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determination of ibuprofen in presence of its degradation products, "Performance comparison between monolithic C18 and conventional C18 particle- packed columns in the liquid chromatographic", E.A.Abdullah, 2011. Abstract

Analytical Chemistry: An Indian Journal, (2011)

Procházka, R., A. Bartková, L. Němcová, M. Murín, A. Gad, K. Marcollová, V. Kinterová, A. Lucas-Hahn, and J. Laurinčík, "The Role of MAPK3/1 and AKT in the Acquisition of High Meiotic and Developmental Competence of Porcine Oocytes Cultured In Vitro in FLI Medium", International Journal of Molecular Sciences, vol. 22, no. 20, 2021. AbstractWebsite

The developmental potential of porcine oocytes cultured in vitro was remarkably enhanced in a medium containing FGF2, LIF and IGF1 (FLI) when compared to a medium supplemented with gonadotropins and EGF (control). We analyzed the molecular background of the enhanced oocyte quality by comparing the time course of MAPK3/1 and AKT activation, and the expression of genes controlled by these kinases in cumulus-oocyte complexes (COCs) cultured in FLI and the control medium. The pattern of MAPK3/1 activation in COCs was very similar in both media, except for a robust increase in MAPK3/1 phosphorylation during the first hour of culture in the FLI medium. The COCs cultured in the FLI medium exhibited significantly higher activity of AKT than in the control medium from the beginning up to 16 h of culture; afterwards a deregulation of AKT activity occurred in the FLI medium, which was not observed in the control medium. The expression of cumulus cell genes controlled by both kinases was also modulated in the FLI medium, and in particular the genes related to cumulus-expansion, signaling, apoptosis, antioxidants, cell-to-cell communication, proliferation, and translation were significantly overexpressed. Collectively, these data indicate that both MAPK3/1 and AKT are implicated in the enhanced quality of oocytes cultured in FLI medium.

Probert, P. M., A. C. Leitch, M. P. Dunn, S. K. Meyer, J. M. Palmer, T. M. Abdelghany, A. F. Lakey, M. P. Cooke, H. Talbot, C. Wills, et al., "Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis.", Journal of hepatology, vol. 69, issue 5, pp. 1123-1135, 2018. Abstract

BACKGROUND & AIMS: Primary biliary cholangitis (PBC) is an autoimmune-associated chronic liver disease triggered by environmental factors, such as exposure to xenobiotics, which leads to a loss of tolerance to the lipoic acid-conjugated regions of the mitochondrial pyruvate dehydrogenase complex, typically to the E2 component. We aimed to identify xenobiotics that might be involved in the environmental triggering of PBC.

METHODS: Urban landfill and control soil samples from a region with high PBC incidence were screened for xenobiotic activities using analytical, cell-based xenobiotic receptor activation assays and toxicity screens.

RESULTS: A variety of potential xenobiotic classes were ubiquitously present, as identified by their interaction with xenobiotic receptors - aryl hydrocarbon receptor, androgen receptor and peroxisome proliferator activated receptor alpha - in cell-based screens. In contrast, xenoestrogens were present at higher levels in soil extracts from around an urban landfill. Furthermore, two landfill sampling sites contained a chemical(s) that inhibited mitochondrial oxidative phosphorylation and induced the apoptosis of a hepatic progenitor cell. The mitochondrial effect was also demonstrated in human liver cholangiocytes from three separate donors. The chemical was identified as the ionic liquid [3-methyl-1-octyl-1H-imidazol-3-ium] (M8OI) and the toxic effects were recapitulated using authentic pure chemical. A carboxylate-containing human hepatocyte metabolite of M8OI, bearing structural similarity to lipoic acid, was also enzymatically incorporated into the E2 component of the pyruvate dehydrogenase complex via the exogenous lipoylation pathway in vitro.

CONCLUSIONS: These results identify, for the first time, a xenobiotic in the environment that may be related to and/or be a component of an environmental trigger for PBC. Therefore, further study in experimental animal models is warranted, to determine the risk of exposure to these ionic liquids.

LAY SUMMARY: Primary biliary cholangitis is a liver disease in which most patients have antibodies to mitochondrial proteins containing lipoic acid binding site(s). This paper identified a man-made chemical present in soils around a waste site. It was then shown that this chemical was metabolized into a product with structural similarity to lipoic acid, which was capable of replacing lipoic acid in mitochondrial proteins.

