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Eissa, I. H., H. Mohammad, O. A. Qassem, W. Younis, T. M. Abdelghany, A. Elshafeey, M. A. R. M. Moustafa, M. N. Seleem, and A. S. Mayhoub, "{Diphenylurea derivatives for combating methicillin-and vancomycinresistant Staphylococcus aureus}", {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY}, vol. {130}, {23 RUE LINOIS, 75724 PARIS, FRANCE}, {ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER}, pp. {73-85}, {APR 21}, Submitted. Abstract

{A new class of diphenylurea was identified as a novel antibacterial scaffold with an antibacterial spectrum that includes highly resistant staphylococcal isolates, namely methicillin-and vancomycin-resistant Staphylococcus aureus (MRSA & VRSA). Starting with a lead compound 3 that carries an aminoguanidine functionality from one side and a n-butyl moiety on the other ring, several analogues were prepared. Considering the pharmacokinetic parameters as a key factor in structural optimization, the structureactivity-relationships (SARs) at the lipophilic side chain were rigorously examined leading to the discovery of the cycloheptyloxyl analogue 21n as a potential drug-candidate. This compound has several notable advantages over vancomycin and linezolid including rapid killing kinetics against MRSA and the ability to target and reduce the burden of MRSA harboring inside immune cells (macrophages). Furthermore, the potent anti-MRSA activity of 21n was confirmed in vivo using a Caenorhabditis elegans animal model. The present study provides a foundation for further development of diphenylurea compounds as potential therapeutic agents to address the burgeoning challenge of bacterial resistance to antibiotics. (C) 2017 Elsevier Masson SAS. All rights reserved.}

Ammar, M. E., X. Ruan, E. G. R. Davies, M. Dyck, S. Jeffrey, F. Qiu, and J. Unterschultz, {Challenges and Opportunities Associated With Expanding the Irrigation Sector in Southern Alberta}, , no. 1, Edmonton, AB, University of Alberta, pp. 44, 2014. Abstract
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Brockington, I., P. Chandra, H. Dubowitz, D. Jones, S. Moussa, J. Nakku, and I. Quadros Ferre, "WPA guidance on the protection and promotion of mental health in children of persons with severe mental disorders", World Psychiatry, vol. 10, issue 2, pp. 93 - 102, 2011. Abstract

This guidance details the needs of children, and the qualities of parenting that meet those needs. Parental mental disorders can damage the foetus during pregnancy through the action of drugs, prescribed or abused. Pregnancy and the puerperium can exacerbate or initiate mental illness in susceptible women. After their birth, the children may suffer from the social disadvantage associated with severe mental illness. The parents (depending on the disorder, its severity and its persistence) may have intermittent or prolonged difficulties with parenting, which may sometimes result in childhood psychological disturbance or child maltreatment. This guidance considers ways of preventing, minimizing and remedying these effects. Our recommendations include: education of psychiatrists and related professions about the effect of parental mental illness on children; revision of psychiatric training to increase awareness of patients as caregivers, and to incorporate relevant assessment and intervention into their treatment and rehabilitation; the optimum use of pharmacological treatment during pregnancy; pre-birth planning when women with severe mental illness become pregnant; development of specialist services for pregnant and puerperal women, with assessment of their efficacy; community support for parenting by mothers and fathers with severe mental disorders; standards
of good practice for the management of child maltreatment when parents suffer from mental illness; the importance of multi-disciplinary teamwork when helping these families, supporting their children and ensuring child protection; the development of child and adolescent mental health services worldwide.
Key words: Parenting, severe mental illness, mother-infant relationship, substance abuse, childhood mental disorders, child maltreatment, child and adolescent mental health services
(World Psychiatry 2011;10:93-102)
PMID: 21633678 [PubMed] Free PMC Article

Qotb, M., M. Shohaieb, and A. Abbas, "Women's Entrepreneurship", ISBE, Paris, France, 2016.
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Rimoin, A. W., C. F. L. Walker, R. A. Chitale, H. S. Hamza, A. Vince, D. Gardovska, A. L. da Cunha, S. Qazi, and M. C. Steinhoff, "Variation in clinical presentation of childhood group A streptococcal pharyngitis in four countries.", Journal of tropical pediatrics, vol. 54, issue 5, pp. 308-12, 2008 Oct. Abstract

