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S, M., S. A, C. J, D. C. P, and C. K, "A novel silk suture-assisted laparoscopic technique for the repair of a gastrocolic fistula in a pediatric patient", Journal of Pediatric Surgery, vol. 13, pp. 45-47, 2016.
S, A., H. M, B. A, K. L, and A. M, "Contribution of Posterior Corneal Astigmatism to Total Corneal Astigmatism in a Sample of Egyptian Population", Clinical ophthalmology , vol. Volume 2020:14, issue 1177-5483, pp. 3325—3330, 2020.
S, H., S. HS, K. N, H. A, H. M, S. N, A. NT, F. M, NADA.M, salah.h, et al., "Kasr Al-Ainy Proposed Protocol for Diagnosis and Treatment of Multiple Sclerosis. I: Diagnosis", Egyptian Journal of Neurology, Psychiatry & Neurosurgery, 2015.
osman. S, A. A. H. Z, A. A. W. E, and undefined, Conflict resolution behaviors among addict adolescents in Egypt, , 2015. artical.pdf
S, I., M. G, A. Aziza, and A. M, "Comparative Killing Activity of Different Nanoparticles and Nano-composites Based on Dermanyssus gallinae. ", Nano Biomed. Eng., vol. 12, issue 4, pp. 338-350, 2020. comparative_killing_activity.pdf
S, L., S. T, R. M, FarrohKhY, A. Z, and Y. T, "Synthesis, characterization and cytotoxic evaluation of graphene oxide nanosheets: in vitro liver cancer model.", Asian Pac J Cancer Prev , vol. 18, issue 4, pp. 955-961, 2017.
S, E., B. D, al hawary m, and sany I, "Recipient site preparation by cryoblebbing in melanocyte keratinocyte transplantation procedure over the fingers in vitiligo: A pilot study", Dermatol Ther, vol. 33, issue 6, pp. :e14199., 2020.
S, O., K. A, S. AE, and M. MN, "Serum Beta-2 Microglobulin: a Possible Marker for Disease Progression in Egyptian Patients with Chronic HCV Related Liver Diseas", Asian Pac J Cancer Prevention, vol. 16, issue 17, pp. 7825-9, 1975 Oct 27, 2015. ahmed_khairy_b2_microglobulin.pdf
S, S., E. - M. SA, S. HF, E. - B. RA, and S. W, "Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever", Iran J Med Sci, vol. 41, issue 1, pp. 2-8, 2016.
S, F., S. Sabet, F. A. Abu Zahra, and A. A. El-Ghor, "Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis.", PloS one, vol. 13, issue 10, pp. e0206130, 2018. Abstract

Therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been reported in several animal models of liver fibrosis. Interleukin (IL) 17A, IL6 and Stat3 have been described to play crucial roles in chronic liver injury. However, the modulatory effect of MSCs on these markers was controversial in different diseases. BM-MSCs might activate the IL6/STAT3 signaling pathway and promote cell invasion in hepatocellular carcinoma, but the immunomodulatory role of BM-MSCs on IL17A/IL6/STAT3 was not fully elucidated in liver fibrosis. In the present study, we evaluated the capacity of the BM-MSCs in the modulation of cytokines milieu and signal transducers, based on unique inflammatory genes Il17a and Il17f and their receptors Il17rc and their effect on the IL6/STAT3 pathway in CCl4-induced liver fibrosis in rats. A single dose of BM-MSCs was administered to the group with induced liver fibrosis, and the genes and proteins of interest were evaluated along six weeks after treatment. Our results showed a significant downregulation of Il17a, Il17ra, il17f and Il17rc genes. In accordance, BM-MSCs administration declined IL17, IL2 and IL6 serum proteins and downregulated IL17A and IL17RA proteins in liver tissue. Interestingly, BM-MSCs downregulated both Stat3 mRNA expression and p-STAT3, while Stat5a gene was downregulated and p-STAT5 protein was elevated. Also P-SMAD3 and TGFβR2 proteins were downregulated in response to BM-MSCs treatment. Collectively, we suggest that BM-MSCs might play an immunomodulatory role in the treatment of liver fibrosis through downregulation of IL17A affecting IL6/STAT3 signaling pathway.

