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Poznyak, A. S., H. Alazki, and H. M. Soliman, "Attractive ellipsoidal design for robust stabilization of time-delay stochastic power systems under a series of lightning surges", Computers and Electrical Engineering, vol. 116, pp. art. no. 109228, 2024.
Poznyak, A. S., H. Alazki, H. M. Soliman, and R. Ahshan, "Ellipsoidal Design of Robust Stabilization of Power Systems Exposed to a Cycle of lightning Surges Modeled by Continuous-Time Markov Jumps", energies, vol. 16, issue 1, pp. art. no. 414, 2023.
Pouyanfar, S., Y. Tao, A. Mohan, H. Tian, A. S. Kaseb, K. Gauen, R. Dailey, S. Aghajanzadeh, Y. - H. Lu, S. - C. Chen, et al., "Dynamic Sampling in Convolutional Neural Networks for Imbalanced Data Classification", IEEE Conference on Multimedia Information Processing and Retrieval, 2018.
Poursarebani, N., T. Seidensticker, R. Koppolu, C. Trautewig, P. Gawroński, F. Bini, G. Govind, T. Rutten, S. Sakuma, A. Tagiri, et al., "The Genetic Basis of Composite Spike Form in Barley and "Miracle-Wheat"", Genetics, 2015. 2015_genetics.115.176628.full_.pdf
Poursarebani, N., C. Trautewig, H. M. Youssef, T. Schnurbusch, and et al, "COMPOSITUM 1 contributes to the architectural simplification of barley inflorescence via meristem identity signals", Nature Communications, vol. 11, pp. 5138, 2020.
Pouloudi, A., "Stakeholder {Analysis} as a {Fron}-{End} to {Knowledge} {Elicitation}", AI & Society, vol. 11, pp. 112–137, 1997. Abstract
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Potts, C., Human and {Organisational} {Factors} and {Environments} for {Information} {System} {Design}, , no. DoC 86/6: Department of Computing, Imperial College of Science, Technology & Medicine, University of London, 1986. Abstract

users need to evaluate IS while still under development

Potter, S., A. Trickey, T. Rattay, R. L. O'Connell, R. Dave, E. Baker, L. Whisker, J. Skillman, M. D. Gardiner, R. D. Macmillan, et al., "Therapeutic mammaplasty is a safe and effective alternative to mastectomy with or without immediate breast reconstruction.", The British journal of surgery, vol. 107, issue 7, pp. 832-844, 2020. Abstract

BACKGROUND: Therapeutic mammaplasty (TM) may be an alternative to mastectomy, but few well designed studies have evaluated the success of this approach or compared the short-term outcomes of TM with mastectomy with or without immediate breast reconstruction (IBR). Data from the national iBRA-2 and TeaM studies were combined to compare the safety and short-term outcomes of TM and mastectomy with or without IBR.

METHODS: The subgroup of patients in the TeaM study who underwent TM to avoid mastectomy were identified, and data on demographics, complications, oncology and adjuvant treatment were compared with those of patients undergoing mastectomy with or without IBR in the iBRA-2 study. The primary outcome was the percentage of successful breast-conserving procedures in the TM group. Secondary outcomes included postoperative complications and time to adjuvant therapy.

RESULTS: A total of 2916 patients (TM 376; mastectomy 1532; mastectomy and IBR 1008) were included in the analysis. Patients undergoing TM were more likely to be obese and to have undergone bilateral surgery than those having IBR. However, patients undergoing mastectomy with or without IBR were more likely to experience complications than the TM group (TM: 79, 21·0 per cent; mastectomy: 570, 37·2 per cent; mastectomy and IBR: 359, 35·6 per cent; P < 0·001). Breast conservation was possible in 87·0 per cent of patients who had TM, and TM did not delay adjuvant treatment.

CONCLUSION: TM may allow high-risk patients who would not be candidates for IBR to avoid mastectomy safely. Further work is needed to explore the comparative patient-reported and cosmetic outcomes of the different approaches, and to establish long-term oncological safety.

Pospieszczyk, A., A. M. Harith, and B. Stritzker, "LATTICE TEMPERATURE OF GaAs AND Si DURING PULSED LASER ANNEALING", Le Journal de Physique Colloques, vol. 44, no. C5: EDP Sciences, pp. C5–129, 1983. Abstract
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Pospieszczyk, A., A. M. Harith, and B. Stritzker, "Pulsed laser annealing of GaAs and Si: Combined reflectivity and time-of-flight measurements", Journal of Applied Physics, vol. 54, no. 6: AIP Publishing, pp. 3176–3182, 1983. Abstract
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Porter, M., "What is strategy?", Havard Business Review, vol. 74, pp. 61–78, 1996. Abstract
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Porter, J. B., M. Evangeli, and A. El-Beshlawy, "Challenges of adherence and persistence with iron chelation therapy.", International journal of hematology, vol. 94, issue 5, pp. 453-60, 2011 Nov. Abstract

