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Probert, P. M., A. C. Leitch, M. P. Dunn, S. K. Meyer, J. M. Palmer, T. M. Abdelghany, A. F. Lakey, M. P. Cooke, H. Talbot, C. Wills, et al., "Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis.", Journal of hepatology, vol. 69, issue 5, pp. 1123-1135, 2018. Abstract

BACKGROUND & AIMS: Primary biliary cholangitis (PBC) is an autoimmune-associated chronic liver disease triggered by environmental factors, such as exposure to xenobiotics, which leads to a loss of tolerance to the lipoic acid-conjugated regions of the mitochondrial pyruvate dehydrogenase complex, typically to the E2 component. We aimed to identify xenobiotics that might be involved in the environmental triggering of PBC.

METHODS: Urban landfill and control soil samples from a region with high PBC incidence were screened for xenobiotic activities using analytical, cell-based xenobiotic receptor activation assays and toxicity screens.

RESULTS: A variety of potential xenobiotic classes were ubiquitously present, as identified by their interaction with xenobiotic receptors - aryl hydrocarbon receptor, androgen receptor and peroxisome proliferator activated receptor alpha - in cell-based screens. In contrast, xenoestrogens were present at higher levels in soil extracts from around an urban landfill. Furthermore, two landfill sampling sites contained a chemical(s) that inhibited mitochondrial oxidative phosphorylation and induced the apoptosis of a hepatic progenitor cell. The mitochondrial effect was also demonstrated in human liver cholangiocytes from three separate donors. The chemical was identified as the ionic liquid [3-methyl-1-octyl-1H-imidazol-3-ium] (M8OI) and the toxic effects were recapitulated using authentic pure chemical. A carboxylate-containing human hepatocyte metabolite of M8OI, bearing structural similarity to lipoic acid, was also enzymatically incorporated into the E2 component of the pyruvate dehydrogenase complex via the exogenous lipoylation pathway in vitro.

CONCLUSIONS: These results identify, for the first time, a xenobiotic in the environment that may be related to and/or be a component of an environmental trigger for PBC. Therefore, further study in experimental animal models is warranted, to determine the risk of exposure to these ionic liquids.

LAY SUMMARY: Primary biliary cholangitis is a liver disease in which most patients have antibodies to mitochondrial proteins containing lipoic acid binding site(s). This paper identified a man-made chemical present in soils around a waste site. It was then shown that this chemical was metabolized into a product with structural similarity to lipoic acid, which was capable of replacing lipoic acid in mitochondrial proteins.

Procházka, R., A. Bartková, L. Němcová, M. Murín, A. Gad, K. Marcollová, V. Kinterová, A. Lucas-Hahn, and J. Laurinčík, "The Role of MAPK3/1 and AKT in the Acquisition of High Meiotic and Developmental Competence of Porcine Oocytes Cultured In Vitro in FLI Medium", International Journal of Molecular Sciences, vol. 22, no. 20, 2021. AbstractWebsite

The developmental potential of porcine oocytes cultured in vitro was remarkably enhanced in a medium containing FGF2, LIF and IGF1 (FLI) when compared to a medium supplemented with gonadotropins and EGF (control). We analyzed the molecular background of the enhanced oocyte quality by comparing the time course of MAPK3/1 and AKT activation, and the expression of genes controlled by these kinases in cumulus-oocyte complexes (COCs) cultured in FLI and the control medium. The pattern of MAPK3/1 activation in COCs was very similar in both media, except for a robust increase in MAPK3/1 phosphorylation during the first hour of culture in the FLI medium. The COCs cultured in the FLI medium exhibited significantly higher activity of AKT than in the control medium from the beginning up to 16 h of culture; afterwards a deregulation of AKT activity occurred in the FLI medium, which was not observed in the control medium. The expression of cumulus cell genes controlled by both kinases was also modulated in the FLI medium, and in particular the genes related to cumulus-expansion, signaling, apoptosis, antioxidants, cell-to-cell communication, proliferation, and translation were significantly overexpressed. Collectively, these data indicate that both MAPK3/1 and AKT are implicated in the enhanced quality of oocytes cultured in FLI medium.

