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Syunsuke Kanai, Joseph Adu-Gymfi, K. L., J. Ito, R. E. A. Moghaieb, P. Hany El-Shemy, Rashmi Mohapatra, and K. F. Hirofumi Saneoka, "N-deficiency damps out circadian rhythmic changes of stem diameter dynamics in tomato plant", Plant science, vol. 174, issue 2, pp. 183-191, 2008.
Syrovets, T., B. Buechele, M. El Gaafary, R. M. Ayala, A. Abderrazak, D. Couchie, D. F. Mahmood, R. Elhage, C. Vindis, M. Laffargue, et al., "Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin", NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, vol. 389, no. SUPPL 1: SPRINGER ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES, pp. 34–34, 2016. Abstract
Synsuke Kanai, Reda E Moghaieb, H. E. - S. A., R. Panigrahi, J. Ito, H. Saneoka, and K. Fujita, "Potassium deficiency affects water status and photosynthetic rate of the vegetative sink in green house tomato prior to its effects on source activity", Plant science, vol. 180, issue 2, pp. 368-374, 2011.
Sylvette R. Wiener-Vacher, M. D., Rima Obeid, MD, and M. D. Maha Abou-Elew, "Vestibular Impairment after Bacterial Meningitis Delays Infant Posturomotor Development", Journal of Pediatrics, vol. 161, issue 2, pp. 246-251, 2012.
Syed, S. A., A. H. Newman, A. A. Othman, and N. D. Eddington, "Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse.", Journal of pharmaceutical sciences, vol. 97, issue 5, pp. 1993-2007, 2008 May. AbstractWebsite

A second generation of N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]-tropanes (GA 1-69, JHW 005 and JHW 013) binds with high affinity to the dopamine transporter (DAT) and are highly selective toward DAT compared to muscarinic receptor binding (M1). The objective of this study was to characterize brain distribution, pharmacokinetics, and pharmacodynamics [extracellular brain dopamine (DA) levels] of three novel N-substituted benztropine (BZT) analogs in male Sprague-Dawley rats. The BZT analogs displayed a higher distribution (Vd = 8.69-34.3 vs. 0.9 L/kg) along with longer elimination (t l/2: 4.1-5.4 vs. 0.5 h) than previously reported for cocaine. Brain-to-plasma partition coefficients were 1.3-2.5 vs. 2.1 for cocaine. The effect of the BZT analogs on extracellular brain (DA) levels ranged from minimal effects (GA 1-69) to several fold elevation (approximately 850% of basal DA for JHW 013) at the highest dose evaluated. PK/PD analysis of exposure-response data resulted in lower IC50 values for the BZT analogs compared to cocaine indicating their higher potency to inhibit DA reuptake (0.1-0.3 vs. 0.7 mg/L). These BZT analogs possess significantly different PK and PD profiles as compared to cocaine suggesting that further evaluation as cocaine abuse therapeutics is warranted.

Syed, I., V. Khadkikar, and H. H. Zeineldin, "Loss Reduction in Radial Distribution Networks Using a Solid-State Transformer", IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS, vol. 54, issue 5, pp. 5474-5482, 2018.
Ramanan, A. V., A. D. Dick, D. Benton, S. Compeyrot-Lacassagne, D. Dawoud, B. Hardwick, H. Hickey, D. Hughes, A. Jones, P. Woo, et al., "A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial).", Trials, vol. 15, pp. 14, 2014. Abstract

BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Children with JIA are at risk of inflammation of the uvea in the eye (uveitis). Overall, 20% to 25% of paediatric uveitis is associated with JIA. Major risk factors for development of uveitis in JIA are oligoarticular pattern of arthritis, an age at onset of arthritis of less than seven years of age, and antinuclear antibody positivity. In the initial stages of mild to moderate inflammation the uveitis is asymptomatic. This has led to current practice of screening all children with JIA for uveitis. Approximately 12% to 38% of patients with JIA develop uveitis in seven years following onset of arthritis. In 30% to 50% of children with JIA-associated uveitis structural complications are present at diagnosis. Furthermore about 50% to 75% of those with severe uveitis will eventually develop visual impairment secondary to ocular complications such as cataract and glaucoma. Defining the severity of inflammation and structural complications in uveitis patients is now possible following Standardised Uveitis Nomenclature (SUN) guidelines, and modified to incorporate the consensus of end point and outcome criteria into the design of randomised trials. Despite current screening and therapeutic options (pre-biologics) 10% to 15% of children with JIA-associated uveitis may develop bilateral visual impairment and certified legally blind. To date, there remains no controlled trial evidence of benefits of biologic therapy.

