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Kamel, A. M., N. M. El-Sharkawy, R. Othman, and E. Kandeel, "Adhesion molecules expression in CLL: Potential impact on clinical and hematological parameters", Journal of the Egyptian National Cancer Institute, vol. 28, issue 1, 2016. adhesion_molecules_expression_in_cll_potential_impact_on_clinical_and_hematological_parameters.pdf
Kamel, A. M., N. M. El-Sharkawy, R. A. Osman, E. K. Abd El-Fattah, E. El-Noshokaty, T. A. El-Hamid, and E. Z. Kandeel, "Adhesion molecules expression in CLL: Potential impact on clinical and hematological parameters.", Journal of the Egyptian National Cancer Institute, vol. 28, issue 1, pp. 31-7, 2016. Abstract

BACKGROUND: B-cell chronic lymphocytic leukemia (CLL) is marked by the accumulation of CD5+ B lymphocytes within the blood, bone marrow (BM), and secondary lymphoid tissues. Abnormalities in the expression and function of cell adhesion molecules may account for the patterns of intra-nodal growth and hematogenous spread of the malignant cells. Chemokines and integrin-mediated adhesion and trans-endothelial migration (TEM) are central aspects in trafficking and retention of hematopoietic cells in the BM and lymphoid organs.

AIM OF THE WORK: This work was conducted to study adhesion molecules status in CLL and its potential impact on both hematological and clinical parameters.

PATIENTS AND METHODS: The study included 78 newly diagnosed CLL patients. Immunophenotyping was performed on peripheral blood using the chronic lymphoid panel. Adhesion molecules (CD11a, CD11b, CD49d, CD49C, CD29 and CD38) were tested using monoclonal antibodies and analyzed by Flow Cytometry.

RESULTS: Positive correlation was encountered between adhesion molecules: CD38 with CD49d (r=0.25, p=0.028), CD11a with CD11b, CD49d and CD29 (r=0.394, p=0.001; r=0.441, p=<0.01 and r=0.446, p<0.01 respectively) and CD29 with CD49c and CD49d (r=0.437, p<0.01; r=0.674, p<0.01 respectively). CD49c showed negative correlation with Rai staging (r=-0.269, p=0.033). CD11a and CD29 showed a significant relation with splenomegaly (p=0.04 and 0.03 respectively) and CD49d showed a significant relation with lymphadenopathy (p=0.02).

CONCLUSION: The level of different adhesion molecules expression in CLL is apparently reflected on the potential migratory behavior of the leukemic cells to different organs.

Othman, S. H., M. A. Sohsah, M. M. Ghoneim, H. H. Sokkar, S. M. Badawy, and B. E. El-Anadouli, "Adsorption of hazardous ions from radioactive waste on chelating cloth filter", Radiation Physics and Chemistry, vol. 75, no. 2: Elsevier, pp. 278–285, 2006. Abstract
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Darwish A, S. M, A. N, and G. O, "Adult biphenotypic acute leukemia: the Egyptian national cancer institute experience. ", The 21st Congress of the European Hematology Association (EHA) , Denmark, Haematologica, 101:p 680-681: Abst. PB1666. , pp. 680-681, 2016.
Mesraoua, B., M. Abbas, A. D'Souza, F. R. Miyares, M. Hashem, Y. Osman, and D. Deleu, "Adult opsoclonus-myoclonus syndrome following Mycoplasma pneumoniae infection with dramatic response to plasmapheresis.", Acta neurologica Belgica, vol. 111, issue 2, pp. 136, 2011. Abstract
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Ahmed, M. A., N. Okasha, and N. G. Imam, "Advanced imaging techniques for characterization of 0.5BaTiO 3/0.5Ni0.5Zn0.5Fe2O4 multiferroic nanocomposite", Journal of Alloys and Compounds, vol. 557, pp. 130 - 141, 2013. AbstractWebsite

