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S, I. M., Y. A. Elsayed, H. F. Azzam, and R. E. Reyad, "Effectiveness of diet and exercise program in the clinical features of Polycystic Ovarian Syndrome among adolescents", 4th World Congress on Polycystic Ovarian Syndrome, USA, 26 October , 2018. program.pdf
S, T., F. A, T. S, H. A, Darwish AD, E. T, and D. E., " Increased Serum Endoglin and Transforming Growth Factor β1 mRNA Expression and Risk of Hepatocellular Carcinoma in Cirrhotic Egyptian Patients.", Asian Pac J Cancer Prev. , vol. 17, issue 5, pp. 2429-34, 2016. endoglin_april_2016.pdf
S, E. - J., T. HSA, E. MY, G. H, and E. HMS, "Differentiated versus undifferentiated mesenchymal stem cell therapy in paraquat model of Parkinson’s disease", the 20th international congress of Parkinson's disease and movement disorders, Berlin. Germany, 22 June, 2016.
S, A., E. K, H. R, and M. M, "Renal Doppler indices in diabetic children with insulin resistance syndrome.", Pediatr Diabetes. , vol. 11, issue 7, pp. 479-86, 2010.
S, M., S. A, C. J, D. C. P, and C. K, "A novel silk suture-assisted laparoscopic technique for the repair of a gastrocolic fistula in a pediatric patient", Journal of Pediatric Surgery, vol. 13, pp. 45-47, 2016.
S, E. - M., A. -sattar E, H. M, K. T, and O. T, "Screening of Medicinal Plants in Egypt for Anti-Human Immunodeficiency Virus Type-1 (HIV-1) Activity", Journal of the Arab Society for the Medical Research, vol. 4, pp. 1–8, 2009. Abstract
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S, A., H. M, B. A, K. L, and A. M, "Contribution of Posterior Corneal Astigmatism to Total Corneal Astigmatism in a Sample of Egyptian Population", Clinical ophthalmology , vol. Volume 2020:14, issue 1177-5483, pp. 3325—3330, 2020.
S, S. E. - D., F. H. R. L, M. S, and H. R, "Impact of mesenchymal stem cells and Vitamin D on transforming growth factor beta signaling pathway in hepatocellular carcinoma in rats", Asian Pacific Journal of Cancer Prevention, vol. 19 , issue 4, pp. 905-912, 2018.
S, E., A. DM, H. RA, S. S., and S. MA, "Matrix metalloproteinase in acral and non-acral vitiligo.", Photodermatol Photoimmunol Photomed. 2018 May;34(3)., vol. 34, issue (3), pp. :211-213, 2018.
S, E., W. van Geel N, Ezzedine K, Pandya AG, and G. V. B. L. J. E. H. H. J. E. E. L. S. I. A, Bekkenk M, "Validation of a physician global assessment tool for vitiligo extent: Results of an international vitiligo expert meeting.", Pigment Cell Melanoma Res. 2019 Sep;32(5):728-733. doi: 10.1111/pcmr.12784. Epub 2019 May 9., vol. 32, issue 5, pp. 728-733, 2019.
S, T., G. SM, N. M, N. N, L. D, S. I, and G. TA, "Vascular endothelial growth factor G1612A (rs10434) gene polymorphism and neuropsychiatric manifestations in systemic lupus erythematosus patients.", Rev Bras Reumatol, vol. 57, issue 2, pp. 149-153, 2017. Abstractfinal_accept_published_1-s2.0-s2255502116300980-main.pdfWebsite

Aim

To investigate the relation between vascular endothelial growth factor (VEGF) gene polymorphism in systemic lupus erythematosus (SLE) patients and lupus related neuropsychiatric manifestations.

Patients and methods

Sixty adult SLE patients recruited from the Rheumatology and Neurology departments of Cairo University hospitals were classified into two groups; Group A: 30 patients with neuropsychiatric manifestations (NPSLE) and Group B: 30 patients without. For both groups the SNP G1612A (rs10434) of the VEGF gene was genotyped by real time polymerase chain reaction (RT-PCR).

Results

Statistically significant difference was found in genotype and allele frequencies between both groups (AA [70% vs 13.3%, p < 0.001] and GG [10% vs 66.7%, p < 0.001]).