S, T., G. SM, N. M, N. N, L. D, S. I, and G. TA, "Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients.", Rev Bras Reumatol, vol. 57, issue 2, pp. 149-153, 2017. Abstractfinal_accept_published_1-s2.0-s2255502116300980-main.pdfWebsite

Aim

To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations.

Patients and methods

Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR).

Results

Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p < 0.001] and GG [10% vs 66.7%, p < 0.001]).

Conclusion

Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.

S, E., Anbar T, Rasheed H, H. RA, and R. A, "Analysis of symmetricity in the three different (sagittal, transverse and frontal) planes in generalized nonsegmental vitiligo", Indian J Dermatol Venereol Leprol, vol. 87, issue 1, pp. 22-28., 2021.
S, I. M., Y. A. Elsayed, H. F. Azzam, and R. E. Reyad, "Effectiveness of diet and exercise program in the clinical features of Polycystic Ovarian Syndrome among adolescents", 4th World Congress on Polycystic Ovarian Syndrome, USA, 26 October , 2018. program.pdf
S, S., L. HM, M. AN, K. AM, and F. N., " Damage index in childhood-onset systemic lupus erythematosus in Egypt.", Pediatric rheumatology online journal, vol. 9, 2011. AbstractCU-PDF

BACKGROUND: To investigate the prevalence of cumulative organ damage among Egyptian children with juvenile-onset systemic lupus erythematosus (jSLE) and the relationships between the organ damage and the demographic data, clinical variables, and disease activity.
METHODS: A total of 148 patients with jSLE have been followed in the pediatric rheumatology clinic and section at Cairo University. These patients were evaluated by retrospective chart review. The organ system damage due to SLE was measured using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Risk factors for damage were also studied including demographic criteria as well as clinical and laboratory manifestations.
RESULTS: Overall, 43.9% of the patients had damage within a mean of 6.57 ± 3.59 years of disease diagnosis. Neuropsychiatric (NPS-21%) and renal (16.9%) system involvement were observed most frequently, followed by cardiovascular (11.5%), skin (9.5%), pulmonary (6.1%), and ocular (4.8%), with a mean SDI score of 0.93 ± 1.37. In our study, the presence of neuropsychiatric manifestations at diagnosis showed the strongest association with the presence of later disease damage.The number of SLE diagnostic criteria at presentation was strongly associated with the total SDI score, and the renal damage was significantly more prevalent in patients with age at disease diagnosis below 10 years of age. A higher mean disease duration was found in patients with musculoskeletal damage.
CONCLUSION: We found that cumulative organ damage, as measured by the SDI, was present in 43.9% of Egyptian patients with juvenile-onset SLE. The damage was significantly more likely in patients who had more SLE diagnostic criteria at time of disease presentation and NPS manifestations at the time of diagnosis.

S, E., Heba Ismail Gawdat 1, R. H. A. 1, and E. R. Said, "Different methods of enhancing the efficacy of topical tacrolimus in extra-facial vitiligo: A comparative study", J Cosmet Dermatol ., vol. in press, issue in press, pp. in press, 2021.
S, S., Kaddah, and E. E, "Epidemiology of primary nephrotic syndrome in Egyptian children", JNephrol, vol. 25, issue 5, pp. 732-737, 2012. epidemiology_of_ns.pdf
S, K., E. MS, M. HA, Z. T, Salah M, and E. MA, "Renal recoverability in infants with obstructive calcular anuria: is it better than in older children?", Journal of Pediatric Urology, vol. Dec 2013, issue 9, pp. 1178-82, 2013.
S, E. T., G. M., and A. A. E. - M. E., "Poverty and Inequality in the Arab Republic of Egypt’s Poorest Villages", Inequality in the Arab Republic of Egypt: Facts and Perceptions Across People, Time, And Space, Washington D.C., The World Bank, 2014.