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Piles, M., M. H. Bakr, L.Tusell, J. P. Sánchez, E. Blas, J. Ramon, and O. Rafel, "The effect of high environmental temperature on doe performance during lactation", The 10th World Rabbit Congress, . Sharm El-Sheikh, Egypt, 3-6 September, 2012. e-piles.pdf
Pietrzak, M., M. F. Shibl, M. Bröring, O. Kühn, and H. - H. Limbach, "1H/2H NMR studies of geometric H/D isotope effects on the coupled hydrogen bonds in porphycene derivatives", Journal of the American Chemical Society, vol. 129, issue 2: American Chemical Society, pp. 296-304, 2007. Abstract
Pietrzak, M., M. F. Shibl, M. Bröring, O. Kühn, and H. - H. Limbach, "1H/2H NMR Studies of Geometric H/D Isotope Effects on the Coupled Hydrogen Bonds in Porphycene Derivatives", Journal of the American Chemical Society, vol. 129, no. 2: ACS Publications, pp. 296–304, 2007. Abstract
Pietrowski, M. J., A. A. Gabr, S. Kozlov, D. Blum, A. Halle, and K. Carvalho, "Glial purinergic signaling in neurodegeneration", Frontiers in neurology, vol. 12: Frontiers Media SA, pp. 654850, 2021. Abstract
Pierluigi Bianchettia, Fabio Talaricoa, Maria Giuseppina Viglianoa, and M. F. Ali, "Production and characterization of Egyptian blue and Egyptian green frit", Journal of Cultural Heritage , vol. 1, issue -, pp. 179–188, 2000.
Pickford, M., M. A. Gawad, M. HAMDAN, A. N. El-Barkooky, and M. H. Al Riaydh, "New suoid fossils (Mammalia, Artiodactyla) from the Miocene of Moghara, Egypt, and Gebel Zelten, Libya: biochronological implications.", Fossil Imprint, vol. 77, issue 1, pp. 111-125, 2021.
Pichavaram, P., C. D. Palani, C. Patel, Z. Xu, E. shosha, A. Y. Fouda, R. B. Caldwell, and S. P. Narayanan, "Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration.", Frontiers in neuroscience, vol. 12, pp. 956, 2018. Abstract

Dysfunction of retinal neurons is a major cause of vision impairment in blinding diseases that affect children and adults worldwide. Cellular damage resulting from polyamine catabolism has been demonstrated to be a major player in many neurodegenerative conditions. We have previously shown that inhibition of polyamine oxidase (PAO) using MDL 72527 significantly reduced retinal neurodegeneration and cell death signaling pathways in hyperoxia-mediated retinopathy. In the present study, we investigated the impact of PAO inhibition in limiting retinal neurodegeneration in a model of NMDA ()-induced excitotoxicity. Adult mice (8-10 weeks old) were given intravitreal injections (20 nmoles) of NMDA or NMLA (, control). Intraperitoneal injection of MDL 72527 (40 mg/kg body weight/day) or vehicle (normal saline) was given 24 h before NMDA or NMLA treatment and continued until the animals were sacrificed (varied from 1 to 7 days). Analyses of retinal ganglion cell (RGC) layer cell survival was performed on retinal flatmounts. Retinal cryostat sections were prepared for immunostaining, TUNEL assay and retinal thickness measurements. Fresh frozen retinal samples were used for Western blotting analysis. A marked decrease in the neuronal survival in the RGC layer was observed in NMDA treated retinas compared to their NMLA treated controls, as studied by NeuN immunostaining of retinal flatmounts. Treatment with MDL 72527 significantly improved survival of NeuN positive cells in the NMDA treated retinas. Excitotoxicity induced neurodegeneration was also demonstrated by reduced levels of synaptophysin and degeneration of inner retinal neurons in NMDA treated retinas compared to controls. TUNEL labeling studies showed increased cell death in the NMDA treated retinas. However, treatment with MDL 72527 markedly reduced these changes. Analysis of signaling pathways during excitotoxic injury revealed the downregulation of pro-survival signaling molecules p-ERK and p-Akt, and the upregulation of a pro-apoptotic molecule BID, which were normalized with PAO inhibition. Our data demonstrate that inhibition of polyamine oxidase blocks NMDA-induced retinal neurodegeneration and promotes cell survival, thus offering a new therapeutic target for retinal neurodegenerative disease conditions.