We conducted a cross-sectional study from September 2001 to August 2003 during which children between 2 and 12 years of age presenting with complaint of sore throat were recruited from urban pediatric clinics in Brazil, Croatia, Egypt and Latvia. The objective of the study was to compare clinical signs and symptoms of children presenting to urban pediatric clinics with sore throat in and between countries and to identify common clinical criteria predicting group A beta hemolytic streptococcal (GAS) pharyngitis. Using a single standard protocol in all four sites, clinical data were recorded and throat swabs obtained for standard GAS culture in 2040 children. Signs and symptoms were tested for statistical association with GAS positive/negative pharyngitis, and were compared using chi(2) tests, ANOVA and Odds Ratios. Clinical signs of GAS pharyngitis in children presenting to clinics varied significantly between countries, and there were few signs or symptom that could statistically be associated with GAS pharyngitis in all four countries, though several were useful in two or three countries. Our results indicate that the clinical manifestations of pharyngitis in clinics may vary by region. It is therefore critical that clinical decision rules for management of pharyngitis should have local validation.

Quartuccio, L., M. Isola, L. Corazza, S. Retamozo, M. A. - M. El-Menyawi, E. Gremese, M. Sebastiani, N. Pipitone, T. Urraro, V. Conteduca, et al., "Validation Study Of The International Classification Criteria For The Cryoglobulinemic Vasculitis", ARTHRITIS AND RHEUMATISM, vol. 65, pp. S1123–S1124, 2013. Abstract
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Quartuccio, L., M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, M. N. Zoheir, M. A. - M. El-Menyawi, M. N. Salem, D. Sansonno, et al., "Validation of the classification criteria for cryoglobulinaemic vasculitis.", Rheumatology (Oxford, England), vol. 53, issue 12, pp. 2209-13, 2014 Dec. Abstract

OBJECTIVE: The aim of this study was to validate the classification criteria for cryoglobulinaemic vasculitis (CV).

METHODS: Twenty-three centres were involved. New patients with CV (group A) and controls, i.e. subjects with serum cryoglobulins but lacking CV based on the gold standard of clinical judgment (group B) and subjects without cryoglobulins but with clinical features that can be observed in the course of CV (group C), were studied. Positivity of serum cryoglobulins was necessary for CV classification. Sensitivity and specificity of the criteria were calculated by comparing group A vs group B. The group A vs group C comparison was done to demonstrate the possible diagnostic utility of the criteria.

RESULTS: The study included 268 patients in group A, 182 controls in group B and 193 controls in group C (small vessel vasculitis, 51.8%). The questionnaire (at least 2/3 positive answers) showed 89.0% sensitivity and 93.4% specificity; the clinical item (at least 3/4 clinical involvement) showed 75.7% sensitivity and 89.0% specificity and the laboratory item (at least 2/3 laboratory data) showed 80.2% sensitivity and 62.4% specificity. The sensitivity and specificity of the classification criteria (at least 2/3 positive items) were 89.9% and 93.5%, respectively. The comparison of group A with group C demonstrated the clinical utility of the criteria in differentiating CV from CV mimickers.

CONCLUSION: Classification criteria for CV were validated in a second, large, international study confirming good sensitivity and specificity in a complex systemic disease.

Quartuccio, L., M. Isola, L. Corazza, M. Ramos-Casals, S. Retamozo, G. M. Ragab, M. N. Zoheir, M. A. - M. El-Menyawi, M. N. Salem, and D. Sansonno, "Validation of the classification criteria for cryoglobulinaemic vasculitis", Rheumatology, vol. 53, issue 12: Oxford University Press, pp. 2209-2213, 2014. Abstract
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Rimoin, A. W., C. F. L. Walker, H. S. Hamza, N. Elminawi, H. A. Ghafar, A. Vince, A. L. A. da Cunha, S. Qazi, D. Gardovska, and M. C. Steinhoff, "The utility of rapid antigen detection testing for the diagnosis of streptococcal pharyngitis in low-resource settings.", International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, vol. 14, issue 12, pp. e1048-53, 2010 Dec. Abstract

OBJECTIVES: To evaluate the utility of rapid antigen detection testing (RADT) for the diagnosis of group A streptococcal (GAS) pharyngitis in pediatric outpatient clinics in four countries with varied socio-economic and geographic profiles.

METHODS: We prospectively evaluated the utility of a commercial RADT in children aged 2-12 years presenting with symptoms of pharyngitis to urban outpatient clinics in Brazil, Croatia, Egypt, and Latvia between August 2001 and December 2005. We compared the performance of the RADT to culture using diagnostic and agreement statistics, including sensitivity, specificity, and positive and negative predictive values. The Centor scores for GAS diagnosis were used to assess the potential effect of spectrum bias on RADT results.

