Export 132 results:
Sort by: [ Author  (Asc)] Title Type Year
A B C D E F G H I J K L M N O P Q R S T U [V] W X Y Z   [Show ALL]
Fayed, A., M. M. El Nokeety, A. A. Heikal, D. O. Abdulazim, M. M. Naguib, and U. A. A. S. E. Din, "Fibroblast growth factor-23 is a strong predictor of insulin resistance among chronic kidney disease patients.", Renal failure, vol. 40, issue 1, pp. 226-230, 2018 Nov. Abstract

Insulin resistance (IR) is very common among chronic kidney disease (CKD) patients. Disturbance in mineral and bone metabolism (MBD) seems to play a role in the pathogenesis of insulin resistance. Fibroblast growth factor-23 (FGF23) is evolving as the most important link between MBD and many pathologic sequences of CKD. The aim was to evaluate IR in pre-dialysis CKD patients looking for a possible association to mineral metabolism among CKD patients. A total of 100 stage 3-5 CKD patients were selected beside 20 normal control subjects. Homeostatic model assessment of insulin resistance (HOMA-IR) was used to assess IR in selected cases. Both groups were compared for fasting blood glucose (FBG), fasting blood insulin (FBI), HOMA-IR, estimated glomerular filtration rate (eGFR), serum calcium (Ca), phosphorus (P), 25 hydroxy vitamin D (25 OH vit D), parathormone (PTH), and uric acid (UA). Correlation study between HOMA_IR and different studied parameters was performed. HOMA-IR is significantly higher in CKD (8.87 ± 3.48 vs. 3.97 ± 0.34 in CKD vs. control, respectively, p < .001). In addition CKD patients have significantly higher FGF23 (235 ± 22.96 vs. 139 ± 12.3 pg/mL, p < .001), PTH (76.9 ± 15.27 vs. 47.9 ± 2.52 pg/mL, p < .001), P (4.3 ± 0.67 vs. 3.6 ± 0.23 mg/dL, p < .001), and UA (5 ± 1.22 vs. 4.85 ± 0.48 mg/dL, p < .001) and significantly lower Ca (8.2 ± 0.3 vs. 8.9 ± 0.33 mg/dL, p < .001), and 25 (OH) vit D (17 ± 5.63 vs. 37 ± 3.43 ng/mL, p < .001). Stepwise linear regression analysis revealed that BMI, GFR, Ca, P, and FGF23 were the only significant predictors of HOMA IR. Increased IR in CKD is a consequence of the uremic status and is intimately associated with disturbed phosphate metabolism and FGF23. Further studies are needed to look for an underlying mechanism.

Fayed, A., M. M. El Nokeety, A. A. Heikal, K. Marzouk, H. Hammad, D. O. Abdulazim, M. M. Salem, and U. A. Sharaf El Din, "Serum 25-hydroxyvitamin D level is negatively associated with serum phosphorus level among stage 3a-5 chronic kidney disease patients.", Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2018 May 26. Abstract

BACKGROUND: Serum 25-hydroxyvitamin D (25(OH)D) negatively correlates with serum phosphorus level of stage 3a-5 chronic kidney disease (CKD) patients. So far, no explanation has been provided for this negative association.

OBJECTIVE: To confirm this negative association and determine if this relationship is mediated through other known co-morbid factors.

CASES AND METHODS: One hundred (57 male and 43 female) pre-dialysis stage 3a-5 CKD patients were selected. Estimated glomerular filtration rate (eGFR), serum calcium (Ca), phosphorus (P), 25(OH)D, parathyroid hormone (PTH), and intact fibroblast growth factor-23 (FGF23) were assessed. A correlation analysis between serum 25(OH)D and the different parameters studied was performed. Multivariate linear regression analysis was carried out to determine predictors of 25(OH)D.

RESULTS: The negative association between serum 25(OH)D and serum P was confirmed in univariate and multivariate correlation analysis. On the other hand, we failed to detect a significant association between 25(OH)D and serum FGF23. Serum P is the most important independent predictor of 25(OH)D in these patients (partial R=0.15, p<0.0001).

CONCLUSION: Serum P is likely to have a direct negative impact on serum 25(OH)D. Further studies are needed to determine the underlying mechanism.

