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Veksler, D. B., A. V. Muravjov, Y. V. Kachorovskii, T. A. Elkhatib, K. N. Salama, X. - C. Zhang, and M. S. Shur, "Imaging of field-effect transistors by focused terahertz radiation", Solid-State Electronics, vol. 53, issue 6: Pergamon, pp. 571-573, 2009. Abstract
van der Velde, R., M. S. Salama, O. A. Eweys, J. Wen, and Q. Wang, "Soil Moisture Mapping Using Combined Active/Passive Microwave Observations Over the East of the Netherlands", JSTARS, vol. 8, issue 9, pp. 4355 - 4372, 2015. AbstractWebsite

A coarse resolution soil moisture product is downscaled to 1, 5, and 10 km using synthetic aperture radar (SAR) observations acquired over the east of the Netherlands. The combination of phased array L-band SAR (PALSAR) backscatter and VUA-NASA C-band Advanced Microwave Scanning Radiometer-Earth Observing System (AMSR-E) soil moisture product is adopted to mimic the radar/radiometer setup as will be available from NASA's soil moisture active passive (SMAP) mission. The validation of retrievals is based on measurements collected by a sparse network of 20 stations distributed across 50 × 75 km study area selected as one of the key validation sites for the SMAP soil moisture products. Reasonable agreements between the measurements and soil moisture retrieved at 1-, 5-, and 10-km resolution are found that lead to coefficients of determination of 0.37, 0.36, and 0.36, respectively. The retrievals, however, severely overestimate the measured soil moisture, which is attributed to the well-known positive bias of the selected AMSR-E product. After bias-correction, root mean squared differences reach as low as 0.046 m3 m-3 for individual locations and are 0.067, 0.068, and 0.069 m3 m-3 on average for the soil moisture retrieved at 1-, 5-, and 10-km resolutions, respectively. These error levels do not satisfy SMAP's targeted accuracy of 0.04 m3 m-3, but the radar/radiometer setup as well as the characterization of the soil moisture conditions representative are not optimal. On the other hand, it is demonstrated that the sequence of soil moisture maps does capture valuable hydrological and hydrometeorological information.

van der Velde, R., Z. Su, L. Dente, W. Jun, Y. Ma, K. Yang, and O. A. A. Mohamed, "Dragon soil moisture research on the Tib0etan Plateau : powerpoint.. 1s-24s", Abstract from ESA - MOST Dragon 2 symposium, Prague, Czech Republic, 20-24 June, 2011.
Veltink, P. H., H. J. Chizeck, P. E. Crago, and A. El-Bialy, "Nonlinear joint angle control for artificially stimulated muscle", IEEE Transactions on biomedical engineering, vol. 39, no. 4: IEEE, pp. 368–380, 1992. Abstract
Veltink, P. H., A. El-Bialy, H. J. Chizeck, and P. E. Crago, "Nonlinear control of an artificially stimulated muscle-skeleton-load system", Publ by Alliance for Engineering in Medicine & Biology, 1989. Abstract
van der Ven, A. T., B. Kobbe, S. Kohl, S. Shril, H. - M. Pogoda, T. Imhof, H. Ityel, A. Vivante, J. Chen, D. - Y. Hwang, et al., "A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux.", PloS one, vol. 13, issue 1, pp. e0191224, 2018. Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause (40-50%) of chronic kidney disease (CKD) in children. About 40 monogenic causes of CAKUT have so far been discovered. To date less than 20% of CAKUT cases can be explained by mutations in these 40 genes. To identify additional monogenic causes of CAKUT, we performed whole exome sequencing (WES) and homozygosity mapping (HM) in a patient with CAKUT from Indian origin and consanguineous descent. We identified a homozygous missense mutation (c.1336C>T, p.Arg446Cys) in the gene Von Willebrand factor A domain containing 2 (VWA2). With immunohistochemistry studies on kidneys of newborn (P1) mice, we show that Vwa2 and Fraser extracellular matrix complex subunit 1 (Fras1) co-localize in the nephrogenic zone of the renal cortex. We identified a pronounced expression of Vwa2 in the basement membrane of the ureteric bud (UB) and derivatives of the metanephric mesenchyme (MM). By applying in vitro assays, we demonstrate that the Arg446Cys mutation decreases translocation of monomeric VWA2 protein and increases translocation of aggregated VWA2 protein into the extracellular space. This is potentially due to the additional, unpaired cysteine residue in the mutated protein that is used for intermolecular disulfide bond formation. VWA2 is a known, direct interactor of FRAS1 of the Fraser-Complex (FC). FC-encoding genes and interacting proteins have previously been implicated in the pathogenesis of syndromic and/or isolated CAKUT phenotypes in humans. VWA2 therefore constitutes a very strong candidate in the search for novel CAKUT-causing genes. Our results from in vitro experiments indicate a dose-dependent neomorphic effect of the Arg446Cys homozygous mutation in VWA2.

