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Journal Article
Poppe, M., M. Alaasar, A. Lehmann, S. Poppe, M. G. Tamba, M. Kurachkina, A. Eremin, M. Nagaraj, J. K. Vij, X. Cai, et al., "Controlling the formation of heliconical smectic phases by molecular design of achiral bent-core molecules", Journal of Materials Chemistry C, vol. 8, issue 10, pp. 3316-3336, 2020.
El-Ghoul, W., O. El- Tookhy, and S. Gadallah, "Conventional Plain and Positive Contrast Radiographic Imaging of the Skull in Dogs and Cats", Vet. Med., vol. 54, issue 2, no. 2, pp. 359–378, 2005. Abstract

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Radwan, H. G., P. Vignal, N. Collier, L. Dalcin, M. Santillana, and V. M. Calo, "Convergence rates for diffusive shallow water equations (DSW) using higher order polynomials", Journal of the Serbian Society for Computational Mechanics/Vol, vol. 6, no. 1, pp. 160–168, 2012. Abstract
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Amero, P., G. L. R. Lokesh, R. R. Chaudhari, R. Cardenas-Zuniga, T. Schubert, Y. M. Attia, E. Montalvo-Gonzalez, A. M. ElSayed, C. Ivan, Z. Wang, et al., "Conversion of RNA Aptamer into Modified DNA Aptamers Provides for Prolonged Stability and Enhanced Antitumor Activity.", Journal of the American Chemical Society, 2021. Abstract

Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies, are promising as therapeutics because of their minimal side effects. However, the stability and bioavailability of the aptamers pose a challenge. We developed aptamers converted from RNA aptamer to modified DNA aptamers that target phospho-AXL with improved stability and bioavailability. On the basis of the comparative analysis of a library of 17 converted modified DNA aptamers, we selected aptamer candidates, GLB-G25 and GLB-A04, that exhibited the highest bioavailability, stability, and robust antitumor effect in experiments. Backbone modifications such as thiophosphate or dithiophosphate and a covalent modification of the 5'-end of the aptamer with polyethylene glycol optimized the pharmacokinetic properties, improved the stability of the aptamers by reducing nuclease hydrolysis and renal clearance, and achieved high and sustained inhibition of AXL at a very low dose. Treatment with these modified aptamers in ovarian cancer orthotopic mouse models significantly reduced tumor growth and the number of metastases. This effective silencing of the phospho-AXL target thus demonstrated that aptamer specificity and bioavailability can be improved by the chemical modification of existing aptamers for phospho-AXL. These results lay the foundation for the translation of these aptamer candidates and companion biomarkers to the clinic.

Heeringa, S. F., G. Chernin, M. Chaki, W. Zhou, A. J. Sloan, Z. Ji, L. X. Xie, L. Salviati, T. W. Hurd, V. Vega-Warner, et al., "COQ6 Mutations in Human Patients Produce Nephrotic Syndrome with Sensorineural Deafness", Journal of Clinical Investigation, vol. 121, issue 5, 2011. Abstractcu_pdf.pdf

Steroid-resistant nephrotic syndrome (SRNS) is a frequent cause of end-stage renal failure. Identification of single-gene causes of SRNS has generated some insights into its pathogenesis;

Heeringa, S. F., G. Chernin, M. Chaki, W. Zhou, A. J. Sloan, Z. Ji, L. X. Xie, L. Salviati, T. W. Hurd, V. r Vega-Warne, et al., "COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness", Journal of Clinical Investigation, vol. 121, issue 5, pp. 2013-24, 2011.
X, Z., R. SH, X. Y, E. T, Z. AR, A. AO, A. - H. M, T. V, E. SF, F. X, et al., "The Core/E1 Domain of Hepatitis C Virus Genotype 4a in Egypt Does not Contain Viral Mutations or Strains Specific for Hepatocellular Carcinoma", Journal of Clinical Virology, vol. 52, issue 4, 2011. Abstractcu_pdf.pdf

Background: Hepatitis C virus (HCV) infection is a well-documented etiological factor for hepatocellular carcinoma (HCC). As HCV shows remarkable genetic diversity, an interesting and important issue is whether such a high viral genetic diversity plays a role in the incidence of HCC. Prior data on this subject are conflicting.

