Publications

Export 11193 results:
Sort by: [ Author  (Desc)] Title Type Year
A B C D E F G H I J K L M N O P Q R [S] T U V W X Y Z   [Show ALL]
S
Syunsuke Kanai, Joseph Adu-Gymfi, K. L., J. Ito, R. E. A. Moghaieb, P. Hany El-Shemy, Rashmi Mohapatra, and K. F. Hirofumi Saneoka, "N-deficiency damps out circadian rhythmic changes of stem diameter dynamics in tomato plant", Plant science, vol. 174, issue 2, pp. 183-191, 2008.
Synsuke Kanai, Reda E Moghaieb, H. E. - S. A., R. Panigrahi, J. Ito, H. Saneoka, and K. Fujita, "Potassium deficiency affects water status and photosynthetic rate of the vegetative sink in green house tomato prior to its effects on source activity", Plant science, vol. 180, issue 2, pp. 368-374, 2011.
Sylvette R. Wiener-Vacher, M. D., Rima Obeid, MD, and M. D. Maha Abou-Elew, "Vestibular Impairment after Bacterial Meningitis Delays Infant Posturomotor Development", Journal of Pediatrics, vol. 161, issue 2, pp. 246-251, 2012.
Syed, I., V. Khadkikar, and H. H. Zeineldin, "Loss Reduction in Radial Distribution Networks Using a Solid-State Transformer", IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS, vol. 54, issue 5, pp. 5474-5482, 2018.
Syed, S. A., A. H. Newman, A. A. Othman, and N. D. Eddington, "Population pharmacokinetics, brain distribution, and pharmacodynamics of 2nd generation dopamine transporter selective benztropine analogs developed as potential substitute therapeutics for treatment of cocaine abuse.", Journal of pharmaceutical sciences, vol. 97, issue 5, pp. 1993-2007, 2008 May. AbstractWebsite

A second generation of N-substituted 3alpha-[bis(4'-fluorophenyl)methoxy]-tropanes (GA 1-69, JHW 005 and JHW 013) binds with high affinity to the dopamine transporter (DAT) and are highly selective toward DAT compared to muscarinic receptor binding (M1). The objective of this study was to characterize brain distribution, pharmacokinetics, and pharmacodynamics [extracellular brain dopamine (DA) levels] of three novel N-substituted benztropine (BZT) analogs in male Sprague-Dawley rats. The BZT analogs displayed a higher distribution (Vd = 8.69-34.3 vs. 0.9 L/kg) along with longer elimination (t l/2: 4.1-5.4 vs. 0.5 h) than previously reported for cocaine. Brain-to-plasma partition coefficients were 1.3-2.5 vs. 2.1 for cocaine. The effect of the BZT analogs on extracellular brain (DA) levels ranged from minimal effects (GA 1-69) to several fold elevation (approximately 850% of basal DA for JHW 013) at the highest dose evaluated. PK/PD analysis of exposure-response data resulted in lower IC50 values for the BZT analogs compared to cocaine indicating their higher potency to inhibit DA reuptake (0.1-0.3 vs. 0.7 mg/L). These BZT analogs possess significantly different PK and PD profiles as compared to cocaine suggesting that further evaluation as cocaine abuse therapeutics is warranted.

R
Ramanan, A. V., A. D. Dick, D. Benton, S. Compeyrot-Lacassagne, D. Dawoud, B. Hardwick, H. Hickey, D. Hughes, A. Jones, P. Woo, et al., "A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial).", Trials, vol. 15, pp. 14, 2014. Abstract

BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children. Children with JIA are at risk of inflammation of the uvea in the eye (uveitis). Overall, 20% to 25% of paediatric uveitis is associated with JIA. Major risk factors for development of uveitis in JIA are oligoarticular pattern of arthritis, an age at onset of arthritis of less than seven years of age, and antinuclear antibody positivity. In the initial stages of mild to moderate inflammation the uveitis is asymptomatic. This has led to current practice of screening all children with JIA for uveitis. Approximately 12% to 38% of patients with JIA develop uveitis in seven years following onset of arthritis. In 30% to 50% of children with JIA-associated uveitis structural complications are present at diagnosis. Furthermore about 50% to 75% of those with severe uveitis will eventually develop visual impairment secondary to ocular complications such as cataract and glaucoma. Defining the severity of inflammation and structural complications in uveitis patients is now possible following Standardised Uveitis Nomenclature (SUN) guidelines, and modified to incorporate the consensus of end point and outcome criteria into the design of randomised trials. Despite current screening and therapeutic options (pre-biologics) 10% to 15% of children with JIA-associated uveitis may develop bilateral visual impairment and certified legally blind. To date, there remains no controlled trial evidence of benefits of biologic therapy.