Due to advances in medical sciences, many chronic diseases that formerly resulted in early death can now be effectively managed with long-term treatment regimens. Patients with potentially fatal anemias, for example, can be treated with ongoing blood transfusions and iron chelation therapy. Ensuring adherence and persistence is challenging, as the benefits of therapy are not perceived immediately. Poor adherence severely compromises the effectiveness of treatment and, therefore, improving compliance in terms of quality of life and health economics is critical. Although adherence to chelation therapy is generally poor, the availability of oral iron chelators may help to improve patient compliance. For chronic conditions such as thalassemia major, even when oral chelation therapy is available, support by an integrated team including a clinical psychologist and nurse specialist working with the treatment center is recommended to achieve optimal results.

Porter, J. B., M. Evangeli, and A. El-Beshlawy, "The Challenges of Adherence and Persistence With Iron Chelation Therapy", International Journal of Hematology, vol. 94, issue 5, pp. 453-460, 2011. AbstractCU-PDF

Due to advances in medical sciences, many chronic diseases that formerly resulted in early death can now be effectively managed with long-term treatment regimens. Patients with potentially fatal anemias, for example, can be treated with ongoing blood transfusions and iron chelation therapy. Ensuring adherence and persistence is challenging, as the benefits of therapy are not perceived immediately. Poor adherence severely compromises the effectiveness of treatment and, therefore improving compliance in terms of quality of life and health economics is critical. Although adherence to chelation therapy is generally poor, the availability of oral iron chelators may help to improve patient compliance. For chronic conditions such as thalassemia major, even when oral chelation therapy is available, support by an integrated team including a clinical psychologist and nurse specialist working with the treatment center is recommended to achieve optimal results

Porter, J. B., M. Elalfy, A. Taher, Y. Aydinok, S. - H. Lee, P. Sutcharitchan, A. El-Ali, J. Han, and A. El-Beshlawy, "Limitations of serum ferritin to predict liver iron concentration responses to deferasirox therapy in patients with transfusion-dependent thalassaemia.", European journal of haematology, vol. 98, issue 3, pp. 280-288, 2017 Mar. Abstract

BACKGROUND: In transfusion-dependent anaemias, while absolute serum ferritin levels broadly correlate with liver iron concentration (LIC), relationships between trends in these variables are unclear. These relationships are important because serum ferritin changes are often used to adjust or switch chelation regimens when liver magnetic resonance imaging (MRI) is unavailable.

OBJECTIVES AND METHODS: This post hoc analysis of the EPIC study compared serum ferritin and LIC in 317 patients with transfusion-dependent thalassaemia before and after 1 yr of deferasirox.

RESULTS: Serum ferritin responses (decreases) occurred in 73% of patients, 80% of whom also have decreased LIC. However, 52% of patients without a serum ferritin response did decrease LIC and by >1 mg Fe/g dw (median 3.9) in 77% of cases. Absolute serum ferritin and LIC values correlated significantly only when serum ferritin was <4000 ng/mL (r = 0.59; P < 0.0001) and not at higher levels (≥4000 ng/mL; r = 0.19). Serum ferritin response was accompanied by decreased LIC in 89% and 70% of cases when serum ferritin was <4000 or ≥4000 ng/mL, respectively.

CONCLUSIONS: As serum ferritin non-response was associated with LIC decrease in over half of patients, use of liver MRI may be particularly useful for differentiating true from apparent non-responders to deferasirox based on serum ferritin trends alone.

Portaels, F., W. M. Meyers, A. Ablordey, A. G. Castro, K. Chemlal, P. de Rijk, P. Elsen, K. Fissette, A. G. Fraga, R. Lee, et al., "First cultivation and characterization of Mycobacterium ulcerans from the environment.", PLoS neglected tropical diseases, vol. 2, issue 3, pp. e178, 2008. Abstract

BACKGROUND: Mycobacterium ulcerans disease, or Buruli ulcer (BU), is an indolent, necrotizing infection of skin, subcutaneous tissue and, occasionally, bones. It is the third most common human mycobacteriosis worldwide, after tuberculosis and leprosy. There is evidence that M. ulcerans is an environmental pathogen transmitted to humans from aquatic niches; however, well-characterized pure cultures of M. ulcerans from the environment have never been reported. Here we present details of the isolation and characterization of an M. ulcerans strain (00-1441) obtained from an aquatic Hemiptera (common name Water Strider, Gerris sp.) from Benin.