Lackner, M., S. G. de Hoog, L. Yang, L. F. Moreno, S. A. Ahmed, F. Andreas, J. Kaltseis, M. Nagl, C. Lass-Flörl, B. Risslegger, et al., Correction to: Proposed nomenclature for Pseudallescheria, Scedosporium and related genera, , vol. 113, issue 1, pp. 193 - 194, 2022. AbstractWebsite
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EL-Tookhy, O. M., F. A. Torad, A. M. Abu-Seida, and A. H. Osman, "The Correlation between Ultrasonographic Diagnosis and Histopathological Findings in Some Ocular Affections in Donkeys", Egypt. Vet, vol. 67, issue 1, pp. 59-75, 2007. Abstract

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Dawoud, D. M., A. Haines, D. Wonderling, J. Ashe, J. Hill, M. Varia, P. Dyer, and J. Bion, "Cost Effectiveness of Advanced Pharmacy Services Provided in the Community and Primary Care Settings: A Systematic Review.", PharmacoEconomics, vol. 37, issue 10, pp. 1241-1260, 2019. Abstract

BACKGROUND: Pharmacists working in community and primary care are increasingly developing advanced skills to provide enhanced services, particularly in dealing with minor acute illness. These services can potentially free-up primary care physicians' time; however, it is not clear whether they are sufficiently cost effective to be recommended for wider provision in the UK.

OBJECTIVE: The aim of this study was to review published economic evaluations of enhanced pharmacy services in the community and primary care settings.

METHODS: We undertook a systematic review of economic evaluations of enhanced pharmacy services to inform NICE guidelines for emergency and acute care. The review protocol was developed and agreed with the guideline committee. The National Health Service Economic Evaluation Database, Health Technology Assessment Database, Health Economic Evaluations Database, MEDLINE and EMBASE were searched in December 2016 and the search was updated in March 2018. Studies were assessed for applicability and methodological quality using the NICE Economic Evaluation Checklist.

RESULTS: Of 3124 records, 13 studies published in 14 papers were included. The studies were conducted in the UK, Spain, The Netherlands, Australia, Italy and Canada. Settings included community pharmacies, primary care/general practice surgeries and patients' homes. Most of the studies were assessed as partially applicable with potentially serious limitations. Services provided in community and primary care settings were found to be either dominant or cost effective, at a £20,000 per quality-adjusted life-year threshold, compared with usual care. Those delivered in the patient's home were not found to be cost effective.

CONCLUSIONS: Advanced pharmacy services appear to be cost effective when delivered in community and primary care settings, but not in domiciliary settings. Expansion in the provision of these services in community and primary care can be recommended for wider implementation.

Vansompel, H., A. Rasekh, A. Hemeida, J. Vierendeels, and P. Sergeant, "Coupled electromagnetic and thermal analysis of an axial flux PM machine", IEEE Transactions on Magnetics, vol. 51, issue 11: IEEE, pp. 1-4, 2015. Abstract
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Prabu, P., K. Venkatachalam, A. S. Alluhaidan, R. Marzouk, M. Hadjouni, and S. A. El_Rahman, "Covid-19 CT Lung Image Segmentation Using Adaptive Donkey and Smuggler Optimization Algorithm", Computers, Materials & Continua, vol. 71, issue 1, pp. 1133-1152, 2022.
Hasanin, A., K. de Vasconcellos, and M. Abdulatif, "COVID-19 in Africa: Current difficulties and future challenges considering the ACCCOS study.", Anaesthesia, critical care & pain medicine, vol. 40, issue 4, pp. 100912, 2021.
Hasanin, A., K. de Vasconcellos, and M. Abdulatif, "COVID-19 in Africa: Current difficulties and future challenges considering the ACCCOS study.", Anaesthesia, critical care & pain medicine, vol. 40, issue 4, pp. 100912, 2021.
Tan, E. H., A. G. Sena, A. Prats-Uribe, S. C. You, W. - U. - R. Ahmed, K. Kostka, C. Reich, S. L. DuVall, K. E. Lynch, M. E. Matheny, et al., "COVID-19 in patients with autoimmune diseases: characteristics and outcomes in a multinational network of cohorts across three countries.", Rheumatology (Oxford, England), vol. 60, issue SI, pp. SI37-SI50, 2021. Abstract

OBJECTIVE: Patients with autoimmune diseases were advised to shield to avoid coronavirus disease 2019 (COVID-19), but information on their prognosis is lacking. We characterized 30-day outcomes and mortality after hospitalization with COVID-19 among patients with prevalent autoimmune diseases, and compared outcomes after hospital admissions among similar patients with seasonal influenza.

