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S, T., F. A, T. S, H. A, Darwish AD, E. T, and D. E., " Increased Serum Endoglin and Transforming Growth Factor β1 mRNA Expression and Risk of Hepatocellular Carcinoma in Cirrhotic Egyptian Patients.", Asian Pac J Cancer Prev. , vol. 17, issue 5, pp. 2429-34, 2016. endoglin_april_2016.pdf
S, I., E. S, S. A, and N. M, "Electromyography: A quantitative measure of the degree of prosthesis’ retention", Basic Research Journal of Medicine and Clinical Sciences, vol. 1, issue 2, pp. 25-32, 2012. qemg_in_prosthesis.pdf
S, F., S. Sabet, F. A. Abu Zahra, and A. A. El-Ghor, "Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis.", PloS one, vol. 13, issue 10, pp. e0206130, 2018. Abstract

Therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been reported in several animal models of liver fibrosis. Interleukin (IL) 17A, IL6 and Stat3 have been described to play crucial roles in chronic liver injury. However, the modulatory effect of MSCs on these markers was controversial in different diseases. BM-MSCs might activate the IL6/STAT3 signaling pathway and promote cell invasion in hepatocellular carcinoma, but the immunomodulatory role of BM-MSCs on IL17A/IL6/STAT3 was not fully elucidated in liver fibrosis. In the present study, we evaluated the capacity of the BM-MSCs in the modulation of cytokines milieu and signal transducers, based on unique inflammatory genes Il17a and Il17f and their receptors Il17rc and their effect on the IL6/STAT3 pathway in CCl4-induced liver fibrosis in rats. A single dose of BM-MSCs was administered to the group with induced liver fibrosis, and the genes and proteins of interest were evaluated along six weeks after treatment. Our results showed a significant downregulation of Il17a, Il17ra, il17f and Il17rc genes. In accordance, BM-MSCs administration declined IL17, IL2 and IL6 serum proteins and downregulated IL17A and IL17RA proteins in liver tissue. Interestingly, BM-MSCs downregulated both Stat3 mRNA expression and p-STAT3, while Stat5a gene was downregulated and p-STAT5 protein was elevated. Also P-SMAD3 and TGFβR2 proteins were downregulated in response to BM-MSCs treatment. Collectively, we suggest that BM-MSCs might play an immunomodulatory role in the treatment of liver fibrosis through downregulation of IL17A affecting IL6/STAT3 signaling pathway.

S, H., E. H. M, H. S, E. TM, and et al, "Machine Learning Prediction Models for Diagnosing Hepatocellular Carcinoma with HCV-related Chronic Liver Disease", Computer Methods and Programs in Biomedicine, vol. 196, pp. 105551, 2020.
S, A. E., M. H, Z. A. H. E. R. A, T. A, and O. W, Role of PETCT in patients with metastases of unknown primary, , Cairo, Cairo, 2013.
S, I., M. G, A. Aziza, and A. M, "Comparative Killing Activity of Different Nanoparticles and Nano-composites Based on Dermanyssus gallinae. ", Nano Biomed. Eng., vol. 12, issue 4, pp. 338-350, 2020. comparative_killing_activity.pdf
S, M., M. A, L. A, E. H, S. S, and W. O, "Oligoclonal bands and levels of interleukin 4, interleukin 10, and tumor necrosis factor alpha in idiopathic intracranial hypertension Egyptian patients", The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, vol. 55, issue 88, 2019.
S, E., BahaaS, F. M, and G. HI, "Fractional Carbon Dioxide Laser is Effective in Amelioration of Pruritus in Primary Cutaneous Amyloidosis: A Clinical and Biochemical Study", Lasers Surg Med, vol. in press, issue in press, pp. in press, 2021.
S, S., E. MF, M. I, E. - S. GS, and R. M, "Aluminium and lead abnormalities in children on haemodialysis: relationship with some medications", Archives of Medical Science, vol. 6, issue 3, pp. 420-429, 2010. aluminium1final_pdf.pdf
S, S. E. - D., F. H. R. L, M. S, and H. R, "Impact of mesenchymal stem cells and Vitamin D on transforming growth factor beta signaling pathway in hepatocellular carcinoma in rats", Asian Pacific Journal of Cancer Prevention, vol. 19 , issue 4, pp. 905-912, 2018.
osman. S, A. A. H. Z, A. A. W. E, and undefined, Conflict resolution behaviors among addict adolescents in Egypt, , 2015. artical.pdf
S, E., Abdallah M, El Mofty M, and anber t, "CXCL-10 and Interleukin-6 are reliable serum markers for vitiligo activity: A multicenter cross-sectional study.", Pigment Cell Melanoma Res. , vol. 31, issue (2), 2018.
S,  G. E. M., A. M. A, E. H. HM, and E. F. A, "Cytotoxic activity of phenolic constituents from Echinocloa crus-galli against four human cancer cell lines.", Brazilian Journal of Pharmacognosy, vol. 26, issue http://dx.doi.org/10.1016/j.bjp.2015.07.026, pp. 62-67, 2016.
S, E., Heba Ismail Gawdat 1, R. H. A. 1, and E. R. Said, "Different methods of enhancing the efficacy of topical tacrolimus in extra-facial vitiligo: A comparative study", J Cosmet Dermatol ., vol. in press, issue in press, pp. in press, 2021.
S, E. T., G. M., and A. A. E. - M. E., "Poverty and Inequality in the Arab Republic of Egypt’s Poorest Villages", Inequality in the Arab Republic of Egypt: Facts and Perceptions Across People, Time, And Space, Washington D.C., The World Bank, 2014.
S, O., K. A, S. AE, and M. MN, "Serum Beta-2 Microglobulin: a Possible Marker for Disease Progression in Egyptian Patients with Chronic HCV Related Liver Diseas", Asian Pac J Cancer Prevention, vol. 16, issue 17, pp. 7825-9, 1975 Oct 27, 2015. ahmed_khairy_b2_microglobulin.pdf
S, L., S. C, N. G, A. ZSO, C. G, E. - B. HA, D. Q, and W. J, "Pharmacological Inhibitors of NAD Biosynthesis as Potential Anticancer Agents", Recent Pat Anticancer Drug Discov., vol. 12, issue 3, pp. 190-207, 2017.
S, S., R. S, L. HM, E. H. S, M. H, and F. Y, "MEFV gene mutations in Egyptian children with Henoch-Schonlein purpura", Pediatr Rheumatol Online J, issue 12, pp. 14, 2014.
S, A., H. M, B. A, K. L, and A. M, "Contribution of Posterior Corneal Astigmatism to Total Corneal Astigmatism in a Sample of Egyptian Population", Clinical ophthalmology , vol. Volume 2020:14, issue 1177-5483, pp. 3325—3330, 2020.
S, E. - J., T. HSA, E. MY, G. H, and E. HMS, "Differentiated versus undifferentiated mesenchymal stem cell therapy in paraquat model of Parkinson’s disease", the 20th international congress of Parkinson's disease and movement disorders, Berlin. Germany, 22 June, 2016.
S, A., E. K, H. R, and M. M, "Renal Doppler indices in diabetic children with insulin resistance syndrome.", Pediatr Diabetes. , vol. 11, issue 7, pp. 479-86, 2010.
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