METHODS/DESIGN: This study will randomise 154 patients aged 2 to 18 years with active JIA-associated uveitis (despite methotrexate (MTX) treatment for at least 12 weeks). All participants will be treated for 18 months, with follow up of 3 years from randomisation (continuing on MTX throughout). All participants will receive a stable dose of MTX and in addition either adalimumab (20 mg/0.8 ml for patients<30 kg or 40 mg/0.8 ml for patients weighing 30 kg or more, subcutaneous (s/c) injection every 2 weeks based on body weight), or placebo (0.8 ml as appropriate according to body weight) s/c injection every 2 weeks.

DISCUSSION: This is the first randomised controlled trial that will assess the clinical effectiveness, safety and cost effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis.


Swileam, G. S., R. R. Shahin, H. M. Nasr, and K. S. Essa, "ASSESSMENT OF SOIL VARIABILITY USING ELECTRICAL RESISTIVITY TECHNIQUE FOR NORMAL ALLUVIAL SOILS, EGYPT", Plant Archives, vol. 19, issue 1, pp. 905-912, 2019. plant_archives_1.pdf
Swileam, G. S., R. R. Shahin, H. M. Nasr, and K. S. Essa, "Spatial variability assessment of Nile alluvial soils using electrical resistivity technique", Eurasian Journal of Soil Science, vol. 8, issue 2, pp. 110-117, 2019. eurasian_journal_of_soil_science_1.pdf
Swielim, G. A., E. F. Khalifa, and S. M. EL-Gammal, "Anatomical studies on the venous drainage of the pelvic limb of the chicken", Kafrelsheikh Vet. Med. J., vol. 10, issue 1687-1456, pp. 277-315, 2012.
Swielim, G. E. A., Atlas Anatomy of the Horse, , Riga, Latvia , Noor Publishing, 2019. Website
Swielim, G. A., E. F. Khalifa, and S. M. EL-Gammal, "Anatomical studies on the arterial blood supply of the pelvic limb of chicken", SCVMJ, issue 1110-6298, 2012.
Swielim, G. E. A., Atlas Anatomy of small Ruminants, , Riga, Latvia , Noor Publishing, 2019. Website
Swielim, G. E. A., Splanchnology of Domestic Animals, , Riga, Latvia , Noor Publishing, 2019. Website
Swidan, M. M., T. M. Sakr, M. A. Motaleb, A. A. El-Bary, and M. T. El-Kolaly, "Preliminary assessment of radioiodinated fenoterol and reproterol as potential scintigraphic agents for lung imaging", J Radioanal Nucl Chem, vol. 303, pp. 531–539, 2015.
Swidan, A., S. Khattab, Y. Abouelseoud, and H. Elkamchouchi, "A secure geographical routing protocol for highly-dynamic aeronautical networks", Military Communications Conference, MILCOM 2015 - 2015 IEEE, pp. 708-713, Oct, 2015. Abstract
Swidan, M. M., T. M. Sakr, M. A. Motaleb, A. A. El-Bary, and M. T. El-Kolaly, "Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging", JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 57, pp. 593–599, 2014.
SWH, H., "Cerebellar nuclei and connections in man.", Anatomy Physiology Biochem Int J (APBIJ), vol. 1, issue 1, pp. 555552, 1916. apbij.ms_.id_.555552-2.pdf
SWG, B., F. A, and F. S, "The Warm-Up Phenomenon in Diabetic Patients with Chronic Stable Angina", Heart Mirror Journal , vol. 5, issue 3, pp. 393-398, 2011. Abstract