New techniques are used to synthesis and characterize 0.5BaTiO 3/0.5Ni0.5Zn0.5Fe2O4; (BTO/NZF) multiferroic nanocomposite. Improved citrate autocombustion preparation technique is used to synthesis ferromagnetic and ferroelectric phases of the investigated nanocomposite. Atomic force microscope (AFM) is one of the important tools for imaging, measuring, and manipulating matter at the nanoscale. AFM is used at different sample areas to confirm the data obtained from scanning electron microscope (SEM) and transmission electron microscope (TEM). Moreover AFM gives 3D visualization for the surface texture and roughness showing the morphology of the two distinguishes phases. The traditional characterizations techniques have been used such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) to identify the formation of the two individual phases separately and to study the chemical composition of the prepared nanocomposite respectively. © 2013 Elsevier B.V. All rights reserved.

Nadi, L. E., A. A. Fetouh, G. A. Mehana, H. Imam, H. A. Moniem, K. E. A. Sayed, and M. M. Omar, "Advanced Laboratory for High Density Physics (ALHDP)", Modern Trends in Physics Research, World Scientific, Cairo, Egypt, pp. 182-187 , 2013.
Lazarus, J. V., H. E. Mark, Q. M. Anstee, J. P. Arab, R. L. Batterham, L. Castera, H. Cortez-Pinto, J. Crespo, K. Cusi, A. M. Dirac, et al., "Advancing the global public health agenda for NAFLD: a consensus statement.", Nature reviews. Gastroenterology & hepatology, vol. 19, issue 1, pp. 60-78, 2022. Abstract

Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver disease that affects approximately one-quarter of the global adult population, causing a substantial burden of ill health with wide-ranging social and economic implications. It is a multisystem disease and is considered the hepatic component of metabolic syndrome. Unlike other highly prevalent conditions, NAFLD has received little attention from the global public health community. Health system and public health responses to NAFLD have been weak and fragmented, and, despite its pervasiveness, NAFLD is largely unknown outside hepatology and gastroenterology. There is only a nascent global public health movement addressing NAFLD, and the disease is absent from nearly all national and international strategies and policies for non-communicable diseases, including obesity. In this global Delphi study, a multidisciplinary group of experts developed consensus statements and recommendations, which a larger group of collaborators reviewed over three rounds until consensus was achieved. The resulting consensus statements and recommendations address a broad range of topics - from epidemiology, awareness, care and treatment to public health policies and leadership - that have general relevance for policy-makers, health-care practitioners, civil society groups, research institutions and affected populations. These recommendations should provide a strong foundation for a comprehensive public health response to NAFLD.

Koeck, J., Y. Abo-Madyan, S. Olms-Hofmann, F. Stieler, F. Wenz, H. Etch, and F. Lohr, "Advantages of Intensity-Modulated Therapy (IMRT) & reduction of target volume in treatment of mediastinal Hodgkin Lymphoma (HL): A planning study analyzing 3D-RT vs. IMRT & Involved Field (IF) vs. Involved Node (IN)", STRAHLENTHERAPIE UND ONKOLOGIE, vol. 186: URBAN & VOGEL NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY, pp. 76–76, 2010. Abstract
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Attia, D., K. Elsaeed, W. Elakel, T. Elbaz, A. Omar, A. Yosry, M. H. Elsayed, M. Said, M. El Raziky, M. Anees, et al., "The adverse effects of interferon-free regimens in 149 816 chronic hepatitis C treated Egyptian patients.", Alimentary pharmacology & therapeutics, vol. 47, issue 9, pp. 1296-1305, 2018. Abstract

BACKGROUND: Interferon-free regimens are associated with high sustained virological response; however, associated adverse effects have yet to be fully reported.

AIM: To evaluate the adverse effects associated with the different direct-acting antiviral drug (DAA) regimens in Egyptian patients.

METHODS: This multicenter retrospective study included all adverse effects during and after treatment with DAA regimens of 149 816 chronic hepatitis C treated Egyptian patients. Patients received sofosbuvir (SOF)/ribavirin (RBV) (n = 21 835), SOF/simeprevir (n = 24 215) SOF/daclatasvir (DCV) (n = 58 477), SOF/DCV/RBV (n = 45 188) and paritaprevir/ombitasvir/ritonavir/RBV (n = 101). The duration of treatment varied between 12 and 24 weeks. All changes in the treatment regimens, discontinuation, mortality, and serious side effects were reported.

