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Journal Article
Nascimento, M. M. F., L. Selbmann, S. Sharifynia, A. M. S. Al-Hatmi, H. Voglmayr, V. A. Vicente, S. Deng, A. Kargl, T. A. A. Moussa, H. S. Al-Zahrani, et al., "Arthrocladium, an unexpected human opportunist in Trichomeriaceae (Chaetothyriales)", Fungal biology: Elsevier, 2015. Abstract
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Rohaim, M. A., E. Clayton, I. Sahin, J. Vilela, M. E. Khalifa, M. Q. Al-Natour, M. Bayoumi, A. C. Poirier, M. Branavan, M. Tharmakulasingam, et al., "Artificial Intelligence-Assisted Loop Mediated Isothermal Amplification (ai-LAMP) for Rapid Detection of SARS-CoV-2", Viruses, vol. 12, pp. 972-990, 2020.
Kluyts, H. - L., Y. le Manach, D. M. Munlemvo, F. Madzimbamuto, A. Basenero, Y. Coulibaly, S. Rakotoarison, V. Gobin, A. L. Samateh, M. S. Chaibou, et al., The ASOS Surgical Risk Calculator: development and validation of a tool for identifying African surgical patients at risk of severe postoperative complications, , vol. 121, issue 6, pp. 1357 - 1363, 2018. AbstractWebsite

BackgroundThe African Surgical Outcomes Study (ASOS) showed that surgical patients in Africa have a mortality twice the global average. Existing risk assessment tools are not valid for use in this population because the pattern of risk for poor outcomes differs from high-income countries. The objective of this study was to derive and validate a simple, preoperative risk stratification tool to identify African surgical patients at risk for in-hospital postoperative mortality and severe complications.
Methods
ASOS was a 7-day prospective cohort study of adult patients undergoing surgery in Africa. The ASOS Surgical Risk Calculator was constructed with a multivariable logistic regression model for the outcome of in-hospital mortality and severe postoperative complications. The following preoperative risk factors were entered into the model; age, sex, smoking status, ASA physical status, preoperative chronic comorbid conditions, indication for surgery, urgency, severity, and type of surgery.
Results
The model was derived from 8799 patients from 168 African hospitals. The composite outcome of severe postoperative complications and death occurred in 423/8799 (4.8%) patients. The ASOS Surgical Risk Calculator includes the following risk factors: age, ASA physical status, indication for surgery, urgency, severity, and type of surgery. The model showed good discrimination with an area under the receiver operating characteristic curve of 0.805 and good calibration with c-statistic corrected for optimism of 0.784.
Conclusions
This simple preoperative risk calculator could be used to identify high-risk surgical patients in African hospitals and facilitate increased postoperative surveillance.
Clinical trial registration
NCT03044899.

Sharma;, D.;S. S. V., S.;A. K. V. Verma;, A. A. Abdelhadi;, and A. Hossain, "Assessment of agroeconomic indicators of Sesamum indicum L. as influenced by application of boron at different levels and plant growth stages", Molecules 2021, 26(21), 6699; https://doi.org/10.3390/molecules26216699, 2021.
Gohar, S. M., I. Dieset, N. E. Steen, R. H. Mørch, T. S. J. Vedal, E. J. Reponen, V. M. Steen, O. A. Andreassen, and I. Melle, "Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders.", Acta psychiatrica Scandinavica, vol. 139, issue 5, pp. 464-471, 2019. Abstract

OBJECTIVE: Associations between suicidality and lipid dysregulation are documented in mental illness, but the potential role of leptin remains unclear. We examined the association between leptin and suicidal behaviour in schizophrenia, together with the influence of other clinical and biological indices.

METHOD: We recruited a sample of 270 participants with schizophrenia spectrum diagnoses. Blood samples were analysed for leptin, while symptom severity was assessed by Positive and Negative Syndrome Scale (PANSS) and Inventory of Depressive Symptomatology (IDS-C). Patients' history of suicidal behaviour was categorized into three subgroups based on IDS-C suicide subscale: No suicidal behaviour, mild/moderate suicidal behaviour and severe suicidal behaviour with/without attempts.

RESULTS: Mild/moderate suicidal behaviour was present in 17.4% and severe suicidal behaviour in 34.8%. Both groups were significantly associated with female gender (OR = 6.0, P = 0.004; OR = 5.9, P = 0.001), lower leptin levels (OR = 0.4, P = 0.008; OR = 0.5, P = 0.008) and more severe depression (OR = 1.2, P < 0.001; OR = 1.1, P < 0.001) respectively. Smoking (OR = 2.6, P = 0.004), younger age of onset (OR = 0.9, P = 0.003) and less use of leptin-increasing medications (OR = 0.5, P = 0.031) were associated with severe/attempts group, while higher C-reactive protein CRP (OR = 1.3, P = 0.008) was associated with mild/moderate group.