Probasco, W., A. M. Haleem, J. Yu, B. J. Sangeorzan, J. T. Deland, and S. J. Ellis, "Assessment of coronal plane subtalar joint alignment in peritalar subluxation via weight-bearing multiplanar imaging.", Foot & ankle international, vol. 36, issue 3, pp. 302-9, 2015 Mar. Abstract

BACKGROUND: Patients with adult-acquired flatfoot deformity (AAFD) develop peritalar subluxation, which may stem from valgus inclination of the inferior surface of the talus. We hypothesized that patients with AAFD would have an increased valgus tilt of the subtalar joint in the coronal plane compared to controls when assessed with a novel multiplanar weight-bearing imaging (MP-WB).

METHODS: Eighteen normal and 36 stage II AAFD patients scheduled to undergo operative reconstruction were evaluated by MP-WB through measuring 3 novel angles of the subtalar joint in the coronal view: (1) angle between inferior facet of the talus and the horizontal/floor (inftal-hor), (2) angle between inferior and superior facets of the talus (inftal-suptal), and (3) angle between inferior facet of the talus and superior facet of the calcaneus (inftal-supcal). Intra- and interobserver reliability were evaluated via intraclass correlation coefficients (ICCs). Differences in angles between AAFD patients and controls were evaluated using Wilcoxon rank-sum test.

RESULTS: Intra- and interobserver reliability were excellent for inftal-hor (ICC .942 and .991, respectively) and inftal-suptal (ICC .948 and .989, respectively), and moderate-good for inftal-supcal (ICC .604 and .742, respectively). Inftal-hor and inftal-suptal angles were found to be significantly greater in AAFD patients (P < 0.001) at all 3 locations along the posterior subtalar joint, while inftal-supcal did not demonstrate a significant difference (P = .741). While controls exhibited varus orientation at the anterior aspect of the joint, AAFD patients maintained a valgus orientation throughout.

CONCLUSION: Inftal-hor and inftal-suptal angles provided a reliable means of evaluating the orientation of the subtalar joint axis in AAFD via MP-WB, and showed that the subtalar joint had increased valgus orientation in AAFD compared to controls. This may allow for identification of patients at risk for developing AAFD, and could potentially be used in guiding operative reconstruction.

Prince, A., F. H. Khan, B. F. Matthews, N. Islam, and S. S. Natarajan, "TRANSCRIPTOME AND PROTEOME ALTERATIONS DURING THE NEMATODE-SOYBEAN INTERACTION", NEMATROPICA, vol. 44, issue 2, pp. 137-145, 2014. transcriptome_and_proteome_alterations_during_the_nematode-soybean_interaction.pdf
Prince, A. M., and A. F. Tohamy, "Mitochondrial alterations after cadmium-induced oxidative stress in mice brain", the IV Usual Veteriner Farmakoloji ve Toksikoloji kongresi, Turkey, 2013.
Prince, A., M. A. Gad, I. W. Hasani, M. Warda, and A. Elbehairy, "Potential Therapeutic role of Mesenchymal Stem Cell in Delayed Wound Healing of Diabetic Rats", Der Pharmacia Lettre, vol. 8, issue 15, pp. 62-68, 2016. 3._potential_therapeutic_role_of_mesenchymal_stem_cell.pdf
Prieto-Blanco, M. C., N. Jornet-Martínez, Y. Moliner-Martínez, C. Molins-Legua, R. Herráez-Hernández, V. J. Andrés, and P. Campins-Falcó, "Development of a polydimethylsiloxane–thymol/nitroprusside composite based sensor involving thymol derivatization for ammonium monitoring in water samples", Science of The Total Environment, vol. 503–504, pp. 105 - 112, 2015. AbstractWebsite

Abstract This report describes a polydimethylsiloxane (PDMS)-thymol/nitroprusside delivery composite sensor for direct monitoring of ammonium in environmental water samples. The sensor is based on a \{PDMS\} support that contains the Berthelot's reaction reagents. To prepare the PDMS–thymol/nitroprusside composite discs, thymol and nitroprusside have been encapsulated in the \{PDMS\} matrix, forming a reagent release support which significantly simplifies the analytical measurements, since it avoids the need to prepare derivatizing reagents and sample handling is reduced to the sampling step. When, the PDMS–thymol/nitroprusside composite was introduced in water samples spontaneous release of the chromophore and catalyst was produced, and the derivatization reaction took place to form the indothymol blue. Thus, qualitative analysis of NH4+ could be carried out by visual inspection, but also, it can be quantified by measuring the absorbance at 690 nm. These portable devices provided good sensitivity (LOD < 0.4 mg L− 1) and reproducibility (RSD < 10%) for the rapid detection of ammonium. The PDMS–NH4+ sensor has been successfully applied to determine ammonium in water samples and in the aqueous extracts of particulate matter \{PM10\} samples. Moreover, the reliability of the method for qualitative analysis has been demonstrated. Finally, the advantages of the PDMS–NH4+ sensor have been examined by comparing some analytical and complementary characteristics with the properties of well-established ammonium determination methods.

