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Periyasamy, S., V. Karthik, P. Senthil Kumar, B. J. Isabel, T. Temesgen, B. M. Hunegnaw, B. B. Melese, B. A. Mohamed, and D. - V. N. Vo, Chemical, physical and biological methods to convert lignocellulosic waste into value-added products. A review, , vol. 20, issue 2, pp. 1129 - 1152, 2022. AbstractWebsite

Actual agricultural practices produce about 998 million tonnes of agricultural waste per year. Therefore, converting lignocellulosic wastes into energy, chemicals, and other products is a major goal for the future circular economy. The major challenge of lignocellulosic biorefineries is to transform individual components of lignocellulosic biomass into valuable products. Here we review lignocellulosic biomasses such as coffee husk, wheat straw, rice straw, corn cob, and banana pseudostem. We present pretreatment technologies such as milling, microwave irradiation, acidic, alkaline, ionic liquid, organosolv, ozonolysis, steam explosion, ammonia fiber explosion, and CO2 explosion methods. These methods convert biomass into monomers and polymers. For that, the concoction pretreatment methods appear promising.

Ramos-Casals, M., N. Acar-Denizli, A. Vissink, P. Brito-Zerón, X. Li, F. Carubbi, R. Priori, N. Toplak, C. Baldini, E. Faugier-Fuentes, et al., "Childhood-onset of primary Sjögren's syndrome: phenotypic characterization at diagnosis of 158 children.", Rheumatology (Oxford, England), vol. 60, issue 10, pp. 4558-4567, 2021. Abstract

OBJECTIVES: To characterize the phenotypic presentation at diagnosis of childhood-onset primary SS.

METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry using worldwide data-sharing cooperative merging of pre-existing clinical SS databases from the five continents. For this study, we selected those patients in whom the disease was diagnosed below the age of 19 years according to the fulfilment of the 2002/2016 classification criteria.

RESULTS: Among the 12 083 patients included in the Sjögren Big Data Registry, 158 (1.3%) patients had a childhood-onset diagnosis (136 girls, mean age of 14.2 years): 126 (80%) reported dry mouth, 111 (70%) dry eyes, 52 (33%) parotid enlargement, 118/122 (97%) positive minor salivary gland biopsy and 60/64 (94%) abnormal salivary US study, 140/155 (90%) positive ANA, 138/156 (89%) anti-Ro/La antibodies and 86/142 (68%) positive RF. The systemic EULAR Sjögren's syndrome disease activity index (ESSDAI) domains containing the highest frequencies of active patients included the glandular (47%), articular (26%) and lymphadenopathy (25%) domains. Patients with childhood-onset primary SS showed the highest mean ESSDAI score and the highest frequencies of systemic disease in 5 (constitutional, lymphadenopathy, glandular, cutaneous and haematological) of the 12 ESSDAI domains, and the lowest frequencies in 4 (articular, pulmonary, peripheral nerve and CNS) in comparison with patients with adult-onset disease.

CONCLUSIONS: Childhood-onset primary SS involves around 1% of patients with primary SS, with a clinical phenotype dominated by sicca features, parotid enlargement and systemic disease. Age at diagnosis plays a key role in modulating the phenotypic expression of the disease.

Veys, K. R. P., M. A. Elmonem, M. van Dyck, M. C. Janssen, E. A. M. Cornelissen, K. Hohenfellner, G. Prencipe, L. P. van den Heuvel, and E. Levtchenko, "Chitotriosidase as a Novel Biomarker for Therapeutic Monitoring of Nephropathic Cystinosis.", Journal of the American Society of Nephrology : JASN, 2020 Apr 09. Abstract

BACKGROUND: Nephropathic cystinosis, a hereditary lysosomal storage disorder caused by dysfunction of the lysosomal cotransporter cystinosin, leads to cystine accumulation and cellular damage in various organs, particularly in the kidney. Close therapeutic monitoring of cysteamine, the only available disease-modifying treatment, is recommended. White blood cell cystine concentration is the current gold standard for therapeutic monitoring, but the assay is technically demanding and is available only on a limited basis. Because macrophage-mediated inflammation plays an important role in the pathogenesis of cystinosis, biomarkers of macrophage activation could have potential for the therapeutic monitoring of cystinosis.