METHODS: A multinational network cohort study was conducted using electronic health records data from Columbia University Irving Medical Center [USA, Optum (USA), Department of Veterans Affairs (USA), Information System for Research in Primary Care-Hospitalization Linked Data (Spain) and claims data from IQVIA Open Claims (USA) and Health Insurance and Review Assessment (South Korea). All patients with prevalent autoimmune diseases, diagnosed and/or hospitalized between January and June 2020 with COVID-19, and similar patients hospitalized with influenza in 2017-18 were included. Outcomes were death and complications within 30 days of hospitalization.

RESULTS: We studied 133 589 patients diagnosed and 48 418 hospitalized with COVID-19 with prevalent autoimmune diseases. Most patients were female, aged ≥50 years with previous comorbidities. The prevalence of hypertension (45.5-93.2%), chronic kidney disease (14.0-52.7%) and heart disease (29.0-83.8%) was higher in hospitalized vs diagnosed patients with COVID-19. Compared with 70 660 hospitalized with influenza, those admitted with COVID-19 had more respiratory complications including pneumonia and acute respiratory distress syndrome, and higher 30-day mortality (2.2-4.3% vs 6.32-24.6%).

CONCLUSION: Compared with influenza, COVID-19 is a more severe disease, leading to more complications and higher mortality.

Sen, P., L. Gupta, J. B. Lilleker, V. Aggarwal, S. Kardes, M. Milchert, T. Gheita, B. Salim, T. Velikova, A. E. Gracia-Ramos, et al., "COVID-19 vaccination in autoimmune disease (COVAD) survey protocol.", Rheumatology international, vol. 42, issue 1, pp. 23-29, 2022. Abstract

The coronavirus disease-2019 (COVID-19) pandemic continues to be a cause of unprecedented global morbidity and mortality. Whilst COVID-19 vaccination has emerged as the only tangible solution to reducing poor clinical outcomes, vaccine hesitancy continues to be an obstacle to achieving high levels of vaccine uptake. This represents particular risk to patients with autoimmune diseases, a group already at increased risk of hospitalization and poor clinical outcomes related to COVID-19 infection. Whilst there is a paucity of long-term safety and efficacy data of COVID-19 vaccination in patients with autoimmune diseases, the current evidence strongly suggests that the benefits of vaccination outweigh the risks of adverse effects and disease flares. Herein, we report the protocol of the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study, an ongoing international collaborative study involving 29 countries and over 110 investigators.

Akuffo, R., J. A. M. Brandful, A. Zayed, A. Adjei, N. Watany, N. T. Fahmy, R. Hughes, B. Doman, S. V. Voegborlo, D. Aziati, et al., "Crimean-Congo hemorrhagic fever virus in livestock ticks and animal handler seroprevalence at an abattoir in Ghana", BMC infectious diseases, vol. 16, no. 1: BioMed Central, pp. 324, 2016. Abstract
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Chisholm, K., E. Dueger, N. T. Fahmy, H. A. T. Samaha, A. Zayed, M. Abdel-Dayem, and J. T. Villinski, "Crimean-Congo hemorrhagic fever virus in ticks from imported livestock, Egypt", Emerging infectious diseases, vol. 18, no. 1: Centers for Disease Control and Prevention, pp. 181, 2012. Abstract
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Shaheen, A. A. M., M. T. A. Omar, and H. Vernon, "Cross-cultural Adaptation, Reliability, and Validity of the Arabic Version of Neck Disability Index in Patients With Neck Pain ", Spain , vol. 38, issue 10, pp. E609-E615, 2013.
Vlaar, A., P. ten Klooster, E. Taal, R. Gheith, A. El-Garf, J. Rasker, and M. van de Laar, "A Cross-Cultural Study of Pain Intensity in Egyptian and Dutch Women With Rheumatoid Arthritis", .J Pain, vol. 8, issue 9, pp. 730-736, 2007.
Vlaar, A. P., P. M. T. Klooster, E. Taal, R. E. Gheith, A. K. El-Garf, J. J. Rasker, and M. A. V. de Laar, "A Cross-Cultural Study Of Pain Intensity In Egyptian And Dutch Women With Rheumatoid Arthritis", J Pain, vol. 9, issue 8, pp. 730-6, 2007.
Panneerdoss, S., V. K. Eedunuri, P. Yadav, S. Timilsina, S. Rajamanickam, S. Viswanadhapalli, N. Abdelfattah, B. C. Onyeagucha, X. Cui, Z. Lai, et al., "Cross-talk among writers, readers, and erasers of mA regulates cancer growth and progression.", Science advances, vol. 4, issue 10, pp. eaar8263, 2018 Oct. Abstract