Conclusion

Polymorphism in the gene coding for VEGF may be associated with increased incidence of neuropsychiatric lupus in SLE patients.

S, S., E. - M. SA, S. HF, E. - B. RA, and S. W, "Bone Mineral Density in Egyptian Children with Familial Mediterranean Fever", Iran J Med Sci, vol. 41, issue 1, pp. 2-8, 2016.
S, E., E. - J. S, K. M, E. G. A, and E. B, "Trans-orbital sonography versus visual evoked potentials in acute demyelinating optic neuritis", Multiple Sclerosis and related didorders, vol. 40, pp. 101934, 2020.
S, E., B. D, al hawary m, and sany I, "Recipient site preparation by cryoblebbing in melanocyte keratinocyte transplantation procedure over the fingers in vitiligo: A pilot study", Dermatol Ther, vol. 33, issue 6, pp. :e14199., 2020.
S, L., S. T, R. M, FarrohKhY, A. Z, and Y. T, "Synthesis, characterization and cytotoxic evaluation of graphene oxide nanosheets: in vitro liver cancer model.", Asian Pac J Cancer Prev , vol. 18, issue 4, pp. 955-961, 2017.
S, B., N. S. Gadallah M, M. M. A. B. I. Youssef A, Costa A, and E. E, "Breast screening in the emerging world: high prevalence of breast cancer in Cairo", Breast., vol. 2005 Oct, issue Oct;14(5), pp. 340-6, 2005.
S, O., K. A, S. AE, and M. MN, "Serum Beta-2 Microglobulin: a Possible Marker for Disease Progression in Egyptian Patients with Chronic HCV Related Liver Diseas", Asian Pac J Cancer Prevention, vol. 16, issue 17, pp. 7825-9, 1975 Oct 27, 2015. ahmed_khairy_b2_microglobulin.pdf
S, L., S. C, N. G, A. ZSO, C. G, E. - B. HA, D. Q, and W. J, "Pharmacological Inhibitors of NAD Biosynthesis as Potential Anticancer Agents", Recent Pat Anticancer Drug Discov., vol. 12, issue 3, pp. 190-207, 2017.
S, E., Anbar T, Rasheed H, H. RA, and R. A, "Analysis of symmetricity in the three different (sagittal, transverse and frontal) planes in generalized nonsegmental vitiligo", Indian J Dermatol Venereol Leprol, vol. 87, issue 1, pp. 22-28., 2021.
S, S., L. HM, M. AN, K. AM, and F. N., " Damage index in childhood-onset systemic lupus erythematosus in Egypt.", Pediatric rheumatology online journal, vol. 9, 2011. AbstractCU-PDF

BACKGROUND: To investigate the prevalence of cumulative organ damage among Egyptian children with juvenile-onset systemic lupus erythematosus (jSLE) and the relationships between the organ damage and the demographic data, clinical variables, and disease activity.
METHODS: A total of 148 patients with jSLE have been followed in the pediatric rheumatology clinic and section at Cairo University. These patients were evaluated by retrospective chart review. The organ system damage due to SLE was measured using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). Risk factors for damage were also studied including demographic criteria as well as clinical and laboratory manifestations.
RESULTS: Overall, 43.9% of the patients had damage within a mean of 6.57 ± 3.59 years of disease diagnosis. Neuropsychiatric (NPS-21%) and renal (16.9%) system involvement were observed most frequently, followed by cardiovascular (11.5%), skin (9.5%), pulmonary (6.1%), and ocular (4.8%), with a mean SDI score of 0.93 ± 1.37. In our study, the presence of neuropsychiatric manifestations at diagnosis showed the strongest association with the presence of later disease damage.The number of SLE diagnostic criteria at presentation was strongly associated with the total SDI score, and the renal damage was significantly more prevalent in patients with age at disease diagnosis below 10 years of age. A higher mean disease duration was found in patients with musculoskeletal damage.
CONCLUSION: We found that cumulative organ damage, as measured by the SDI, was present in 43.9% of Egyptian patients with juvenile-onset SLE. The damage was significantly more likely in patients who had more SLE diagnostic criteria at time of disease presentation and NPS manifestations at the time of diagnosis.