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Ali, M. A., M. I. Mohamed, M. A. Megahed, T. M. Abdelghany, and undefined, "- Cholesterol-Based Nanovesicles Enhance the In Vitro Cytotoxicity, Ex Vivo Intestinal Absorption, and In Vivo Bioavailability of Flutamide", Pharmaceutics , vol. 13, issue 11, pp. 1-22, 2021.
Morgan, A. M., Mona K Galal, Marwa A Ibrahim, A. M. Hussien, E. I. Hassanen, H. A. Ogaly, S. A. A. Dulmani, F. A. M. Al‐Zahrani, S. Kamel, and undefined, "The ameliorative effect of N‐acetylcysteine against penconazole induced neurodegenerative and neuroinflammatory disorders in rats", J Biochem Mol Toxicol. 2021;e22884: 1-11, vol. e22884:, pp. 1-11, 2021.
A, S. M., Allam M, Heck QK, Urbanaviciute I, R. T, Stuart D, Zakhrabekova S, Börner A, Pillen K, Hansson M, et al., "Analyses of MADS-box genes suggest HvMADS56 to regulate lateral spikelet development in barley", Plants, vol. 10, 2021.
M.T., K., M. S. Uddin, P. Jeandet, T. B. Emran, S. Mitra, G. M. Albadrani, A. A. SAYED, and M. M. Abdel-Daim, Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential, , 2021.
Uitentuis, S. E., A. Wolkerstorfer, J. M. Bae, S. Esmat, R. M. Mogawer, N. Ragab, S. Y. Chuah, T. Passeron, N. van Geel, S. T. G. Thng, et al., "Assessing the minimal important change in the vitiligo extent score and the self-assessment vitiligo extent score.", Journal of the American Academy of Dermatology, vol. 85, issue 5, pp. 1363-1364, 2021.
Usama, M., F. Abdelaziem, W. Rashed, E. Maher, M. E. Beltagy, and W. Zekri, "ASSESSMENT OF POSTURAL STABILITY IN CHILDREN WITH POSTERIOR FOSSA TUMOR", Turkish Journal of Physiotherapy and Rehabilitation, vol. 32(3), pp. 12267-12273, 2021.
El Raziky, M. E. S., N. A. Zayed, Y. S. Ibrahim, F. Elrashdy, R. M. H. Shahin, M. Hassany, M. E. Serafy, W. Doss, V. N. Uversky, A. Yosry, et al., "Association analysis of genetic variants of sodium taurocholate co-transporting polypeptide NTCP gene (SLC10A1) and HBV infection status in a cohort of Egyptian patients", Gastroenterology Insights, vol. 12, issue 4, pp. 384-393, 2021.
Iwama, H., S. Mehanna, M. Imasaka, S. Hashidume, H. Nishiura, K. -ichi Yamamura, C. Suzuki, Y. Uchiyama, E. Hatano, and M. Ohmuraya, "Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis", Scientific Reports, vol. 11, issue 1, pp. 6596, 2021.
Mittal, P., A. Saharan, R. Verma, F. M. A. Altalbawy, M. A. Alfaidi, G. E. - S. Batiha, W. Akter, R. K. Gautam, M. S. Uddin, and M. S. Rahman, "Dendrimers: A New Race of Pharmaceutical Nanocarriers", BioMed Research International, vol. 16, pp. 1-11, 2021. farag_1.pdf
Ziade1, N., T. Arayssi, B. E. Zorkany, A. Daher, G. A. Karam, M. A. J. M. A. Mashaleh, A. Aiko, E. Alam, S. A. Emadi, M. A. Mashaleh, et al., "Development of an Educational Video for Self-Assessment οf Patients with RA: Steps, Challenges, and Responses", MEDITERRANEAN JOURNAL OF RHEUMATOLOGY, vol. 32, issue 1, pp. 66 - 73, 2021.
Kumon, K., S. M. Afify, G. Hassan, S. Ueno, S. Monzur, H. M. Nawara, H. A. A. Quora, M. Sheta, Y. Xu, X. Fu, et al., "Differentiation of cancer stem cells into erythroblasts in the presence of CoCl.", Scientific reports, vol. 11, issue 1, pp. 23977, 2021. Abstract

