Publications

Export 1959 results:
Sort by: [ Author  (Asc)] Title Type Year
A B C D E F G H I J K L M N O P Q R S [T] U V W X Y Z   [Show ALL]
T
de Torres, L. F. C., D. Ribeiro, R. Hirata Jr, L. G. C. Pacheco, M. C. Souza, L. S. dos Santos, C. S. dos Santos, M. Salah, M. M. da Costa, and M. G. Ribeiro, "Multiplex polymerase chain reaction to identify and determine the toxigenicity of Corynebacterium spp with zoonotic potential and an overview of human and animal infections", Memórias do Instituto Oswaldo Cruz, vol. 108, issue 3: SciELO Brasil, pp. 272-279, 2013. Abstract
n/a
Torres, V. J., A. S. Attia, W. J. Mason, M. I. Hood, B. D. Corbin, F. C. Beasley, K. L. Anderson, D. L. Stauff, W. H. McDonald, L. J. Zimmerman, et al., "Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia", Infection and immunity, 2010/01/27, vol. 78, no. 4, pp. 1618-28, Apr, 2010. AbstractWebsite

The tremendous success of Staphylococcus aureus as a pathogen is due to the controlled expression of a diverse array of virulence factors. The effects of host environments on the expression of virulence factors and the mechanisms by which S. aureus adapts to colonize distinct host tissues are largely unknown. Vertebrates have evolved to sequester nutrient iron from invading bacteria, and iron availability is a signal that alerts pathogenic microorganisms when they enter the hostile host environment. Consistent with this, we report here that S. aureus senses alterations in the iron status via the ferric uptake regulator (Fur) and alters the abundance of a large number of virulence factors. These Fur-mediated changes protect S. aureus against killing by neutrophils, and Fur is required for full staphylococcal virulence in a murine model of infection. A potential mechanistic explanation for the impact of Fur on virulence is provided by the observation that Fur coordinates the reciprocal expression of cytolysins and a subset of immunomodulatory proteins. More specifically, S. aureus lacking fur exhibits decreased expression of immunomodulatory proteins and increased expression of cytolysins. These findings reveal that Fur is involved in initiating a regulatory program that organizes the expression of virulence factors during the pathogenesis of S. aureus pneumonia.

Toson, M. A., S. A. A. El-Latif, and M. R. M. Ibrahim, "Growth performance of NZW rabbits fed diets containing cassava leaves and stems meal as a substitution of clover hay meal", Egyptian Journal of Nutrition and Feeds, vol. 2, pp. 541-549, 1999. Abstract
n/a
Tossi, A., H. Gorner, A. M. Aboul-Enein, and D. Schulte-Frohlinde, "Interaction of ruthenium complexes with nucleic acids. DNA damage via photosensitized radical production", Free Rad. Res. Comms., , vol. 6, issue 2-3, pp. 171-173, 1989.
Tosson, A. M. S., H. A. H. Fahmy, and M. A. F. El-Yazeed, "{DRUS}: A new proposed interoperable {DRM} hardware-software solution", The 4th International Computer Engineering Conference, Giza, Egypt, dec, 2008. Abstract

The advent of consumer digital media products has vastly increased the concerns of copyright-dependent organizations within the music and movie industries. This has led to the emergence of the Digital Rights Management (DRM) field which provides solutions to prevent unauthorized access to digital content in general. Many DRM solutions were implemented and suggested but they mainly suffer from interoperability issue. In this work, we propose a new DRM system and discuss its interoperability advantage over today's DRM solutions.

Tosson, A. M. S., K. S. Amr, and M. B. Taher, "Polymorphisms in folate-metabolizing genes as risk factors for congenital heart defects in Down Syndrome in Egypt", IJBR, vol. 6, issue 12, pp. 963-966, 2015.
Tosson, A. M. S., D. Koptan, R. A. Aal, and M. A. Hady, "Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study", Jornal de Pediatria, vol. 97, issue 6, pp. 623-628, 2021.
Tosson, A. M. S., and C. P. Speer, "Microbial Pathogens Causative of Neonatal Sepsis in Arabic Countries", The Journal of Maternal-Fetal and Neonatal Medicinel, 2011. Abstract

Objective: Neonatal sepsis is a major cause of morbidity and mortality worldwide. We analyzed the spectrum of pathogens causing neonatal sepsis in various Arabic countries