METHODS: We conducted a 2-year prospective, longitudinal study in which 61 patients with cystinosis who were receiving cysteamine therapy were recruited from three European reference centers. Each regular care visit included measuring four biomarkers of macrophage activation: IL-1, IL-6, IL-18, and chitotriosidase enzyme activity.

RESULTS: A multivariate linear regression analysis of the longitudinal data for 57 analyzable patients found chitotriosidase enzyme activity and IL-6 to be significant independent predictors for white blood cell cystine levels in patients of all ages with cystinosis; a receiver operating characteristic analysis ranked chitotriosidase as superior to IL-6 in distinguishing good from poor therapeutic control (on the basis of white blood cell cystine levels of <2 nmol 1/2 cystine/mg protein or ≥2 nmol 1/2 cystine/mg protein, respectively). Moreover, in patients with at least one extrarenal complication, chitotriosidase significantly correlated with the number of extrarenal complications and was superior to white blood cell cystine levels in predicting the presence of multiple extrarenal complications.

CONCLUSIONS: Chitotriosidase enzyme activity holds promise as a biomarker for use in therapeutic monitoring of nephropathic cystinosis.

Abdelnaeem, A. O., R. Vining, and A. Rehan Youssef, "Classification of pregnancy related non-specific low back pain and pelvic girdle pain: a systematic review", Physical Therapy Reviews, vol. 24, issue 3-4, pp. 156 - 174, 2019. AbstractWebsite
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DeVore, A. E., J. L. Jorizzo, N. Vigneswaran, B. K. Rodu, S. Onal, S. C. Foster, S. K. Frankel, M. I. Schwarz, S. J. Oh, G. Ragab, et al., "Clinical manifestations common to vasculitis", Vasculitis: Oxford University Press, pp. 115, 2007. Abstract
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DeVore, A. E., J. L. Jorizzo, N. Vigneswaran, B. K. Rodu, S. Onal, S. C. Foster, S. K. Frankel, M. I. Schwarz, S. J. Oh, and G. Ragab, "Clinical manifestations common to vasculitis", Vasculitis: Oxford University Press, pp. 115, 2007. Abstract
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Khayyal, M. T., M. A. El-Ghazaly, A. S. el-Khatib, A. M. Hatem, P. J. F. de Vries, S. el-Shafei, and M. M. Khattab, "A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients", Fundamental & clinical pharmacology, vol. 17, no. 1: Wiley Online Library, pp. 93–102, 2003. Abstract
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Khayyal, M. T., M. A. El-Ghazaly, A. S. el-Khatib, A. M. Hatem, P. J. F. de Vries, S. el-Shafei, and M. M. Khattab, "A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients.", Fundamental & clinical pharmacology, vol. 17, issue 1, pp. 93-102, 2003 Feb. Abstract

The aqueous extract of propolis has been formulated as a nutritional food product and administered, as an adjuvant to therapy, to patients with mild to moderate asthma daily for 2 months in the framework of a comparative clinical study in parallel with a placebo preparation. The diagnosis of asthma was made according to the criteria of patient classification of the National Institutes of Health and Global Initiative for Asthma Management. At inclusion, the pulmonary forced expiratory volume in the first second (FEV1) as a percentage of the forced vital capacity (FVC) was more than 80% in mild persistent cases, and between 60 and 80% in moderate persistent cases, showing an increase in the degree of reversibility of > 15% in FEV1. All patients were on oral theophylline as controller therapy, none was receiving oral or inhaled corticosteroids, none had other comorbidities necessitating medical treatment, and all were from a middle-class community and had suffered from asthma for the last 2-5 years. Twenty-four patients received the placebo, with one drop-out during the study, while 22 received the propolis extract, with no drop-outs. The age range of the patients was 19-52 years; 36 were male and 10 female. The number of nocturnal attacks was recorded on a weekly basis, while pulmonary function tests were performed on all patients at the beginning of the trial, 1 month later and at the termination of the trial. Immunological parameters, including various cytokines and eicosanoids known to play a role in asthma, were measured in all patients at the beginning of the trial and 2 months later. Analysis of the results at the end of the clinical study revealed that patients receiving propolis showed a marked reduction in the incidence and severity of nocturnal attacks and improvement of ventilatory functions. The number of nocturnal attacks dropped from an average of 2.5 attacks per week to only 1. The improvement in pulmonary functions was manifested as a nearly 19% increase in FVC, a 29.5% increase in FEV1, a 30% increase in peak expiratory flow rate (PEFR), and a 41% increase in the forced expiratory flow rate between 25 and 75% of the vital capacity (FEF25-75). The clinical improvement was associated with decreases by 52, 65, 44 and 30%, respectively, of initial values for the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, ICAM-1, interleukin (IL)-6 and IL-8, and a 3-fold increase in the 'protective' cytokine IL-10. The levels of prostaglandins E2 and F2alpha and leukotriene D4 were decreased significantly to 36, 39, and 28%, respectively, of initial values. Patients on the placebo preparation showed no significant improvement in ventilatory functions or in the levels of mediators. The findings suggest that the aqueous propolis extract tested is potentially effective as an adjuvant to therapy in asthmatic patients. The benefits may be related to the presence in the extract of caffeic acid derivatives and other active constituents.