METHODOLOGY/PRINCIPAL FINDINGS: One culture from a homogenate of a Gerris sp. in BACTEC became positive for IS2404, an insertion sequence with more than 200 copies in M. ulcerans. A pure culture of M. ulcerans 00-1441 was obtained on Löwenstein-Jensen medium after inoculation of BACTEC culture in mouse footpads followed by two other mouse footpad passages. The phenotypic characteristics of 00-1441 were identical to those of African M. ulcerans, including production of mycolactone A/B. The nucleotide sequence of the 5' end of 16S rRNA gene of 00-1441 was 100% identical to M. ulcerans and M. marinum, and the sequence of the 3' end was identical to that of the African type except for a single nucleotide substitution at position 1317. This mutation in M. ulcerans was recently discovered in BU patients living in the same geographic area. Various genotyping methods confirmed that strain 00-1441 has a profile identical to that of the predominant African type. Strain 00-1441 produced severe progressive infection and disease in mouse footpads with involvement of bone.

CONCLUSION: Strain 00-1441 represents the first genetically and phenotypically identified strain of M. ulcerans isolated in pure culture from the environment. This isolation supports the concept that the agent of BU is a human pathogen with an environmental niche.

Porst, H., A. Burnett, G. Brock, H. Ghanem, F. Giuliano, S. Glina, W. Hellstrom, A. Martin-Morales, A. Salonia, and I. Sharlip, "SOP Conservative (Medical and Mechanical) Treatment of Erectile Dysfunction", The Journal of Sexual Medicine, vol. 10, issue 1, pp. 130–171, 2013. Abstractsop_conservative_medical_and_mechanical_treatment_of_erectile_dysfunction..pdfWebsite

Introduction.  Erectile dysfunction (ED) is the most frequently treated male sexual dysfunction worldwide. ED is a chronic condition that exerts a negative impact on male self-esteem and nearly all life domains including interpersonal, family, and business relationships.

Aim.  The aim of this study is to provide an updated overview on currently used and available conservative treatment options for ED with a special focus on their efficacy, tolerability, safety, merits, and limitations including the role of combination therapies for monotherapy failures.

Methods.  The methods used were PubMed and MEDLINE searches using the following keywords: ED, phosphodiesterase type 5 (PDE5) inhibitors, oral drug therapy, intracavernosal injection therapy, transurethral therapy, topical therapy, and vacuum-erection therapy/constriction devices. Additionally, expert opinions by the authors of this article are included.

Results.  Level 1 evidence exists that changes in sedentary lifestyle with weight loss and optimal treatment of concomitant diseases/risk factors (e.g., diabetes, hypertension, and dyslipidemia) can either improve ED or add to the efficacy of ED-specific therapies, e.g., PDE5 inhibitors. Level 1 evidence also exists that treatment of hypogonadism with total testosterone < 300 ng/dL (10.4 nmol/L) can either improve ED or add to the efficacy of PDE5 inhibitors. There is level 1 evidence regarding the efficacy and safety of the following monotherapies in a spectrum-wide range of ED populations: PDE5 inhibitors, intracavernosal injection therapy with prostaglandin E1 (PGE1, synonymous alprostadil) or vasoactive intestinal peptide (VIP)/phentolamine, and transurethral PGE1 therapy. There is level 2 evidence regarding the efficacy and safety of the following ED treatments: vacuum-erection therapy in a wide range of ED populations, oral L-arginine (3–5 g), topical PGE1 in special ED populations, intracavernosal injection therapy with papaverine/phentolamine (bimix), or papaverine/phentolamine/PGE1 (trimix) combination mixtures. There is level 3 evidence regarding the efficacy and safety of oral yohimbine in nonorganic ED. There is level 3 evidence that combination therapies of PDE5 inhibitors + either transurethral or intracavernosal injection therapy generate better efficacy rates than either monotherapy alone. There is level 4 evidence showing enhanced efficacy with the combination of vacuum-erection therapy + either PDE5 inhibitor or transurethral PGE1 or intracavernosal injection therapy. There is level 5 evidence (expert opinion) that combination therapy of PDE5 inhibitors + L-arginine or daily dosing of tadalafil + short-acting PDE5 inhibitors pro re nata may rescue PDE5 inhibitor monotherapy failures. There is level 5 evidence (expert opinion) that adding either PDE5 inhibitors or transurethral PGE1 may improve outcome of penile prosthetic surgery regarding soft (cold) glans syndrome. There is level 5 evidence (expert opinion) that the combination of PDE5 inhibitors and dapoxetine is effective and safe in patients suffering from both ED and premature ejaculation. Porst H, Burnett A, Brock G, Ghanem H, Giuliano F, Glina S, Hellstrom W, Martin-Morales A, Salonia A, Sharlip I, and the ISSM Standards Committee for Sexual Medicine. SOP conservative (medical and mechanical) treatment of erectile dysfunction. J Sex Med 2013;10:130–171.

