutrition , vol. 69, issue 6, pp. 673-677, 2019.
Wishahy, A. M. K., M. M. Elkottby, K. H. K. Bahaaeldin, and A. M. Y. Elhennawy, "Usefulness of laparoscopy for determining the location of transitional zone in patients with inconclusive barium enema for Hirschsprung’s disease: a prospective clinical trial", Annals of Pediatric Surgery, vol. 14, issue 3, pp. 146-150, 2018. Abstract
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Wishahy, A. M. K., M. M. Elkottby, K. H. K. Bahaaeldin, and A. M. Y. Elhennawy, "Usefulness of laparoscopy for determining the location of transitional zone in patients with inconclusive barium enema for Hirschsprung's disease: A prospective clinical trial", Annals of Pediatric Surgery, vol. 14, pp. 146–150, 2018.
Wishahy, A. M. K., H. Seleim, M. Qinawy, W. Mohamed, O. Mansour, K. S. Abdullateef, R. Elkadi, H. Raslan, A. Arafa, and T. Yassin, "Short-term effects of mitomycin C infiltration for caustic oesophageal strictures in children", Journal of Pediatric Gastroenterology and Nutrition, vol. 69, issue 6: LWW, pp. 673-677, 2019. Abstract
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Wishahi, M., E. Hafiz, A. M. K. Wishahy, and M. Badawy, "Telocytes, c-Kit positive cells, Smooth muscles, and collagen in the ureter of pediatric patients with congenital primary obstructive megaureter: elucidation of etiopathology", Ultrastructural Pathology, vol. 45, issue 3, pp. 257-265, 2021.
Wishahi, M., E. Hafiz, A. M. K. Wishahy, and M. Badawy, "Telocytes, c-Kit positive cells, Smooth muscles, and collagen in the ureter of pediatric patients with congenital primary obstructive megaureter: elucidation of etiopathology", Ultrastructural Pathology, vol. 45, issue 3: Taylor & Francis, pp. 257-265, 2021. Abstract
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Winter, H., T. M. El-Sherbini, E. Bloemen, F. J. De Heer, and A. Salop, "A comparison between radiative and non-radiative deexcitation after electron capture by multiple charged ions", Physics Letters A, vol. 68, issue 2: Elsevier, pp. 211-214, 1978. Abstract
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Winter, H., T. M. El-Sherbini, E. Bloemen, F. J. De Heer, and A. Salop, "A comparison between radiative and non-radiative deexcitation after electron capture by multiple charged ions", Physics Letters A, vol. 68, no. 2: Elsevier, pp. 211–214, 1978. Abstract
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Winkler, A. S., M. Leonardi, B. D. Michael, F. Abd-Allah, W. Carroll, and A. Guekht, "A WHO resolution on epilepsy and other neurological disorders.", The Lancet. Neurology, vol. 20, issue 3, pp. 171-172, 2021.