Price, N. E., K. M. Johnson, J. Wang, M. I. Fekry, Y. Wang, and K. S. Gates, "Interstrand DNA-DNA cross-link formation between adenine residues and abasic sites in duplex DNA.", Journal of the American Chemical Society, vol. 136, issue 9, pp. 3483-90, 2014 Mar 5. Abstract

The loss of a coding nucleobase from the structure of DNA is a common event that generates an abasic (Ap) site (1). Ap sites exist as an equilibrating mixture of a cyclic hemiacetal and a ring-opened aldehyde. Aldehydes are electrophilic functional groups that can form covalent adducts with nucleophilic sites in DNA. Thus, Ap sites present a potentially reactive aldehyde as part of the internal structure of DNA. Here we report evidence that the aldehyde group of Ap sites in duplex DNA can form a covalent adduct with the N(6)-amino group of adenine residues on the opposing strand. The resulting interstrand DNA-DNA cross-link occurs at 5'-ApT/5'-AA sequences in remarkably high yields (15-70%) under physiologically relevant conditions. This naturally occurring DNA-templated reaction has the potential to generate cross-links in the genetic material of living cells.

Priatmoko, S., M. Kabil, Y. Purwoko, and L. D. Dávid, "Rethinking {Sustainable} {Community}-{Based} {Tourism}: {A} {Villager}'s {Point} of {View} and {Case} {Study} in {Pampang} {Village}, {Indonesia}", Sustainability, vol. 13, no. 6, pp. 1–15, 2021. Abstract

Community-based tourism (CBT) considers one sustainable form of tourism to enhance tourists' and local communities' relationships. By investigating and studying the previous scientific production of the CBT field in general and, in particular, rural CBT, the researchers found that the local communities' roles in shaping this type of tourism have been given great importance. This literature mainly focuses on rural CBT from the academic researcher's perspective. This study aimed to understand the villager's view on rural sustainable CBT in Pampang Village, Indonesia. In our research, we used the triangulation method based on three kinds of data: in-depth structured interviews, non-participant field observations, and quantitative sustainability aspects of the local attractions. The research results helped us design a model for the formation of sustainable rural CBT activities in Indonesia, which depends on formal and informal leader figures in the community instead of only the community's solidarity, as much previous research has indicated.

Priatmoko, S., M. Kabil, V. László, E. I. Pallás, and L. D. Dávid, "Reviving an unpopular tourism destination through the placemaking approach: {Case} study of {Ngawen} temple, {Indonesia}", Sustainability (Switzerland), vol. 13, no. 12, 2021. Abstract

Changes in tourists' behavior in recent times have been considered a driving force for emphasizing the importance of unpopular tourism destinations as one of the key potentials in the tourism industry in any nation. On the road to reviving unpopular tourism destinations, this study aims to identify the potential tourism aspect and development of the Ngawen Temple in Indonesia. This research applies the placemaking approach as the main strategy for resurrecting Ngawen Temple. By using visitor surveys, visitor flows, and community surveys, this research obtains a clearer assessment for determining the planning development of Ngawen Temple. The research results revealed that unpopular destinations still have the potential to be developed and bring more benefits to the local economy by conducting a comprehensive placemaking approach. Accordingly, possible strategies based on various literature and field observations can provide clues to stakeholders on how to use their tourism assets to improve local communities' economies. Some of the most frequently proposed strategies are the following: link the unpopular destination with other popular ones through structured tourism trips; design a “tourist trap,” which is a created place to hold tourists longer in a destination using new additional facilities; improve the infrastructure; and establish more creative tourism spaces, such as tourism centers.

Preston, J. R., J. R. San Sebastian, and A. F. McFee, "The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents", Mutation Research/Genetic Toxicology, vol. 189, issue 2: Elsevier, pp. 175-183, 1987. Abstract
Pressman, R. S., Software {Engineering} - {A} {Practitioner}'s {Approach}, , 2nd, Singapore, McGraw-Hill, 1992. Abstract
Pressman, R. G., Software {Engineering} - {A} {Practitioner}'s {Approach}, , 3rd (European), New York, McGraw-Hill, 1994. Abstract
Prendes, R. G., C. Ginja, J. Kantanen, N. Ghanem, D. R. Kugonza, M. L. Makgahlela, M. A. M. Groenen, and R. P. M. A. Crooijmans, "Integrative QTL mapping and selection signatures in Groningen White Headed cattle inferred from whole-genome sequences", Plos One , vol. 17, pp. e0276309-e0276328, 2022.
Preedy, V. R., R. Rajendram, and C. R. Martin, "Metabolism and Pathophysiology of Bariatric Surgery Nutrition, Procedures, Outcomes, and Adverse Effects", Metabolism and Pathophysiology of Bariatric Surgery Nutrition, Procedures, Outcomes, and Adverse Effects, London, Elsevier Inc., 2016.
Prats-Uribe, A., A. G. Sena, L. Y. H. Lai, W. - U. - R. Ahmed, H. Alghoul, O. Alser, T. M. Alshammari, C. Areia, W. Carter, P. Casajust, et al., "Use of repurposed and adjuvant drugs in hospital patients with covid-19: multinational network cohort study.", BMJ (Clinical research ed.), vol. 373, pp. n1038, 2021. Abstract

OBJECTIVE: To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents.

