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Pasha, A., H. Zeineldin, E. F. El-Saadany, and S. A. Kaabi, "Optimal allocation of distributed generation for planning master–slave controlled microgrids", IET Generation, Transmission & Distribution, vol. 13, issue 16, pp. 3704-3712, 2019.
Pasko, D. A., M. D. Churchwell, N. N. Salama, and B. A. Mueller, "Longitudinal Hemodiafilter Performance in Modeled Continuous Renal Replacement Therapy.", Blood Purification, vol. 32, issue 2, pp. 82-88, 2011. pasko.pdf
Pasko, D. A., M. D. Churchwell, N. N. Salama, and B. A. Mueller, "Longitudinal Hemodiafilter Performance in Modeled Continuous Renal Replacement Therapy", Blood Purification, vol. 32, issue 2, pp. 82–88, 2011. CU-PDF.pdf
Patel, A. P., J. L. Fisher, E. Nichols, F. Abd-Allah, J. Abdela, A. Abdelalim, H. N. Abraha, D. Agius, F. Alahdab, and T. Alam, "Global, regional, and national burden of brain and other CNS cancer, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016", The Lancet Neurology, vol. 18, issue 4: Elsevier, pp. 376-393, 2019. Abstract
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Patel, S. N. D. H., S. S. Ibrahim, M. A. Yehia, and G. K. Hargrave, "Investigation of premixed turbulent combustion in a semi-confined explosion chamber", Experimental Thermal and Fluid Science, vol. 27, no. 4: Elsevier, pp. 355–361, 2003. Abstractabstract_paper_2003.docx

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Patel, M. N., A. Aboumohamed, and A. Hemal, "Does transition from the da Vinci Si to Xi robotic platform impact single-docking technique for robot-assisted laparoscopic nephroureterectomy?", BJU international, vol. 116, issue 6, pp. 990-4, 2015 Dec. Abstract

OBJECTIVES: To describe our robot-assisted nephroureterectomy (RNU) technique for benign indications and RNU with en bloc excision of bladder cuff (BCE) and lymphadenectomy (LND) for malignant indications using the da Vinci Si and da Vinci Xi robotic platform, with its pros and cons. The port placement described for Si can be used for standard and S robotic systems. This is the first report in the literature on the use of the da Vinci Xi robotic platform for RNU.

PATIENTS AND METHODS: After a substantial experience of RNU using different da Vinci robots from the standard to the Si platform in a single-docking fashion for benign and malignant conditions, we started using the newly released da Vinci Xi robot since 2014. The most important differences are in port placement and effective use of the features of da Vinci Xi robot while performing simultaneous upper and lower tract surgery. Patient positioning, port placement, step-by-step technique of single docking RNU-LND-BCE using the da Vinci Si and da Vinci Xi robot are shown in an accompanying video with the goal that centres using either robotic system benefit from the hints and tips. The first segment of video describes RNU-LND-BCE using the da Vinci Si followed by the da Vinci Xi to highlight differences. There was no need for patient repositioning or robot re-docking with the new da Vinci Xi robotic platform.

RESULTS: We have experience of using different robotic systems for single docking RNU in 70 cases for benign (15) and malignant (55) conditions. The da Vinci Xi robotic platform helps operating room personnel in its easy movement, allows easier patient side-docking with the help of its boom feature, in addition to easy and swift movements of the robotic arms. The patient clearance feature can be used to avoid collision with the robotic arms or the patient's body. In patients with challenging body habitus and in situations where bladder cuff management is difficult, modifications can be made through reassigning the camera to a different port with utilisation of the retargeting feature of the da Vinci Xi when working on the bladder cuff or in the pelvis. The vision of the camera used for da Vinci Xi was initially felt to be inferior to that of the da Vinci Si; however, with a subsequent software upgrade this was much improved. The base of the da Vinci Xi is bigger, which does not slide and occasionally requires a change in table placement/operating room setup, and requires side-docking especially when dealing with very tall and obese patients for pelvic surgery.

CONCLUSIONS: RNU alone or with LND-BCE is a challenging surgical procedure that addresses the upper and lower urinary tract simultaneously. Single docking and single robotic port placement for RNU-LND-BCE has evolved with the development of different generations of the robotic system. These procedures can be performed safely and effectively using the da Vinci S, Si or Xi robotic platform. The new da Vinci Xi robotic platform is more user-friendly, has easy installation, and is intuitive for surgeons using its features.