van der Ven, A. T., D. M. Connaughton, H. Ityel, N. Mann, M. Nakayama, J. Chen, A. Vivante, D. - Y. Hwang, J. Schulz, D. A. Braun, et al., "Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract.", Journal of the American Society of Nephrology : JASN, vol. 29, issue 9, pp. 2348-2361, 2018 Sep. Abstract

BACKGROUND: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most prevalent cause of kidney disease in the first three decades of life. Previous gene panel studies showed monogenic causation in up to 12% of patients with CAKUT.

METHODS: We applied whole-exome sequencing to analyze the genotypes of individuals from 232 families with CAKUT, evaluating for mutations in single genes known to cause human CAKUT and genes known to cause CAKUT in mice. In consanguineous or multiplex families, we additionally performed a search for novel monogenic causes of CAKUT.

RESULTS: In 29 families (13%), we detected a causative mutation in a known gene for isolated or syndromic CAKUT that sufficiently explained the patient's CAKUT phenotype. In three families (1%), we detected a mutation in a gene reported to cause a phenocopy of CAKUT. In 15 of 155 families with isolated CAKUT, we detected deleterious mutations in syndromic CAKUT genes. Our additional search for novel monogenic causes of CAKUT in consanguineous and multiplex families revealed a potential single, novel monogenic CAKUT gene in 19 of 232 families (8%).

CONCLUSIONS: We identified monogenic mutations in a known human CAKUT gene or CAKUT phenocopy gene as the cause of disease in 14% of the CAKUT families in this study. Whole-exome sequencing provides an etiologic diagnosis in a high fraction of patients with CAKUT and will provide a new basis for the mechanistic understanding of CAKUT.

Venghat, S., and et al, "Comparative evaluation of smear layer removal efficacy using QMIX 2in 1,Chistosan, Smear Clear and Glyde. (Prof. Emad Daif was a peer reviewer for this article).", British Journal of Medicine and Medical Research, vol. 13, issue 4, pp. 1-8, 2016.
Verma, A., and M. SA, "The Impact of Covid-19 on Mental Health in Allied Health Undergraduate Students during Lockdown Phase: An Observational Study", Psychology & Psychological Research International Journal, vol. 5, issue 3, pp. 1-9, 2020. research.pdf
Verma, A. R., V. M. Patel, S. Mikhail, and E. Zacharakis, "An unusual presentation of late oesophagojejunal anastomotic leak after total D2 gastrectomy.", Annals of the Royal College of Surgeons of England, vol. 94, issue 2, pp. e106-8, 2012 Mar. Abstract

Oesophagojejunal anastomotic leak usually presents in the early post-operative period with abdominal pain and sepsis. We report a case of late anastomotic leak presenting as epigastric pain with hyperamylasaemia and discuss the differential diagnosis.

Veronica Strong, Sergey Dubin, M. E. - K. F., and B. W. R. K. H. B. Andrew Lech, Yue Wang, "Patterning and Electronic Tuning of Laser Scribed Graphene for Flexible All-Carbon Devices", ACS Nano, vol. 6, pp. 1395-1403, 2012. acs_nano-2012.pdf
Verri, V., G. G. Gentili, A. Radwan, M. D'Amico, and A. V. Raisanen, "Reconfigurable high impedance surface with graphene", Antennas & Propagation Conference (LAPC), 2016 Loughborough: IEEE, pp. 1–4, 2016. Abstract
Veshkini, A., A. Mohammadi-Sangcheshmeh, N. Ghanem, A. H. Abazari-kia, E. Mottaghi, R. Kamaledini, H. Deldar, I. Ozturk, and E. L. Gastal, "Oocyte maturation with royal jelly increases embryo development and reduces apoptosis in goats", Animal. Reproduction, vol. 15, issue 2, pp. 124-134, 2018.
Veys, K. R., M. A. Elmonem, F. O. Arcolino, L. van den Heuvel, and E. Levtchenko, "Nephropathic cystinosis: an update.", Current opinion in pediatrics, 2017 Jan 18. Abstract

PURPOSE OF REVIEW: Over the past few decades, cystinosis, a rare lysosomal storage disorder, has evolved into a treatable metabolic disease. The increasing understanding of its pathophysiology has made cystinosis a prototype disease, delivering new insights into several fundamental biochemical and cellular processes.