CONCLUSION: Lower leptin levels were associated with higher severity of suicidal behaviour in schizophrenia.

Vivian H. Chu; Lawrence P. Park; Eugene Athan, F. D.; T. F.;;, C. L.; J. M.; D. M.; J. S.; C. M. W. Tribouilloy;, D. - M.; J. P.; N. F. لndez- H.; F. N.; H. M. Rizk;, and V. K.; E. G.; J. H.;M. H.; A. P. M. Wang;, "Association Between Surgical Indications, Operative Risk, and Clinical Outcome in Infective Endocarditis A Prospective Study From the International Collaboration on Endocarditis", Circulation, vol. 131, issue 131, pp. 131-140, 2015. circulation-2015-chu-131-40.pdf
Elbendary, A., M. Valdebran, S. Velasquez, J. Truong, D. J. Pravda, and E. Blochin, "Asymptomatic Soft Erythematous Dome Shaped Papule on the Chest: Challenge.", The American Journal of dermatopathology, vol. 39, issue 11, pp. e155, 2017 Nov.
Elbendary, A., M. Valdebran, S. Velasquez, J. Truong, D. J. Pravda, and E. Blochin, "Asymptomatic Soft Erythematous Dome-Shaped Papule on the Chest: Answer.", The American Journal of dermatopathology, vol. 39, issue 11, pp. 867-869, 2017 Nov.
Reponen, E. J., I. Dieset, M. Tesli, R. H. Mørch, M. Aas, T. S. J. Vedal, E. Haug, O. K. Drange, N. E. Steen, S. Hope, et al., "Atherogenic Lipid Ratios Related to Myeloperoxidase and C-Reactive Protein Levels in Psychotic Disorders.", Frontiers in psychiatry, vol. 11, pp. 672, 2020. Abstract

Background: Cardiovascular disease (CVD) is a major cause of premature death in patients with psychotic disorders, where dyslipidemia occurs frequently. In the pathogenesis of these serious mental disorders, a low-grade inflammation seems to be a possible contributor. Concurrently, systemic inflammation and its interplay with dyslipidemia is a central driver in the pathogenesis of CVD. We hypothesize that evaluation of atherogenic lipid ratios together with inflammatory markers reflecting different inflammatory pathways with relevance for atherogenesis, could give novel information on immune-related mechanisms involved in early CVD risk in patients with psychotic disorders.

Methods: As a measure for CVD risk we calculated atherogenic lipid ratios using established sex-specific cut-offs: Total cholesterol/high-density lipoprotein; HDL-c (TC/HDL) and triglyceride/HDL-c (TG/HDL) were evaluated in 571 schizophrenia (SCZ) and 247 bipolar disorder (BD) patients, and in 99 healthy controls (HC). In addition, as a measure of low-grade inflammation, we measured fasting plasma levels of nine stable atherogenic inflammatory markers in patients (SCZ, BD) and in HC. The elevated inflammatory markers and CVD risk in patients, as reflected by TC/HDL and TG/HDL, were further assessed in multivariable analyses adjusting for comorbid cardio-metabolic risk factors.

Results: A markedly higher proportion (26%-31%) of patients had increased TC/HDL and TG/HDL ratios compared with HC. Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and myeloperoxidase (MPO) were higher (p<0.05, p<0.001) in patients with psychotic disorders than in HC, and hs-CRP and MPO were independently associated with atherogenic lipid ratios in the multivariable analyses.

Conclusions: Our findings suggest that low-grade inflammation and abnormal neutrophil activation may cause increased CVD risk in patients with psychotic disorders. These mechanisms should be further examined to determine the potential for development of novel risk evaluation strategies.

Salehi, B., S. M. Ezzat, P. V. Fokou, S. Albayrak, S. Vlaisavljevic,, Jouini R, and et al, "Athyrium Plants - Review on Phytopharmacy Properties", Journal of Traditional and Complementary Medicine , vol. DOI.10.1016/j.jtcme.2018.09.001, 2018.
Elamein, M., H. Bower, C. Valderrama, D. Zedan, H. Rihawi, K. Almilaji, M. Abdelhafeez, N. Tabbal, N. Almhawish, S. Maes, et al., "Attacks against health care in Syria, 2015-16: results from a real-time reporting tool.", Lancet (London, England), vol. 390, issue 10109, pp. 2278-2286, 2017 Nov 18. Abstract

BACKGROUND: Collecting credible data on violence against health services, health workers, and patients in war zones is a massive challenge, but crucial to understanding the extent to which international humanitarian law is being breached. We describe a new system used mainly in areas of Syria with a substantial presence of armed opposition groups since November, 2015, to detect and verify attacks on health-care services and describe their effect.