determination of ibuprofen in presence of its degradation products, "Performance comparison between monolithic C18 and conventional C18 particle- packed columns in the liquid chromatographic", E.A.Abdullah, 2011. Abstract

Analytical Chemistry: An Indian Journal, (2011)

determination of ibuprofen in presence of its degradation products, "Performance comparison between monolithic C18 and conventional C18 particle- packed columns in the liquid chromatographic", E.A.Abdullah, 2011. Abstract

Analytical Chemistry: An Indian Journal, (2011)

Prof. Dr. Mona Atteya Mahmoud Hana Professor of Pediatrics, Faculty of medicine, C. U., C. U. Dr. Mohamed Mohamed Ismail Elkanishy Lecturer of Pediatrics, Faculty of medicine, C. U. Dr. Rania Zakaria Hassen Abu Elezz Lecturer of Radiology, Faculty of medicine, and M. S. E. A.(M.B.B.Ch.), Screening for Cardiovascular Malformations and Complications in Turner Syndrome, , Cairo, Cairo university, 2014. 3._abstract.docx22.result.docxfinal_proposal_00.pdf1.cover_pages.docx20._patients__methods.docx
Prof. Dr. Mona Atteya Mahmoud Hana Professor of Pediatrics, Faculty of medicine, C. U., C. U. Dr. Mohamed Mohamed Ismail Elkanishy Lecturer of Pediatrics, Faculty of medicine, C. U. Dr. Rania Zakaria Hassen Abu Elezz Lecturer of Radiology, Faculty of medicine, and M. S. E. A.(M.B.B.Ch.), Screening for Cardiovascular Malformations and Complications in Turner Syndrome, , Cairo, Cairo university, 2014. 3._abstract.docx22.result.docxfinal_proposal_00.pdf1.cover_pages.docx
Prof. Dr. Mona Atteya Mahmoud Hana Professor of Pediatrics, Faculty of medicine, C. U., C. U. Dr. Mohamed Mohamed Ismail Elkanishy Lecturer of Pediatrics, Faculty of medicine, C. U. Dr. Rania Zakaria Hassen Abu Elezz Lecturer of Radiology, Faculty of medicine, and M. S. E. A.(M.B.B.Ch.), Screening for Cardiovascular Malformations and Complications in Turner Syndrome, , Cairo, Cairo university, 2014. 3._abstract.docx22.result.docxfinal_proposal_00.pdf1.cover_pages.docx20._patients__methods.docx
Prof. Dr. Mona Atteya Mahmoud Hana Professor of Pediatrics, Faculty of medicine, C. U., C. U. Dr. Mohamed Mohamed Ismail Elkanishy Lecturer of Pediatrics, Faculty of medicine, C. U. Dr. Rania Zakaria Hassen Abu Elezz Lecturer of Radiology, Faculty of medicine, and M. S. E. A.(M.B.B.Ch.), Screening for Cardiovascular Malformations and Complications in Turner Syndrome, , Cairo, Cairo university, 2014. 3._abstract.docx22.result.docxfinal_proposal_00.pdf1.cover_pages.docx
Prof. Dr. Mona Atteya Mahmoud Hana Professor of Pediatrics, Faculty of medicine, C. U., C. U. Dr. Mohamed Mohamed Ismail Elkanishy Lecturer of Pediatrics, Faculty of medicine, C. U. Dr. Rania Zakaria Hassen Abu Elezz Lecturer of Radiology, Faculty of medicine, and M. S. E. A.(M.B.B.Ch.), Screening for Cardiovascular Malformations and Complications in Turner Syndrome, , Cairo, Cairo university, 2014. 3._abstract.docx22.result.docxfinal_proposal_00.pdf1.cover_pages.docx