Tosson, A. M. S., K. Glaser, T. Weinhage, D. Foell, M. S. Aboualam, A. A. Edris, M. E. Ansary, S. Lotfy, and C. P. Speer, "Evaluation of the S100 protein A12 as a biomarker of neonatal sepsis", The Journal of Maternal-Fetal & Neonatal Medicine , 2019.
Totonji, A., M. H. Sayyouh, M. E. Dokla, and N. El-Khatib, "A laboratory study on enhanced oil recovery from Saudi oil fields by surfactant-polymer flooding", Journal of Engineering Sciences, vol. 2, issue 2, pp. pp.285-301, 1985.
Totonji, A., N. El-Khatib, M. Dokla, and M. H. Sayyouh, Laboratory and numerical investigation of enhanced recovery for Saudi oil fields by surfactant and polymer flooding, , Saudi Arabia , Published by King Abduylaziz City for Science and Technology, SANCST, 1990.
Totonji, A., M. E. Dokla, M. H. Sayyouh, and N. El-Khatib, "Effect of high salinity on interfacial tension, phase behavior, and adsorption in surfactant-oil-brine systems", Journal of Engineering Sciences, vol. 13, issue 1, pp. 171-190, 1987.
Touch, T., C. Oeurng, Y. Jiang, and A. Mokhtar, "Integrated Modeling of Water Supply and Demand Under Climate Change Impacts and Management Options in Tributary Basin of Tonle Sap Lake, Cambodia", Water, vol. 12, no. 9: Multidisciplinary Digital Publishing Institute, pp. 2462, 2020. Abstract
n/a
Toukhy, S. H. E. -, F. M. Kamel, I. El-Sayyed, and M. F. Haridy, "EFFECT OF STORAGE ON MICRO TENSILE BOND STRENGTH OF VARIOUS TYPES OF FLOWABLE COMPOSITE", EGYPTIAN DENTAL JOURNAL, vol. 60, issue 1, pp. 983-989, 2014. effect_of_storage.pdf
Toukhy, A., S. Fayed, N. Sabry, and M. Shawki, "The Impact of an Established Pharmaceutical Care Pathway on Drug Related Problems in an Intensive Care Unit", American Journal of the Medical Sciences, vol. 362, no. 2, pp. 143-153, 2021. AbstractWebsite
n/a
Toukhy, A., S. Fayed, N. Sabry, and M. Shawki, "The Impact of an Established Pharmaceutical Care Pathway on Drug Related Problems in an Intensive Care Unit", American Journal of the Medical Sciences, vol. 362, issue 2, pp. 143 - 153, 2021. AbstractWebsite

Background: The incidence of drug related problems (DRPs) in intensive care units (ICU) is higher compared to any other wards in the hospital, requiring a structured pathway to ensure optimum detection of DRPs. The study aimed to evaluate the impact of implementing a pharmaceutical care pathway on the detection and management of DRPs in an ICU. Methods: The study was conducted in a general ICU and included three phases: tool preparation phase included the development of a core measures reference pathway and daily working scenario flow-charts, a control phase where the patient files and pharmacists' case assessment notes were retrospectively reviewed to detect the rate of DRPs before pathway implementation and a prospective phase similar to the control phase but with the implementation of the new pathway. The number and classification of DRPs and required core measures in the control and implementation phases were documented. Results: Using the new pathway, the detection of unmet core measures increased from 7.3% in the control phase to 99% in the implementation phase (p-value <0.001). The prevalence of unidentified DRPs/1000 patients' service days decreased from 98.1 in the control phase to 27.08 in the implementation phase (p-value <0.001). However, there was no significant difference between the phases regarding mortality rate and length of ICU stay. Conclusions: The implementation of a unified pharmaceutical care pathway improved the detection of DRPs in ICU patients. © 2021 Southern Society for Clinical Investigation

Toulany, M., M. Iida, S. Keinath, F. F. Iyi, K. Mueck, B. Fehrenbacher, W. Y. Mansour, M. Schaller, D. L. Wheeler, and P. H. Rodemann, "Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.", Oncotarget, vol. 7, issue 28, pp. 43746-43761, 2016 Jul 12. Abstract

