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Victoria, S., H. Amaral, I. Mulamitsi, S. Bhatnagar, H. Moustafa, H. Kartunihardja, F. Sundram, and K. Britton, "CRF on in vivo imaging for infection (sepsis) and inflammation", European Congress Nuclear Medicine, Berlin, 29 Aug- 4 Sept, Submitted.
Mohamed, G., P. Murray, E. Nagy, and K. Vrzalikova, "Epstein–Barr virus, the germinal centre and the development of Hodgkin’s lymphoma", Journal of General Virology, vol. 95, issue 10.1099/vir.0.066712-0, pp. 1861–1869, Submitted. 1861.full_.pdf
Sakr, O. G., R. M. García-García, M. Arias-Álvarez, P. L. Lorenzo, P. Millán, B. Velasco, P. G. Rebollar, I. Badiola, A. Pérez de Rozas, and D. Menoyo, 9 de Febrero de 2012, , Submitted. Abstract
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Adly, A., D. Davino, A. Giustiniani, and C. Visone, Details of selected paper, , Submitted. Abstract
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Adly, A., D. Davino, A. Giustiniani, and C. Visone, Details of selected paper, , Submitted. Abstract
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Clemente, C. S., A. Mahgoub, D. Davino, and C. Visone, EQUIVALENTE 3-PORTE DI UN DISPOSITIVO DI ENERGY HARVESTING, , Submitted. Abstract
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Addis, T. R., B. Visscher, J. J. T. Addis, A. Gegov, G. Galal, and N. Clarke, Exploring {Architectural} {Modelling} to {Understand} {System} {Evolution}, , Submitted. Abstract
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O’GRADY, K. E. V. I. N., C. E. Patton, R. H. Victora, R. S. Indeck, D. Melton, B. Dieny, R. Hasegawa, D. C. Jiles, T. D. Lee, Y. Miura, et al., IEEE MAGNETICS SOCIETY, , Submitted. Abstract
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d’Aquino, M., C. Serpico, C. Visone, and A. Adly, Modelli matematici di isteresi basati su una nuova classe di isteroni Play, , Submitted. Abstract
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Bhangu, A., A. O. Ademuyiwa, M. L. Aguilera, P. Alexander, S. W. Al-Saqqa, G. Borda-Luque, A. Costas-Chavarri, T. M. Drake, F. Ntirenganya, E. J. Fitzgerald, et al., "Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study", The Lancet Infectious DiseasesThe Lancet Infectious Diseases: Elsevier, Submitted. AbstractWebsite

BackgroundSurgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.BackgroundSurgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.

Abdel-Aziz, H., W. Wadie, D. M. Abdallah, B. Vinson, O. Kelber, D. Weiser, and M. T. Khayyal, "Wirkung von STW 5 in einem experimentellen Kolitis-Modell", Zeitschrift für Gastroenterologie, vol. 46, issue 09, pp. P362, Submitted. Abstract
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Ahmed, A. A., A. A. Mohamed, I. A. Guled, H. M. Elamin, A. H. Abou-Zeid, J. Loko Roka, R. Van den Bergh, S. Au, E. De Plecker, R. Zachariah, et al., Womens/Reproductive Health:[32], , Submitted. Abstract
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In Press
Veeramachaneni, C., and et al, "Retreatment efficacy of propoint and guttapercha- A cone beam computed tomography analysis. (Prof. Emad was a peer reviewer for this article).", British Journal of Medicine and Medical Research, In Press.
2022
El-Sayed, R., S. Seddik, and L. W. Rizkallah, "Expert Systems in Academic Advising", Proceedings of the International Conference on Advanced Intelligent Systems and Informatics 2021, Cham, Springer International Publishing, pp. 198–207, 2022. Abstract

For any college or university student, selecting the right courses in which to enrol is a critical choice that has the potential to positively or negatively affects the student's academic performance. For this reason, universities offer academic advisors, which study the case of each student and recommend the right courses based on the student's status. This process is expensive and time-consuming, therefore, researchers have proposed solutions to automate it. In this paper, we focus on solutions based on expert systems. To this end, we summarize and analyze six selected works that propose different expert systems to solve the problem of academic advising. The analysis aims to provide an overview about the used approaches as well as highlight areas of improvements. The goal is to help any researcher interested in the problem to take the first step towards learning about existing approaches, their advantages, and their drawbacks. Overall, existing approaches show great potential of expert systems in the problem of academic advising.