Prof. Samir, A. K., E. A. Dr. El-Sayed, and A. Y. Yassmen, "Parameter Estimation for Three-Parameter Kappa Distribution Under Type II Censored Samples", Journal of Applied Sciences Research, 2009.
Prof. Samir, A. K., E. A. Dr. El-Sayed, and A. Y. Yassmen, "Parameter Estimation for Kappa Distribution with Four-Parameter Under Type II Censored Samples", Australian Journal of Basic and Applied Sciences, 2011.
Prof.Dr.A.Zohdi, P. D. A. E. Samman, and D. W. E. Halaby, Recent modalities in treatment of craniopharyngioma, , Cairo, Cairo University, 2008.
Prof.Dr.Adel Fouda(Professor of Public Health, Faculty of Medicine, E. - Z. U.), F. N. C. U.)- of Dr. Magda A. Abd ElFattah(Lecturer of Nursing Administration, and S..S.(M. N. H. G. & degree in Administration), "Transformational And Transactional Leadership Behaviors 'Adoption And Its Relation To Nursing Services Quality Management As Perceived By First- Level Nurse Managers In A Military Hospital", New Egyptian Medical Journal , vol. vol.43 , issue no.6, 2010. 3.docx
faculty of commerce Prof/ Osama Mohamed Zaki, professor of accounting, C. U., C. U. faculty of commerce Dr. Bassant Badreddin, lecturer, and C. U. faculty of commerce Menna Mortada Mahfouz, asistant lecturer, "Improving Financial Reporting in Egyptian Universities A Case Study", International Journal of Academic Research, vol. 3, issue 2(4), pp. 1-13, 2016. improving_financial_reporting_in_egyptian_universities_a_case_study.pdf
Psychalinos, C., A. S. Elwakil, A. G. Radwan, and K. Biswas, "Guest editorial: fractional-order circuits and systems: theory, design, and applications", Circuits, Systems, and Signal Processing, vol. 35, no. 6: Springer US, pp. 1807–1813, 2016. Abstract
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Psychalinos, C., A. S. Elwakil, A. G. Radwan, and K. Biswas, "Guest editorial: fractional-order circuits and systems: theory, design, and applications", Circuits, Systems, and Signal Processing, vol. 35: Springer US, pp. 1807–1813, 2016. Abstract
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PTD, E. S. M. F., E. E. PTD, and W. T. PTD, "Assessment of Postural Stability in Patients with Low Back Pain", Bull. Fac. Ph. Th. Cairo Univ, vol. 15, no. 1, pp. 1, 2010. Abstract
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de la Puente, P., N. Quan, R. S. Hoo, B. Muz, R. C. Gilson, M. Luderer, J. King, S. Achilefu, N. N. Salama, R. Vij, et al., "Newly established myeloma-derived stromal cell line MSP-1 supports multiple myeloma proliferation, migration, and adhesion and induces drug resistance more than normal-derived stroma.", Haematologica, vol. 101, issue 7, pp. e307-11, 2016 Jul. salama-_haematologica_2016.pdf
de la Puente, P., M. J. Luderer, C. Federico, A. Jin, R. C. Gilson, C. Egbulefu, K. Alhallak, S. Shah, B. Muz, J. Sun, et al., "Enhancing proteasome-inhibitory activity and specificity of bortezomib by CD38 targeted nanoparticles in multiple myeloma.", Journal of controlled release : official journal of the Controlled Release Society, vol. 270, pp. 158-176, 2017 Nov 28, 2018. Abstractj_of_controlled_release_2018.pdf