Khayyal, M. T., M. A. El-Ghazaly, A. S. el-Khatib, A. M. Hatem, P. J. F. de Vries, S. el-Shafei, and M. M. Khattab, "A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients.", Fundamental & clinical pharmacology, vol. 17, issue 1, pp. 93-102, 2003 Feb. Abstract

The aqueous extract of propolis has been formulated as a nutritional food product and administered, as an adjuvant to therapy, to patients with mild to moderate asthma daily for 2 months in the framework of a comparative clinical study in parallel with a placebo preparation. The diagnosis of asthma was made according to the criteria of patient classification of the National Institutes of Health and Global Initiative for Asthma Management. At inclusion, the pulmonary forced expiratory volume in the first second (FEV1) as a percentage of the forced vital capacity (FVC) was more than 80% in mild persistent cases, and between 60 and 80% in moderate persistent cases, showing an increase in the degree of reversibility of > 15% in FEV1. All patients were on oral theophylline as controller therapy, none was receiving oral or inhaled corticosteroids, none had other comorbidities necessitating medical treatment, and all were from a middle-class community and had suffered from asthma for the last 2-5 years. Twenty-four patients received the placebo, with one drop-out during the study, while 22 received the propolis extract, with no drop-outs. The age range of the patients was 19-52 years; 36 were male and 10 female. The number of nocturnal attacks was recorded on a weekly basis, while pulmonary function tests were performed on all patients at the beginning of the trial, 1 month later and at the termination of the trial. Immunological parameters, including various cytokines and eicosanoids known to play a role in asthma, were measured in all patients at the beginning of the trial and 2 months later. Analysis of the results at the end of the clinical study revealed that patients receiving propolis showed a marked reduction in the incidence and severity of nocturnal attacks and improvement of ventilatory functions. The number of nocturnal attacks dropped from an average of 2.5 attacks per week to only 1. The improvement in pulmonary functions was manifested as a nearly 19% increase in FVC, a 29.5% increase in FEV1, a 30% increase in peak expiratory flow rate (PEFR), and a 41% increase in the forced expiratory flow rate between 25 and 75% of the vital capacity (FEF25-75). The clinical improvement was associated with decreases by 52, 65, 44 and 30%, respectively, of initial values for the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, ICAM-1, interleukin (IL)-6 and IL-8, and a 3-fold increase in the 'protective' cytokine IL-10. The levels of prostaglandins E2 and F2alpha and leukotriene D4 were decreased significantly to 36, 39, and 28%, respectively, of initial values. Patients on the placebo preparation showed no significant improvement in ventilatory functions or in the levels of mediators. The findings suggest that the aqueous propolis extract tested is potentially effective as an adjuvant to therapy in asthmatic patients. The benefits may be related to the presence in the extract of caffeic acid derivatives and other active constituents.