Eid, K., Q. Lu, S. sayed abdel-Azeim, A. Soliman, A. M. Abdullah, A. M. Abdelgwad, R. P. Forbes, K. I. Ozoemena, R. S. Varma, and M. Shibl, "Highly Exfoliated Ti3C2Tx MXene Nanosheets Atomically Doped with Cu for Efficient Electrochemical CO2 Reduction: An Experimental and Theoretical Study", Journal of Materials Chemistry A: Royal Society of Chemistry, 2022. Abstract
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2021
Goncalves, D. R., J. Leroy, S. Van Hees, I. Xhonneux, P. E. J. Bols, F. Kiekens, and W. F. A. Marei, "Cellular uptake of polymeric nanoparticles by bovine cumulus-oocyte complexes and their effect on in vitro developmental competence", Eur J Pharm Biopharm, 2020/11/29, vol. 158, pp. 143-155, Jan, 2021. AbstractWebsite

Polymeric nanoparticles (NPs) are produced using bio-compatible and bio-degradable materials such as PLGA (Poly(lactic-co-glycolic acid)). This technology provides a valuable tool to deliver molecules to the subcellular level with a relatively low risk of cytotoxicity. However their use in the field of reproductive biotechnology is not yet scientifically substantiated. The aim of the present study was to test if PLGA NPs can be taken-up by cumulus-enclosed oocytes as a first step towards potential oocyte-targeted applications to enhance oocyte quality and fertility. We conducted a series of experiments using bovine in vitro oocyte maturation as a model to study FITC-conjugated PLGA internalization (using laser-scanning confocal microscopy) and the effect of some important physical (particle size) and chemical (conjugation with PEG) modifications. We show evidence that PLGA NPs can be taken-up by cumulus cells and to a less extent by the enclosed oocytes regardless of the NP size. The NP transfer to the oocyte appear to be transcellular (via cumulus cells and transzonal projections) and paracellular (via zona pellucida). The PLGA NPs were detected in the vicinity of the oocyte as quick as 2 h post-exposure in a protein-free medium and did not compromise cumulus cell viability nor subsequent early embryo development or embryo quality. These results suggest that PLGA NPs may have promising applications as carriers for drug or molecule delivery targeting cumulus cells and oocytes.

Gaggiano, C., D. Rigante, J. Hernández-Rodríguez, A. Vitale, M. Tarsia, A. Soriano, G. Lopalco, F. Iannone, M. Abdel Jaber, R. Giacomelli, et al., "Anakinra and canakinumab for patients with R92Q-associated autoinflammatory syndrome: a multicenter observational study from the AIDA Network", Therapeutic Advances in Musculoskeletal DiseaseTherapeutic Advances in Musculoskeletal Disease, vol. 13: SAGE Publications, pp. 1759720X211037178, 2021. AbstractWebsite

Background:This study aims at describing the therapeutic outcome of patients carrying the R92Q variant in the TNFRSF1A gene treated with anakinra (ANA) or canakinumab (CAN) and identifying any factors predictive of complete response to IL-1 inhibition.Methods:Clinical data of patients treated with ANA or CAN for recurrent inflammatory attacks due to the presence of the R92Q variant were retrospectively collected and analysed.Results:Data about 20 treatment courses with IL-1 inhibitors (16 with ANA and 4 with CAN) from 19 patients were collected. Mean age at disease onset was 20.2?±?14.8 years. In 5 cases (26%) the R92Q variant was found in a family member affected by recurrent fever. The therapeutic response was complete in 13(68%) and partial in 2 patients (11%); treatment failure was observed in 4 cases (21%). Median AIDAI decreased from 10 (interquartile range [IQR]?=?28) to 0 (IQR?=?1) at the 12-month follow-up visit (p?<?0.001). Mean ESR and median CRP dropped respectively from 40.8?±?24.8 to 9.1?±?4.5 mm/h (p?<?0.001) and from 3.0 (IQR?=?1.9) to 0.3 (IQR?=?0.3) mg/dl (p?<?0.001) after 12 months of treatment. A steroid-sparing effect was observed from the third month of treatment (p?<?0.01). Thirteen patients (65%) were still on treatment at the last follow-up visit (median duration of treatment 17 (IQR?=?38) months). The presence of R92Q mutation in a symptomatic relative (p?=?0.022), the relapsing remitting disease course (p?<?0.001) and the presence of migratory erythematous skin rashes during fever attacks (p?=?0.005) were associated with complete efficacy of IL-1 inhibitors.Conclusions:R92Q patients showed a favourable response to ANA and CAN, particularly when the mutation segregated in a family member and when a relapsing-remitting disease course or TNF-α receptor-associated periodic syndrome (TRAPS) typical skin rash were observed. In the subgroup of patients not taking advantage of IL-1 blockage different molecular mechanisms underlying the autoinflammatory picture are likely to exist.