Cancer stem cells (CSCs) are subpopulations in the malignant tumors that show self-renewal and multilineage differentiation into tumor microenvironment components that drive tumor growth and heterogeneity. In previous studies, our group succeeded in producing a CSC model by treating mouse induced pluripotent stem cells. In the current study, we investigated the potential of CSC differentiation into blood cells under chemical hypoxic conditions using CoCl. CSCs and miPS-LLCcm cells were cultured for 1 to 7 days in the presence of CoCl, and the expression of VEGFR1/2, Runx1, c-kit, CD31, CD34, and TER-119 was assessed by RT-qPCR, Western blotting and flow cytometry together with Wright-Giemsa staining and immunocytochemistry. CoCl induced significant accumulation of HIF-1α changing the morphology of miPS-LLCcm cells while the morphological change was apparently not related to differentiation. The expression of VEGFR2 and CD31 was suppressed while Runx1 expression was upregulated. The population with hematopoietic markers CD34 and c-kit was immunologically detected in the presence of CoCl. Additionally, high expression of CD34 and, a marker for erythroblasts, TER-119, was observed. Therefore, CSCs were suggested to differentiate into erythroblasts and erythrocytes under hypoxia. This differentiation potential of CSCs could provide new insight into the tumor microenvironment elucidating tumor heterogenicity.

Avella, A. B. -, R. Hotakainen, M. A. Shehhi, A. Urzi, L. A. M. Selim, and N. A. Menabawy, "A disorder clinically resembling cystic fibrosis caused by biallelic variants in the AGR2 gene", journal of medical genetics, pp. 1-9, 2021. jmedgenet-2021-108150.full_.pdf
Ibrahim, S. A., M. A. Radwan, and M. A. Nix, Dual-loop regulated switched capacitor DC-DC converter, : US Patent 10,958,162, 2021.
Sattui, S. E., J. W. Liew, K. Kennedy, E. Sirotich, M. Putman, T. T. Moni, A. Akpabio, D. Alpízar-Rodríguez, F. Berenbaum, I. Bulina, et al., "Early experience of COVID-19 vaccination in adults with systemic rheumatic diseases: results from the COVID-19 Global Rheumatology Alliance Vaccine Survey.", RMD open, vol. 7, issue 3, 2021. Abstract

BACKGROUND: We describe the early experiences of adults with systemic rheumatic disease who received the COVID-19 vaccine.

METHODS: From 2 April to 30 April 2021, we conducted an online, international survey of adults with systemic rheumatic disease who received COVID-19 vaccination. We collected patient-reported data on clinician communication, beliefs and intent about discontinuing disease-modifying antirheumatic drugs (DMARDs) around the time of vaccination, and patient-reported adverse events after vaccination.

RESULTS: We analysed 2860 adults with systemic rheumatic diseases who received COVID-19 vaccination (mean age 55.3 years, 86.7% female, 86.3% white). Types of COVID-19 vaccines were Pfizer-BioNTech (53.2%), Oxford/AstraZeneca (22.6%), Moderna (21.3%), Janssen/Johnson & Johnson (1.7%) and others (1.2%). The most common rheumatic disease was rheumatoid arthritis (42.3%), and 81.2% of respondents were on a DMARD. The majority (81.9%) reported communicating with clinicians about vaccination. Most (66.9%) were willing to temporarily discontinue DMARDs to improve vaccine efficacy, although many (44.3%) were concerned about rheumatic disease flares. After vaccination, the most reported patient-reported adverse events were fatigue/somnolence (33.4%), headache (27.7%), muscle/joint pains (22.8%) and fever/chills (19.9%). Rheumatic disease flares that required medication changes occurred in 4.6%.

CONCLUSION: Among adults with systemic rheumatic disease who received COVID-19 vaccination, patient-reported adverse events were typical of those reported in the general population. Most patients were willing to temporarily discontinue DMARDs to improve vaccine efficacy. The relatively low frequency of rheumatic disease flare requiring medications was reassuring.

Glasbey, J. C., D. Nepogodiev, J. F. F. Simoes, O. Omar, E. Li, M. L. Venn, PGDME, M. K. Abou Chaar, V. Capizzi, D. Chaudhry, et al., "Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study", Journal of Clinical Oncology, vol. 39, no. 1, pp. 66-78, 2021. AbstractWebsite

PURPOSEAs cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway.PATIENTS AND METHODSThis international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation).RESULTSOf 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76).CONCLUSIONWithin available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.