Emad-Eldin, S., O. Abdelaziz, M. Harth, Manar Hussein, N. - E. Nour-Eldin, and T. J. Vogl, "The clinical utility of FDG-PET/CT in follow up and restaging of breast cancer patients", EJRNM, vol. 44, pp. 937-943, 2013. the_clinical_utility_of_fdg-petct_in_follow_up_and_restaging_of_breast_cancer_patients.pdf
Canter, D., C. Long, A. Kutikov, E. Plimack, I. Saad, M. Oblaczynski, F. Zhu, R. Viterbo, D. Y. T. Chen, R. G. Uzzo, et al., "Clinicopathological outcomes after radical cystectomy for clinical T2 urothelial carcinoma: further evidence to support the use of neoadjuvant chemotherapy.", BJU international, vol. 107, issue 1, pp. 58-62, 2011 Jan. Abstract

OBJECTIVE: To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC).

PATIENTS AND METHODS: We identified 212 patients with cT2 tumours who underwent RC at our institution without NC. Pathological assessment of RC specimens was correlated with clinical stage. The impact of various clinicopathological factors on the outcome of patients with cT2 disease was analysed.

RESULTS: In total, 153/212 (73.2%) patients with cT2 bladder cancer had either pT3/T4 or pN+ tumours at RC. Moreover, only 58/153 (37.9%) of these patients received adjuvant chemotherapy. The median follow-up was 28 (months 0.6-107.5) (range). The 5-year recurrence-free survival and cancer-specific survival (CSS) was 56.5% and 59.5%, respectively. On multivariate analysis, increasing age (hazard ratio [HR] 1.04; P= 0.04), advanced pathological stage (HR 1.83; P= 0.02), and positive lymph nodes (HR 3.72; P= 0.001) were adversely associated with CSS, while receipt of adjuvant chemotherapy was protective of disease-specific mortality (HR 0.45; P= 0.04).

CONCLUSIONS: Pathological upstaging is prevalent and survival remains modest in patients with cT2 tumours treated with RC without NC. Unfortunately, only 40% of patients that had locally advanced and/or regionally metastatic disease received adjuvant treatment. These data further support the value of NC for patients with muscle-invasive bladder cancer, even in those with apparent clinically organ-confined tumours.

Morsy, M. M., J. L. Goodall, G. L. O'Neil, J. M. Sadler, D. Voce, G. Hassan, and C. Huxley, "A cloud-based flood warning system for forecasting impacts to transportation infrastructure systems", Environmental Modelling & Software, vol. 107, pp. 231-244, 2018.
Alfalah, S., W. M. I. Hassan, A. Verma, N. Al.-Hashimi, M. M. Khader, and R. Nekovei, "CO2 Reduction to Renewable Hydrocarbon Fuel—Mimicking Natural Photosynthesis", MRS ADVANCES, vol. 2, issue 55, pp. 3383-3388, 2017.
Vannozzi, A., D. C. J. Wong, J. Höll, I. Hmmam, J. T. Matus, J. Bogs, T. Ziegler, I. Dry, G. Barcaccia, and M. Lucchin, "Combinatorial regulation of stilbene synthase genes by WRKY and MYB transcription factors in grapevine", Vitis vinifera, pp. 1043–1059, 2018. Abstract

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Vannozzi, A., D. C. J. Wong, J. Höll, I. Hmmam, J. T. Matus, J. Bogs, T. Ziegler, I. Dry, G. Barcaccia, and M. Lucchin, "Combinatorial regulation of stilbene synthase genes by WRKY and MYB transcription factors in grapevine (Vitis vinifera L.)", Plant and Cell Physiology, vol. 59, issue 5, pp. 1043–1059, 2018.
Vannozzi, A., D. C. J. Wong, J. Höll, I. Hmmam, J. T. Matus, J. Bogs, T. Ziegler, I. Dry, G. Barcaccia, and M. Lucchin, "Combinatorial regulation of stilbene synthase genes by WRKY and MYB transcription factors in grapevine (Vitis vinifera L.)", Plant and Cell Physiology, vol. 59, no. 5: Oxford University Press, pp. 1043–1059, 2018. Abstract
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Chatrchyan, S., V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, E. Aguilo, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, et al., "Combined search for the quarks of a sequential fourth generation", Physical Review D - Particles, Fields, Gravitation and Cosmology, vol. 86, no. 11, 2012. AbstractWebsite
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Safir, F., N. Vu, L. F. Tadesse, K. Firouzi, N. Banaei, S. S. Jeffrey, A. A. E. Saleh, B. P. T. Khuri-Yakub, and J. A. Dionne, "Combining Acoustic Bioprinting with AI-Assisted Raman Spectroscopy for High-Throughput Identification of Bacteria in Blood.", Nano letters, vol. 23, issue 6, pp. 2065-2073, 2023. Abstract