RECENT FINDINGS: In this review, we aim to provide an overview of the latest advances in the pathogenetic, clinical, and therapeutic aspects of cystinosis.

SUMMARY: The development of alternative therapeutic monitoring strategies and new systemic and ocular cysteamine formulations might improve outcome of cystinosis patients in the near future. With the dawn of stem cell based therapy and new emerging gene-editing technologies, novel tools have become available in the search for a cure for cystinosis.

Veys, K. R. P., M. A. Elmonem, M. van Dyck, M. C. Janssen, E. A. M. Cornelissen, K. Hohenfellner, G. Prencipe, L. P. van den Heuvel, and E. Levtchenko, "Chitotriosidase as a Novel Biomarker for Therapeutic Monitoring of Nephropathic Cystinosis.", Journal of the American Society of Nephrology : JASN, 2020 Apr 09. Abstract

BACKGROUND: Nephropathic cystinosis, a hereditary lysosomal storage disorder caused by dysfunction of the lysosomal cotransporter cystinosin, leads to cystine accumulation and cellular damage in various organs, particularly in the kidney. Close therapeutic monitoring of cysteamine, the only available disease-modifying treatment, is recommended. White blood cell cystine concentration is the current gold standard for therapeutic monitoring, but the assay is technically demanding and is available only on a limited basis. Because macrophage-mediated inflammation plays an important role in the pathogenesis of cystinosis, biomarkers of macrophage activation could have potential for the therapeutic monitoring of cystinosis.

METHODS: We conducted a 2-year prospective, longitudinal study in which 61 patients with cystinosis who were receiving cysteamine therapy were recruited from three European reference centers. Each regular care visit included measuring four biomarkers of macrophage activation: IL-1, IL-6, IL-18, and chitotriosidase enzyme activity.

RESULTS: A multivariate linear regression analysis of the longitudinal data for 57 analyzable patients found chitotriosidase enzyme activity and IL-6 to be significant independent predictors for white blood cell cystine levels in patients of all ages with cystinosis; a receiver operating characteristic analysis ranked chitotriosidase as superior to IL-6 in distinguishing good from poor therapeutic control (on the basis of white blood cell cystine levels of <2 nmol 1/2 cystine/mg protein or ≥2 nmol 1/2 cystine/mg protein, respectively). Moreover, in patients with at least one extrarenal complication, chitotriosidase significantly correlated with the number of extrarenal complications and was superior to white blood cell cystine levels in predicting the presence of multiple extrarenal complications.

CONCLUSIONS: Chitotriosidase enzyme activity holds promise as a biomarker for use in therapeutic monitoring of nephropathic cystinosis.

Veys, K. R. P., M. A. Elmonem, F. Dhaenens, M. van Dyck, M. M. C. H. Janssen, E. A. M. Cornelissen, K. Hohenfellner, A. Reda, P. Quatresooz, B. van den Heuvel, et al., "Enhanced Intrinsic Skin Aging in Nephropathic Cystinosis Assessed by High-Definition Optical Coherence Tomography.", The Journal of investigative dermatology, 2019 Apr 22. Abstract
Vialykh, E. A., S. A. Ilarionov, H. M. Abdelrahman, and I. A. Vialykh, "Changes in Amino Acids Content in Humic Acids Repetitively Extracted From Peat And Sod-Podzolic Soils", Canadian Journal of Soil Science, vol. 94, issue 5, pp. 575-583, 2014. AbstractWebsite

Amino acids (AAs) and peptides are thought to be part of humic acids (HAs) but debate whether they are an integral part of the HAs is still going. Humic acids sequentially extracted from peat and sod-podzolic soil were analyzed for their AAs content, elemental composition and by FTIR spectroscopy. Extracted HAs were hydrolyzed in 6 M HCl for 16 h for AAs release, which was detected by capillary electrophoresis system. Alanine, arginine, sum of aspartic acid and asparagine, sum of cysteic acid and cysteine, sum of glutamic acid and glutamine, glycine, histidine, leucine and isoleucine, lysine, methionine, phenylalanine, proline, serine, threonine, tyrosine, valine were identified. The total content of hydrolysable AAs in sod-podzol HAs increased by 6.2–8.2% with increasing the extraction cycles while an inverse tendency was observed for AAs released from peat HAs. Moreover, individual AAs expressed as percentages of total AAs were constant values with coefficients of variation lower than 20% for the studied HAs.