Patel, M. A., M. H. H. AbouGhaly, and K. Chadwick, "The discovery and investigation of a crystalline solid solution of an active pharmaceutical ingredient", International Journal of Pharmaceutics, vol. 532, no. 1, pp. 166 - 176, 2017. AbstractWebsite

Abstract Understanding the phase behavior of crystal forms is essential in drug formulation development, as physical stability of the active pharmaceutical ingredient (API) is critical to achieving the desired bioavailability. Solvents greatly impact the physical stability of crystalline solids, resulting in a variety of well-known phase transitions, such as hydrate/solvate formation. However, solvent incorporation may also result in the formation of a less-known crystalline solid solutions (CSSs). The identification and characterization of \{CSSs\} and their effect on \{API\} physicochemical properties have not been investigated. This is the first reported instance of a \{CSS\} for an API. An exhaustive study of the phase behavior of the enantiotropically related polymorphs, I and II, of Benzocaine in water and ethanol revealed that Form I formed a \{CSS\} with water below 294.5 K. Construction of the phase diagrams of Forms I and İI\} in water and ethanol revealed that \{CSS\} formation significantly decreased the phase transition temperature between Forms I and İI\} in water. This change resulted from the increased disorder in the lattice of Form I due to the presence of water. This work demonstrates the importance of understanding the formation of \{CSSs\} on the thermodynamic behavior of crystalline pharmaceutical solids.

Patel, S. N. D. H., S. S. Ibrahim, and M. A. Yehia, "Flamelet surface density modelling of turbulent deflagrating flames in vented explosions", Journal of Loss Prevention in the Process Industries, vol. 16, no. 6: Elsevier, pp. 451–455, 2003. Abstractfsd_modelling_of_turbulent_deflagrating_flames.pdf

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Patel, D., P. Mohanty, L. Di Biase, J. E. Sanchez, M. H. Shaheen, D. J. Burkhardt, M. Bassouni, J. Cummings, Y. Wang, W. R. Lewis, et al., "Outcomes and complications of catheter ablation for atrial fibrillation in females", Heart Rhythm, vol. 7, no. 2: Elsevier, pp. 167–172, 2010. Abstract
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Patel, C., Z. Xu, E. Shosha, J. Xing, R. Lucas, R. W. Caldwell, R. B. Caldwell, and S. P. Narayanan, "Treatment with polyamine oxidase inhibitor reduces microglial activation and limits vascular injury in ischemic retinopathy.", Biochimica et biophysica acta, vol. 1862, issue 9, pp. 1628-39, 2016 Sep. Abstract

Retinal vascular injury is a major cause of vision impairment in ischemic retinopathies. Insults such as hyperoxia, oxidative stress and inflammation contribute to this pathology. Previously, we showed that hyperoxia-induced retinal neurodegeneration is associated with increased polyamine oxidation. Here, we are studying the involvement of polyamine oxidases in hyperoxia-induced injury and death of retinal vascular endothelial cells. New-born C57BL6/J mice were exposed to hyperoxia (70% O2) from postnatal day (P) 7 to 12 and were treated with the polyamine oxidase inhibitor MDL 72527 or vehicle starting at P6. Mice were sacrificed after different durations of hyperoxia and their retinas were analyzed to determine the effects on vascular injury, microglial cell activation, and inflammatory cytokine profiling. The results of this analysis showed that MDL 72527 treatment significantly reduced hyperoxia-induced retinal vascular injury and enhanced vascular sprouting as compared with the vehicle controls. These protective effects were correlated with significant decreases in microglial activation as well as levels of inflammatory cytokines and chemokines. In order to model the effects of polyamine oxidation in causing microglial activation in vitro, studies were performed using rat brain microvascular endothelial cells treated with conditioned-medium from rat retinal microglia stimulated with hydrogen peroxide. Conditioned-medium from activated microglial cultures induced cell stress signals and cell death in microvascular endothelial cells. These studies demonstrate the involvement of polyamine oxidases in hyperoxia-induced retinal vascular injury and retinal inflammation in ischemic retinopathy, through mechanisms involving cross-talk between endothelial cells and resident retinal microglia.

Patel, M. A., M. H. H. AbouGhaly, J. V. Schryer-Praga, and K. Chadwick, The effect of ionotropic gelation residence time on alginate cross-linking and properties, , vol. 155, pp. 362 - 371, 2017/1/2/. AbstractWebsite

AbstractThe ability to engineer biocompatible polymers with controllable properties is highly desirable. One such approach is to cross-link carbohydrate polymers using ionotropic gelation (IG). Previous studies have investigated the effect of curing time on alginate cross-linking. Herein, we discuss a novel study detailing the effect of IG residence time (IGRT) on the cross-linking of alginate with calcium ions (Ca2+) along with water migration (syneresis) and their subsequent impact on the pharmaceutical properties of alginate particles. IGRT was shown to have a significant effect on particle size, porosity, density, mechanical strength and swelling of calcium alginate particles as well as drug release mechanism. Furthermore, we describe a novel application of electron dispersive spectroscopy (EDS), in conjunction with Fourier Transform- infra red (FT-IR) spectroscopy, to analyze and monitor the changes in Ca2+ concentration during cross-linking. A simple procedure to determine the concentration and distribution of the surface and internal Ca2+ involved in alginate cross-linking was successfully developed.