Picard, S., G. Ananthakrishnan, P. Wik, O. Engwall, and S. Abdou, "Detection of specific mispronunciations using audiovisual features.", AVSP, pp. 7–2, 2010. Abstract
Phuong, N., G. Afolayan, H. Stützel, R. Uptmoor, and M. El-Soda, "Unraveling the genetic complexity underlying sorghum response to water availability", PLOS ONE, vol. 14, issue 4: Public Library of Science, pp. e0215515 - , 2019/04/18. AbstractWebsite

Understanding the adaptation mechanisms of sorghum to drought and the underlying genetic architecture may help to improve its production in a wide range of environments. By crossing a high yielding parent (HYP) and a drought tolerant parent (DTP), we obtained 140 recombinant inbred lines (RILs), which were genotyped with 120 DArT and SSR markers covering 14 linkage groups (LGs). A subset of 100 RILs was evaluated three times in control and drought treatments to genetically dissect their response to water availability. Plants with early heading date (HD) in the drought treatment maintained yield (YLD) level by reducing seed number SN and increasing hundred seed weight (HSW). In contrast, early HD in the control treatment increased SN, HSW and YLD. In total, 133 significant QTL associated with the measured traits were detected in ten hotspot regions. Antagonistic, pleiotropic effects of a QTL cluster mapped on LG-6 may explain the observed trade-offs between SN and HSW: Alleles from DTP reduced SN and the alleles from HYP increased HSW under drought stress, but not in the control treatment. Our results illustrate the importance of considering genetic and environmental factors in QTL mapping to better understand plant responses to drought and to improve breeding programs.

Philoppes, J. N., M. A. Khedr, M. H. A. Hassan, G. Kamel, and P. H. O. E. B. E. F. LAMIE, "New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics", Bioorganic Chemistry, vol. 100, pp. 103944, 2020.
Philip, Aboul Ela, A. El-Gawad, and M. F. Aly, " Facies and Paleoecology of the lower Cretaceous Rocks of Gebel Manzour, Maghara area, North Sinai, Egypt. . ", Egypt. Egypt. J. Geol., vol. 1-2, pp. 173-197, 1989.
Phelps, J. H., A. I. Abd El-Rahman, V. Kunc, and C. L. Tucker III, "A model for fiber length attrition in injection-molded long-fiber composites", Composites Part A: Applied Science and Manufacturing, vol. 51: Elsevier, pp. 11–21, 2013. Abstract
PhD, M. M.;, and M. M.;F. PhD, "Investigating the environmental performance of the wind catcher in Jeddah", Second International Conference on Islamic Heritage Architecture and Art, Islamic Heritage, Malta, Malta, 18 Apr. 2018.
PhD, M. M.;F., "BIOMIMICRY ARCHITECTURE - NEW DIMENSIONS OF CREATIVITY: An exploratory approach in academia", International Journal of Engineering & Technology (UAE), vol. 7, issue 4.5, pp. 641-644, 2018.
Phadke, A. C., A. M. Mansour, and E. W. Huang, "Methodology for application of model test data in TLP global design", 25th International Conference on Offshore Mechanics and Arctic Engineering: American Society of Mechanical Engineers, pp. 469–476, 2006. Abstract
Pfau, A., and M. A. I. Salem, "STUDIES ON BODY COMPOSITION OF CATTLE BY ISOTOPE DILUTION ANALYSIS", Proc Symp. an Iso. study on physiol. of domest. Anim. IAEA/FAO, pp. 21-34, 1972. Abstract
Pfau, A., and M. A. I. Salem, "STUDIES ON BODY COMPOSITION OF CATTLE BY ISOTOPE DILUTION ANALYSIS", Proc Symp. an Iso. study on physiol. of domest. Anim. IAEA/FAO, pp. 21-34, 1972. Abstract
Pfannkuche, K., S. Neuss, F. Pillekamp, L. P. Frenzel, W. Attia, T. Hannes, J. Salber, M. Hoss, M. Zenke, B. K. Fleischmann, et al., "Fibroblasts Facilitate the Engraftment of Embryonic Stem Cell-Derived Cardiomyocytes on Three-Dimensional Collagen Matrices and Aggregation in Hanging Drops", STEM CELLS AND DEVELOPMENT, vol. 19, issue 10, pp. 1589-1599, 2010.
Pfahler, F., E. Leitgeb, and T. Ismail, "Electromagnetic influence of video walls on the operability of wireless microphones on event stages", Broadband Communications for Next Generation Networks and Multimedia Applications (CoBCom), International Conference on: IEEE, pp. 1–5, 2016. Abstract
Peyvandi, F., P. M. Mannucci, I. Garagiola, A. El-Beshlawy, M. Elalfy, V. Ramanan, P. Eshghi, S. Hanagavadi, R. Varadarajan, M. Karimi, et al., "A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A.", The New England journal of medicine, vol. 374, issue 21, pp. 2054-64, 2016 May 26. Abstract