RESULTS: Two thousand four hundred and seventy-two children were enrolled at four sites. The prevalence of GAS by throat culture varied by country (range 24.5-39.4%) and by RADT (range 23.9-41.8%). Compared to culture, RADT sensitivity ranged from 72.4% to 91.8% and specificity ranged from 85.7% to 96.4%. The positive predictive value ranged from 67.9% to 88.6% and negative predictive value ranged from 88.1% to 95.7%.

CONCLUSIONS: In limited-resource regions where microbiological diagnosis is not feasible or practical, RADTs should be considered an option that can be performed in a clinic and provide timely results.

Qot, E., Abdulsamad, and M. F. Aly, "Upper Cretaceous macrofossils from Jardas al'Abid area, Al Jabal Al Akhadar northeast Libya: A systematic palaeontology", Egypt. Jour. Paleontol. , vol. 13, pp. 185-254, 2013.
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Ahmed, H. E., E. A. Youssef, M. A. Kord, and E. A. Qaid, "Trehalose Accumulation in Wheat Plant Promotes Sucrose and Starch Biosynthesis.", Jordan Journal of Biological Sciences, vol. 6, no. 2, 2013. Abstract
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Rimoin, A. W., N. A. Hoff, C. L. Fischer Walker, H. S. Hamza, A. Vince, N. A. Rahman, S. Andrasevic, S. Emam, D. Vukelic, N. Elminawi, et al., "Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial.", Clinical pediatrics, vol. 50, issue 6, pp. 535-42, 2011 Jun. Abstract

BACKGROUND: Primary prevention of acute rheumatic fever is achieved by proper antibiotic treatment of group A β -hemolytic streptococcal (GAS) pharyngitis.

METHODS: To assess noninferiority of oral amoxicillin to intramuscular benzathine penicillin G (IM BPG). Children (2 to 12 years) meeting enrollment criteria were randomized 1:1 to receive antibiotic treatment in 2 urban outpatient clinics in Egypt and Croatia.

RESULTS: A total of 558 children (Croatia = 166, Egypt = 392) were randomized, with 368 evaluable in an intention-to-treat (ITT) analysis, and 272 evaluable in the per protocol (PP) analysis. In Croatia, ITT and PP treatment success rates were comparable for IM BPG and amoxicillin (2.5% difference vs 1.1% difference, respectively). In Egypt, amoxicillin was not comparable with IM BPG in ITT analysis (15.1% difference), but was comparable in PP analysis (-9.3% difference).

CONCLUSION: If compliance is a major issue, a single dose of IM BPG may be preferable for treatment of GAS pharyngitis.

Rimoin, A. W., N. A. Hoff, C. F. L. Walker, PhD, H. S. Hamza, A. Vince, N. A. Rahman, S. Andrasevic, S. Emam, D. Vukelic, et al., "Treatment of Streptococcal Pharyngitis with Once-Daily Amoxicillin Versus Intramuscular Benzathine Penicillin G in Low-Resource Settings: A Randomized Controlled Trial", Clinical Pediatrics, 2011. Abstractcu_pdf.pdf

{Background: Primary prevention of acute rheumatic fever is achieved by proper antibiotic treatment of group A b -hemolytic streptococcal (GAS) pharyngitis. Methods: To assess noninferiority of oral amoxicillin to intramuscular benzathine penicillin G (IM BPG). Children (2 to 12 years) meeting enrollment criteria were randomized 1:1 to receive antibiotic treatment in 2 urban outpatient clinics in Egypt and Croatia. Results: A total of 558 children (Croatia = 166