Mandour, A. S., A. E. Mahmoud, A. O. Ali, K. Matsuura, H. Samir, H. A. Abdelmageed, D. Ma, T. Yoshida, L. Hamabe, A. Uemura, et al., "Expression of cardiac copper chaperone encoding genes and their correlation with cardiac function parameters in goats", Veterinary Research Communications, vol. 45, pp. 305–317 (2021), 2021. mandour2021_article_expressionofcardiaccopperchape.pdf
Mandour, A. S., A. E. Mahmoud, A. O. Ali, K. Matsuura, H. Samir, H. A. Abdelmageed, D. Ma, T. Yoshida, L. Hamabe, A. Uemura, et al., "Expression of cardiac copper chaperone encoding genes and their correlation with cardiac function parameters in goats", Veterinary Research Communications, vol. 45, pp. 305–317 (2021), 2021. mandour2021_article_expressionofcardiaccopperchape.pdf
Mahmoudi, M., W. Bejaoui, M. B. Ali, A. Hedfi, M. Almalki, N. Essid, E. Mahmoudi, R. Rizk, O. Pacioglu, D. Urkmez, et al., "How effective is wastewater treatment? A case study under the light of taxonomic and feeding features of meiobenthic nematodes", Environmental Science and Pollution Research, vol. 29, issue 2022, pp. 2566–2578, 2021.
Errichetti, E., B. S. Ankad, A. K. Jha, S. Sonthalia, B. N. Akay, R. Bakos, Y. J. Bhat, M. Bosseila, R. Braun, H. Cabo, et al., "International Dermoscopy Society criteria for non-neoplastic dermatoses (general dermatology): validation for skin of color through a Delphi expert consensus.", International journal of dermatology, 2021. Abstract

BACKGROUND: The International Dermoscopy Society (IDS) recently released a set of five basic dermoscopic parameters (vessels, scales, follicular findings, "other structures," and specific clues) encompassing a total of 31 subitems to standardize the use of dermoscopy in non-neoplastic dermatoses, yet they have been developed taking into account Caucasian/Asian skin, with consequent possible limitations if used in dark skin.

OBJECTIVES: To validate the abovementioned criteria for the use in dark-skinned patients (phototypes IV-VI) through an expert consensus.

METHODS: The two-round Delphi method was adopted, with an iterative process consisting of two rounds of email questionnaires. Potential panelists were recruited via e-mail from all over the world based on their expertise on dermoscopy of non-neoplastic dermatoses in skin of color.

RESULTS: Twenty-two panelists took part in the validation process. All of the five originally proposed parameters and subitems reached agreement during the first round, aside from "follicular red dots." Additionally, during round 1, five new subitems were proposed (perifollicular scales distribution, follicular openings obliteration, broken hairs, eccrine pigmentation, and eccrine ostia obliteration), along with the possibility to change the denomination of parameter 3 (from "follicular findings" to "follicular/eccrine findings") and split it into two subparameters ("follicular findings" and "eccrine findings"). All such proposals reached agreement during the second round and therefore were included in the final list, for a total of 37 items.

CONCLUSIONS: Although nearly all the dermoscopic criteria originally proposed by the IDS are applicable even to darker phototypes, several additional variables need to be assessed.

Kalantar-Zadeh, K., P. Kam-Tao Li, E. Tantisattamo, L. Kumaraswami, V. Liakopoulos, S. - F. Lui, I. Ulasi, S. Andreoli, A. Balducci, S. Dupuis, et al., "Living well with kidney disease by patient and care-partner empowerment: kidney health for everyone everywhere.", Kidney international, vol. 99, issue 2, pp. 278-284, 2021. Abstract

Living with chronic kidney disease (CKD) is associated with hardships for patients and their care partners. Empowering patients and their care partners, including family members and friends involved in their care, may help minimize the burden and consequences of CKD-related symptoms to enable increased life participation. There is a need to broaden the focus on living well with kidney disease and reengagement in life, including emphasis on the patient being in control. The World Kidney Day (WKD) Joint Steering Committee has declared 2021 the year of "Living Well with Kidney Disease" in an effort to increase education about and awareness of the important goal of patient empowerment and life participation. This calls for the development and implementation of validated patient-reported outcome measures to assess and address areas of life participation in routine care. It could be supported by regulatory agencies as a metric for quality care or to support labeling claims for medicines and devices. Funding agencies could establish targeted calls for research that address the priorities of patients. Patients with kidney disease and their care partners should feel supported to live well through concerted efforts by kidney care communities, including during pandemics. In the overall wellness program for patients with kidney disease, the need for prevention should be reiterated. Early detection with prolonged course of wellness despite kidney disease, after effective secondary and tertiary prevention programs, should be promoted. WKD 2021 continues to call for increased awareness of the importance of preventive measures across populations, professionals, and policy makers, applicable to both developed and developing countries.