Vaselli, M., M. A. Harith, V. Palleschi, G. Salvetti, and D. P. Singh, "Screening effect of impurities in metals: a possible explanation of the process of cold nuclear fusion", Il Nuovo Cimento D, vol. 11, no. 6: Springer, pp. 927–932, 1989. Abstract
Vassen, W., E. A. J. M. Bente, and W. Hogervorst, "CW laser excitation of the barium 6sng and 6snh Rydberg series from the metastable 6s5d 1.3 D and 5d2 1G4 states", Journal of Physics B: Atomic and Molecular Physics, vol. 20, no. 11: IOP Publishing, pp. 2383, 1987. Abstract
Vasso Apostolopoulos, Joanna Bojarska, T. - T. C. S. E., R. N. K. Krzysztof Kaczmarek, John Matsoukas, and K. K. E. M. S. I. T. Maha AlKhazindar, Vanessa Barriga, "A global review on short peptides: frontiers and perspectives", Molecules, vol. 26, issue 2, pp. 430-, 2021.
Vaupel, P. W., "The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia", Klinische Pädiatrie, vol. 209, issue 04: © Georg Thieme Verlag KG Stuttgart· New York, pp. 243-249, 1997. Abstract
Vavassori, S., J. Chou, L. E. Faletti, V. Haunerdinger, L. Opitz, P. Joset, C. J. Fraser, S. Prader, X. Gao, L. A. Schuch, et al., "Multisystem inflammation and susceptibility to viral infections in human ZNFX1 deficiency.", The Journal of allergy and clinical immunology, 2021. Abstract

BACKGROUND: Recognition of viral nucleic acids is one of the primary triggers for a type I interferon-mediated antiviral immune response. Inborn errors of type I interferon immunity can be associated with increased inflammation and/or increased susceptibility to viral infections as a result of dysbalanced interferon production. NFX1-type zinc finger-containing 1 (ZNFX1) is an interferon-stimulated double-stranded RNA sensor that restricts the replication of RNA viruses in mice. The role of ZNFX1 in the human immune response is not known.

OBJECTIVE: We studied 15 patients from 8 families with an autosomal recessive immunodeficiency characterized by severe infections by both RNA and DNA viruses and virally triggered inflammatory episodes with hemophagocytic lymphohistiocytosis-like disease, early-onset seizures, and renal and lung disease.

METHODS: Whole exome sequencing was performed on 13 patients from 8 families. We investigated the transcriptome, posttranscriptional regulation of interferon-stimulated genes (ISGs) and predisposition to viral infections in primary cells from patients and controls stimulated with synthetic double-stranded nucleic acids.

RESULTS: Deleterious homozygous and compound heterozygous ZNFX1 variants were identified in all 13 patients. Stimulation of patient-derived primary cells with synthetic double-stranded nucleic acids was associated with a deregulated pattern of expression of ISGs and alterations in the half-life of the mRNA of ISGs and also associated with poorer clearance of viral infections by monocytes.

CONCLUSION: ZNFX1 is an important regulator of the response to double-stranded nucleic acids stimuli following viral infections. ZNFX1 deficiency predisposes to severe viral infections and a multisystem inflammatory disease.

Vazhappilly CG, S. E, Ramadan W, Menon V, Al-Azawi AM, Tarazi H, Abdu-Allah H, El-Shorbagi AN, and E. - A. R., "Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types.", Invest New Drugs. 2019 , vol. 37(2), pp. 252-261, 2019. invest_new_drugs_1.pdf
Vázquez, H. C., S. Jäger, W. Wolter, M. Zschöck, M. A. C. Vázquez, and A. Elsayed, Genotyping of Staphylococcus aureus isolated from dairy herds in Mexico, , vol. 21, issue 4: Universidad del Zulia, pp. 308 - 316, 2011. Abstract
Vázquez, H. C., A. M. I. R. EL SAYED, S. Y. B. I. L. L. E. JAGER, A. L. B. E. R. JOACHIM, C. R. I. S. T. O. P. H. LAMMLER, and W. I. L. F. R. I. E. D. WOTER, Estudio comparativo de las características de Staphylococcus aureus aislados de casos de mastitis clínica y subclínica en México, , vol. 37, issue 002, 2009. Abstract
Veeramachaneni, C., and et al, "Retreatment efficacy of propoint and guttapercha- A cone beam computed tomography analysis. (Prof. Emad was a peer reviewer for this article).", British Journal of Medicine and Medical Research, In Press.
Veksler, D. B., A. V. Muraviev, T. A. Elkhatib, K. N. Salama, and M. S. Shur, "Plasma wave FET for sub-wavelength THz imaging", 2007 International Semiconductor Device Research Symposium: IEEE, pp. 1-2, 2007. Abstract
Veksler, D. B., A. V. Muravjov, Y. V. Kachorovskii, T. A. Elkhatib, K. N. Salama, X. - C. Zhang, and M. S. Shur, "Imaging of field-effect transistors by focused terahertz radiation", Solid-State Electronics, vol. 53, issue 6: Pergamon, pp. 571-573, 2009. Abstract
van der Velde, R., M. S. Salama, O. A. Eweys, J. Wen, and Q. Wang, "Soil Moisture Mapping Using Combined Active/Passive Microwave Observations Over the East of the Netherlands", JSTARS, vol. 8, issue 9, pp. 4355 - 4372, 2015. AbstractWebsite

