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Journal Article
Mansour, A. M., A. G. Elnahry, K. Tripathy, R. E. Foster, C. - J. Mehanna, R. Vishal, C. Çavdarlı, A. Arrigo, and M. B. Parodi, "Analysis of optical coherence angiography in cystoid macular oedema associated with gyrate atrophy.", Eye (London, England), vol. 35, issue 6, pp. 1766-1774, 2021. Abstract

BACKGROUND: To evaluate the relationship between superficial, deep foveal avascular zone (FAZ) and foveal cyst areas in eyes with cystoid macular oedema (CMO) associated with gyrate atrophy of the choroid and retina (GA).

METHODS: This is a retrospective collaborative multicenter study of optical coherence tomography-angiography (OCTA) images in GA. Superficial and deep FAZ and foveal cyst were measured using Image J by two independent experts. Values were corrected for myopia magnification. These values were compared with age-matched controls from normative data.

RESULTS: Twenty-three eyes from 12 patients with GA and CMO were included in the study. The mean ± standard deviation age was 22 ± 19.7 years, mean Snellen spectacle-corrected visual acuity of 20/70 with mean myopia of 5.7 ± 4.1 dioptres. Qualitatively, no focal occlusion of superficial and deep capillary plexus was noted. Mean superficial FAZ area (0.484 ± 0.317 mm), deep FAZ area (0.626 ± 0.452 mm), and foveal cyst area (0.630 ± 0.503 mm) were significantly larger than superficial and deep FAZ areas in controls of same age range (p < 0.001). Macular cyst area correlated with superficial FAZ area (R = 0.59; p = 0.0057) and more strongly with deep FAZ area (R = 0.69; p < 0.001).

CONCLUSIONS: The superficial and deep FAZ area in GA-associated CMO were noted to be significantly larger than in controls. It seems that RPE dysfunction leads to foveal cyst enlargement displacing the capillary plexus with resultant enlarged superficial and deep FAZ area.

Mohamed, M., I. El-Sabagh, Y. Vashie, V. Jagrite, M. A. E. Salem, M. A. Al-Ramadan, A. M. Al-Ali, and S. Kumar, "Analysis of the beak and feather disease viral genome indicates evidence of multiple introduction events into Saudi Arabia", Virus Research, vol. 295, pp. 198279, 2021.
Salam, Z. A. -, V. Palleschi, and M.A.Harith, "Analytical and mathematical methods for revealing hidden details in ancient manuscripts and paintings: A review", journal of advanced researches, vol. 17, pp. 31-42, 2019.
Salam, Z. A. -, V. Palleschi, and M.A.Harith, "Analytical and mathematical methods for revealing hidden details in ancient manuscripts and paintings: A review", journal of advanced researches, vol. 17, pp. 31-42, 2019.
De Bisschop, J., P. Sergeant, A. Hemeida, H. Vansompel, and L. Dupre, "Analytical Model for Combined Study of Magnet Demagnetization and Eccentricity Defects in Axial Flux Permanent Magnet Synchronous Machines", IEEE Transactions on Magnetics: IEEE, 2017. Abstract

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De Bisschop, J., P. Sergeant, A. Hemeida, H. Vansompel, and L. Dupre, "Analytical Model for Combined Study of Magnet Demagnetization and Eccentricity Defects in Axial Flux Permanent Magnet Synchronous Machines", IEEE Transactions on Magnetics: IEEE, 2017. Abstract

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Chatrchyan, S., V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, et al., "Angular analysis and branching fraction measurement of the decay B0→K*0μ+μ-", Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy Physics, vol. 727, no. 1-3, pp. 77-100, 2013. AbstractWebsite
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Al-Souti, A., W. Gallardo, M. Claereboudt, O. Mahgoub, R. Mendoza, A. De Dois, C. Vazquez, E. Cruz, D. Ricque, C. Aguilera, et al., "Animal by-products-the case for recycling: Possibilities for profitable nutritional upgrading.", International Journal of Poultry Science, vol. 17, no. 8: orgz, pp. 143–151, 2001. Abstract
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Hoff, S., J. Halbritter, D. Epting, V. Frank, T. M. Nguyen, J. van Reeuwijk, C. Boehlke, C. Schell, T. Yasunaga, M. Helmstädter, et al., "ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3", Nature Genetics, vol. 45, issue 8, pp. 951–956, 2013. AbstractWebsite