DESIGN: Multinational network cohort study.

SETTING: Hospital electronic health records from the United States, Spain, and China, and nationwide claims data from South Korea.

PARTICIPANTS: 303 264 patients admitted to hospital with covid-19 from January 2020 to December 2020.

MAIN OUTCOME MEASURES: Prescriptions or dispensations of any drug on or 30 days after the date of hospital admission for covid-19.

RESULTS: Of the 303 264 patients included, 290 131 were from the US, 7599 from South Korea, 5230 from Spain, and 304 from China. 3455 drugs were identified. Common repurposed drugs were hydroxychloroquine (used in from <5 (<2%) patients in China to 2165 (85.1%) in Spain), azithromycin (from 15 (4.9%) in China to 1473 (57.9%) in Spain), combined lopinavir and ritonavir (from 156 (<2%) in the VA-OMOP US to 2,652 (34.9%) in South Korea and 1285 (50.5%) in Spain), and umifenovir (0% in the US, South Korea, and Spain and 238 (78.3%) in China). Use of adjunctive drugs varied greatly, with the five most used treatments being enoxaparin, fluoroquinolones, ceftriaxone, vitamin D, and corticosteroids. Hydroxychloroquine use increased rapidly from March to April 2020 but declined steeply in May to June and remained low for the rest of the year. The use of dexamethasone and corticosteroids increased steadily during 2020.

CONCLUSIONS: Multiple drugs were used in the first few months of the covid-19 pandemic, with substantial geographical and temporal variation. Hydroxychloroquine, azithromycin, lopinavir-ritonavir, and umifenovir (in China only) were the most prescribed repurposed drugs. Antithrombotics, antibiotics, H2 receptor antagonists, and corticosteroids were often used as adjunctive treatments. Research is needed on the comparative risk and benefit of these treatments in the management of covid-19.

Prastowo, S., A. Amin, F. Rings, E. Held, S. D. Wondim, G. A. E, C. Neuhoff, E. Tholen, C. Looft, K. Schellander, et al., "Fateful triad of reactive oxygen species, mitochondrial dysfunction and lipid accumulation is associated with expression outline of the AMP-activated protein kinase pathway in bovine blastocysts", Reproduction, Fertility and Development, vol. 29 , pp. 890-905, 2016.
Prastowo, S., A. Amin, F. Rings, E. Held, S. D. Wondim, A. Gad, C. Neuhoff, E. Tholen, C. Looft, K. Schellander, et al., "Fateful triad of reactive oxygen species, mitochondrial dysfunction and lipid accumulation is associated with expression outline of the AMP-activated protein kinase pathway in bovine blastocysts", Reproduction, Fertility and Development, vol. 29, issue 5: CSIRO PUBLISHING, pp. 890-905, 2017. Abstract


Prastowo, S., A. Amin, and M. H. Sohel, "Identifying Candidate MicroRNAs in MicroRNA-AMPK Gene Interaction Regulating Lipid Accumulation of Bovine Granulosa Cell Luteinization: An In Silico Study‏", Proceeding of the 1st International Conference on Tropical Agriculture, Yogyakarta, Indonesia, 29August 431-438, 2017.
Pramiti, T. T., M. A. Moharram, and A. A. Kishk, "Geometry perturbation of dielectric resonator for same frequency operation as radiator and filter", General Assembly and Scientific Symposium of the International Union of Radio Science (URSI GASS), 2017 XXXIInd, pp. 1-3, 2017. Abstract
Prabu, P., K. Venkatachalam, A. S. Alluhaidan, R. Marzouk, M. Hadjouni, and S. A. El_Rahman, "Covid-19 CT Lung Image Segmentation Using Adaptive Donkey and Smuggler Optimization Algorithm", Computers, Materials & Continua, vol. 71, issue 1, pp. 1133-1152, 2022.
Poznyak, A. S., H. Alazki, H. M. Soliman, and R. Ahshan, "Ellipsoidal Design of Robust Stabilization of Power Systems Exposed to a Cycle of lightning Surges Modeled by Continuous-Time Markov Jumps", energies, vol. 16, issue 1, pp. art. no. 414, 2023.