RESULTS: Adverse effects developed in 2475 (1.7%) (mean age [54 ± 9], male gender [53%]) patients. Serious side effects developed in 68% of these patients, and SOF/RBV was the most common causing regimen (73%, P < 0.001). Anaemia and hyperbilirubinemia were the most common side effects (731/149816, 0.5% and 463/149816, 0.3%, respectively) and SOF/RBV (588/21835, 3% and 353/21835, 1.6%, respectively) showed the highest incidence in the treated patients. Hepatocellular carcinoma and mortality were reported in 0.02% and 0.06% of all treated patients, respectively. Patients with liver cirrhosis showed higher incidence of serious side effects (Log rank P = 0.045) and mortality (Log rank P = 0.025) than patients without liver cirrhosis. Male gender (P = 0.012), lower haemoglobin (P < 0.001), platelets (P < 0.001) and albumin (P = 0.001), higher bilirubin (P = 0.002) and cirrhosis (P < 0.001) were factors associated with serious side effects development.

CONCLUSION: Adverse effects associated with DAAs are few, anaemia being the most common. SOF/RBV regimen showed the highest rate of side effects while SOF/DCV showed the least.

Osman, M., J. Chávez, and K. Venayagamoorthy, "Aerodynamic Methods for Estimating Turbulent Fluxes Over Irrigated Crops", AGU Hydrology Days, 2017. Abstract
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Mudawi, H. M. Y., S. S. Fedail, M. McHembe, N. B. Hadj, I. Mostafa, M. Kagimu, W. Sweidan, A. M. Moussa, O. S. Ojo, M. B. Redae, et al., "The African Middle Eastern Society for Digestive Oncology mission against viral hepatitis and hepatocellular carcinoma.", Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, vol. 14, issue 1, pp. 31-3, 2013 Mar. Abstract
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NH, A., A. - E. OM, B. DM, E. Salem, G. E, E. M, and I. AS, "Age at diagnosis in women with non-metastatic breast cancer: Is it related to prognosis", JENCI, vol. 26, pp. 23-30, 2014.
Towab, A. S. M. A., E. A. W. Khalil, Z. A. H. Osman, and Z. Mokhtar, "Age Differences in Physical and Emotional Reactivity to Daily Stressors among Psychiatric Nurses", . Journal of American Science, vol. 8, issue 12, pp. 1501-1507, 2012. Abstract

Stressors encountered in daily life aspects, such as home, and work may increase
physical and emotional reactivity to stress especially in persons working in the
nursing field. Characteristics of the individual as age may limit or increase his
reactivity to daily stressors. The aim of this study is to examine the age differences in
physical and emotional reactivity to daily stressors among nurses working in AlAbbassia
Mental Health Hospital. A descriptive correlational design was utilized for
the current study. Sample of convenience of 100 psychiatric nurses working in AlAbbassia
Mental Health Hospital were divided into two groups "middle age group"
and "young age group". Four tools were utilized in the current study including sociodemographic
Data Sheet, Daily Stressors Scale, Physical Symptoms of Stress Scale,
and Psychological Distress Scale. The results showed that: middle adult group of
nurses reported physical and emotional reactivity to daily stress less than younger
adult group of nurses. The study concludes that, age plays an important role in
controlling emotional and physical reactivity to stress amongnurses working in AlAbbassia
Mental Health Hospital. Further investigation is needed to examine age
groups' difference to stress, as well as, other factors that may be influential in stress
development.