The importance of RNA methylation in biological processes is an emerging focus of investigation. We report that altering mA levels by silencing either -adenosine methyltransferase METTL14 (methyltransferase-like 14) or demethylase ALKBH5 (ALKB homolog 5) inhibits cancer growth and invasion. METTL14/ALKBH5 mediate their protumorigenic function by regulating mA levels of key epithelial-mesenchymal transition and angiogenesis-associated transcripts, including transforming growth factor-β signaling pathway genes. Using MeRIP-seq (methylated RNA immunoprecipitation sequencing) analysis and functional studies, we find that these target genes are particularly sensitive to changes in mA modifications, as altered mA status leads to aberrant expression of these genes, resulting in inappropriate cell cycle progression and evasion of apoptosis. Our results reveal that METTL14 and ALKBH5 determine the mA status of target genes by controlling each other's expression and by inhibiting mA reader YTHDF3 (YTH -methyladenosine RNA binding protein 3), which blocks RNA demethylase activity. Furthermore, we show that ALKBH5/METTL14 constitute a positive feedback loop with RNA stability factor HuR to regulate the stability of target transcripts. We discover that hypoxia alters the level/activity of writers, erasers, and readers, leading to decreased mA and consequently increased expression of target transcripts in cancer cells. This study unveils a previously undefined role for mA in cancer and shows that the collaboration among writers-erasers-readers sets up the mA threshold to ensure the stability of progrowth/proliferation-specific genes, and protumorigenic stimulus, such as hypoxia, perturbs that mA threshold, leading to uncontrolled expression/activity of those genes, resulting in tumor growth, angiogenesis, and progression.

Panneerdoss, S., S. Viswanadhapalli, N. Abdelfattah, B. C. Onyeagucha, S. Timilsina, T. A. Mohammad, Y. Chen, M. Drake, K. Vuori, R. T. Kumar, et al., "Cross-talk between miR-471-5p and autophagy component proteins regulates LC3-associated phagocytosis (LAP) of apoptotic germ cells.", Nature communications, vol. 8, issue 1, pp. 598, 2017 09 19. Abstract

Phagocytic clearance of apoptotic germ cells by Sertoli cells is vital for germ cell development and differentiation. Here, using a tissue-specific miRNA transgenic mouse model, we show that interaction between miR-471-5p and autophagy member proteins regulates clearance of apoptotic germ cells via LC3-associated phagocytosis (LAP). Transgenic mice expressing miR-471-5p in Sertoli cells show increased germ cell apoptosis and compromised male fertility. Those effects are due to defective engulfment and impaired LAP-mediated clearance of apoptotic germ cells as miR-471-5p transgenic mice show lower levels of Dock180, LC3, Atg12, Becn1, Rab5 and Rubicon in Sertoli cells. Our results reveal that Dock180 interacts with autophagy member proteins to constitute a functional LC3-dependent phagocytic complex. We find that androgen regulates Sertoli cell phagocytosis by controlling expression of miR-471-5p and its target proteins. These findings suggest that recruitment of autophagy machinery is essential for efficient clearance of apoptotic germ cells by Sertoli cells using LAP.Although phagocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogenesis, little of the mechanism is known. Here the authors show that Sertoli cells employ LC3-associated phagocytosis (LAP) by recruiting autophagy member proteins to clear apoptotic germ cells.