METHODS: All Turkey health cluster organisations with a physical presence in Syria, either through deployed and locally employed staff, were asked to participate in the Monitoring Violence against Health Care (MVH) alert network. The Turkey hub of the health cluster, a UN-activated humanitarian health coordination body, received alerts from health cluster partners via WhatsApp and an anonymised online data-entry tool. Field staff were asked to seek further information by interviewing victims and other witnesses when possible. The MVH data team triangulated alerts to identify individual events and distributed a preliminary flash update of key information (location, type of service, modality of attack, deaths, and casualties) to partners, WHO, United Nations Office for the Coordination of Humanitarian Affairs, and donors. The team also received and entered alerts from several large non-health cluster organisations (known as external partners, who do their own information-gathering and verification processes before sharing their information). Each incident was then assessed in a stringent process of information-matching. Attacks were deemed to be verified if they were reported by a minimum of one health cluster partner and one external partner, and the majority of the key datapoints matched. Alerts that did not meet this standard were deemed to be unverified. Results were tabulated to describe attack occurrence and impact, disaggregated where possible by age, sex, and location.

FINDINGS: Between early November, 2015, and Dec 31 2016, 938 people were directly harmed in 402 incidents of violence against health care: 677 (72%) were wounded and 261 (28%) were killed. Most of the dead were adult males (68%), but the highest case fatality (39%) was seen in children aged younger than 5 years. 24% of attack victims were health workers. Around 44% of hospitals and 5% of all primary care clinics in mainly areas with a substantial presence of armed opposition groups experienced attacks. Aerial bombardment was the main form of attack. A third of health-care services were hit more than once. Services providing trauma care were attacked more than other services.

INTERPRETATION: The data system used in this study addressed double-counting, reduced the effect of potentially biased self-reports, and produced credible data from anonymous information. The MVH tool could be feasibly deployed in many conflict areas. Reliable data are essential to show how far warring parties have strayed from international law protecting health care in conflict and to effectively harness legal mechanisms to discourage future perpetrators.

FUNDING: None.

Vilela, J., M. A. Rohaim, and M. Munir, "Avian Orthoavulavirus Type-1 as Vaccine Vector against Respiratory Viral Pathogens in Animal and Human.", Vaccines, vol. 10, issue 2, 2022. Abstract

Avian orthoavulaviruses type-1 (AOaV-1) have recently transitioned from animal vaccine vector to a bona fide vaccine delivery vehicle in human. Owing to induction of robust innate and adaptive immune responses in mucus membranes in both birds and mammals, AOaVs offer an attractive vaccine against respiratory pathogens. The unique features of AOaVs include over 50 years of safety profile, stable expression of foreign genes, high infectivity rates in avian and mammalian hosts, broad host spectrum, limited possibility of recombination and lack of pre-existing immunity in humans. Additionally, AOaVs vectors allow the production of economical and high quantities of vaccine antigen in chicken embryonated eggs and several GMP-grade mammalian cell lines. In this review, we describe the biology of AOaVs and define protocols to manipulate AOaVs genomes in effectively designing vaccine vectors. We highlighted the potential and established portfolio of AOaV-based vaccines for multiple respiratory and non-respiratory viruses of veterinary and medical importance. We comment on the limitations of AOaV-based vaccines and propose mitigations strategies. The exploitation of AOaVs vectors is expanding at an exciting pace; thus, we have limited the scope to their use as vaccines against viral pathogens in both animals and humans.

Chatrchyan, S., V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, et al., "Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at √s NN=2.76TeV", Physical Review Letters, vol. 109, no. 2, 2012. AbstractWebsite
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Viscardi, R. M., A. A. Othman, H. E. Hassan, N. D. Eddington, E. Abebe, M. L. Terrin, D. A. Kaufman, and K. B. Waites, "Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose.", Antimicrobial agents and chemotherapy, vol. 57, issue 5, pp. 2127-33, 2013 May. AbstractWebsite