A coarse resolution soil moisture product is downscaled to 1, 5, and 10 km using synthetic aperture radar (SAR) observations acquired over the east of the Netherlands. The combination of phased array L-band SAR (PALSAR) backscatter and VUA-NASA C-band Advanced Microwave Scanning Radiometer-Earth Observing System (AMSR-E) soil moisture product is adopted to mimic the radar/radiometer setup as will be available from NASA's soil moisture active passive (SMAP) mission. The validation of retrievals is based on measurements collected by a sparse network of 20 stations distributed across 50 × 75 km study area selected as one of the key validation sites for the SMAP soil moisture products. Reasonable agreements between the measurements and soil moisture retrieved at 1-, 5-, and 10-km resolution are found that lead to coefficients of determination of 0.37, 0.36, and 0.36, respectively. The retrievals, however, severely overestimate the measured soil moisture, which is attributed to the well-known positive bias of the selected AMSR-E product. After bias-correction, root mean squared differences reach as low as 0.046 m3 m-3 for individual locations and are 0.067, 0.068, and 0.069 m3 m-3 on average for the soil moisture retrieved at 1-, 5-, and 10-km resolutions, respectively. These error levels do not satisfy SMAP's targeted accuracy of 0.04 m3 m-3, but the radar/radiometer setup as well as the characterization of the soil moisture conditions representative are not optimal. On the other hand, it is demonstrated that the sequence of soil moisture maps does capture valuable hydrological and hydrometeorological information.

van der Velde, R., Z. Su, L. Dente, W. Jun, Y. Ma, K. Yang, and O. A. A. Mohamed, "Dragon soil moisture research on the Tib0etan Plateau : powerpoint.. 1s-24s", Abstract from ESA - MOST Dragon 2 symposium, Prague, Czech Republic, 20-24 June, 2011.
Veltink, P. H., H. J. Chizeck, P. E. Crago, and A. El-Bialy, "Nonlinear joint angle control for artificially stimulated muscle", IEEE Transactions on biomedical engineering, vol. 39, no. 4: IEEE, pp. 368–380, 1992. Abstract
Veltink, P. H., A. El-Bialy, H. J. Chizeck, and P. E. Crago, "Nonlinear control of an artificially stimulated muscle-skeleton-load system", Publ by Alliance for Engineering in Medicine & Biology, 1989. Abstract
van der Ven, A. T., D. M. Connaughton, H. Ityel, N. Mann, M. Nakayama, J. Chen, A. Vivante, D. - Y. Hwang, J. Schulz, D. A. Braun, et al., "Whole-Exome Sequencing Identifies Causative Mutations in Families with Congenital Anomalies of the Kidney and Urinary Tract.", Journal of the American Society of Nephrology : JASN, vol. 29, issue 9, pp. 2348-2361, 2018 Sep. Abstract

BACKGROUND: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most prevalent cause of kidney disease in the first three decades of life. Previous gene panel studies showed monogenic causation in up to 12% of patients with CAKUT.

METHODS: We applied whole-exome sequencing to analyze the genotypes of individuals from 232 families with CAKUT, evaluating for mutations in single genes known to cause human CAKUT and genes known to cause CAKUT in mice. In consanguineous or multiplex families, we additionally performed a search for novel monogenic causes of CAKUT.

