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2020
El-Gendy, D. M., A. R. M. Hameed, A. M. Al-Enizi, M. Bakrey, M. Ubaidullah, and A. Yousef, "Synthesis and characterization of WC@GNFs as an efficient supercapacitor electrode material in acidic medium", ceramics international, vol. 46, issue 17, pp. 27437-27445, 2020. 3ak.pdf
Hegab, H., U. Umer, A. Esawi, and H. A. Kishawy, "Tribological mechanisms of nano-cutting fluid minimum quantity lubrication: a comparative performance analysis model", The International Journal of Advanced Manufacturing Technology, vol. 108, issue 9: Springer London, pp. 3133-3139, 2020. Abstract
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Ahmed, M. K., S. F. Mansour, R. Ramadan, M. Afifi, M. S. Mostafa, S. I. El-dek, and V. Uskoković, "Tuning the composition of new brushite/vivianite mixed systems for superior heavy metal removal efficiency from contaminated waters", Journal of Water Process Engineering, 2020. 10.1016j.jwpe_.2019.101090.pdf
Ahmed, M. K., S. F. Mansour, R. Ramadan, M. Afifi, M. S. Mostafa, S. I. El-dek, and V. Uskoković, "Tuning the composition of new brushite/vivianite mixed systems for superior heavy metal removal efficiency from contaminated waters", Journal of Water Process Engineering, vol. 34: Elsevier, pp. 101090, 2020. Abstract
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Nishizono, H., M. Darwish, H. Uosaki, N. Masuyama, M. Seki, H. Abe, N. Yachie, and R. Yasuda, "Use of Freeze-thawed Embryos for High-efficiency Production of Genetically Modified Mice", Journal of Visualized Experiments, issue 158, pp. e60808, 2020.
Elrashdy, F., E. M. Redwan, and V. N. Uversky, "Why COVID-19 Transmission Is More Efficient and Aggressive Than Viral Transmission in Previous Coronavirus Epidemics?", Biomolecules, vol. 10, issue 9, 2020. Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing a pandemic of coronavirus disease 2019 (COVID-19). The worldwide transmission of COVID-19 from human to human is spreading like wildfire, affecting almost every country in the world. In the past 100 years, the globe did not face a microbial pandemic similar in scale to COVID-19. Taken together, both previous outbreaks of other members of the coronavirus family (severe acute respiratory syndrome (SARS-CoV) and middle east respiratory syndrome (MERS-CoV)) did not produce even 1% of the global harm already inflicted by COVID-19. There are also four other CoVs capable of infecting humans (HCoVs), which circulate continuously in the human population, but their phenotypes are generally mild, and these HCoVs received relatively little attention. These dramatic differences between infection with HCoVs, SARS-CoV, MERS-CoV, and SARS-CoV-2 raise many questions, such as: Why is COVID-19 transmitted so quickly? Is it due to some specific features of the viral structure? Are there some specific human (host) factors? Are there some environmental factors? The aim of this review is to collect and concisely summarize the possible and logical answers to these questions.

2019
Eldeeb, H. B., H. A. I. Selmy, H. M. Elsayed, R. I. Badr, and M. Uysal, "Efficient Resource Allocation Scheme for Multi-User Hybrid VLC/IR Networks", 2019 IEEE Photonics Conference (IPC), San Antonio, TX, USA, USA, 29 Sept.-3 Oct. , 2019.
Phuong, N., G. Afolayan, H. Stützel, R. Uptmoor, and M. El-Soda, "Unraveling the genetic complexity underlying sorghum response to water availability", PLOS ONE, vol. 14, issue 4: Public Library of Science, pp. e0215515 - , 2019/04/18. AbstractWebsite

Understanding the adaptation mechanisms of sorghum to drought and the underlying genetic architecture may help to improve its production in a wide range of environments. By crossing a high yielding parent (HYP) and a drought tolerant parent (DTP), we obtained 140 recombinant inbred lines (RILs), which were genotyped with 120 DArT and SSR markers covering 14 linkage groups (LGs). A subset of 100 RILs was evaluated three times in control and drought treatments to genetically dissect their response to water availability. Plants with early heading date (HD) in the drought treatment maintained yield (YLD) level by reducing seed number SN and increasing hundred seed weight (HSW). In contrast, early HD in the control treatment increased SN, HSW and YLD. In total, 133 significant QTL associated with the measured traits were detected in ten hotspot regions. Antagonistic, pleiotropic effects of a QTL cluster mapped on LG-6 may explain the observed trade-offs between SN and HSW: Alleles from DTP reduced SN and the alleles from HYP increased HSW under drought stress, but not in the control treatment. Our results illustrate the importance of considering genetic and environmental factors in QTL mapping to better understand plant responses to drought and to improve breeding programs.