Ureaplasma respiratory tract colonization is associated with bronchopulmonary dysplasia (BPD) in preterm infants. Previously, we demonstrated that a single intravenous (i.v.) dose of azithromycin (10 mg/kg of body weight) is safe but inadequate to eradicate Ureaplasma spp. in preterm infants. We performed a nonrandomized, single-arm open-label study of the pharmacokinetics (PK) and safety of intravenous 20-mg/kg single-dose azithromycin in 13 mechanically ventilated neonates with a gestational age between 24 weeks 0 days and 28 weeks 6 days. Pharmacokinetic data from 25 neonates (12 dosed with 10 mg/kg i.v. and 13 dosed with 20 mg/kg i.v.) were analyzed using a population modeling approach. Using a two-compartment model with allometric scaling of parameters on body weight (WT), the population PK parameter estimates were as follows: clearance, 0.21 liter/h × WT(kg)(0.75) [WT(kg)(0.75) indicates that clearance was allometrically scaled on body weight (in kilograms) with a fixed exponent of 0.75]; intercompartmental clearance, 2.1 liters/h × WT(kg)(0.75); central volume of distribution (V), 1.97 liters × WT (kg); and peripheral V, 17.9 liters × WT (kg). There was no evidence of departure from dose proportionality in azithromycin exposure over the tested dose range. The calculated area under the concentration-time curve over 24 h in the steady state divided by the MIC90 (AUC24/MIC90) for the single dose of azithromycin (20 mg/kg) was 7.5 h. Simulations suggest that 20 mg/kg for 3 days will maintain azithromycin concentrations of >MIC50 of 1 μg/ml for this group of Ureaplasma isolates for ≥ 96 h after the first dose. Azithromycin was well tolerated with no drug-related adverse events. One of seven (14%) Ureaplasma-positive subjects and three of six (50%) Ureaplasma-negative subjects developed physiologic BPD. Ureaplasma was eradicated in all treated Ureaplasma-positive subjects. Simulations suggest that a multiple-dose regimen may be efficacious for microbial clearance, but the effect on BPD remains to be determined.

Seras, J., C. D{\'ıez-Gil, E. Vazquez, S. Krabbenborg, E. Rodr{\'ıguez-Carmona, J. L. Corchero, R. M. Ferraz, M. Cano-Sarabia, I. Ratera, N. Ventosa, et al., "Bacterially produced inclusion bodies as biocompatible materials for substrate-dependent mammalian cell proliferation", Journal of Biotechnology, vol. 150: Elsevier, pp. 434–435, 2010. Abstract
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Bouwman, J., W. Ludwig, Z. Awad, K. I. Oberg, G. W. Fuchs, E. F. Van Dishoeck, and H. Linnartz, "Band profiles and band strengths in mixed H2O: CO ices", arXiv preprint arXiv:0712.2137, 2007. Abstract
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Oing, C., P. Tennstedt, R. Simon, J. Volquardsen, K. Borgmann, C. Bokemeyer, C. Petersen, E. Dikomey, K. Rothkamm, and W. Y. Mansour, "BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy.", Cancer letters, vol. 423, pp. 60-70, 2018 06 01. Abstract

Here we report that BCL2 blocks DNA double strand break (DSB) repair via nonhomologous end-joining (NHEJ), through sequestration of KU80 protein outside the nucleus. We find that this effect is associated with a repair switch to the error-prone PARP1-dependent end-joining (PARP1-EJ). We present in-vitro proof-of-concept for therapeutic targeting of this switch using PARP inhibitor to specifically enhance the radiosensitivity of BCL2-overexpressing cells. Given its erroneous behavior, PARP1-EJ might allow for the accumulation of genetic alterations and tumor progression. Consistently, we report an inverse correlation between BCL2 expression and biochemical recurrence-free survival of 10.259 prostate cancer (PCa) patients who underwent primary radical-prostatectomy for localized disease. Further, we evaluated retrospectively the impact of BCL2 expression on clinical outcome of 1.426 PCa patients, who had been given salvage radiotherapy at relapse after radical prostatectomy. In line with its role in blocking NHEJ, BCL2 over-expressers showed significantly better response to salvage radiotherapy compared to low-expressers. Collectively, our findings identify BCL2 status in PCa as a putative predictor of (i) radiotherapy response and (ii) response to treatment with PARP inhibitor olaparib as a radiosensitizing agent.