Hegazy, M. T., M. A. Hussein, L. Quartuccio, M. Fawzy, and N. Zoheir, "Treatment of Cryoglobulinemic Vasculitis with Sofosbuvir in Four Combination Protocols", ACR/ARHP, Washington DC, 15 November,2016. acrabstracts_org_abstract_treatment_of_cryoglobulinemic_vasc.pdf
Hegazy, M. T., G. Ragab, and L. Quartuccio, "Treatment of Cryoglobulinemic Vasculitis with Sofosbuvir in Four Combination Protocols", American College of Rheumatology, Washington, DC, USA, 15 november 2016. abstract_60780.pdf
Hegazy, M. T., G. Ragab, and L. Quartuccio, "Treatment of Cryoglobulinemic Vasculitis with Sofosbuvir in Four Combination Protocols", American College of Rheumatology, Washington, DC, USA, 15 november 2016. abstract_60780.pdf
Hegazy, M. T., M. A. Hussein, L. Quartuccio, M. Fawzy, N. Zoheir, M. I. Ellawindi, M. Bond, C. Mazzaro, A. E. Ray, and M. E. S. El Raziky, "Treatment of cryoglobulinemic vasculitis with sofosbuvir in four combination protocols", ARTHRITIS & RHEUMATOLOGY, vol. 68: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2016. Abstract
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Shen, F., C. - X. Wu, Y. Yao, P. Peng, Z. - Y. Qin, Y. Wang, Y. Zheng, L. - F. Zhou, N. Gohar, M. Shehata, et al., "Transition over 35 Years in the Incidence Rates of Primary Central Nervous System Tumors in Shanghai, China and Histological Subtyping Based on a Single Center Experience Spanning 60 Years", Asian Pacific Journal of Cancer Prevention, vol. 14, no. 12, pp. 7385–7393, 2013. Abstract
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Hosani, A. M., Z. Qu, and H. H. Zeineldin, "A Transient Stiffness Measure for Islanding Detection of Multi-DG Systems", IEEE Transactions on Power Delivery, vol. 30, issue 2, pp. 986-995, 2015.
Qindeel, R. A. B. I. A., L. G. Bousiakou, W. Tawfik, W. A. Farooq, N. H. Alonizan, S. Alsaleh, and D. Siachos, "Trace element analysis using ICP-MS in the shallow aquifers of the Haier region, Saudi Arabia", Middle-East Journal of Scientific Research, vol. 23, no. 8, pp. 1941–1948, 2015. Abstract
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Qindeel, R. A. B. I. A., L. G. Bousiakou, W. Tawfik, W. A. Farooq, N. H. Alonizan, S. Alsaleh, and D. Siachos, "Trace element analysis using ICP-MS in the shallow aquifers of the Haier region, Saudi Arabia", Middle-East Journal of Scientific Research, vol. 23, issue 8, pp. 1941-1948, 2015. Abstract
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Tawfik, W., L. G. Bousiakou, R. Qindeel, W. A. Farooq, N. H. Alonizan, and A. J. Fatani, "Trace analysis of heavy metals in groundwater samples using laser induced breakdown spectroscopy (LIBS)", Optoelectronics and Advanced Materials, Rapid Communications, vol. 9, no. 1-2: National Institute of Optoelectronics, pp. 185-192, 2015. AbstractWebsite

This work focuses on the application of laser induced breakdown spectroscopy (LIBS) in order to detect Cr, Mn, Cu, Cd, Mg and Fe in groundwater samples from the Haier basin near Riyadh, Saudi Arabia. Considering that this is a particularly arid region, the extensively use of such groundwaters for irrigation purposes needs to be continuously monitored for elements presenting potential toxicity risks for the human health. In this method, commercial wooden sticks have been used as a substrate that absorbs the liquid sample to transform laser liquid interaction to laser solid interaction. Using the fundamental wavelength of Nd:YAG laser, the generated plasma emissions were monitored for elemental analysis. The signal-to-noise ratio SNR was optimized using laser pulse energy of 100mJ at 1064nm, while the ICDD camera detector has gate delay of 15 μs and width of 5 μs. In particular after samples analysis from three different wells it was found that, despite the presence of Mn, Mg and Fe, there was no detection of Cr, Cu and Cd. It is also found that the relative concentrations of the elemental content of the collected changed from one well to the other. The observed results reveal that LIBS offers a promising detection technology that not only allows the detection of a plethora of elements in the lab, but also has the potential to identify elements on site offering an immediate insight for any environmental investigation. © 2015, National Institute of Optoelectronics. All rights reserved.

Tawfik, W., L. G. Bousiakou, R. A. B. I. A. Qindeel, W. A. Farooq, N. H. Alonizan, A. J. Fatani, and others, "Trace analysis of heavy metals in groundwater samples using laser induced breakdown spectroscopy (LIBS)", The Optoelectronics and Advanced Materials–Rapid Communications, vol. 9, pp. 185–192, 2015. Abstract
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Tawfik, W., L. G. Bousiakou, R. A. B. I. A. Qindeel, W. A. Farooq, N. H. Alonizan, and A. J. Fatani, "Trace analysis of heavy metals in groundwater samples using laser induced breakdown spectroscopy (LIBS)", Opt. Electron. Adv. Mater., vol. 9, pp. 185-192, 2015. Abstract
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