Nephronophthisis is an autosomal recessive cystic kidney disease that leads to renal failure in childhood or adolescence. Most NPHP gene products form molecular networks. Here we identify ANKS6 as a new NPHP family member that connects NEK8 (NPHP9) to INVS (NPHP2) and NPHP3. We show that ANKS6 localizes to the proximal cilium and confirm its role in renal development through knockdown experiments in zebrafish and Xenopus laevis. We also identify six families with ANKS6 mutations affected by nephronophthisis, including severe cardiovascular abnormalities, liver fibrosis and situs inversus. The oxygen sensor HIF1AN hydroxylates ANKS6 and INVS and alters the composition of the ANKS6-INVS-NPHP3 module. Knockdown of Hif1an in Xenopus results in a phenotype that resembles loss of other NPHP proteins. Network analyses uncovered additional putative NPHP proteins and placed ANKS6 at the center of this NPHP module, explaining the overlapping disease manifestation caused by mutation in ANKS6, NEK8, INVS or NPHP3.

El-Amin, M., P. Virk, M. A. R. Elobeid, Z. M. Almarhoon, Z. K. Hassan, S. A. Omer, N. M. Merghani, M. H. Daghestani, and E. M. Al-Olayan, "Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats.", Pakistan journal of pharmaceutical sciences, vol. 26, issue 2, pp. 359-65, 2013. Abstract

Phytotherapy has a promising future in the management of diabetes, considered to be less toxic and free from side effects as compared to the use of synthetic drugs. The aim of the present study was to assess the antidiabetic possible of orally administered aqueous extracts of Murraya koenigii (ML) and Olea europaea (OL) leaves (100 and 200 mg/kg doses), in streptozotocin (70 mg/kg) induced diabetic rats. Metformin was used as a standard drug. Blood glucose, cholesterol, triglycerides, creatinine levels and body weight were estimated. ML and OL administration showed significant decrease (p>0.05) in cholesterol, triglyceride, and serum glucose levels (range 55.6%-64.6%) compared to the metformin (62.7%); however, there was no significant effect on body weight and serum creatinine. Our results suggest that both the ML and OL possess a potent antihyperglycemic and hypolipidemic effect, which may be due to the presence of antioxidants such as carbazole alkaloids and polyphenols.

Abderrazak, A., D. Couchie, D. F. Darweesh Mahmood, R. Elhage, C. Vindis, M. Laffargue, V. Matéo, B. Büchele, M. R. Ayala, M. El Gaafary, et al., "Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet.", Circulation, vol. 131, issue 12, pp. 1061-70, 2015 Mar 24. Abstract

BACKGROUND: This study was designed to evaluate the effect of arglabin on the NLRP3 inflammasome inhibition and atherosclerotic lesion in ApoE2Ki mice fed a high-fat Western-type diet.

METHODS AND RESULTS: Arglabin was purified, and its chemical identity was confirmed by mass spectrometry. It inhibited, in a concentration-dependent manner, interleukin (IL)-1β and IL-18, but not IL-6 and IL-12, production in lipopolysaccharide and cholesterol crystal-activated cultured mouse peritoneal macrophages, with a maximum effect at ≈50 nmol/L and EC50 values for both cytokines of ≈ 10 nmol/L. Lipopolysaccharide and cholesterol crystals did not induce IL-1β and IL-18 production in Nlrp3(-/-) macrophages. In addition, arglabin activated autophagy as evidenced by the increase in LC3-II protein. Intraperitoneal injection of arglabin (2.5 ng/g body weight twice daily for 13 weeks) into female ApoE2.Ki mice fed a high-fat diet resulted in a decreased IL-1β plasma level compared with vehicle-treated mice (5.2±1.0 versus 11.7±1.1 pg/mL). Surprisingly, arglabin also reduced plasma levels of total cholesterol and triglycerides to 41% and 42%, respectively. Moreover, arglabin oriented the proinflammatory M1 macrophages into the anti-inflammatory M2 phenotype in spleen and arterial lesions. Finally, arglabin treatment markedly reduced the median lesion areas in the sinus and whole aorta to 54% (P=0.02) and 41% (P=0.02), respectively.