The establishment of more effective treatments that can circumvent chemoresistance in Multiple Myeloma (MM) is a priority. Although bortezomib (BTZ) is one of the most potent proteasome inhibitors available, still possesses limitations related to dose limiting side effects. Several strategies have been developed to improve the delivery of chemotherapies to MM by targeting different moieties expressed on MM cells to nanoparticle delivery systems (NPs), which have failed mainly due to their heterogeneous expression on these cells. Our goal was to test CD38 targeted chitosan NPs as novel targeting moiety for MM to improve the potency and efficacy of BTZ in MM cells and reduce the side effects in healthy tissue. We have showed preferential BTZ release in tumor-microenvironment, specific binding to MM cells, and an improved drug cellular uptake through BTZ diffusion from the surface and endocytosed NPs, which translated in enhanced proteasome inhibition and robust cytotoxic effect on MM cells when BTZ was administered through anti-CD38 chitosan NPs. Furthermore, the anti-CD38 chitosan NPs specifically delivered therapeutic agents to MM cells improving therapeutic efficacy and reducing side effects in vivo. The anti-CD38 chitosan NPs showed low toxicity profile allowing enhancement of proteasome-inhibitory activity and specificity of BTZ by endocytosis-mediated uptake of CD38 representing a promising therapy in MM.

de la Puente, P., B. Muz, A. Jin, F. Azab, M. Luderer, N. N. Salama, and A. K. Azab, "MEK inhibitor, TAK-733 reduces proliferation, affects cell cycle and apoptosis, and synergizes with other targeted therapies in multiple myeloma.", Blood cancer journal, vol. 6, pp. e399, 2016 Feb 26. salama-_blood_cancer_j_2016.pdf
de la Puente, P., N. Fettig, M. J. Luderer, A. Jin, S. Shah, B. Muz, V. Kapoor, S. M. Goddu, N. N. Salama, C. Tsien, et al., "Injectable Hydrogels for Localized Chemotherapy and Radiotherapy in Brain Tumors.", Journal of pharmaceutical sciences, vol. 107, pp. 922-933, 2017 Nov 21, 2018. Abstractj_pharm_sci-_2018.pdf

Overall survival of patients with newly diagnosed glioblastoma (GBM) remains dismal at 16 months with state-of-the-art treatment that includes surgical resection, radiation, and chemotherapy. GBM tumors are highly heterogeneous, and mechanisms for overcoming tumor resistance have not yet fully been elucidated. An injectable chitosan hydrogel capable of releasing chemotherapy (temozolomide [TMZ]) while retaining radioactive isotopes agents (iodine, [131I]) was used as a vehicle for localized radiation and chemotherapy, within the surgical cavity. Release from hydrogels loaded with TMZ or 131I was characterized in vitro and in vivo and their efficacy on tumor progression and survival on GBM tumors was also measured. The in vitro release of 131I was negligible over 42 days, whereas the TMZ was completely released over the first 48 h. 131I was completely retained in the tumor bed with negligible distribution in other tissues and that when delivered locally, the chemotherapy accumulated in the tumor at 10-fold higher concentrations than when delivered systemically. We found that the tumors were significantly decreased, and survival was improved in both treatment groups compared to the control group. Novel injectable chemo-radio-hydrogel implants may potentially improve the local control and overall outcome of aggressive, poor prognosis brain tumors.

Puetz, M., M. Bohrer, S. Mai, M. Polednik, D. Wolff, Y. Abo-Madyan, F. Lohr, and F. Wenz, "Local control of the brain metastases after igSRS (image guided stereotactic radiosurgery) with the Sequential Tomotherapy (MIMiC)", STRAHLENTHERAPIE UND ONKOLOGIE, vol. 186: URBAN & VOGEL NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY, pp. 116–116, 2010. Abstract
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Pushpan, S. K., S. Venkatraman, V. G. Anand, J. Sankar, D. Parmeswaran, S. Ganesan, and T. K. Chandrashekar, "Porphyrins in photodynamic therapy-a search for ideal photosensitizers", Current Medicinal Chemistry-Anti-Cancer Agents, vol. 2, issue 2: Bentham Science Publishers, pp. 187-207, 2002. Abstract
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Pusiol, A., F. Marzona, D. Cucchiaro, L. Castriotta, S. Usai, M. Narduzzi, C. Pilotto, I. Liguoro, R. Tosolini, and E. Passone, "Articles online first", Minerva Pediatrica, 2020. Abstract
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