Background In subjects with coronary artery disease (CAD), the angina induced by initial exercise is
attenuated with re-exercise after a brief rest. This warm-up phenomenon believed to be due
to ischemic preconditioning is related to the opening of cardiac ATP-sensitive K channels (K
ATP). Blockers of these K ATP channels such as the sulphonylurea drugs can lead to loss of
ischemic preconditioning.
Objective This study aimed to examine the effects of three different sulfonylureas: glibenclamide,
gliclazide and glimepiride, on the warm-up phenomenon by analyzing the results of 2
consecutive exercise tests in diabetic patients with coronary artery disease (CAD).
Methods Forty patients with chronic stable angina: 30 patients having type 2 diabetes mellitus (DM)
and 10 non diabetic patients (group D) were enrolled in the study. The DM patients were
divided into 3 groups according to the type of sulfonylurea drug they are receiving: Group
A (glibenclamide), Group B (gliclazide) and group C (glimepiride). All the patients were
subjected to 2 consecutive exercise tests with a 15-minute recovery period between the 2 tests..
Results There was no significant increase in peak heart rate, systolic blood pressure and rate pressure
product during test 2 compared to test 1 in groups B, C and D but not in group A patients. There
was a statistically significant increase in the time to onset of chest pain (p <0.007 for B, C and
p <0.005 for D), time to onset of 1 mm ST segment depression (p <0.007 for B, C and p <0.03 for
D) and exercise duration (p <0.01 for B; p <0.008 for C and p <0.02 for D) in test 2 compared to
test 1 in groups B, C and D but not in group A. There was also a significant decrease in time to ST
segment recovery to baseline in test 2 compared to test 1 in groups B,C and D (p <0.005 in the 3
groups) but not in group A.
Conclusions Glibenclamide, but not gliclazide or glimepiride abolished the warm-up phenomenon, the
clinical counterpart of ischemic preconditioning in type 2 DM patients with CAD.

SWG, B., A. SA, B. DA, and E. - T. SMR, "Psoriasis: a localized skin disorder or a systemic inflammatory disease affecting left ventricular myocardial function.", European Heart Failure Annual meeting , Belgrade, Serbia, 2012.
SWG, B., S. SM, E. MZ, and R. HZ, "Impact of waist circumference on hospital outcome and coronary angiographic findings of patients with acute ST-segment elevation myocardial infarction", The Egyptian Heart Journal, vol. 67, pp. 159-165, 2015. Abstract

Abstract Background: Several studies showed that ST-segment elevation myocardial infarction
(STEMI) patients with high body mass index (BMI) have better in-hospital outcomes.
Aim: This study examined the impact of waist circumference (WC) on the hospital outcome and
coronary angiographic extent of STEMI patients.
Methods: We evaluated 142 consecutive patients with STEMI. Patients were classified into 2
groups according to WC. Group A (n=72) had increased WC (WC > 88/102 cm for women/
men). Group B (n= 70) had normal WC. A primary composite outcome of in-hospital mortality
and cardiovascular complications namely heart failure, cardiogenic shock, serious arrhythmias,
re-infarction, post infarction angina, a secondary outcome of in-hospital mortality and coronary
angiographic findings were compared between the 2 groups.
Results: Group A patients were significantly older, had a significantly higher prevalence of hypertension
(HTN), diabetes mellitus (DM) and were significantly less likely to be smokers compared to group B. There was no statistically significant difference in the primary outcome between the 2
groups. WC as a categorical or as a continuous variable did not have any significant influence
on the secondary outcome of in-hospital mortality even after adjustment for other predictors of
death. Age was the only statistically significant predictor for mortality (p= 0.01). Coronary angiography
revealed no statistically significant difference in the number of diseased coronary vessels,number of coronary lesions or Gensini score between the 2 groups.
Conclusion: A high WC, had no favorable impact on in-hospital mortality, cardiovascular complications
or coronary angiographic extent in STEMI patients.