Viana, M. V. C., H. Figueiredo, R. Ramos, L. C. Guimarães, F. L. Pereira, F. A. Dorella, S. A. K. Selim, M. Salaheldean, A. Silva, and A. R. Wattam, "Comparative genomic analysis between Corynebacterium pseudotuberculosis strains isolated from buffalo", PloS one, vol. 12, issue 4: Public Library of Science, pp. e0176347, 2017. Abstract
Viana, M. V. C., H. Figueiredo, R. Ramos, L. C. Guimarães, F. L. Pereira, F. A. Dorella, S. A. K. Selim, M. Salaheldean, A. Silva, and A. R. Wattam, "Comparative genomic analysis between Corynebacterium pseudotuberculosis strains isolated from buffalo", PloS one, vol. 12, issue 4: Public Library of Science, pp. e0176347, 2017. Abstract
Vichinsky, E., A. El-Beshlawy, A. Al Zoebie, A. Kamdem, S. Koussa, T. Chotsampancharoen, A. Bruederle, G. Gilotti, J. Han, and M. Elalfy, "Long-term safety and efficacy of deferasirox in young pediatric patients with transfusional hemosiderosis: Results from a 5-year observational study (ENTRUST).", Pediatric blood & cancer, vol. 64, issue 9, 2017 Sep. Abstract

BACKGROUND: Children with red blood cell disorders may receive regular transfusions from an early age and consequently accumulate iron. Adequate iron chelation therapy can prevent organ damage and delayed growth/development. Deferasirox is indicated for treatment of pediatric patients with chronic iron overload due to transfusional hemosiderosis; however, fewer than 10% of patients in the registration studies were aged 2 to less than 6 years.

PROCEDURE: Deferasirox, a once-daily oral iron chelator, was evaluated in young pediatric patients with transfusional hemosiderosis during the observational 5-year ENTRUST study. Patients aged 2 to less than 6 years at enrollment received deferasirox according to local prescribing information, with the primary objective of evaluating safety, specifically renal and hepatic function. Serum ferritin was observed as a surrogate efficacy parameter.

RESULTS: In total, 267 patients (mean age 3.2 years) predominantly with β-thalassemia (n = 176, 65.9%) were enrolled. Mean ± standard deviation deferasirox dose was 25.8 ± 6.5 mg/kg per day over a median of 59.9 months. A total of 145 patients (54.3%) completed 5 years' treatment. The proportion of patients with two or more consecutive postbaseline measurements (≥7 days apart) of serum creatinine higher than age-adjusted upper limit of normal (ULN) and alanine aminotransferase more than five times the ULN was 4.4% (95% confidence interval [CI]: 2.1-7.9) and 4.0% (95% CI: 1.8-7.4), respectively. Median serum ferritin decreased from 1,702 ng/ml at baseline to 1,127 ng/ml at 5 years. There were no new safety signals.

CONCLUSIONS: Safety and efficacy of deferasirox in young pediatric patients in this long-term, observational study in everyday clinical practice were consistent with the known deferasirox profile.

Victor, B. C., A. Anbalagan, M. M. Mohamed, B. F. Sloane, and D. Cavallo-Medved, "Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion", Breast Cancer Res, vol. 13, pp. R115, 2011.
Victor, B. C., A. Anbalagan, M. M. Mohamed, B. F. Sloane, and D. Cavallo-Medved, "Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion", Breast Cancer Research, 2011. Abstract

Introduction: Inflammatory breast cancer (IBC) is an aggressive, metastatic and highly angiogenic form of locally advanced breast cancer with a relatively poor three-year survival rate. Breast cancer invasion has been linked to proteolytic activity at the tumor cell surface. Here we explored a role for active cathepsin B on the cell surface in the invasiveness of IBC.

Victoria, S., H. Amaral, I. Mulamitsi, S. Bhatnagar, H. Moustafa, H. Kartunihardja, F. Sundram, and K. Britton, "CRF on in vivo imaging for infection (sepsis) and inflammation", European Congress Nuclear Medicine, Berlin, 29 Aug- 4 Sept, Submitted.
Vighi, M., P. Gramatica, F. Consolaro, R. Todeschini, F. AylloHn, E. Garcia-Vazquez, J. C. Brodeur, F. Økland, B. Finstad, and G. D. Dixon, Papers to Appear in, , 2001. Abstract