Polychronopoulou, K., A. A. AlKhoori, A. M. Efstathiou, M. A. Jaoude, C. M. Damaskinos, M. A. Baker, A. Almutawa, D. H. Anjum, M. A. Vasiliades, A. Belabbes, et al., "Design Aspects of Doped CeO2 for Low-Temperature Catalytic CO Oxidation: Transient Kinetics and DFT Approach", ACS Applied Materials & InterfacesACS Applied Materials & Interfaces, vol. 13, issue 19: American Chemical Society, pp. 22391 - 22415, 2021. AbstractWebsite
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Alarfaj, R., M. El-Soda, L. Antanaviciute, R. Vickerstaff, P. Hand, R. J. Harrison, and C. Wagstaff, "Mapping QTL underlying fruit quality traits in an F1 strawberry population", The Journal of Horticultural Science and BiotechnologyThe Journal of Horticultural Science and Biotechnology, vol. 96, issue 5: Taylor & Francis, pp. 634 - 645, 2021. AbstractWebsite
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Mohamed, M., I. El-Sabagh, Y. Vashie, V. Jagrite, M. A. E. Salem, M. A. Al-Ramadan, A. M. Al-Ali, and S. Kumar, "Analysis of the beak and feather disease viral genome indicates evidence of multiple introduction events into Saudi Arabia", Virus Research, vol. 295, pp. 198279, 2021.
Sharma;, D.;S. S. V., S.;A. K. V. Verma;, A. A. Abdelhadi;, and A. Hossain, "Assessment of agroeconomic indicators of Sesamum indicum L. as influenced by application of boron at different levels and plant growth stages", Molecules 2021, 26(21), 6699; https://doi.org/10.3390/molecules26216699, 2021.
Elfishawi, M., G. Mossallam, D. G. Augusto, G. Montero-Martin, H. de Bruin, L. Van de Pasch, P. J. Norman, E. Rozemuller, M. Fernandez-Vina, A. Abrudescu, et al., "Behçet disease, new insights in disease associations and manifestations: a next-generation sequencing study.", Clinical and experimental immunology, 2021. Abstract

Behçet disease is a multi-system disease associated with human leukocyte antigen (HLA) class I polymorphism. High-resolution next-generation sequencing (NGS) with haplotype analysis has not been performed previously for this disease. Sixty Egyptian patients diagnosed according to the International Study Group (ISG) criteria for Behçet disease and 160 healthy geographic and ethnic-matched controls were genotyped for HLA class I loci (HLA-A, B, C). For HLA class II loci (DRB1, DRB3/4/5, DQA1, DQB1, DPA1, DPB1), 40 control samples were genotyped. High-resolution HLA genotyping was performed using NGS and the results were analyzed. Clinical manifestations were oral ulcers (100%), genital ulcers (100%), eye (55%) and neurological (28%) and vascular involvement (35%). HLA-B*51:08 [odds ratio (OR) = 19·75, 95% confidence interval (CI) = 6·5-79; P < 0·0001], HLA-B*15:03 (OR = 12·15, 95% CI = 3·7-50·7; P < 0·0001), HLA-C*16:02 (OR = 6·53, 95% CI = 3-14; P < 0·0001), HLA-A*68:02 (OR = 3·14, 95% CI = 1·1-8·9; P < 0·01) were found to be associated with Behçet disease, as were HLA-DRB1*13:01 and HLA-DQB1*06:03 (OR = 3·39, 95% CI = 0·9-18·9; P = 0·04 for both). By contrast, HLA-A*03:01 (OR = 0·13, 95% CI = 0-0·8; P = 0·01) and HLA-DPB1*17:01 were found to be protective (OR = 0·27, 95% CI = 0·06-1·03; P = 0·02). We identified strong linkage disequilibrium between HLA-B*51:08 and C*16:02 and A*02:01 in a haplotype associated with Behçet disease. HLA-B*51:08 was significantly associated with legal blindness (OR = 2·98, 95% CI = 1·06-8·3; P = 0·01). In Egyptian Behçet patients, HLA-B*51:08 is the most common susceptibility allele and holds poor prognosis for eye involvement.

Vitrano, A., A. Meloni, W. A. Pollina, M. Karimi, A. El-Beshlawy, M. Hajipour, V. Di Marco, S. H. Ansari, A. Filosa, P. Ricchi, et al., "A complication risk score to evaluate clinical severity of thalassaemia syndromes.", British journal of haematology, vol. 192, issue 3, pp. 626-633, 2021. Abstract

The thalassaemia syndromes (TS) show different phenotype severity. Developing a reliable, practical and global tool to determine disease severity and tailor treatment would be of great value. Overall, 7910 patients were analysed with the aim of constructing a complication risk score (CoRS) to evaluate the probability of developing one or more complications. Nine independent variables were included in the investigation as predictors. Logistic regression models were used for Group A [transfusion-dependent thalassaemia (TDT)], Group B [transfused non-TDT (NTDT)] and Group C (non-transfused NTDT). Statistically significant predictors included age (years), haemoglobin levels, hepatic transaminases [alanine aminotransferase (ALT) and aspartate aminotransferase] and left-ventricular ejection fraction (LVEF) for Group A; age (years), age at first chelation (months), ALT and LVEF for Group B; and age (years), mean serum ferritin (SF) levels and LVEF for Group C. The area under the receiver operating characteristic curve was 84·5%, 82·1% and 80·0% for Groups A, Group B and Group C respectively, suggesting the models had good discrimination. Finally, the CoRS for each group was categorised into four risk classes (low, intermediate, high, and very high) using the centiles of its distribution. In conclusion, we have developed a CoRS for TS that can assist physicians in prospectively tailoring patients' treatment.