Patel-Hett, S., E. J. Martin, B. M. Mohammed, S. Rakhe, M. Nolte, J. Kuhn, C. J. Barrett, D. D. Pittman, D. Brophy, and J. E. Murphy, Pf-06741086, a monoclonal antibody with Tissue Factor Pathway Inhibitor (tfpi) neutralizing activity, improves coagulation parameters in global hemostatic assays in hemophilic whole blood and plasma, , vol. 22, pp. 79, 2016. Abstract
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of in of Patients, I. G. D. N. A. M. T. O. C. C., "Impact of Global DNA Methylation in Treatment Outcome of Colorectal Cancer Patients", Frontiers in Pharmacology, vol. 9, pp. 1173, 2018.
Patil, D., R. Gupta, D. P. Sethi, M. Ezzat, T. ElGhazaly, M. Gheith, A. Ibrahim, T. ElGhazaly, M. Gheith, I. Robindro, et al., EFFECTIVE & PERSONALIZD WEB USAGE MINING BASED ON CLIENT DATA, , 2013. Abstract
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Patonay, G., G. Chapman, M. M. Henary, and W. Abdelwahab, "Fluorescent multidye copolymerized silica nanoparticles for bioanalytical applications (Conference Presentation)", Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X, vol. 10508: International Society for Optics and Photonics, pp. 105080B, 2018. Abstract
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Patonay, G., W. Abdelwahab, and M. Salim, "Separation and identification of forced degradation products of pharmaceuticals using simple analytical techniques", 252nd ACS National Meeting & Exposition, Philadelphia, PA, United States, pp. ANYL-193, 2016. Abstract
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Patonay, G., G. Chapman, M. Henary, and W. Abdelwahab, "Copolymerized fluorescent silica nanoparticles for labels and molecular recognition", 252nd ACS National Meeting & Exposition, Philadelphia, PA, United States, pp. ANYL-241, 2016. Abstract
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Patonay, G., M. Henary, W. Abdelwahab, and G. Chapman, "Applications of Copolymerized Silica Nanoparticles", SCIX2016, Reno, NV, United States, 2016. Abstract
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Patrick, P., Impact of {SOA} on enterprise information architectures, : ACM, pp. 844 – 848, jun, 2005. Abstract

Enterprises are looking to find new and cost effective means to leverage existing investments in IT infrastructure and incorporate new capabilities in order to improve business productivity. As a means to improve the integration of applications hosted both internal and external to the enterprise, enterprises are turning to Service Oriented Architectures.In this paper, we describe some of the major aspects associated with the introduction of a Service Oriented Architecture and the impact that it can have on an enterprise's information architecture. We outline the concept of exposing data sources as services and discuss the critical integration aspects that need to be addressed including data access, data transformation, and integration into an over arching enterprise security scheme. The paper suggests alternatives, utilizing a Service Oriented Architecture approach, to promote flexible, extensible, and evolvable information architectures.

Patrick, D. A., M. A. Ismail, R. K. Arafa, T. Wenzler, X. Zhu, T. Pandharkar, S. K. Jones, K. A. Werbovetz, R. Brun, D. W. Boykin, et al., "Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.", Journal of medicinal chemistry, vol. 56, issue 13, pp. 5473-94, 2013 Jul 11. Abstract

4,4″-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against T rypanosoma brucei rhodesiense , Trypanosoma cruzi , Plasmodium falciparum , and Leishmania amazonensis . Twenty-three compounds were highly active against T. b. rhodesiense or P. falciparum. Most noteworthy were amidines 1, 10, and 11 with IC50 of 4 nM against T. b. rhodesiense, and dimethyltetrahydropyrimidinyl analogues 4 and 9 with IC50 values of ≤ 3 nM against P. falciparum. Bis-pyridylimidamide derivative 31 was 25 times more potent than benznidazole against T. cruzi and slightly more potent than amphotericin B against L. amazonensis. Terphenyldiamidine 1 and dipyridylbenzene analogues 23 and 25 each cured 4/4 mice infected with T. b. rhodesiense STIB900 with four daily 5 mg/kg intraperitoneal doses, as well as with single doses of ≤ 10 mg/kg. Derivatives 5 and 28 (prodrugs of 1 and 25) each cured 3/4 mice with four daily 25 mg/kg oral doses.

Patton, M. Q., Qualitative {Evaluation} and {Research} {Methods}, , 2nd, Newbury Park, CA, Sage Publications, 1990. Abstract

heuristic research, ethnomethodology and symbolic interactionism are approaches derived from phenomenology

Patton, M. Q., How to use qualitative methods in evaluation, , Newbury Park, CA, Sage Publications, 1987. Abstract
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Patton, M. Q., Utilization-{Focused} {Evaluation}, , 2nd, Beverly Hills, California, Sage Publications, 1986. Abstract
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