Elfishawi, M., G. Mossallam, D. G. Augusto, G. Montero-Martin, H. de Bruin, L. Van de Pasch, P. J. Norman, E. Rozemuller, M. Fernandez-Vina, A. Abrudescu, et al., "Behçet disease, new insights in disease associations and manifestations: a next-generation sequencing study.", Clinical and experimental immunology, 2021. Abstract

Behçet disease is a multi-system disease associated with human leukocyte antigen (HLA) class I polymorphism. High-resolution next-generation sequencing (NGS) with haplotype analysis has not been performed previously for this disease. Sixty Egyptian patients diagnosed according to the International Study Group (ISG) criteria for Behçet disease and 160 healthy geographic and ethnic-matched controls were genotyped for HLA class I loci (HLA-A, B, C). For HLA class II loci (DRB1, DRB3/4/5, DQA1, DQB1, DPA1, DPB1), 40 control samples were genotyped. High-resolution HLA genotyping was performed using NGS and the results were analyzed. Clinical manifestations were oral ulcers (100%), genital ulcers (100%), eye (55%) and neurological (28%) and vascular involvement (35%). HLA-B*51:08 [odds ratio (OR) = 19·75, 95% confidence interval (CI) = 6·5-79; P < 0·0001], HLA-B*15:03 (OR = 12·15, 95% CI = 3·7-50·7; P < 0·0001), HLA-C*16:02 (OR = 6·53, 95% CI = 3-14; P < 0·0001), HLA-A*68:02 (OR = 3·14, 95% CI = 1·1-8·9; P < 0·01) were found to be associated with Behçet disease, as were HLA-DRB1*13:01 and HLA-DQB1*06:03 (OR = 3·39, 95% CI = 0·9-18·9; P = 0·04 for both). By contrast, HLA-A*03:01 (OR = 0·13, 95% CI = 0-0·8; P = 0·01) and HLA-DPB1*17:01 were found to be protective (OR = 0·27, 95% CI = 0·06-1·03; P = 0·02). We identified strong linkage disequilibrium between HLA-B*51:08 and C*16:02 and A*02:01 in a haplotype associated with Behçet disease. HLA-B*51:08 was significantly associated with legal blindness (OR = 2·98, 95% CI = 1·06-8·3; P = 0·01). In Egyptian Behçet patients, HLA-B*51:08 is the most common susceptibility allele and holds poor prognosis for eye involvement.

Adeola HA, N. A. G. M. F. S. M. H. A., B. A, V. R, V. A, V. D, K. D, M. V, R. MH, S. AA, and A. - D. MM, Bioactive compounds and their libraries: An insight into prospective phytotherapeutics approach for oral mucocutaneous cancers, , 2021.
Mohamed, M. E., Z. Al-Yacoub, and J. Vedakumar, "Biocatalytic desulfurization of thiophenic compounds and crude oil by newly isolated bacteria", Front. Microbiol., vol. 6, issue 112, pp. 1-12, 2015.
Salwa Hamdi, N. E., M. A. Verina Ishak, M. A. Sara Ahmed, and M. K. Mohamed Abd El-Ghany, "Biological Extraction, HPLC Quantification and Medical Applications of Astaxanthin Extracted from Crawfish “Procambarus clarkii” Exoskeleton By-Product", Biology, vol. 11, issue 1215, pp. 1-12, 2022.
Aloisi, G., M. Baudrand, C. Lécuyer, J. - M. Rouchy, R. D. Pancost, M. A. M. Aref, and V.Grossi, "Biomarker and isotope evidence for microbially-mediated carbonate formation from gypsum and petroleum hydrocarbons", Chemical Geology, vol. 347 , issue 6, pp. 199-207, 2013. biomarker_and_isotope_evidence_for_microbially-mediated_carbonate_formation_vol_347_p_199-207.pdf
D{'}Hooge, F., S. A. Elfeky, S. E. Flower, S. I. Pascu, A. T. A. Jenkins, J. M. H. Van Den Elsen, T. D. James, and J. S. Fossey, "Biotinylated boronic acid fluorophore conjugates: Quencher elimination strategy for imaging and saccharide detection", RSC Advances, vol. 2, no. 8, pp. 3274-3280, 2012. Abstract
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Elbendary, A., J. Griffin, M. Valdebran, and D. M. Elston, "Bluish gray hyperpigmentation on the face and neck.", Cutis, vol. 99, issue 3, pp. E13-E15, 2017 03.
Hezode, C., G. M. Hirschfield, W. Ghesquiere, W. Sievert, M. Rodriguez-Torres, S. D. Shafran, P. J. Thuluvath, H. A. Tatum, I. Waked, G. E. Esmat, et al., "BMS-790052, A NS5A REPLICATION COMPLEX INHIBITOR, COMBINED WITH PEGINTERFERON ALFA-2A AND RIBIVIRIN IN TREATMENT-NAIVE HCV-GENO-TYPE 1 OR 4 PATIENTS: PHASE 2B AI444010 STUDY INTERIM WEEK 12 RESULTS", HEPATOLOGY, vol. 54, no. 1, pp. 474A-475A, OCT, 2011. Abstract
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