Identifying pathogens in complex samples such as blood, urine, and wastewater is critical to detect infection and inform optimal treatment. Surface-enhanced Raman spectroscopy (SERS) and machine learning (ML) can distinguish among multiple pathogen species, but processing complex fluid samples to sensitively and specifically detect pathogens remains an outstanding challenge. Here, we develop an acoustic bioprinter to digitize samples into millions of droplets, each containing just a few cells, which are identified with SERS and ML. We demonstrate rapid printing of 2 pL droplets from solutions containing , , and blood; when they are mixed with gold nanorods (GNRs), SERS enhancements of up to 1500× are achieved.We then train a ML model and achieve ≥99% classification accuracy from cellularly pure samples and ≥87% accuracy from cellularly mixed samples. We also obtain ≥90% accuracy from droplets with pathogen:blood cell ratios <1. Our combined bioprinting and SERS platform could accelerate rapid, sensitive pathogen detection in clinical, environmental, and industrial settings.

Lefrant, J. - Y., D. Benhamou, M. - O. Fischer, R. Pirracchio, B. Allaouchiche, S. Bastide, M. Biais, A. Blet, L. Bouvet, O. Brissaud, et al., "Comments on: Reducing the Risks of Nuclear War-The Role of Health Professionals.", Anaesthesia, critical care & pain medicine, pp. 101314, 2023.
Elbendary, A., M. Vldebran, C. M. Blattner, S. Velasquez, D. Yaich, J. YoungII, and D. M. Elston, "Common and Dangerous Skin Infections", Current Dermatology Reports, vol. 5, issue 1, pp. 30-41, 2016.
Vosoughi, A., T. Zhang, K. S. Shohdy, P. J. Vlachostergios, D. C. Wilkes, B. Bhinder, S. T. Tagawa, D. M. Nanus, A. M. Molina, H. Beltran, et al., "Common germline-somatic variant interactions in advanced urothelial cancer", Nature Communications, vol. 11, issue 1, pp. 6195 - 6195, 2020/12//. Abstract

The prevalence and biological consequences of deleterious germline variants in urothelial cancer (UC) are not fully characterized. We performed whole-exome sequencing (WES) of germline DNA and 157 primary and metastatic tumors from 80 UC patients. We developed a computational framework for identifying putative deleterious germline variants (pDGVs) from WES data. Here, we show that UC patients harbor a high prevalence of pDGVs that truncate tumor suppressor proteins. Deepening somatic loss of heterozygosity in serial tumor samples is observed, suggesting a critical role for these pDGVs in tumor progression. Significant intra-patient heterogeneity in germline-somatic variant interactions results in divergent biological pathway alterations between primary and metastatic tumors. Our results characterize the spectrum of germline variants in UC and highlight their roles in shaping the natural history of the disease. These findings could have broad clinical implications for cancer patients.

Venghat, S., and et al, "Comparative evaluation of smear layer removal efficacy using QMIX 2in 1,Chistosan, Smear Clear and Glyde. (Prof. Emad Daif was a peer reviewer for this article).", British Journal of Medicine and Medical Research, vol. 13, issue 4, pp. 1-8, 2016.
Viana, M. V. C., H. Figueiredo, R. Ramos, L. C. Guimarães, F. L. Pereira, F. A. Dorella, S. A. K. Selim, M. Salaheldean, A. Silva, and A. R. Wattam, "Comparative genomic analysis between Corynebacterium pseudotuberculosis strains isolated from buffalo", PloS one, vol. 12, issue 4: Public Library of Science, pp. e0176347, 2017. Abstract
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Viana, M. V. C., H. Figueiredo, R. Ramos, L. C. Guimarães, F. L. Pereira, F. A. Dorella, S. A. K. Selim, M. Salaheldean, A. Silva, and A. R. Wattam, "Comparative genomic analysis between Corynebacterium pseudotuberculosis strains isolated from buffalo", PloS one, vol. 12, issue 4: Public Library of Science, pp. e0176347, 2017. Abstract
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