Nour-Eldin, N. - E. A., M. Alsubhi, T. Gruber-Rouh, T. J. Vogl, B. Kaltenbach, H. H. Soliman, W. E. Hassan, S. M. Abolyazid, and N. N. Naguib, "CT-Guided Drainage of Pericardial Effusion after Open Cardiac Surgery.", Cardiovascular and interventional radiology, vol. 40, issue 8, pp. 1223-1228, 2017 Aug. Abstract

PURPOSE: This study was designed to evaluate the safety and efficacy of CT-guided drainage of the pericardial effusion in patients after cardiac surgery.

MATERIALS AND METHODS: The study included 128 consecutive patients (82 males, 46 females; mean age 66.6 years, SD: 4.2) complicated by pericardial effusion or hemopericardium after cardiac surgeries between June 2008 and June 2016. The medical indication for therapeutic pericardiocentesis in all patients was hemodynamic instability caused by pericardial effusion. The treatment criteria for intervention were evidence of pericardial tamponade with ejection fraction (EF) <50%. The preintervention ejection fraction was determined echocardiographically with value between 30 and 40%. Exclusion criteria for drainage were hemodynamically unstable patients or impaired coagulation profile (INR <1.8 or platelet count <75,000). Drains (8F-10F) were applied using Seldinger's technique under CT guidance.

RESULTS: Pericardiocentesis and placement of a percutaneous pericardial drain was technically successful in all patients. The mean volume of evacuated pericardial effusion was 260 ml (range 80-900 ml; standard deviation [SD]: ±70). Directly after pericardiocentesis, there was a significant improvement of the ejection fraction to 40-55% (mean: 45%; SD: ±5; p < 0.05). The mean percentage increase of the EF following pericardial effusion drainage was 10%. The drainage was applied anteriorly (preventricular) in 39 of 128 (30.5%), retroventricularly in 33 of 128 (25.8%), and infracardiac in 56 of 128 (43.8%). Recurrence rate of pericardial effusion after removal of drains was 4.7% (67/128). Complete drainage was achieved in retroventricular and infracardiac positioning of the catheter (p < 0.05) in comparison to the preventricular position of the catheter. Recorded complications included minimal asymptomatic pneumothorax and pneumomediastinum 2.3% (3/128) and sinus tachycardia 3.9% (5/128).

CONCLUSION: CT-guided drainage of postoperative pericardial effusion is a minimally invasive technique for the release of the tamponade effect of the effusion and improvement of cardiac output.

Gruber-Rouh, T., N. N. N. Naguib, M. Beeres, P. Kleine, T. J. Vogl, V. Jacobi, M. Alsubhi, and N. A. Nour-Eldin, "CT-guided hook-wire localisation prior to video-assisted thoracoscopic surgery of pulmonary lesions.", Clinical radiology, vol. 72, issue 10, pp. 898.e7-898.e11, 2017 Oct. Abstract

AIM: To assess the feasibility, safety, and efficacy of computed tomography (CT)-guided pulmonary nodule localisation using a hooked guide wire before video-assisted thoracoscopic surgery (VATS).

MATERIALS AND METHODS: The study included 79 patients with a history of malignancies outside the lung associated with pulmonary nodules. Mean lesion size was 0.7 cm (range 0.5-1.8 cm) and the mean lesion distance to the pleural surface was 1.5 cm (range 0.2-5 cm). All lesions (n=82) were marked with a 22-G hook wire. The technique was designed to insert the tip of the hook wire within or maximally 1 cm from the edge of the lesion. The Mann-Whitney U-test was used for univariate analyses and Fisher's exact test for categorical values.

RESULTS: The hooked guide wire was positioned successfully in all 82 pulmonary nodules within mean time of 9 minutes (8-20 minutes, SD: 2.5 minutes). The procedure time was inversely proportional to the size of the lesion (Spearman correlation factor 0.7). Minimal pneumothoraces were observed in five patients (7.6%). Pneumothorax was not correlated to the histopathology of the pulmonary nodules (p>0.09). Focal perilesional pulmonary haemorrhage developed in four patients (5%). Both haemorrhage and pneumothorax were significantly correlated to lesions <10 mm (p=0.02 and 0.01 respectively). The volume of resected lung tissue was significantly correlated to lesions of increased distance from the pleural surface ≥2.5 cm in comparison to lesions of <2.5 cm from the pleural surface.

CONCLUSION: CT-guided pulmonary nodule localisation prior to VATS could enable safe, accurate surgical guidance for the localisation of small pulmonary nodules.