Badawy, T., Y. Kyumoto-Nakamura, N. Uehara, J. Zhang, S. Sonoda, H. Hiura, T. Yamaza, A. Kukita, and T. Kukita, "Osteoblast lineage-specific cell-surface antigen (A7) regulates osteoclast recruitment and calcification during bone remodeling.", Laboratory investigation; a journal of technical methods and pathology, 2019 Feb 11. Abstract

Bone remodeling is a continuous process characterized by highly coordinated cell-cell interactions in distinct multi-cellular units. Osteoclasts, which are specialized bone resorbing cells, play a central role in bone remodeling. Although the RANKL/RANK axis determines the gross number of osteoclasts present in bone tissue, detailed molecular events regulating bone remodeling related to osteoclast recruitment, initiation of bone remodeling, and coupling of bone resorption and bone formation are still ambiguous. We hypothesized that osteoblast-specific cell-surface molecules contribute to the molecular modulation of bone remodeling. Therefore, we searched for regulatory cell-surface molecules expressed on osteoblasts by use of B-cell hybridoma technology. We obtained a monoclonal antibody A7 (A7 MAb) highly specific to cells of osteoblast-lineage. Here we describe the expression pattern and possible role of A7 antigen specifically recognized by A7 MAb. In vitro, A7 antigen was expressed on cell-surface of osteoblasts and osteoblast-like bone marrow stromal cells. In vivo, A7 antigen was detected in a subset of bone surface osteoblasts and in osteocytes, with a typical cell membrane expression pattern. Tissue array analysis showed only a limited expression of A7 antigen in osteocytes close to the bone surface. Immunoblotting and immunoprecipitation analysis showed that A7 antigen is a lineage-specific cell-surface protein with an approximate molecular weight of 45 KDa. Cross-linking of cell-surface A7 antigen in cultures of osteoclastogenesis showed stimulation of osteoclast formation. Marked suppression of calcification in primary osteoblast cultures was observed when A7 antigen was cross-linked with anti-A7 antigen MAb, A7 MAb. These data suggest that A7 antigen regulates recruitment of osteoclasts and triggering of calcification. A7 antigen may be an important molecule involved in the precise regulation of bone remodeling.

Kari, V., S. K. Raul, J. M. Henck, J. Kitz, F. Kramer, R. L. Kosinsky, N. Übelmesser, W. Y. Mansour, J. Eggert, M. Spitzner, et al., "The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness.", Clinical epigenetics, vol. 11, issue 1, pp. 4, 2019 01 07. Abstract

BACKGROUND: Disruptor of telomeric silencing 1-like (DOT1L) is a non-SET domain containing methyltransferase known to catalyze mono-, di-, and tri-methylation of histone 3 on lysine 79 (H3K79me). DOT1L-mediated H3K79me has been implicated in chromatin-associated functions including gene transcription, heterochromatin formation, and DNA repair. Recent studies have uncovered a role for DOT1L in the initiation and progression of leukemia and other solid tumors. The development and availability of small molecule inhibitors of DOT1L may provide new and unique therapeutic options for certain types or subgroups of cancer.

METHODS: In this study, we examined the role of DOT1L in DNA double-strand break (DSB) response and repair by depleting DOT1L using siRNA or inhibiting its methyltransferase activity using small molecule inhibitors in colorectal cancer cells. Cells were treated with different agents to induce DNA damage in DOT1L-depleted or -inhibited cells and analyzed for DNA repair efficiency and survival. Further, rectal cancer patient samples were analyzed for H3K79me3 levels in order to determine whether it may serve as a potential marker for personalized therapy.

