Objective: To evaluate uterine artery blood flow and subendometrial blood flow in women with unexplained recurrent miscarriage (RM) compared to normal fertile women.

n/a

Children with hemiplegic cerebral palsy have impairments in bimanual coordination
above and beyond their unilateral impairments.
Aim of the study: The current study was conducted to examine the effect of hand-arm bimanual
intensive therapy (HABIT) on the affected upper extremity use in children with hemiplegic cerebral
palsy.
Subjects and procedures: Thirty hemiparetic children ranged in age from 3 to7 years with mild to
moderate hand involvement participated in this study and they were divided equally into two
groups (control and study). Children in the study group were engaged in play and functional activities that provided structured bimanual practice 3 h per day for 12 weeks, while children in the control group received traditional physical therapy program directed toward improving upper
extremity use. Each child in the two groups was evaluated before and after the suggested treatment
duration for detecting the level of hand performance using the Peabody Developmental Test of
Motor Proficiency and hand grip strength by a hand held dynamometer.
Results: Children in both groups demonstrated improved scores on the Hand grip strength while
only children in the study group showed significant improvement in fine-motor performance scores
(p < 0.05).
Conclusion: The results suggest that, hand-arm bimanual intensive therapy appears to have a
positive impact on hand function in children with hemiparetic cerebral palsy.

BACKGROUND/AIMS: Colorectal cancer is one of the common cancers of the gastrointestinal tract in Egypt. It is characterized by a relatively earlier onset compared to that in the western world. Studying genetic alterations involved in colorectal cancer progression may help in identifying molecular biomarkers that can be used for early detection.

METHODOLOGY: We analyzed DNA isolated from 83 cases including 38 colorectal carcinomas, 23 polyps (16 of which were adenomatous) and 22 cases with inflammatory bowel disease (IBD). Mutations at KLF6 tumor suppressor gene (exon 1-4) were examined by PCR-SSCP silver staining technique followed by direct sequencing. 10p15 LOH was analyzed using KLF6 M1, KLF6 M2 and KLF6 M4 markers by microsatellite assay.

RESULTS: KLF6 mutations were found in 45%, 27% and 26% of colorectal carcinoma, ulcerative colitis and polyp cases, respectively. Most of the mutations detected were located at exon 2. The majority of mutations found in KLF6 were missense mutation and their type and locations were different from those previously described in the western population. The frequencies of LOH at the three markers examined were 29%, 36%, and 52% for colorectal carcinomas, IBD, and polyp cases, respectively. LOH was detected in mutant KLF6 as well as wild type. No significant association was found between genetic alterations examined with different clinicopathological factors.

CONCLUSIONS: Our data highlights for the first time an association of KLF6 gene in colorectal cancer in an Egyptian population. Detecting mutational sites different from those in western population is a characteristic feature in our study which may be related to environmental and/or genetic factors that have to be further identified.