Despite the significant contribution of radiotherapy to non-small lung cancer (NSCLC), radioresistance still occurs. One of the major radioresistance mechanisms is the hyperactivation of the PI3K/Akt pathway in which Akt facilitates the repair of DNA double-strand breaks (DSBs) through the stimulation of DNA-PKcs. We investigated if targeting PI3K would be a potential approach for enhancing the radiosensitivity of K-RAS mutated (K-RASmut) NSCLC cell lines A549 and H460. Short-term (1-2 h) pre-treatment of cells with the PI3K inhibitor PI-103 (1 μM) inhibited Akt/DNA-PKcs activity, blocked DSBs repair and induced radiosensitivity, while long-term (24 h) pre-treatment did not. Lack of an effect after 24 h of PI-103 pre-treatment was due to reactivation of K-Ras/MEK/ERK-dependent Akt. However, long-term treatment with the combination of PI-103 and MEK inhibitor PD98059 completely blocked reactivation of Akt and impaired DSBs repair through non-homologous end joining (NHEJ) leading to radiosensitization. The effect of PI3K inhibition on Akt signaling was also tested in A549 mouse xenografts. P-Akt and P-DNA-PKcs were inhibited 30 min post-irradiation in xenografts, which were pretreated by PI-103 30 min before irradiation. However, Akt was reactivated 30 min post-irradiation in tumors, which were pre-treated for 3 h with PI-103 before irradiation. After a 24 h pretreatment with PI-103, a significant reactivation of Akt was achieved 24 h after irradiation. Thus, due to MEK/ERK-dependent reactivation of Akt, targeting PI3K alone is not a suitable approach for radiosensitizing K-RASmut NSCLC cells, indicating that dual targeting of PI3K and MEK is an efficient approach to improve radiotherapy outcome.

Toulany, M., M. Iida, S. Keinath, F. F. Iyi, K. Mueck, B. Fehrenbacher, W. Y. Mansour, M. Schaller, D. L. Wheeler, and P. H. Rodemann, "Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.", Oncotarget, vol. 7, issue 28, pp. 43746-43761, 2016 Jul 12. Abstract

Despite the significant contribution of radiotherapy to non-small lung cancer (NSCLC), radioresistance still occurs. One of the major radioresistance mechanisms is the hyperactivation of the PI3K/Akt pathway in which Akt facilitates the repair of DNA double-strand breaks (DSBs) through the stimulation of DNA-PKcs. We investigated if targeting PI3K would be a potential approach for enhancing the radiosensitivity of K-RAS mutated (K-RASmut) NSCLC cell lines A549 and H460. Short-term (1-2 h) pre-treatment of cells with the PI3K inhibitor PI-103 (1 μM) inhibited Akt/DNA-PKcs activity, blocked DSBs repair and induced radiosensitivity, while long-term (24 h) pre-treatment did not. Lack of an effect after 24 h of PI-103 pre-treatment was due to reactivation of K-Ras/MEK/ERK-dependent Akt. However, long-term treatment with the combination of PI-103 and MEK inhibitor PD98059 completely blocked reactivation of Akt and impaired DSBs repair through non-homologous end joining (NHEJ) leading to radiosensitization. The effect of PI3K inhibition on Akt signaling was also tested in A549 mouse xenografts. P-Akt and P-DNA-PKcs were inhibited 30 min post-irradiation in xenografts, which were pretreated by PI-103 30 min before irradiation. However, Akt was reactivated 30 min post-irradiation in tumors, which were pre-treated for 3 h with PI-103 before irradiation. After a 24 h pretreatment with PI-103, a significant reactivation of Akt was achieved 24 h after irradiation. Thus, due to MEK/ERK-dependent reactivation of Akt, targeting PI3K alone is not a suitable approach for radiosensitizing K-RASmut NSCLC cells, indicating that dual targeting of PI3K and MEK is an efficient approach to improve radiotherapy outcome.

Touny, A., M. M. Saleh, and M. A. Al-Omair, "Metal Implants for Hard Tissue Restoration", Metal Implants for Hard Tissue Restoration, Germany, LAP Lambert Academic Publishing, ISBN: 978-3-659-96706-1 , 2016. chapter-_biomedical.pdf
Touny, A. H., R. H. Tammam, and M. M. Saleh, "Electrocatalytic oxidation of formaldehyde on nanoporous nickel phosphate modified electrode", Applied Catalysis B: Environmental, vol. 224, pp. 1017–1026, 2018. electrocatalytic_oxidation_of_formaldehyde_on_nanoporous_nickel_phosphate.pdf
Tourism