Popper, K., The {Logic} of {Scientific} {Discovery}, , London, Hutchinson, 1968. Abstract
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Poppe, M., M. Alaasar, A. Lehmann, S. Poppe, M. G. Tamba, M. Kurachkina, A. Eremin, M. Nagaraj, J. K. Vij, X. Cai, et al., "Controlling the formation of heliconical smectic phases by molecular design of achiral bent-core molecules", Journal of Materials Chemistry C, vol. 8, issue 10, pp. 3316-3336, 2020.
Poole-Wilson, P. A., and G. A. Langer, "Effect of pH on ionic exchange and function in rat and rabbit myocardium.", The American journal of physiology, vol. 229, issue 3, pp. 570-81, 1975 Sep. Abstract

The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.

Poole-Wilson, P. A., and G. A. Langer, "Effect of pH on ionic exchange and function in rat and rabbit myocardium.", The American journal of physiology, vol. 229, issue 3, pp. 570-81, 1975 Sep. Abstract

The effects of pH variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. The pH and PCO2 of the control perfusate were 7.40 and 39 mmHg, respectively. In the rabbit septum a metabolic acidosis (pH equals 6.82, PCO2 equals 39 mmHg) caused a loss of 16% of control tension in 12 min. Na+ and K+ exchange were unaltered. A comparable respiratory acidosis (pH equals 6.81, PCO2 equals 159 mmHg) caused a 51% loss of tension in 2 min. Na+ exchange was unaltered but K+ efflux fell from 8.9 +/- 0.6 (mean +/- SE) to 4.9 +/- 0.3 mmol/kg dry wt per min (P less than 0.001, n equals 10). A net gain of K+ of 16.9 +/- 1.7 (n equals 14) mmol/kg dry wt occurred and was attributable to a delayed fall in K+ influx relative to efflux over 15 min. The net gain could not be mimicked by epinephrine administration or blocked by propranolol and was absent in the beating rat septum and the quiescent rabbit septum. These results suggest that the net uptake of K+, which appears to be dependent on a period of depolarization, and the changes of contractility are controlled by the H+ ion concentration at a cellular site whose exchange with the extracellular space is characterized by a considerable restriction of diffusion. Changes of contractility are not related to the net uptake of K+.

Ponugoti, N., B. Rudran, A. M. R. SELIM, S. Nahas, and H. Magill, "Infrapatellar versus suprapatellar approach for intramedullary nailing of the tibia: a systematic review and meta-analysis.", Journal of orthopaedic surgery and research, vol. 16, issue 1, pp. 94, 2021. Abstract

BACKGROUND: Intramedullary nailing (IMN) is a conventional technique for the treatment of tibial shaft fractures. It has been suggested that the suprapatellar (SP) approach holds advantages over the traditional infrapatellar (IP) approach. Current literature lacks adequate data to provide robust clinical recommendations. This meta-analysis aims to determine the efficacy of infrapatellar versus suprapatellar techniques for IMN.

METHODS: An up-to-date literature search of the Embase, Medline, and registry platform databases was performed. The search was conducted using a predesigned search strategy and all eligible literature was critically appraised for methodological quality via the Cochrane's collaboration tool. Fluoroscopy time, operative time, pain score, knee function, deep infection, non-union and secondary operation rates were all considered.

CONCLUSION: A total of twelve studies were included in the meta-analysis. The results of this analysis show that suprapatellar nailing is associated with reduced post-operative pain scores and improved functional outcomes. The data suggest no significant difference in terms of operative times, fluoroscopy times, rates of deep infection, non-union or secondary procedures when compared to infra-patellar techniques. Further studies are required to confirm these findings and assess long-term results.

Ponter, A. R. S., and M. M. Megahed, "Creep and plastic ratchetting in cyclically thermally loaded structures", Physical Non-Linearities in Structural Analysis: Springer Berlin Heidelberg, pp. 220–227, 1981. Abstract
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Ponter, A. R. S., and M. M. Megahed, "Creep and plastic ratchetting in cyclically thermally loaded structures", Physical Non-Linearities in Structural Analysis: Springer Berlin Heidelberg, pp. 220–227, 1981. Abstract
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Polychronopoulou, K., A. F. Zedan, M. AlKetbi, S. Stephen, M. Ather, M. S. Katsiotis, J. Arvanitidis, D. Christofilos, A. F. Isakovic, and S. AlHassan, "Tailoring the efficiency of an active catalyst for CO abatement through oxidation reaction: The case study of samarium-doped ceria", Journal of environmental chemical engineering, vol. 6, no. 1: Elsevier, pp. 266–280, 2018. Abstract

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