METHODS/DESIGN: This study will randomise 154 patients aged 2 to 18 years with active JIA-associated uveitis (despite methotrexate (MTX) treatment for at least 12 weeks). All participants will be treated for 18 months, with follow up of 3 years from randomisation (continuing on MTX throughout). All participants will receive a stable dose of MTX and in addition either adalimumab (20 mg/0.8 ml for patients<30 kg or 40 mg/0.8 ml for patients weighing 30 kg or more, subcutaneous (s/c) injection every 2 weeks based on body weight), or placebo (0.8 ml as appropriate according to body weight) s/c injection every 2 weeks.

DISCUSSION: This is the first randomised controlled trial that will assess the clinical effectiveness, safety and cost effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis.

TRIAL REGISTRATION: ISRCTN10065623.

S
Swileam, G. S., R. R. Shahin, H. M. Nasr, and K. S. Essa, "Spatial variability assessment of Nile alluvial soils using electrical resistivity technique", Eurasian Journal of Soil Science, vol. 8, issue 2, pp. 110-117, 2019. eurasian_journal_of_soil_science_1.pdf
Swileam, G. S., R. R. Shahin, H. M. Nasr, and K. S. Essa, "ASSESSMENT OF SOIL VARIABILITY USING ELECTRICAL RESISTIVITY TECHNIQUE FOR NORMAL ALLUVIAL SOILS, EGYPT", Plant Archives, vol. 19, issue 1, pp. 905-912, 2019. plant_archives_1.pdf
Swielim, G. E. A., Splanchnology of Domestic Animals, , Riga, Latvia , Noor Publishing, 2019. Website
Swielim, G. A., E. F. Khalifa, and S. M. EL-Gammal, "Anatomical studies on the venous drainage of the pelvic limb of the chicken", Kafrelsheikh Vet. Med. J., vol. 10, issue 1687-1456, pp. 277-315, 2012.
Swielim, G. E. A., Atlas Anatomy of the Horse, , Riga, Latvia , Noor Publishing, 2019. Website
Swielim, G. A., E. F. Khalifa, and S. M. EL-Gammal, "Anatomical studies on the arterial blood supply of the pelvic limb of chicken", SCVMJ, issue 1110-6298, 2012.
Swielim, G. E. A., Atlas Anatomy of small Ruminants, , Riga, Latvia , Noor Publishing, 2019. Website
Swidan, A., S. Khattab, Y. Abouelseoud, and H. Elkamchouchi, "A secure geographical routing protocol for highly-dynamic aeronautical networks", Military Communications Conference, MILCOM 2015 - 2015 IEEE, pp. 708-713, Oct, 2015. Abstract
n/a
Swidan, M. M., T. M. Sakr, M. A. Motaleb, A. A. El-Bary, and M. T. El-Kolaly, "Radioiodinated acebutolol as a new highly selective radiotracer for myocardial perfusion imaging", JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 57, pp. 593–599, 2014.
Swidan, M. M., T. M. Sakr, M. A. Motaleb, A. A. El-Bary, and M. T. El-Kolaly, "Preliminary assessment of radioiodinated fenoterol and reproterol as potential scintigraphic agents for lung imaging", J Radioanal Nucl Chem, vol. 303, pp. 531–539, 2015.
SWH, H., "Cerebellar nuclei and connections in man.", Anatomy Physiology Biochem Int J (APBIJ), vol. 1, issue 1, pp. 555552, 1916. apbij.ms_.id_.555552-2.pdf
SWG, B., I. R, G. H, and Z. A, "Platelet Count and Function in Patients with Aortic Stenosis of Different Degrees of Severity", The Egyptian Heart Journal, vol. 54, pp. 400 -406, 2002.
SWG, B., E. M, A. AR, and H. MS, "Assessment of left ventricular function in systemic lupus erythematosus patients by speckle tracking echocardiography: Relation to circulating endothelial progenitor cells", The Egyptian Rheumatologist, vol. 37, pp. S33-S41, 2015. Abstract