BACKGROUND: The development of neutralizing anti-factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy.

METHODS: We conducted a randomized trial to assess the incidence of factor VIII inhibitors among patients treated with plasma-derived factor VIII containing von Willebrand factor or recombinant factor VIII. Patients who met the eligibility criteria (male sex, age <6 years, severe hemophilia A, and no previous treatment with any factor VIII concentrate or only minimal treatment with blood components) were included from 42 sites.

RESULTS: Of 303 patients screened, 264 underwent randomization and 251 were analyzed. Inhibitors developed in 76 patients, 50 of whom had high-titer inhibitors (≥5 Bethesda units). Inhibitors developed in 29 of the 125 patients treated with plasma-derived factor VIII (20 patients had high-titer inhibitors) and in 47 of the 126 patients treated with recombinant factor VIII (30 patients had high-titer inhibitors). The cumulative incidence of all inhibitors was 26.8% (95% confidence interval [CI], 18.4 to 35.2) with plasma-derived factor VIII and 44.5% (95% CI, 34.7 to 54.3) with recombinant factor VIII; the cumulative incidence of high-titer inhibitors was 18.6% (95% CI, 11.2 to 26.0) and 28.4% (95% CI, 19.6 to 37.2), respectively. In Cox regression models for the primary end point of all inhibitors, recombinant factor VIII was associated with an 87% higher incidence than plasma-derived factor VIII (hazard ratio, 1.87; 95% CI, 1.17 to 2.96). This association did not change in multivariable analysis. For high-titer inhibitors, the hazard ratio was 1.69 (95% CI, 0.96 to 2.98). When the analysis was restricted to recombinant factor VIII products other than second-generation full-length recombinant factor VIII, effect estimates remained similar for all inhibitors (hazard ratio, 1.98; 95% CI, 0.99 to 3.97) and high-titer inhibitors (hazard ratio, 2.59; 95% CI, 1.11 to 6.00).

CONCLUSIONS: Patients treated with plasma-derived factor VIII containing von Willebrand factor had a lower incidence of inhibitors than those treated with recombinant factor VIII. (Funded by the Angelo Bianchi Bonomi Foundation and others; number, NCT01064284; EudraCT number, 2009-011186-88.).

Pettigrew, A. M., Contextualist {Research} and the {Study} of {Organizational} {Change} {Processes}, : North-Holland, pp. 53–78, 1985. Abstract

meanings are not discovered but created by a process of making