RESULTS: In 29 families (13%), we detected a causative mutation in a known gene for isolated or syndromic CAKUT that sufficiently explained the patient's CAKUT phenotype. In three families (1%), we detected a mutation in a gene reported to cause a phenocopy of CAKUT. In 15 of 155 families with isolated CAKUT, we detected deleterious mutations in syndromic CAKUT genes. Our additional search for novel monogenic causes of CAKUT in consanguineous and multiplex families revealed a potential single, novel monogenic CAKUT gene in 19 of 232 families (8%).

CONCLUSIONS: We identified monogenic mutations in a known human CAKUT gene or CAKUT phenocopy gene as the cause of disease in 14% of the CAKUT families in this study. Whole-exome sequencing provides an etiologic diagnosis in a high fraction of patients with CAKUT and will provide a new basis for the mechanistic understanding of CAKUT.

van der Ven, A. T., B. Kobbe, S. Kohl, S. Shril, H. - M. Pogoda, T. Imhof, H. Ityel, A. Vivante, J. Chen, D. - Y. Hwang, et al., "A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux.", PloS one, vol. 13, issue 1, pp. e0191224, 2018. Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause (40-50%) of chronic kidney disease (CKD) in children. About 40 monogenic causes of CAKUT have so far been discovered. To date less than 20% of CAKUT cases can be explained by mutations in these 40 genes. To identify additional monogenic causes of CAKUT, we performed whole exome sequencing (WES) and homozygosity mapping (HM) in a patient with CAKUT from Indian origin and consanguineous descent. We identified a homozygous missense mutation (c.1336C>T, p.Arg446Cys) in the gene Von Willebrand factor A domain containing 2 (VWA2). With immunohistochemistry studies on kidneys of newborn (P1) mice, we show that Vwa2 and Fraser extracellular matrix complex subunit 1 (Fras1) co-localize in the nephrogenic zone of the renal cortex. We identified a pronounced expression of Vwa2 in the basement membrane of the ureteric bud (UB) and derivatives of the metanephric mesenchyme (MM). By applying in vitro assays, we demonstrate that the Arg446Cys mutation decreases translocation of monomeric VWA2 protein and increases translocation of aggregated VWA2 protein into the extracellular space. This is potentially due to the additional, unpaired cysteine residue in the mutated protein that is used for intermolecular disulfide bond formation. VWA2 is a known, direct interactor of FRAS1 of the Fraser-Complex (FC). FC-encoding genes and interacting proteins have previously been implicated in the pathogenesis of syndromic and/or isolated CAKUT phenotypes in humans. VWA2 therefore constitutes a very strong candidate in the search for novel CAKUT-causing genes. Our results from in vitro experiments indicate a dose-dependent neomorphic effect of the Arg446Cys homozygous mutation in VWA2.

Venghat, S., and et al, "Comparative evaluation of smear layer removal efficacy using QMIX 2in 1,Chistosan, Smear Clear and Glyde. (Prof. Emad Daif was a peer reviewer for this article).", British Journal of Medicine and Medical Research, vol. 13, issue 4, pp. 1-8, 2016.
Verma, A., and M. SA, "The Impact of Covid-19 on Mental Health in Allied Health Undergraduate Students during Lockdown Phase: An Observational Study", Psychology & Psychological Research International Journal, vol. 5, issue 3, pp. 1-9, 2020. research.pdf
Verma, A. R., V. M. Patel, S. Mikhail, and E. Zacharakis, "An unusual presentation of late oesophagojejunal anastomotic leak after total D2 gastrectomy.", Annals of the Royal College of Surgeons of England, vol. 94, issue 2, pp. e106-8, 2012 Mar. Abstract

Oesophagojejunal anastomotic leak usually presents in the early post-operative period with abdominal pain and sepsis. We report a case of late anastomotic leak presenting as epigastric pain with hyperamylasaemia and discuss the differential diagnosis.

Veronica Strong, Sergey Dubin, M. E. - K. F., and B. W. R. K. H. B. Andrew Lech, Yue Wang, "Patterning and Electronic Tuning of Laser Scribed Graphene for Flexible All-Carbon Devices", ACS Nano, vol. 6, pp. 1395-1403, 2012. acs_nano-2012.pdf