CONCLUSIONS: Arglabin reduces inflammation and plasma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype in ApoE2.Ki mice fed a high-fat diet. Consequently, a marked reduction in atherosclerotic lesions was observed. Thus, arglabin may represent a promising new drug to treat inflammation and atherosclerosis.

Amin, R., B. Krammer, N. Abdel-Kader, T. Verwanger, and A. El-Ansary, "Antibacterial effect of some benzopyrone derivatives", European journal of medicinal chemistry, vol. 45, no. 1: Elsevier, pp. 372–378, 2010. Abstract
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Amin, R., B. Krammer, N. Abdel-Kader, T. Verwanger, and A. El-Ansary, "Antibacterial effect of some benzopyrone derivatives", European Journal of Medicinal Chemistry, vol. 45, pp. 372–378, 2010.
Amin, R., B. Krammer, N. Abdel-Kader, T. Verwanger, and A. El-Ansary, "Antibacterial effect of some benzopyrone derivatives", European journal of medicinal chemistry, vol. 45, no. 1: Elsevier Masson, pp. 372–378, 2010. Abstract
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Kaup, R. M., M. T. Khayyal, and E. J. Verspohl, "Antidiabetic effects of a standardized Egyptian rice bran extract.", Phytotherapy research : PTR, vol. 27, issue 2, pp. 264-71, 2013 Feb. Abstract

An extract was prepared from Egyptian stabilized rice bran and standardized to contain 2% γ-oryzanol in addition to its content of other bioactives, notably tocotrienol and policosanol. The standardized extract was found to have a concentration-dependent effect on insulin release in vitro, which, however, is not mediated by γ-tocotrienol in rice bran (detected by HPLC) as could have been expected. Policosanol and γ-oryzanol have insulinotropic effects. The in vitro data of rice bran directly translate into in vivo data of rats by using a glucose tolerance test (increase in plasma insulin). Tocotrienols are well known for their apoptotic effect on tumor cells; nevertheless, an attempt was made to study glucose uptake in HEP-G2 cells, which needs to induce an insulin-resistant state by TNF-α. The Egyptian rice bran extract has an antidiabetic effect. γ-Oryzanol, which is a possible precursor of the insulinotropic compound ferulic acid, is a candidate for this effect. Therefore, it is reasonable to assume that the prevalence of diabetes or at least a prediabetic (type 2) situation can be ameliorated by the investigated rice bran extract. The potential usefulness of the extract as a nutraceutical is currently undergoing more thorough investigations.

Kaup, R. M., M. T. Khayyal, and E. J. Verspohl, "Antidiabetic effects of a standardized Egyptian rice bran extract.", Phytotherapy research : PTR, vol. 27, issue 2, pp. 264-71, 2013 Feb. Abstract

An extract was prepared from Egyptian stabilized rice bran and standardized to contain 2% γ-oryzanol in addition to its content of other bioactives, notably tocotrienol and policosanol. The standardized extract was found to have a concentration-dependent effect on insulin release in vitro, which, however, is not mediated by γ-tocotrienol in rice bran (detected by HPLC) as could have been expected. Policosanol and γ-oryzanol have insulinotropic effects. The in vitro data of rice bran directly translate into in vivo data of rats by using a glucose tolerance test (increase in plasma insulin). Tocotrienols are well known for their apoptotic effect on tumor cells; nevertheless, an attempt was made to study glucose uptake in HEP-G2 cells, which needs to induce an insulin-resistant state by TNF-α. The Egyptian rice bran extract has an antidiabetic effect. γ-Oryzanol, which is a possible precursor of the insulinotropic compound ferulic acid, is a candidate for this effect. Therefore, it is reasonable to assume that the prevalence of diabetes or at least a prediabetic (type 2) situation can be ameliorated by the investigated rice bran extract. The potential usefulness of the extract as a nutraceutical is currently undergoing more thorough investigations.