Towab, A., A. S. M. Khalil, E. A. W. Osman, and Z. Mokhtar, "Age Differences in Reactivity to Daily Stressors: The Role of Personal Control", Journal of American Science, vol. 8, issue 12, 2012. cu_pdf.pdf
Okasha, A., and C. Johnson, "Agent-based computational economics: Studying the effect of different levels of rationality on inflation and unemployment", 2009 IEEE Symposium on Computational Intelligence for Financial Engineering: IEEE, pp. 20–27, 2009. Abstract
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Elnawawy M, S., A. E. Okasha, and H. A. Hosny, "Agent-based models of administrative corruption: an overview", International Journal of Modelling and Simulation: Taylor & Francis, pp. 1–9, 2021. Abstract
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Osman, H., "Agent-based simulation of urban infrastructure asset management activities", Automation in Construction, vol. 28: Elsevier, pp. 45–57, 2012. Abstract
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Dufva, O., M. Kankainen, T. Kelkka, N. Sekiguchi, S. Adnan Awad, S. Eldfors, B. Yadav, H. Kuusanmäki, D. Malani, E. I. Andersson, et al., "Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target", Nature communications, vol. 9, no. 1: Nature Publishing Group, pp. 1–12, 2018. Abstract
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Abdelaziz, A. O., D. Omran, M. M. Nabil, T. Elbaz, A. Abdelmaksoud, I. El Attar, and H. Shousha, "Aggressive Treatment of Performance Status 1 and 2 HCC Patients Significantly Improves Survival - an Egyptian Retrospective Cohort Study of 524 Cases.", Asian Pac J Cancer Prev. , vol. 17, issue 5, pp. 2539-43., 2016.
Abdelaziz, A. O., D. Omran, M. M. Nabeel, T. M. Elbaz, A. H. Abdelmaksoud, I. El Attar, and H. I. Shousha, "Aggressive Treatment of Performance Status 1 and 2 HCC Patients Significantly Improves Survival - an Egyptian Retrospective Cohort Study of 524 Cases.", Asian Pacific journal of cancer prevention : APJCP, vol. 17, issue 5, pp. 2539-43, 2016. Abstract

BACKGROUND: In the Barcelona Clinic Liver Cancer (BCLC) system, only sorafenib is suggested for HCC patients having performance status (PS) 1 or 2 even if they have treatable lesions. In the current study, we aimed to explore the outcome of using aggressive treatment for HCC patients with PS 1 and 2.

MATERIALS AND METHODS: Five hundred and twenty four patients with HCC were enrolled in this study and divided into 2 groups: 404 PS 1 and 120 PS 2. Of the included 524 patients, 136 recceived non-aggressive supportive treatment and sorafenib, while 388 patients were offered aggressive treatment in the form of surgical resection, transplantation, percutaneous ablation, trans-arterial chemoembolization and/or chemoperfusion. All the patients were followed up for a period of 2 years to determine their survival.

RESULTS: Most HCC patients were CHILD A and B grades (89.4% versus 85.0%, for PS1 and PS2, respectively). Patients with PS1 were significantly younger. Out of the enrolled 524 patients, 388 were offered aggressive treatment, 253 (65.2%) having their lesions fully ablated, 94 (24.2%) undergoing partial ablation and 41 patients with no ablation (10.6%). The median survival of the patients with PS 1 who were offered aggressive treatment was 20 months versus 9 months only for those who were offered supportive treatment and sorafenib (<0.001). Regarding HCC patients with PS 2, the median survivals were similarly 19.7 months versus 8.7 months only (<0.001).

CONCLUSIONS: Aggressive treatment of HCC patients with PS 1 and 2 significantly improves their survival. Revising the BCLC guidelines regarding such patients is recommended.

Calafiore, A. M., A. L. Iaco, H. Kheirallah, A. A. Sheikha, H. A. Sayed, M. E. Rasheed, A. Allam, M. O. Awadi, J. J. Alfonso, A. A. Osman, et al., "Ahmed AbdEl-Razek Osman", International Journal of Cardiology, vol. 241, pp. 103-108, 2017. Severe ischemic cardiomyopathy with mechanical complications: Still a surgical disease
Calafiore, A. M., S. Prapas, A. Osman, and M. D. Mauro, "Ahmed AbdEl-Razek Osman", Annals of Translational Medicine., vol. 5, pp. 168, 2017. Coronary artery bypass grafting off-pump or on-pump: another brick in the wall
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