Background Systemic lupus erythematosus (SLE) is an autoimmune disease associated with reduced number and impaired function of endothelial progenitor cells (EPCs) responsible for vascular regeneration. Aim The aim of this study was to assess left ventricular (LV) function of SLE patients using the relatively new speckle tracking echocardiography (STE) and examine whether any detected abnormalities of LV function have any relation with peripheral circulating EPCs level. Methods Fifty SLE patients and 25 healthy controls were subjected to quantification of peripheral circulating VEGFR2+/CD133+ and VEGFR2+/CD34+ EPCs, transthoracic echocardiography (TTE), tissue Doppler imaging (TDI) and STE. Results Patients showed a significantly lower CD133+/VEGFR2+ EPCs (p= 0.009) and CD34+/VEGFR2+ EPCs counts (p= 0.0001) compared to controls. TTE/TDI revealed a significantly lower LV ejection fraction (EF) (p=0.007), higher LV end systolic dimensions (p=0.02), myocardial performance index (MPI) (p=0.0001) and mitral flow E/lateral annulus E' ratio (p=0.002) in patients compared to controls. STE showed a significantly lower global longitudinal strain (GLS) (p value <0.001), global circumferential strain (GCS) (p<0.001) and global strain rate during isovolumic relaxation period (GSRivr) (p=0.01) in patients compared to controls. No correlation was detected between age of the patients, duration of disease, prednisolone dose or intake duration, use of azathioprine vs. cyclophosphamide, SLE disease activity index, LV MPI, LV EF, CD133+/VEGFR2+ EPCs or CD34+/VEGFR2+ EPCs count and GLS. By multiple logistic regression analysis, the independent variables affecting GCS and GSRivr were the prednisolone dose and the LVEF respectively. (95% CI = -0.46 to -0.03; p= 0.03 and 95% CI = 0.001 to 0.01; p=0.021; respectively). Conclusion
STE detected subclinical systolic and diastolic abnormalities of LV function in SLE patients. These abnormalities of LV function did not show however any relation with the significantly lower EPCs count detected in patients.

SWG, B., A. S, B. D, and E. S, "Psoriasis: A Localized Skin Disorder or a Systemic Inflammatory Disease Affecting Left Ventricular Myocardial Function ", Heart Mirror Journal , vol. 6, issue 1, pp. 41-49, 2012. Abstract

Psoriasis, recently considered a systemic inflammatory disease, is associated with increased
cardiovascular morbidity and mortality. Inflammation can affect left ventricular function via
multiple mechanisms.
Objective Our aim was to determine the usefulness of using the relatively new tissue Doppler imaging
(TDI) in detecting left ventricular (LV) function abnormalities which may be underestimated
by conventional Doppler echocardiography (DE) in psoriasis patients.
Methods Thirty young patients with psoriasis (mean age36.9±9.2 yrs), without cardiovascular risk
factors or clinically evident cardiovascular disease and 30 healthy age and sex-matched
controls were subjected to DE and TDI. High-sensitivity C-reactive protein (hs-CRP), serum
homocysteine (Hcys) were also measured.
Results The serum hs-CRP and Hcys levels were significantly higher in patients compared to controls
(10.6±5.2 vs. 1.1±0.6mg/dl and 21.8±13.4 vs. 13.6±6.0μmol/l; both p <0.0001; respectively).
As regards DE, there was no statistically significant difference in LV dimensions, ejection
fraction, mitral Doppler flow E, A wave peak velocities, E/A ratio, or isovolumic relaxation time
(IVRT). As regards TDI, the peak systolic annular velocity (S), the early peak e’ and the late
peak a’ diastolic annular velocities were significantly lower in patients compared to controls
(9.6±1.6 vs. 10.9±1.0cm/sec; p <0.007; 12.6±2.6 vs. 14.6±1.2cm/sec; p <0.001 and 10.1±2.3 vs.
12.5±2.2cm/sec; p <0.002; respectively). The TDI derived IVCT and IVRT were significantly
prolonged in patients compared to controls (78.9±15.3 vs. 68.8±9.5msec; p <0.01 and 83.6±17.8
vs. 69.2±6.1msec; p <0.001 respectively). Significant negative correlations between hs-CRP
(r= -0.47; p= 0.017), Hcys (r= -0.61; p= 0.001) levels and e’ peak velocity, and between Hcys
level and S peak velocity (r= -0.52; p= 0.008) and a significant positive correlation between Hcys
level and TDI derived IVRT (r= 0.48; p= 0.014) were noted in patients.
Conclusions Mitral annular systolic and diastolic abnormalities detected by TDI, in patients with psoriasis
may be a useful marker for early heart failure in this group of patients.

SWG, B., S. SM, E. MZ, and R. HZ, "Impact of waist Impact of waist circumference on hospital outcome and coronary angiographic findings of patients with acute ST-segment elevation myocardial infarction.", Tenth International Congress on Coronary Artery Disease , Florence, Italy, October, 2013.
SWG, B., G. B, and Z. A, "Long Term Clinical and Echocardiographic Follow up of Percutaneous Dilatation of Mitral Valve using the Metallic Valvulotome", The Egyptian Heart Journal, vol. 54, pp. 621-629, 2002.
Tourism