Kaup, R. M., M. T. Khayyal, and E. J. Verspohl, "Antidiabetic effects of a standardized Egyptian rice bran extract.", Phytotherapy research : PTR, vol. 27, issue 2, pp. 264-71, 2013 Feb. Abstract

An extract was prepared from Egyptian stabilized rice bran and standardized to contain 2% γ-oryzanol in addition to its content of other bioactives, notably tocotrienol and policosanol. The standardized extract was found to have a concentration-dependent effect on insulin release in vitro, which, however, is not mediated by γ-tocotrienol in rice bran (detected by HPLC) as could have been expected. Policosanol and γ-oryzanol have insulinotropic effects. The in vitro data of rice bran directly translate into in vivo data of rats by using a glucose tolerance test (increase in plasma insulin). Tocotrienols are well known for their apoptotic effect on tumor cells; nevertheless, an attempt was made to study glucose uptake in HEP-G2 cells, which needs to induce an insulin-resistant state by TNF-α. The Egyptian rice bran extract has an antidiabetic effect. γ-Oryzanol, which is a possible precursor of the insulinotropic compound ferulic acid, is a candidate for this effect. Therefore, it is reasonable to assume that the prevalence of diabetes or at least a prediabetic (type 2) situation can be ameliorated by the investigated rice bran extract. The potential usefulness of the extract as a nutraceutical is currently undergoing more thorough investigations.

Hemeida, A., M. Taha, A. A. - E. Abdallh, H. Vansompel, L. Dupré, and P. Sergeant, "Applicability of fractional slot axial flux permanent magnet synchronous machines in the field weakening region", IEEE Transactions on Energy Conversion, vol. 32, issue 1: IEEE, pp. 111-121, 2017. Abstract
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Hemeida, A., M. Taha, A. A. - E. Abdallh, H. Vansompel, L. Dupré, and P. Sergeant, "Applicability of fractional slot axial flux permanent magnet synchronous machines in the field weakening region", IEEE Transactions on Energy Conversion, vol. 32, issue 1: IEEE, pp. 111-121, 2017. Abstract

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Hemeida, A., M. Taha, A. A. - E. Abdallh, H. Vansompel, L. Dupré, and P. Sergeant, "Applicability of fractional slot axial flux permanent magnet synchronous machines in the field weakening region", IEEE Transactions on Energy Conversion, vol. 32, no. 1: IEEE, pp. 111–121, 2017. Abstract
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Van Sciver, S. W., S. Breon, E. Canavan, B. Helvensteijn, and A. Khalil, "Applied Superconductivity Center, Madison, Wisconsin", Stability of Superconductors in Helium I and Helium II: Institut international du froid, pp. 75, 1981. Abstract
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Quirke, J. C. K., P. Rajasekaran, V. A. Sarpe, A. Sonousi, I. Osinnii, M. Gysin, K. Haldimann, Q. - J. Fang, D. Shcherbakov, S. N. Hobbie, et al., "Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant", Journal of the American Chemical Society, vol. 142, issue 1: American Chemical Society, pp. 530 - 544, 2020. AbstractWebsite

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Bragantini, I., R. Pirelli, M. Barbarino, A. Manzo, V. Vincenzo Zoppi, Hamdan, M., and Y. Abd el-Rahman, "The archaeological mission of “l’orientale” in the central-Eastern Desert of Egypt", Newsletter di Archeologia CISA,, vol. 4, pp. 47-156, 2013.
Gee, H. Y., P. Saisawat, S. Ashraf, T. W. Hurd, V. Vega-Warner, H. Fang, B. B. Beck, O. Gribouval, W. Zhou, K. A. Diaz, et al., "ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling", Journal of Clinical Investigation, vol. 123, issue 8, pp. 3243-53, 2013. AbstractWebsite

Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and -resistant (SRNS) variants. SRNS causes end-stage kidney disease, which cannot be cured. While the disease mechanisms of NS are not well understood, genetic mapping studies suggest a multitude of unknown single-gene causes. We combined homozygosity mapping with whole-exome resequencing and identified an ARHGDIA mutation that causes SRNS. We demonstrated that ARHGDIA is in a complex with RHO GTPases and is prominently expressed in podocytes of rat glomeruli. ARHGDIA mutations (R120X and G173V) from individuals with SRNS abrogated interaction with RHO GTPases and increased active GTP-bound RAC1 and CDC42, but not RHOA, indicating that RAC1 and CDC42 are more relevant to the pathogenesis of this SRNS variant than RHOA. Moreover, the mutations enhanced migration of cultured human podocytes; however, enhanced migration was reversed by treatment with RAC1 inhibitors. The nephrotic phenotype was recapitulated in arhgdia-deficient zebrafish. RAC1 inhibitors were partially effective in ameliorating arhgdia-associated defects. These findings identify a single-gene cause of NS and reveal that RHO GTPase signaling is a pathogenic mediator of SRNS.