Gamal, S. M., S. S. Mohamed, M. Tantawy, I. Siam, undefined, and M. H. Niazy, "Lupus-related vasculitis in a cohort of systemic lupus erythematosus patients", Archives of Rheumatology, vol. 36, issue 4, pp. 595-602, 2021. 2021-36-4-595-692-eng.pdf
Ramadan, R., M. K. Ahmed, and V. Uskoković, "Magnetic, microstructural and photoactivated antibacterial features of nanostructured Co–Zn ferrites of different chemical and phase compositions", Journal of Alloys and Compounds, vol. 856: Elsevier, pp. 157013, 2021. Abstract
Hassan, G., S. M. Afify, J. Du, H. M. Nawara, M. Sheta, S. Monzur, M. H. Zahra, H. A. Abu Quora, H. Mansour, S. El-Ghlban, et al., "MEK1/2 is a bottleneck that induces cancer stem cells to activate the PI3K/AKT pathway.", Biochemical and biophysical research communications, vol. 583, pp. 49-55, 2021. Abstract

Cancer stem cells (CSCs) are responsible for cancer initiation, drug resistance, and aggressive tumor phenotypes. Our lab has established a novel method to induce CSCs from induced pluripotent stem (iPS) cells in a microenvironment mimicking chronic inflammation. The converted cells acquired CSC characteristics and developed malignant tumors. Recently, we demonstrated that nonmutagenic chemical inhibitors accelerated the conversion of mouse iPS (miPS) cells into CSCs. Here, we investigated the effects of AZD-6244, a MEK1/2-specific inhibitor, on the conversion of iPS cells into CSCs. The miPS cells were cultured for one week in the presence of the conditioned medium (CM) of Lewis lung carcinoma (LLC) cells and AZD-6244, PD0325901, a pan-MEK inhibitor, or GDC-0879, a B-Raf inhibitor. As a result, AZD-6244 enhanced the conversion of iPS cells into CSCs and upregulated AKT phosphorylation as same as GDC-0879 and PD0325901. The converted cells maintained their self-renewal ability and stemness gene expression. The expression of the CSC markers CD24, CD44 and CD133 was higher in the cells cultured with MAPK inhibitors than in those cultured without MAPK inhibitors. Moreover, converted cells gained migration and invasion abilities assessed by in vitro assays. Therefore, the inhibition of MEK1/2 was found to be critical for the conversion of normal stem cells into CSCs in the tumor-inducing microenvironment.

Kumar, B., S. Dhar, S. Paul, V. Paramesh, A. Dass, P. K. Upadhyay, A. Kumar, S. A. M. Abdelmohsen, F. H. Alkallas, T. Z. K. El-Abedin, et al., "Microbial Biomass Carbon, Activity of Soil Enzymes, Nutrient Availability, Root Growth, and Total Biomass Production in Wheat Cultivars under Variable Irrigation and Nutrient Management", Agronomy, vol. 11, no. 4, 2021. AbstractWebsite

Intensive mono-cropping without a balanced supply of nutrients and declining water resources are degrading soil health, and as a consequence, agriculture production is becoming unsustainable and causing environmental degradation. The field experiment was conducted during Rabi season to assess the effect of an irrigation schedule, nutrient management, and wheat (Triticum aestivum L.) varieties on soil microbial biomass carbon (SMBC) and soil enzymes activities. Two nutrient levels, recommended rate of chemical fertilizer (RDF) and 50% RDF + 50% recommended dose of nitrogen (RDN) through farmyard manure (FYM) designated as Integrated Nutrient Sources (INS), and three irrigations levels, one irrigation at crown root initiation (CRI), two irrigations at CRI and flowering stages, and five irrigations at all main stages of the crop (CRI, tillering, jointing, flowering, and grain filling) were allocated to main-plots while four varieties of wheat, HD 2967, WR 544, HD 2987, and HD 2932, were allocated to sub-plots. The results revealed that SMBC and activities of dehydrogenase, alkaline phosphatase enzymes, and acid phosphatase were higher under restricted irrigation (irrigation at CRI stage) than other irrigation schedules. SMBC, dehydrogenase, acid phosphatase, and alkaline phosphatase activities were 73.0 µg g soil−1, 86.0 µg TPF g soil−1d−1, 39.6 µg PNP g soil−1 h1, and 81.8 µg PNP g−1 soil h−1, respectively, with the use of INS that was higher than RDF. Root weight and root volume followed a similar pattern. Applying single irrigation at CRI left behind the maximum available nitrogen (166.4 kg ha−1) in soil compared to other irrigation schedules and it was highest (149.31 kg ha−1) with the use of INS. Moreover, total organic carbon (TOC) was 0.44 and 0.43% higher with irrigation at CRI stages and the use of INS, respectively. The INS with single irrigation at the CRI stage is important to improve the root growth, SMBC dehydrogenase, alkaline phosphatase, and acid phosphatase enzyme activity in the wheat production system.