RESULTS: Our results indicate that DOT1L is required for a proper DNA damage response following DNA double-strand breaks by regulating the phosphorylation of the variant histone H2AX (γH2AX) and repair via homologous recombination (HR). Importantly, we show that small molecule inhibitors of DOT1L combined with chemotherapeutic agents that are used to treat colorectal cancers show additive effects. Furthermore, examination of H3K79me3 levels in rectal cancer patients demonstrates that lower levels correlate with a poorer prognosis.

CONCLUSIONS: In this study, we conclude that DOT1L plays an important role in an early DNA damage response and repair of DNA double-strand breaks via the HR pathway. Moreover, DOT1L inhibition leads to increased sensitivity to chemotherapeutic agents and PARP inhibition, which further highlights its potential clinical utility. Our results further suggest that H3K79me3 can be useful as a predictive and or prognostic marker for rectal cancer patients.

Frank, T. D., A. Carter, D. Jahagirdar, M. H. Biehl, D. Douwes-Schultz, S. L. Larson, M. Arora, L. Dwyer-Lindgren, K. M. Steuben, H. Abbastabar, et al., "Global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017", The Lancet HIVThe Lancet HIV, vol. 6, issue 12: Elsevier, pp. e831 - e859, 2019. AbstractWebsite

BackgroundUnderstanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980?2017 and forecast these estimates to 2030 for 195 countries and territories.BackgroundUnderstanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980?2017 and forecast these estimates to 2030 for 195 countries and territories.

Bishop, D., R. A. Dyer, S. Maswime, R. N. Rodseth, D. van Dyk, H. - L. Kluyts, J. T. Tumukunde, F. D. Madzimbamuto, A. M. Elkhogia, A. K. N. Ndonga, et al., Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study, , vol. 7, issue 4, pp. e513 - e522, 2019. AbstractWebsite

SummaryBackground
Maternal and neonatal mortality is high in Africa, but few large, prospective studies have been done to investigate the risk factors associated with these poor maternal and neonatal outcomes.
Methods
A 7-day, international, prospective, observational cohort study was done in patients having caesarean delivery in 183 hospitals across 22 countries in Africa. The inclusion criteria were all consecutive patients (aged ≥18 years) admitted to participating centres having elective and non-elective caesarean delivery during the 7-day study cohort period. To ensure a representative sample, each hospital had to provide data for 90% of the eligible patients during the recruitment week. The primary outcome was in-hospital maternal mortality and complications, which were assessed by local investigators. The study was registered on the South African National Health Research Database, number KZ_2015RP7_22, and on ClinicalTrials.gov, number NCT03044899.
Findings
Between February, 2016, and May, 2016, 3792 patients were recruited from hospitals across Africa. 3685 were included in the postoperative complications analysis (107 missing data) and 3684 were included in the maternal mortality analysis (108 missing data). These hospitals had a combined number of specialist surgeons, obstetricians, and anaesthetists totalling 0·7 per 100 000 population (IQR 0·2–2·0). Maternal mortality was 20 (0·5%) of 3684 patients (95% CI 0·3–0·8). Complications occurred in 633 (17·4%) of 3636 mothers (16·2–18·6), which were predominantly severe intraoperative and postoperative bleeding (136 [3·8%] of 3612 mothers). Maternal mortality was independently associated with a preoperative presentation of placenta praevia, placental abruption, ruptured uterus, antepartum haemorrhage (odds ratio 4·47 [95% CI 1·46–13·65]), and perioperative severe obstetric haemorrhage (5·87 [1·99–17·34]) or anaesthesia complications (11·47 (1·20–109·20]). Neonatal mortality was 153 (4·4%) of 3506 infants (95% CI 3·7–5·0).
Interpretation
Maternal mortality after caesarean delivery in Africa is 50 times higher than that of high-income countries and is driven by peripartum haemorrhage and anaesthesia complications. Neonatal mortality is double the global average. Early identification and appropriate management of mothers at risk of peripartum haemorrhage might improve maternal and neonatal outcomes in Africa.
Funding
Medical Research Council of South Africa.

Hegab, H., H. A. Kishawy, U. Umer, and A. Mohany, A model for machining with nano-additives based minimum quantity lubrication, , vol. 102, issue 5-8: Springer London, pp. 2013 - 2028, 2019. Abstract
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Khalil, A., W. S. Nasser, T. A. Osman, M. S. Toprak, M. Muhammed, and A. Uheida, Surface modified of polyacrylonitrile nanofibers by TiO2/MWCNT for photodegradation of organic dyes and pharmaceutical drugs under visible light irradiation, , vol. 179, pp. 108788, 2019. AbstractWebsite

This work describes the fabrication of two composite nanofibers systems containing polyacrylonitrile polymer (PAN), Multiwall carbon nanotubes (MWCNT) and Titania (TiO2) nanoparticles. Photodegradation experiments were performed to study the effect of various parameters including pH, catalyst dose, pollutant concentration and reaction time for three model compounds, methylene blue (MB), indigo carmine (IC), and ibuprofen (IBU) under visible light. Morphology and structure of the modified composite nanofibers were characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Thermogravimetric analysis (TGA), Photoluminescence (PL) spectroscopy, Raman spectra, and X-ray Photoelectron Spectra (XPS) analyses. The photocatalytic performance was achieved in a rather short time visible light (<30 min) and under low power intensity (125 W) compared to earlier reports. Kinetics data fitted well using pseudo-first order model to describe the mechanism of photocatalytic degradation processes. The stability and flexibility of the fabricated composite nanofibers allow their application in a continuous flow system and their re-use after several cycles.

Eldeeb, H. B., H. A. I. Selmy, H. M. Elsayed, R. I. Badr, and M. Uysal, "Efficient Resource Allocation scheme for uplink multi-user VLC/IR Channel ", IEEE Photonics Conference, USA, 1 Oct., 2019.
El-kader, A. F. H., N. A. Hakeem, W. H. Osman, A. A. Menazea, and undefined, "Nanosecond Laser Irradiation as New Route for Silver Nanoparticles Precipitation in Glassy Matrix", silicon, vol. 11, pp. 377-381, 2019. paper.pdf
., A. N. A., H. - A. M. Mourad, H. M. Elsayed, M. El-Soudani, and undefined, "Performance of LTE-A Heterogeneous Network using NHFR Method", ICCES, Cairo,Egypt, 2019.
G, W., S. MAR, A. A, and undefined, "Spontaneous spondylodiscitis: review, incidence, management, and clinical outcome in 44 patients", JNS: Neurosurgical Focus, issue January 2019, 2019.
Abdelrahman, R. W., M. M. Mohamed, M. M. Fouad, Y. M. Tohamy, and undefined, "Added value of contrast enhanced mammography in assessemnt of breast asymmetries", BJR, vol. 92, issue 1098, pp. 1-7, 2019.
Mistry, P. K., M. Balwani, H. N. Baris, H. B. Turkia, A. T. Burrow, J. Charrow, G. F. Cox, S. Danda, M. Dragosky, G. Drelichman, et al., "Addendum to Letter to the Editor: Safety, efficacy, and authorization of eliglustat as a first-line therapy in Gaucher disease type 1.", Blood cells, molecules & diseases, vol. 77, pp. 101-102, 2019.
U.T Toman, A.S.O. Hassan, F. M. Owis, and A. S. A. Mohamed, "Blade Shape Optimization of Aircraft Propeller Using Space Mapping Surrogate", Advances in Mechanical Engineering, SAGE, vol. 11, issue 7, pp. 1-16, 2019.
Kassem, N. M., W. S. Makar, H. A. Kassem, S. Talima, M. Tarek, H. Hesham, and undefined, "Circulating miR-34a and miR-125b as Promising non Invasive Biomarkers in Egyptian Locally Advanced Breast Cancer Patients", Asian Pacific Journal of Cancer Prevention, vol. 20, issue 9, pp. 2749-2755, 2019.
Ahmed, M. K., R. Ramadan, S. I. El-dek, and V. Uskoković, "Complex relationship between alumina and selenium-doped carbonated hydroxyapatite as the ceramic additives to electrospun polycaprolactone scaffolds for tissue engineering applications", Journal of Alloys and Compounds, vol. 801: Elsevier, pp. 70-81, 2019. Abstract
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Mabkhot, Y. N., S. S. Al‑Showiman, A. Barakat, S. M. Soliman, N. A. Kheder, M. M. Alharbi, A. Asayari, A. B. Muhsinah, A. Ullah, and S. L. Badshah, "Computational studies of 2-(4-oxo-3-phenylthiazolidin-2-ylidene) malononitrile", BMC Chemistry, vol. 13, pp. 25, 2019.